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The map label for this gene is fba [H]

Identifier: 145296763

GI number: 145296763

Start: 2951905

End: 2952939

Strand: Reverse

Name: fba [H]

Synonym: cgR_2667

Alternate gene names: 145296763

Gene position: 2952939-2951905 (Counterclockwise)

Preceding gene: 145296764

Following gene: 145296762

Centisome position: 89.1

GC content: 56.71

Gene sequence:

>1035_bases
ATGCCTATCGCAACTCCCGAGGTCTATAACGAGATGCTCGATCGTGCTAAGGAAGGCGGATTCGCCTTCCCAGCCATCAA
CTGCACCTCCTCGGAAACCATCAACGCAGCTCTCAAGGGCTTCGCAGAGGCTGAATCTGACGGAATCATCCAGTTCTCCA
CCGGTGGTGCAGAGTTCGGTTCCGGCCTGGCGGTAAAGAACAAGGTCAAGGGCGCAGTTGCGCTTGCAGCCTTCGCCCAC
GAGGCAGCAAAGAGCTACGGCATCAACGTTGCTCTGCACACTGACCACTGCCAGAAGGAAGTCCTGGACGAGTACGTCCG
CCCACTGCTGGCTATCTCCCAGGAGCGCGTCGACCGCGGCGAGCTTCCACTGTTCCAGTCCCACATGTGGGATGGTTCCG
CTGTCCCAATCGACGAGAACCTCGAAATCGCACAGGAGCTGCTGGCTAAGGCCAAAGCAGCGAACATCATCTTGGAAGTT
GAGATCGGTGTTGTCGGTGGCGAAGAAGACGGCGTTGAGGCTAAGGCTGGCGCAAACCTCTACACCTCCCCAGAAGACTT
CGAGAAGACCATCGATGCAATCGGCACCGGTGAGAAGGGCCGCTACCTGCTAGCAGCTACCTTCGGTAACGTCCACGGCG
TTTACAAGCCAGGCAACGTCAAGCTGCGCCCAGAGGTCCTCCTTGAGGGCCAGCAGGTTGCACGCAAGAAGCTTGGACTT
GCAGACGACGCACTTCCATTCGACTTCGTCTTCCACGGTGGCTCAGGCTCCGAGAAGGAAAAGATCGAAGAGGCGCTGAC
CTACGGCGTCATCAAGATGAACGTTGATACTGACACCCAGTACGCATTCACCCGCCCAATCGTCTCCCACATGTTTGAGA
ACTACAACGGCGTTCTCAAGATCGACGGCGAGGTCGGAAACAAGAAGGCTTACGACCCACGCTCTTACATGAAGAAGGCT
GAGCAGAGCATGTCTGAGCGCATCATCGAGTCTTGCCAGGACCTCAAGTCTGTTGGAAAGACCACCGCTAAGTAA

Upstream 100 bases:

>100_bases
ATTGTGAATGTGGGATTATCGGTTCGCGCTTCACCATGTTTCTGCATGATGAAATTACATACATAGTTCAGTGACAGTCA
CCTTTTGGAGGAGACACCTT

Downstream 100 bases:

>100_bases
TCTCAGCAGTAAAAAAGGGCAGTTCCGCATCAGGGGGACTGCCCTTTTTCGTGTCTTCTCATGCTCTTGTGAATATGCAT
AGCTAATCTTGAGGCCATGG

Product: fructose-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase [H]

Number of amino acids: Translated: 344; Mature: 343

Protein sequence:

>344_residues
MPIATPEVYNEMLDRAKEGGFAFPAINCTSSETINAALKGFAEAESDGIIQFSTGGAEFGSGLAVKNKVKGAVALAAFAH
EAAKSYGINVALHTDHCQKEVLDEYVRPLLAISQERVDRGELPLFQSHMWDGSAVPIDENLEIAQELLAKAKAANIILEV
EIGVVGGEEDGVEAKAGANLYTSPEDFEKTIDAIGTGEKGRYLLAATFGNVHGVYKPGNVKLRPEVLLEGQQVARKKLGL
ADDALPFDFVFHGGSGSEKEKIEEALTYGVIKMNVDTDTQYAFTRPIVSHMFENYNGVLKIDGEVGNKKAYDPRSYMKKA
EQSMSERIIESCQDLKSVGKTTAK

Sequences:

>Translated_344_residues
MPIATPEVYNEMLDRAKEGGFAFPAINCTSSETINAALKGFAEAESDGIIQFSTGGAEFGSGLAVKNKVKGAVALAAFAH
EAAKSYGINVALHTDHCQKEVLDEYVRPLLAISQERVDRGELPLFQSHMWDGSAVPIDENLEIAQELLAKAKAANIILEV
EIGVVGGEEDGVEAKAGANLYTSPEDFEKTIDAIGTGEKGRYLLAATFGNVHGVYKPGNVKLRPEVLLEGQQVARKKLGL
ADDALPFDFVFHGGSGSEKEKIEEALTYGVIKMNVDTDTQYAFTRPIVSHMFENYNGVLKIDGEVGNKKAYDPRSYMKKA
EQSMSERIIESCQDLKSVGKTTAK
>Mature_343_residues
PIATPEVYNEMLDRAKEGGFAFPAINCTSSETINAALKGFAEAESDGIIQFSTGGAEFGSGLAVKNKVKGAVALAAFAHE
AAKSYGINVALHTDHCQKEVLDEYVRPLLAISQERVDRGELPLFQSHMWDGSAVPIDENLEIAQELLAKAKAANIILEVE
IGVVGGEEDGVEAKAGANLYTSPEDFEKTIDAIGTGEKGRYLLAATFGNVHGVYKPGNVKLRPEVLLEGQQVARKKLGLA
DDALPFDFVFHGGSGSEKEKIEEALTYGVIKMNVDTDTQYAFTRPIVSHMFENYNGVLKIDGEVGNKKAYDPRSYMKKAE
QSMSERIIESCQDLKSVGKTTAK

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1789293, Length=339, Percent_Identity=39.8230088495575, Blast_Score=242, Evalue=2e-65,
Organism=Escherichia coli, GI87082041, Length=325, Percent_Identity=25.2307692307692, Blast_Score=98, Evalue=8e-22,
Organism=Escherichia coli, GI1789526, Length=317, Percent_Identity=24.9211356466877, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1788072, Length=261, Percent_Identity=26.0536398467433, Blast_Score=64, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322790, Length=348, Percent_Identity=37.0689655172414, Blast_Score=206, Evalue=4e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006411
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 37198; Mature: 37067

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS00602 ALDOLASE_CLASS_II_1 ; PS00806 ALDOLASE_CLASS_II_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIATPEVYNEMLDRAKEGGFAFPAINCTSSETINAALKGFAEAESDGIIQFSTGGAEFG
CCCCCHHHHHHHHHHHHCCCEECCEECCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCC
SGLAVKNKVKGAVALAAFAHEAAKSYGINVALHTDHCQKEVLDEYVRPLLAISQERVDRG
CCCEEHHHHHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCC
ELPLFQSHMWDGSAVPIDENLEIAQELLAKAKAANIILEVEIGVVGGEEDGVEAKAGANL
CCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEEEEEEECCCCCCCCCCCCCCC
YTSPEDFEKTIDAIGTGEKGRYLLAATFGNVHGVYKPGNVKLRPEVLLEGQQVARKKLGL
CCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEECCCCEEECHHHHHCCHHHHHHHCCC
ADDALPFDFVFHGGSGSEKEKIEEALTYGVIKMNVDTDTQYAFTRPIVSHMFENYNGVLK
CCCCCCEEEEEECCCCCHHHHHHHHHHHCEEEEECCCCCCHHHHHHHHHHHHHCCCCEEE
IDGEVGNKKAYDPRSYMKKAEQSMSERIIESCQDLKSVGKTTAK
ECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
PIATPEVYNEMLDRAKEGGFAFPAINCTSSETINAALKGFAEAESDGIIQFSTGGAEFG
CCCCHHHHHHHHHHHHCCCEECCEECCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCC
SGLAVKNKVKGAVALAAFAHEAAKSYGINVALHTDHCQKEVLDEYVRPLLAISQERVDRG
CCCEEHHHHHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCC
ELPLFQSHMWDGSAVPIDENLEIAQELLAKAKAANIILEVEIGVVGGEEDGVEAKAGANL
CCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEEEEEEECCCCCCCCCCCCCCC
YTSPEDFEKTIDAIGTGEKGRYLLAATFGNVHGVYKPGNVKLRPEVLLEGQQVARKKLGL
CCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEECCCCEEECHHHHHCCHHHHHHHCCC
ADDALPFDFVFHGGSGSEKEKIEEALTYGVIKMNVDTDTQYAFTRPIVSHMFENYNGVLK
CCCCCCEEEEEECCCCCHHHHHHHHHHHCEEEEECCCCCCHHHHHHHHHHHHHCCCCEEE
IDGEVGNKKAYDPRSYMKKAEQSMSERIIESCQDLKSVGKTTAK
ECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2615658; 12948626 [H]