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The map label for this gene is msrA

Identifier: 145296930

GI number: 145296930

Start: 3143982

End: 3144635

Strand: Reverse

Name: msrA

Synonym: cgR_2830

Alternate gene names: 145296930

Gene position: 3144635-3143982 (Counterclockwise)

Preceding gene: 145296932

Following gene: 145296929

Centisome position: 94.88

GC content: 54.89

Gene sequence:

>654_bases
ATGGCATGGTTTTTCGCACCCGAACCCGTGATGGTTACCGCTGATGAGGCGCTTAAAGGTGGCAGGCATCCTGTTCTAGA
AAATCCTGCGCCACACACTGTGCTGGGCACTCCTGTAACTGGTCCGTGGAAAGAAGGCCAGCAGCGAATTTGGATTGGCC
TTGGTTGTTTCTGGGGTGTGGAGCAAATGTATTGGCAGATGGATGGCGTTGAGGGAACTTCGGTTGGTTACGCCGGCGGT
TTCACCCCTAATCCCACTTATCGCGAGGTGTGTTCTGGGCGCACCGGCCACACTGAAATCGTGGAGGTTGTTTACGATCC
TTCGAAGATTTCTCTCGAGCAGCTTGTTGCCCGCGGTCTGGAAGCACACGATCCGACTCAGGGTTTCCGCCAGGGTAATG
ATGTGGGAACGCAGTACCGCTCTGCTTATTACACTGAGAACGAAGAGGACGCTGCGCGCGTAAAAGCCGTGGTCGATGCC
TATGGTGAGACGCTGAAACAGCACGGTTTCGGTGAAATCACCACGGAAATCGGTGTCATCAGCCCGTCTGAGTACTTCCT
CGCCGAGGATTACCACCAGCAATACCTGGACAAGAATCCTGACGGCTACTGCCCTCACCATTCCACGGGCATTCCGTGCG
GGGTAGAAGCTTAA

Upstream 100 bases:

>100_bases
CTATTTATCGGGTAGCTGGTCACAAACCCGGAATAATCGGCAGCTGAGTAGGGTTGTAGGTCATAAGGCTTCCTCAATTT
TTGAAAGGAACATTCCTGTT

Downstream 100 bases:

>100_bases
AAGATTTTTGCTTTTCGACGCCTCCCTCCACCTCGGATTACGCTTGGGGCATGACTATCTCCGCGATCCTTTCCGACCTG
GACAACACGCGTAGCTACCG

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase

Number of amino acids: Translated: 217; Mature: 216

Protein sequence:

>217_residues
MAWFFAPEPVMVTADEALKGGRHPVLENPAPHTVLGTPVTGPWKEGQQRIWIGLGCFWGVEQMYWQMDGVEGTSVGYAGG
FTPNPTYREVCSGRTGHTEIVEVVYDPSKISLEQLVARGLEAHDPTQGFRQGNDVGTQYRSAYYTENEEDAARVKAVVDA
YGETLKQHGFGEITTEIGVISPSEYFLAEDYHQQYLDKNPDGYCPHHSTGIPCGVEA

Sequences:

>Translated_217_residues
MAWFFAPEPVMVTADEALKGGRHPVLENPAPHTVLGTPVTGPWKEGQQRIWIGLGCFWGVEQMYWQMDGVEGTSVGYAGG
FTPNPTYREVCSGRTGHTEIVEVVYDPSKISLEQLVARGLEAHDPTQGFRQGNDVGTQYRSAYYTENEEDAARVKAVVDA
YGETLKQHGFGEITTEIGVISPSEYFLAEDYHQQYLDKNPDGYCPHHSTGIPCGVEA
>Mature_216_residues
AWFFAPEPVMVTADEALKGGRHPVLENPAPHTVLGTPVTGPWKEGQQRIWIGLGCFWGVEQMYWQMDGVEGTSVGYAGGF
TPNPTYREVCSGRTGHTEIVEVVYDPSKISLEQLVARGLEAHDPTQGFRQGNDVGTQYRSAYYTENEEDAARVKAVVDAY
GETLKQHGFGEITTEIGVISPSEYFLAEDYHQQYLDKNPDGYCPHHSTGIPCGVEA

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family

Homologues:

Organism=Homo sapiens, GI6912516, Length=205, Percent_Identity=48.780487804878, Blast_Score=193, Evalue=1e-49,
Organism=Homo sapiens, GI208609995, Length=184, Percent_Identity=50.5434782608696, Blast_Score=188, Evalue=3e-48,
Organism=Homo sapiens, GI208609993, Length=122, Percent_Identity=50, Blast_Score=120, Evalue=7e-28,
Organism=Escherichia coli, GI1790665, Length=191, Percent_Identity=48.6910994764398, Blast_Score=168, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17533973, Length=150, Percent_Identity=36.6666666666667, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6320881, Length=169, Percent_Identity=37.8698224852071, Blast_Score=102, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24664627, Length=146, Percent_Identity=34.9315068493151, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI45553131, Length=144, Percent_Identity=34.7222222222222, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24664631, Length=146, Percent_Identity=33.5616438356164, Blast_Score=67, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MSRA_CORGB (A4QHY3)

Other databases:

- EMBL:   AP009044
- RefSeq:   YP_001139751.1
- ProteinModelPortal:   A4QHY3
- SMR:   A4QHY3
- STRING:   A4QHY3
- GeneID:   4993034
- GenomeReviews:   AP009044_GR
- KEGG:   cgt:cgR_2830
- eggNOG:   COG0225
- HOGENOM:   HBG748152
- OMA:   QETSFEQ
- ProtClustDB:   PRK00058
- HAMAP:   MF_01401
- InterPro:   IPR002569
- Gene3D:   G3DSA:3.30.1060.10
- TIGRFAMs:   TIGR00401

Pfam domain/function: PF01625 PMSR; SSF55068 MsrA

EC number: =1.8.4.11

Molecular weight: Translated: 23945; Mature: 23814

Theoretical pI: Translated: 4.48; Mature: 4.48

Prosite motif: NA

Important sites: ACT_SITE 56-56

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAWFFAPEPVMVTADEALKGGRHPVLENPAPHTVLGTPVTGPWKEGQQRIWIGLGCFWGV
CCCEECCCCEEEECHHHHCCCCCCCCCCCCCCCEECCCCCCCCCCCCEEEEEECHHHHHH
EQMYWQMDGVEGTSVGYAGGFTPNPTYREVCSGRTGHTEIVEVVYDPSKISLEQLVARGL
HHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHCCC
EAHDPTQGFRQGNDVGTQYRSAYYTENEEDAARVKAVVDAYGETLKQHGFGEITTEIGVI
CCCCCHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHEEEEC
SPSEYFLAEDYHQQYLDKNPDGYCPHHSTGIPCGVEA
CCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AWFFAPEPVMVTADEALKGGRHPVLENPAPHTVLGTPVTGPWKEGQQRIWIGLGCFWGV
CCEECCCCEEEECHHHHCCCCCCCCCCCCCCCEECCCCCCCCCCCCEEEEEECHHHHHH
EQMYWQMDGVEGTSVGYAGGFTPNPTYREVCSGRTGHTEIVEVVYDPSKISLEQLVARGL
HHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHCCC
EAHDPTQGFRQGNDVGTQYRSAYYTENEEDAARVKAVVDAYGETLKQHGFGEITTEIGVI
CCCCCHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHEEEEC
SPSEYFLAEDYHQQYLDKNPDGYCPHHSTGIPCGVEA
CCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA