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The map label for this gene is mutY [H]

Identifier: 145296667

GI number: 145296667

Start: 2841110

End: 2841880

Strand: Direct

Name: mutY [H]

Synonym: cgR_2574

Alternate gene names: 145296667

Gene position: 2841110-2841880 (Clockwise)

Preceding gene: 145296663

Following gene: 145296668

Centisome position: 85.73

GC content: 58.37

Gene sequence:

>771_bases
GTGATGAGTCAGCAGACTCCTGTGGCTCGAGTGGAGCCGATTTGGCGTGAGTGGATTGCTAAATGGCCAACCCCTGAATC
TTTTGCGAATGCAAGCACCGATGAGGTTTTGCGGGCGTGGGGCAAGTTAGGTTATCCACGTAGGGCGCTGAGGTTGAAGG
AATGTGCGGAGGTGATCGTCGAGAAGCATGCCGGCGAGGTGCCGGATACGGTGGAGGCGCTGCTCGCGTTGCCGGGGATT
GGCGATTATACGGCGCGCGCGGTCGCGGCGTTTCATTTTGGGCAGCGCGTGCCGGTGGTTGATACGAACGTGCGTCGCGT
GTATCAGCGCGCCGTTGCCGGGCGCTACCTTGCGGGGCCTGCGAAAAAGCAAGAGCTTATCGACGTCTCCCTTCTCCTTC
CCAACACTCACGCCCCAGAATTCTCTGCCGCAATAATGGAGTTGGGTGCTCTTATCTGCACGGCCACTTCCCCAAAGTGT
GACACCTGCCCACTGCTTGACCAGTGTCAATGGCAAAAACTTGGCTGTCCCTCTCCGAGTGAAGAGGAGCTGGCTTCAGC
GAAAAAGCGGGTGCAGAAATTTGTGGGAACCGACCGACAAGTCCGCGGCCTGATCATGGACGTGCTGCGCAAAGCCACCG
CACCTGTGCCACTATCCGCGATTGATGTCGTGTGGCCTGACGATGTCCAACGCTCCCGGGCGCTGTTTTCGCTCATTGAG
GACGGACTCGCGGAACAAGATGACGCGGGTTATTTCCATCTGCCACGATAA

Upstream 100 bases:

>100_bases
CACTTTTCAATCAGCCTTGCTCTCCTGGTTTAGAGCAAATGCCCGCGATCTTGCGTGGCGTGATCCCAATACTTCTGCCT
GGGGAATTCTTATTTCTGAG

Downstream 100 bases:

>100_bases
AGCACTGCGCGCCTGCAAAAAACAGTAGGTTTAAGTAATGCTTGGTCTCTCTCGTCGTAAGTTTGCCATGCTCGCTGCCT
TAACTGCGGGAGTAGTTGGC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 256; Mature: 256

Protein sequence:

>256_residues
MMSQQTPVARVEPIWREWIAKWPTPESFANASTDEVLRAWGKLGYPRRALRLKECAEVIVEKHAGEVPDTVEALLALPGI
GDYTARAVAAFHFGQRVPVVDTNVRRVYQRAVAGRYLAGPAKKQELIDVSLLLPNTHAPEFSAAIMELGALICTATSPKC
DTCPLLDQCQWQKLGCPSPSEEELASAKKRVQKFVGTDRQVRGLIMDVLRKATAPVPLSAIDVVWPDDVQRSRALFSLIE
DGLAEQDDAGYFHLPR

Sequences:

>Translated_256_residues
MMSQQTPVARVEPIWREWIAKWPTPESFANASTDEVLRAWGKLGYPRRALRLKECAEVIVEKHAGEVPDTVEALLALPGI
GDYTARAVAAFHFGQRVPVVDTNVRRVYQRAVAGRYLAGPAKKQELIDVSLLLPNTHAPEFSAAIMELGALICTATSPKC
DTCPLLDQCQWQKLGCPSPSEEELASAKKRVQKFVGTDRQVRGLIMDVLRKATAPVPLSAIDVVWPDDVQRSRALFSLIE
DGLAEQDDAGYFHLPR
>Mature_256_residues
MMSQQTPVARVEPIWREWIAKWPTPESFANASTDEVLRAWGKLGYPRRALRLKECAEVIVEKHAGEVPDTVEALLALPGI
GDYTARAVAAFHFGQRVPVVDTNVRRVYQRAVAGRYLAGPAKKQELIDVSLLLPNTHAPEFSAAIMELGALICTATSPKC
DTCPLLDQCQWQKLGCPSPSEEELASAKKRVQKFVGTDRQVRGLIMDVLRKATAPVPLSAIDVVWPDDVQRSRALFSLIE
DGLAEQDDAGYFHLPR

Specific function: Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine:7,8-dihydro-8- oxoguanine (8-oxo-dGTP) [H]

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family [H]

Homologues:

Organism=Homo sapiens, GI115298654, Length=173, Percent_Identity=42.1965317919075, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI115298652, Length=173, Percent_Identity=42.1965317919075, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI115298648, Length=173, Percent_Identity=42.1965317919075, Blast_Score=118, Evalue=4e-27,
Organism=Homo sapiens, GI115298650, Length=173, Percent_Identity=42.1965317919075, Blast_Score=118, Evalue=4e-27,
Organism=Homo sapiens, GI6912520, Length=173, Percent_Identity=42.1965317919075, Blast_Score=118, Evalue=5e-27,
Organism=Homo sapiens, GI190358497, Length=173, Percent_Identity=42.1965317919075, Blast_Score=118, Evalue=5e-27,
Organism=Escherichia coli, GI1789331, Length=174, Percent_Identity=40.8045977011494, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI1787920, Length=131, Percent_Identity=30.5343511450382, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17554540, Length=158, Percent_Identity=26.5822784810127, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR004036
- InterPro:   IPR004035
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF10576 EndIII_4Fe-2S; PF00633 HHH; PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 28327; Mature: 28327

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: PS00764 ENDONUCLEASE_III_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMSQQTPVARVEPIWREWIAKWPTPESFANASTDEVLRAWGKLGYPRRALRLKECAEVIV
CCCCCCCHHHHHHHHHHHHHCCCCCHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHH
EKHAGEVPDTVEALLALPGIGDYTARAVAAFHFGQRVPVVDTNVRRVYQRAVAGRYLAGP
HHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCC
AKKQELIDVSLLLPNTHAPEFSAAIMELGALICTATSPKCDTCPLLDQCQWQKLGCPSPS
CHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCHHHCCCCCCC
EEELASAKKRVQKFVGTDRQVRGLIMDVLRKATAPVPLSAIDVVWPDDVQRSRALFSLIE
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHH
DGLAEQDDAGYFHLPR
HHCCCCCCCCEEECCC
>Mature Secondary Structure
MMSQQTPVARVEPIWREWIAKWPTPESFANASTDEVLRAWGKLGYPRRALRLKECAEVIV
CCCCCCCHHHHHHHHHHHHHCCCCCHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHH
EKHAGEVPDTVEALLALPGIGDYTARAVAAFHFGQRVPVVDTNVRRVYQRAVAGRYLAGP
HHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCC
AKKQELIDVSLLLPNTHAPEFSAAIMELGALICTATSPKCDTCPLLDQCQWQKLGCPSPS
CHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCHHHCCCCCCC
EEELASAKKRVQKFVGTDRQVRGLIMDVLRKATAPVPLSAIDVVWPDDVQRSRALFSLIE
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHH
DGLAEQDDAGYFHLPR
HHCCCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2197596; 2001994; 9278503; 9846876 [H]