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The map label for this gene is disA

Identifier: 145296663

GI number: 145296663

Start: 2836631

End: 2837731

Strand: Direct

Name: disA

Synonym: cgR_2570

Alternate gene names: 145296663

Gene position: 2836631-2837731 (Clockwise)

Preceding gene: 145296662

Following gene: 145296667

Centisome position: 85.59

GC content: 54.68

Gene sequence:

>1101_bases
ATGACACCAACAACCACTCCTGTATCAAACCCAGATGCCCTTGCCCCTGGAACTCAGGATGTGCACACCCTCAAAGGAAC
GCTACAGCGCCTCGCCCCAGGCACCCCACTGCGCGATAGCCTAGACCGCATCGTCCGTGGACACACCGGCGCGTTGATCG
TCATTGGTGACGATGAAAATGTCACCTCGATCTGCGACGGCGGCTTCGAATTCGACGTTCCGTTTGCTGCAACCCGACTC
CGCGAGCTGTGCAAAATGGATGGCGCTGTCATTTTGTCCTCCGACATTGAACGCATCAAACGCGCAAATGTTCAGCTACT
TCCATCCCCAACCTGGCCAACCCAGGAGTCCGGAACCCGCCACCGCTCCGCAGAACGCACAGCACTTCATACCGGTGTGC
CAGTAATTGCGGTATCCGAATCACAAAACACCATCACCCTCTACGTCGAGGGCAAAGCCCACATGTTGGAACAACCATCC
ACCCTGCTTAACCGCGCCAACCAAGCTTTAGGCACCATGGAGCGCTACCGCGATCGCCTTGATCAAGTCAACAACCGCCT
TCATCTAGCTGAACTCCACAGCTACGTCACGGTCATTGATGTTGTTTCTGTCATTCAGCGCGAGGAAATGCTACGCCGAG
TGGGCGAAATCATCGACGGCGATGTCCTCGAACTAGGCAAAGACGCCAAGCAAATTCAGATCCAGCTCAGCGAATTACGT
GGCGATAATGACCGCGAACGTGAATCAATCATCGCCGACTACTTGGTCACAGACGGTATTCCTGCAGATGAGGAAATCTA
CGCAGCCCTCGAAGCGATCTCACATTTAGATGATAAGGCTCTGCTGAAACCTGCCAACATTGCGCGTATTCTCGGACTGC
CGCCAACTGAAGAAGCCCTCGACGAGCCCGTAGCTCCCCGAGGCTACCGCACGCTCAACAGAATTCCTCGAGTGCAAAAA
TTCCTCATGGATAAACTCATCGTGGAATTCGGCAATCTAGATGCGCTGCTCAACGCGTCAGTAGAGGACCTAAGTGCAGT
CGATGGTGTGGGCTCACTGTGGGCACGCCACATCACCGACGGACTTGGCCGTTTAAGTTAG

Upstream 100 bases:

>100_bases
AGCAGTCATCCCCGGAGGCTCAGGCATCAAACAAACAAGCCTGAGAGTCATCGAAGCTTCAACGCTTGCCGAAGCACTTG
CAGCAGTAAGCTTATAAACC

Downstream 100 bases:

>100_bases
GTTAAAGGTCACCGCTGGTGAAGGGTTATTACCAACCACGGTGTGTAGGTAGTAGCCACCAGCGGGGACATCAGTGCGGT
TATTGCACTGGTTTGGCGCT

Product: DNA integrity scanning protein DisA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 366; Mature: 365

Protein sequence:

>366_residues
MTPTTTPVSNPDALAPGTQDVHTLKGTLQRLAPGTPLRDSLDRIVRGHTGALIVIGDDENVTSICDGGFEFDVPFAATRL
RELCKMDGAVILSSDIERIKRANVQLLPSPTWPTQESGTRHRSAERTALHTGVPVIAVSESQNTITLYVEGKAHMLEQPS
TLLNRANQALGTMERYRDRLDQVNNRLHLAELHSYVTVIDVVSVIQREEMLRRVGEIIDGDVLELGKDAKQIQIQLSELR
GDNDRERESIIADYLVTDGIPADEEIYAALEAISHLDDKALLKPANIARILGLPPTEEALDEPVAPRGYRTLNRIPRVQK
FLMDKLIVEFGNLDALLNASVEDLSAVDGVGSLWARHITDGLGRLS

Sequences:

>Translated_366_residues
MTPTTTPVSNPDALAPGTQDVHTLKGTLQRLAPGTPLRDSLDRIVRGHTGALIVIGDDENVTSICDGGFEFDVPFAATRL
RELCKMDGAVILSSDIERIKRANVQLLPSPTWPTQESGTRHRSAERTALHTGVPVIAVSESQNTITLYVEGKAHMLEQPS
TLLNRANQALGTMERYRDRLDQVNNRLHLAELHSYVTVIDVVSVIQREEMLRRVGEIIDGDVLELGKDAKQIQIQLSELR
GDNDRERESIIADYLVTDGIPADEEIYAALEAISHLDDKALLKPANIARILGLPPTEEALDEPVAPRGYRTLNRIPRVQK
FLMDKLIVEFGNLDALLNASVEDLSAVDGVGSLWARHITDGLGRLS
>Mature_365_residues
TPTTTPVSNPDALAPGTQDVHTLKGTLQRLAPGTPLRDSLDRIVRGHTGALIVIGDDENVTSICDGGFEFDVPFAATRLR
ELCKMDGAVILSSDIERIKRANVQLLPSPTWPTQESGTRHRSAERTALHTGVPVIAVSESQNTITLYVEGKAHMLEQPST
LLNRANQALGTMERYRDRLDQVNNRLHLAELHSYVTVIDVVSVIQREEMLRRVGEIIDGDVLELGKDAKQIQIQLSELRG
DNDRERESIIADYLVTDGIPADEEIYAALEAISHLDDKALLKPANIARILGLPPTEEALDEPVAPRGYRTLNRIPRVQKF
LMDKLIVEFGNLDALLNASVEDLSAVDGVGSLWARHITDGLGRLS

Specific function: Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions

COG id: COG1623

COG function: function code R; Predicted nucleic-acid-binding protein (contains the HHH domain)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the disA family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DISA_CORGB (A4QH66)

Other databases:

- EMBL:   AP009044
- RefSeq:   YP_001139484.1
- ProteinModelPortal:   A4QH66
- SMR:   A4QH66
- STRING:   A4QH66
- GeneID:   4992501
- GenomeReviews:   AP009044_GR
- KEGG:   cgt:cgR_2570
- eggNOG:   COG1623
- HOGENOM:   HBG292471
- OMA:   ISVSQSM
- ProtClustDB:   PRK13482
- HAMAP:   MF_01438
- InterPro:   IPR018906
- InterPro:   IPR003390
- InterPro:   IPR010994

Pfam domain/function: PF10635 DisA-linker; PF02457 DisA_N; SSF47781 RuvA_2_like

EC number: NA

Molecular weight: Translated: 40259; Mature: 40128

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPTTTPVSNPDALAPGTQDVHTLKGTLQRLAPGTPLRDSLDRIVRGHTGALIVIGDDEN
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEEEECCCC
VTSICDGGFEFDVPFAATRLRELCKMDGAVILSSDIERIKRANVQLLPSPTWPTQESGTR
HHHHHCCCCEECCCHHHHHHHHHHHCCCCEEEHHHHHHHHHCCEEEECCCCCCCCCCCCH
HRSAERTALHTGVPVIAVSESQNTITLYVEGKAHMLEQPSTLLNRANQALGTMERYRDRL
HHHHHHHHHHCCCCEEEEECCCCEEEEEECCCHHHHCCHHHHHHHHHHHHHHHHHHHHHH
DQVNNRLHLAELHSYVTVIDVVSVIQREEMLRRVGEIIDGDVLELGKDAKQIQIQLSELR
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHHC
GDNDRERESIIADYLVTDGIPADEEIYAALEAISHLDDKALLKPANIARILGLPPTEEAL
CCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHCCHHHHHHHHCCCCCHHHH
DEPVAPRGYRTLNRIPRVQKFLMDKLIVEFGNLDALLNASVEDLSAVDGVGSLWARHITD
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHCCHHHHHHHHHHH
GLGRLS
HHHCCC
>Mature Secondary Structure 
TPTTTPVSNPDALAPGTQDVHTLKGTLQRLAPGTPLRDSLDRIVRGHTGALIVIGDDEN
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEEEECCCC
VTSICDGGFEFDVPFAATRLRELCKMDGAVILSSDIERIKRANVQLLPSPTWPTQESGTR
HHHHHCCCCEECCCHHHHHHHHHHHCCCCEEEHHHHHHHHHCCEEEECCCCCCCCCCCCH
HRSAERTALHTGVPVIAVSESQNTITLYVEGKAHMLEQPSTLLNRANQALGTMERYRDRL
HHHHHHHHHHCCCCEEEEECCCCEEEEEECCCHHHHCCHHHHHHHHHHHHHHHHHHHHHH
DQVNNRLHLAELHSYVTVIDVVSVIQREEMLRRVGEIIDGDVLELGKDAKQIQIQLSELR
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHHC
GDNDRERESIIADYLVTDGIPADEEIYAALEAISHLDDKALLKPANIARILGLPPTEEAL
CCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHCCHHHHHHHHCCCCCHHHH
DEPVAPRGYRTLNRIPRVQKFLMDKLIVEFGNLDALLNASVEDLSAVDGVGSLWARHITD
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHCCHHHHHHHHHHH
GLGRLS
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA