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The map label for this gene is purL

Identifier: 145296583

GI number: 145296583

Start: 2749000

End: 2751288

Strand: Reverse

Name: purL

Synonym: cgR_2491

Alternate gene names: 145296583

Gene position: 2751288-2749000 (Counterclockwise)

Preceding gene: 145296584

Following gene: 145296582

Centisome position: 83.02

GC content: 58.37

Gene sequence:

>2289_bases
ATGAGCACTTTTGTCAATGACACCGTCGAAGACGCAATCAAGACCCCTGAGCTGGATCAGCCATTTGAGGCTCTTGGTCT
GAAAGACGACGAGTACGCGCGCATCAAGGAAATCCTTGGCCGCCGCCCAACCGACGCCGAGCTGACCGTTTACTCCGTCA
TGTGGTCGGAGCACTGCTCCTACAAGTCCTCCAAGGTTCACCTGCGTTACTTCGGTGAAACCACCACTGAGGAAATGGCC
TCTAAGATTCTTGCCGGCATCGGCGAGAACGCTGGTGTGGTCGACATCGGAGACGGCAACGCCGTGACTTTCCGTGTGGA
GTCCCACAACCACCCATCCTTCGTGGAGCCACACCAGGGAGCTGCAACCGGAATCGGTGGCATCGTCCGCGACATTATGG
CTATGGGTGCACGCCCAATCGCTGTGATGGATCAGCTGCGTTTCGGTGCACTGGACAACCCAGACACCCAGCGTGTGCTT
CCTGGCGTTGTTGACGGCATTTCCCACTACGGCAACTGCCTCGGCCTGCCAAACATCGGTGGCGAAACCGTCTTCGACGA
TTCCTACGCAGGTAACCCACTGGTCAACGCACTGTGCGTGGGTACCCTCAAGGTGGAAGACCTCAAGCTTGCATTCGCAT
CCGGCACCGGCAACAAGGTGATCCTGTTCGGTTCCCGCACCGGCCTTGATGGCATCGGTGGCGTGTCCGTCCTGGGTTCC
GCATCCTTCGAAGAAGGCGAAGAGCGCAAGCTCCCAGCTGTTCAGGTTGGCGATCCTTTCGCAGAGAAGGTACTCATCGA
GTGCTGCCTCGAGCTGTACAAGGCAGGCGTAGTGGTCGGTATTCAGGACCTCGGCGGCGGCGGACTTGCGTGTGCAACCT
CTGAGCTGGCAGCCGCTGGCGACGGCGGCATGCGCGTCAACCTGGACAACGTCCCACTGCGCGCAGAGAACATGTCTGCA
GCTGAAATCCTGGCTTCCGAGTCCCAGGAGCGCATGTGTGCTGTTGTCACCCCTGAAAACGTTGAGCGTTTCCTCGAGAT
CTGTGCAAAGTGGGATGTCACCTGCGCAGAAATCGGCGAAGTTACCGACGAGAAGGACCGCTACGTTGTGGTTCACAACG
GTGAAGTAGTTATCGACGCACCTCCATCAACCATCGATGAAGGCCCTGTCTACAACCGCCCAGTTGCTCGCCCTGAGAAC
CAAGACGAACTGCAGCTCGAAGGCGAGATCGCTCGCCCAGTCGACGTTGAAGATATCAAGGCTGCTTGGCTGAAGCTTGT
CGCTTCACCAGCACTTGCCTCCCGCGCATTCATCACCGAGCAGTACGACCGCTACGTCCGCGGCAACACTGTGCAGGCAA
AGAACGCCAACGCTGGCGTCTTGCGTATCGACGAAGAGACCAACCGTGGCGTTGCGATCTCCGCCGACGCATCCGGCCGT
TACACCAAGCTCGAGCCAAACACTGGCGCACAGCTTGCACTGGCAGAGGCTTACCGCAACGTGGTCTCCACCGGTGCACG
CCCAGTGGCTGTCACCAACTGCCTGAACTTTGGTTCCCCAGAAAACGCTGGTGTCATGTGGCAGTTCAAGGAAGCAGTCC
ACGGTCTGGCAGACGGATCCAAGCTTCTGGGCATTCCAGTGTCCGGCGGTAACGTCTCCTTCTACAACCAGACTGGTGAC
GAGCCCATCCTGCCAACCCCAGTCGTGGGTGTCTTGGGTGTCTTGGACAACGTCGAGCAGAGCATCGGCAACGTCCTCCC
ATCCGAGGACAACGATCTCTACCTCCTGGGTGAGACCTTCGACGAGTTCGGCGGTTCCATCTGGCAGCAAGTTTCTGGCG
CTGGCCTTAATGGTCTGCCACCAGTAGTTGACCTGCTCAACGAGCAGCGTCTTGCAGACCTGTTCGTCGGTTCTGATCTG
TTTGCTGCATCCCATGACCTGTCTGAGGGCGGCCTTGGCCAGACTCTCGCAGAGCTTGCCATCCACGCAGACAAGGGCAT
GGATGTTGATCTCTCCCAGATCCACCCATCCCTGTTCACCTCACTGTTTGCAGAGTCCGCTTCCCGCATCGTGGTTGCAA
CCAACCGCGGCGAAGAGCTGGAAAAGCGTGCGGCAGAGCTGGGCGTTCCAGTGTTCAAGCTGGGCCGCACCAACGATTCA
GCTGTCATCGCTGTCAAGGGCGCAGACGTTGAGTTCAATATTTCCGTGGAGGAACTCCGCGAAGCATGGACCAACACCTT
GCCTGAGGCATTCGGTCACGCAGTTGGAGCTAACGCAGTAGTTGGATAA

Upstream 100 bases:

>100_bases
CCGGAACATGCCGTCGAAAAGCTAACCGGCCCATCTATTGATGGCCTGGAGCTGTTCCTGTCCGCCGTTGGCACCATCGC
GGCTTAAGAGGAGTCAAAAT

Downstream 100 bases:

>100_bases
TTTTCTGCTGTGAAGCCGGGTTTCGTTTACGCGAAGCCCGGCTTCTGCTCTTTCTTCCACTAGATTGGATACAACAATTC
AGGGAAGAAAGAAGCGTGAA

Product: phosphoribosylformylglycinamidine synthase II

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase II; FGAM synthase II

Number of amino acids: Translated: 762; Mature: 761

Protein sequence:

>762_residues
MSTFVNDTVEDAIKTPELDQPFEALGLKDDEYARIKEILGRRPTDAELTVYSVMWSEHCSYKSSKVHLRYFGETTTEEMA
SKILAGIGENAGVVDIGDGNAVTFRVESHNHPSFVEPHQGAATGIGGIVRDIMAMGARPIAVMDQLRFGALDNPDTQRVL
PGVVDGISHYGNCLGLPNIGGETVFDDSYAGNPLVNALCVGTLKVEDLKLAFASGTGNKVILFGSRTGLDGIGGVSVLGS
ASFEEGEERKLPAVQVGDPFAEKVLIECCLELYKAGVVVGIQDLGGGGLACATSELAAAGDGGMRVNLDNVPLRAENMSA
AEILASESQERMCAVVTPENVERFLEICAKWDVTCAEIGEVTDEKDRYVVVHNGEVVIDAPPSTIDEGPVYNRPVARPEN
QDELQLEGEIARPVDVEDIKAAWLKLVASPALASRAFITEQYDRYVRGNTVQAKNANAGVLRIDEETNRGVAISADASGR
YTKLEPNTGAQLALAEAYRNVVSTGARPVAVTNCLNFGSPENAGVMWQFKEAVHGLADGSKLLGIPVSGGNVSFYNQTGD
EPILPTPVVGVLGVLDNVEQSIGNVLPSEDNDLYLLGETFDEFGGSIWQQVSGAGLNGLPPVVDLLNEQRLADLFVGSDL
FAASHDLSEGGLGQTLAELAIHADKGMDVDLSQIHPSLFTSLFAESASRIVVATNRGEELEKRAAELGVPVFKLGRTNDS
AVIAVKGADVEFNISVEELREAWTNTLPEAFGHAVGANAVVG

Sequences:

>Translated_762_residues
MSTFVNDTVEDAIKTPELDQPFEALGLKDDEYARIKEILGRRPTDAELTVYSVMWSEHCSYKSSKVHLRYFGETTTEEMA
SKILAGIGENAGVVDIGDGNAVTFRVESHNHPSFVEPHQGAATGIGGIVRDIMAMGARPIAVMDQLRFGALDNPDTQRVL
PGVVDGISHYGNCLGLPNIGGETVFDDSYAGNPLVNALCVGTLKVEDLKLAFASGTGNKVILFGSRTGLDGIGGVSVLGS
ASFEEGEERKLPAVQVGDPFAEKVLIECCLELYKAGVVVGIQDLGGGGLACATSELAAAGDGGMRVNLDNVPLRAENMSA
AEILASESQERMCAVVTPENVERFLEICAKWDVTCAEIGEVTDEKDRYVVVHNGEVVIDAPPSTIDEGPVYNRPVARPEN
QDELQLEGEIARPVDVEDIKAAWLKLVASPALASRAFITEQYDRYVRGNTVQAKNANAGVLRIDEETNRGVAISADASGR
YTKLEPNTGAQLALAEAYRNVVSTGARPVAVTNCLNFGSPENAGVMWQFKEAVHGLADGSKLLGIPVSGGNVSFYNQTGD
EPILPTPVVGVLGVLDNVEQSIGNVLPSEDNDLYLLGETFDEFGGSIWQQVSGAGLNGLPPVVDLLNEQRLADLFVGSDL
FAASHDLSEGGLGQTLAELAIHADKGMDVDLSQIHPSLFTSLFAESASRIVVATNRGEELEKRAAELGVPVFKLGRTNDS
AVIAVKGADVEFNISVEELREAWTNTLPEAFGHAVGANAVVG
>Mature_761_residues
STFVNDTVEDAIKTPELDQPFEALGLKDDEYARIKEILGRRPTDAELTVYSVMWSEHCSYKSSKVHLRYFGETTTEEMAS
KILAGIGENAGVVDIGDGNAVTFRVESHNHPSFVEPHQGAATGIGGIVRDIMAMGARPIAVMDQLRFGALDNPDTQRVLP
GVVDGISHYGNCLGLPNIGGETVFDDSYAGNPLVNALCVGTLKVEDLKLAFASGTGNKVILFGSRTGLDGIGGVSVLGSA
SFEEGEERKLPAVQVGDPFAEKVLIECCLELYKAGVVVGIQDLGGGGLACATSELAAAGDGGMRVNLDNVPLRAENMSAA
EILASESQERMCAVVTPENVERFLEICAKWDVTCAEIGEVTDEKDRYVVVHNGEVVIDAPPSTIDEGPVYNRPVARPENQ
DELQLEGEIARPVDVEDIKAAWLKLVASPALASRAFITEQYDRYVRGNTVQAKNANAGVLRIDEETNRGVAISADASGRY
TKLEPNTGAQLALAEAYRNVVSTGARPVAVTNCLNFGSPENAGVMWQFKEAVHGLADGSKLLGIPVSGGNVSFYNQTGDE
PILPTPVVGVLGVLDNVEQSIGNVLPSEDNDLYLLGETFDEFGGSIWQQVSGAGLNGLPPVVDLLNEQRLADLFVGSDLF
AASHDLSEGGLGQTLAELAIHADKGMDVDLSQIHPSLFTSLFAESASRIVVATNRGEELEKRAAELGVPVFKLGRTNDSA
VIAVKGADVEFNISVEELREAWTNTLPEAFGHAVGANAVVG

Specific function: Unknown

COG id: COG0046

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGAMS family

Homologues:

Organism=Homo sapiens, GI31657129, Length=737, Percent_Identity=24.4233378561737, Blast_Score=110, Evalue=7e-24,
Organism=Escherichia coli, GI48994899, Length=832, Percent_Identity=26.5625, Blast_Score=145, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6321498, Length=826, Percent_Identity=23.365617433414, Blast_Score=118, Evalue=4e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURL_CORGB (A4QGY6)

Other databases:

- EMBL:   AP009044
- RefSeq:   YP_001139404.1
- ProteinModelPortal:   A4QGY6
- SMR:   A4QGY6
- STRING:   A4QGY6
- GeneID:   4994290
- GenomeReviews:   AP009044_GR
- KEGG:   cgt:cgR_2491
- eggNOG:   COG0046
- HOGENOM:   HBG311214
- OMA:   YGNSFGV
- ProtClustDB:   PRK01213
- GO:   GO:0005737
- HAMAP:   MF_00420
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR010074
- InterPro:   IPR016188
- TIGRFAMs:   TIGR01736

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.5.3

Molecular weight: Translated: 80909; Mature: 80777

Theoretical pI: Translated: 4.23; Mature: 4.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTFVNDTVEDAIKTPELDQPFEALGLKDDEYARIKEILGRRPTDAELTVYSVMWSEHCS
CCCCCCHHHHHHHCCCCCCCCHHHHCCCCCHHHHHHHHHCCCCCCCCEEEEEEEHHHHCC
YKSSKVHLRYFGETTTEEMASKILAGIGENAGVVDIGDGNAVTFRVESHNHPSFVEPHQG
CCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCEEECCCCCEEEEEEECCCCCCCCCCCCC
AATGIGGIVRDIMAMGARPIAVMDQLRFGALDNPDTQRVLPGVVDGISHYGNCLGLPNIG
CHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCC
GETVFDDSYAGNPLVNALCVGTLKVEDLKLAFASGTGNKVILFGSRTGLDGIGGVSVLGS
CCCEECCCCCCCHHHHHHEEEEEEEEEEEEEEECCCCCEEEEEECCCCCCCCCCHHHCCC
ASFEEGEERKLPAVQVGDPFAEKVLIECCLELYKAGVVVGIQDLGGGGLACATSELAAAG
CCCCCCHHHCCCEEECCCHHHHHHHHHHHHHHHHCCEEEEEEECCCCCEEEHHHHHHHCC
DGGMRVNLDNVPLRAENMSAAEILASESQERMCAVVTPENVERFLEICAKWDVTCAEIGE
CCCEEEEECCCCCCCCCCCHHHHHHCCCCCCEEEEECHHHHHHHHHHHHCCCCCHHHHHC
VTDEKDRYVVVHNGEVVIDAPPSTIDEGPVYNRPVARPENQDELQLEGEIARPVDVEDIK
CCCCCCCEEEEECCEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCHHHHH
AAWLKLVASPALASRAFITEQYDRYVRGNTVQAKNANAGVLRIDEETNRGVAISADASGR
HHHHHHHHCHHHHHHHHHHHHHHHHHCCCEEEECCCCCCEEEEECCCCCCEEEEECCCCC
YTKLEPNTGAQLALAEAYRNVVSTGARPVAVTNCLNFGSPENAGVMWQFKEAVHGLADGS
EEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEHHHCCCCCCCCCEEEEEHHHHHHHCCCC
KLLGIPVSGGNVSFYNQTGDEPILPTPVVGVLGVLDNVEQSIGNVLPSEDNDLYLLGETF
EEEEEEECCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCH
DEFGGSIWQQVSGAGLNGLPPVVDLLNEQRLADLFVGSDLFAASHDLSEGGLGQTLAELA
HHHHHHHHHHHCCCCCCCCCHHHHHHCHHHHHHHHHCCCHHHHCCCCCCCCHHHHHHHHH
IHADKGMDVDLSQIHPSLFTSLFAESASRIVVATNRGEELEKRAAELGVPVFKLGRTNDS
HHCCCCCCCCHHHHCHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHCCCEEEECCCCCC
AVIAVKGADVEFNISVEELREAWTNTLPEAFGHAVGANAVVG
EEEEEECCCEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
STFVNDTVEDAIKTPELDQPFEALGLKDDEYARIKEILGRRPTDAELTVYSVMWSEHCS
CCCCCHHHHHHHCCCCCCCCHHHHCCCCCHHHHHHHHHCCCCCCCCEEEEEEEHHHHCC
YKSSKVHLRYFGETTTEEMASKILAGIGENAGVVDIGDGNAVTFRVESHNHPSFVEPHQG
CCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCEEECCCCCEEEEEEECCCCCCCCCCCCC
AATGIGGIVRDIMAMGARPIAVMDQLRFGALDNPDTQRVLPGVVDGISHYGNCLGLPNIG
CHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCC
GETVFDDSYAGNPLVNALCVGTLKVEDLKLAFASGTGNKVILFGSRTGLDGIGGVSVLGS
CCCEECCCCCCCHHHHHHEEEEEEEEEEEEEEECCCCCEEEEEECCCCCCCCCCHHHCCC
ASFEEGEERKLPAVQVGDPFAEKVLIECCLELYKAGVVVGIQDLGGGGLACATSELAAAG
CCCCCCHHHCCCEEECCCHHHHHHHHHHHHHHHHCCEEEEEEECCCCCEEEHHHHHHHCC
DGGMRVNLDNVPLRAENMSAAEILASESQERMCAVVTPENVERFLEICAKWDVTCAEIGE
CCCEEEEECCCCCCCCCCCHHHHHHCCCCCCEEEEECHHHHHHHHHHHHCCCCCHHHHHC
VTDEKDRYVVVHNGEVVIDAPPSTIDEGPVYNRPVARPENQDELQLEGEIARPVDVEDIK
CCCCCCCEEEEECCEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCHHHHH
AAWLKLVASPALASRAFITEQYDRYVRGNTVQAKNANAGVLRIDEETNRGVAISADASGR
HHHHHHHHCHHHHHHHHHHHHHHHHHCCCEEEECCCCCCEEEEECCCCCCEEEEECCCCC
YTKLEPNTGAQLALAEAYRNVVSTGARPVAVTNCLNFGSPENAGVMWQFKEAVHGLADGS
EEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEHHHCCCCCCCCCEEEEEHHHHHHHCCCC
KLLGIPVSGGNVSFYNQTGDEPILPTPVVGVLGVLDNVEQSIGNVLPSEDNDLYLLGETF
EEEEEEECCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCH
DEFGGSIWQQVSGAGLNGLPPVVDLLNEQRLADLFVGSDLFAASHDLSEGGLGQTLAELA
HHHHHHHHHHHCCCCCCCCCHHHHHHCHHHHHHHHHCCCHHHHCCCCCCCCHHHHHHHHH
IHADKGMDVDLSQIHPSLFTSLFAESASRIVVATNRGEELEKRAAELGVPVFKLGRTNDS
HHCCCCCCCCHHHHCHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHCCCEEEECCCCCC
AVIAVKGADVEFNISVEELREAWTNTLPEAFGHAVGANAVVG
EEEEEECCCEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA