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The map label for this gene is purM [H]

Identifier: 145296578

GI number: 145296578

Start: 2743866

End: 2744942

Strand: Reverse

Name: purM [H]

Synonym: cgR_2486

Alternate gene names: 145296578

Gene position: 2744942-2743866 (Counterclockwise)

Preceding gene: 145296579

Following gene: 145296575

Centisome position: 82.82

GC content: 59.33

Gene sequence:

>1077_bases
ATGAGTGATCACCAGGACACCACCGCCGAAGGCGTTTCATACGCAGCAGCAGGAGTCGACATCGAAGCCGGCGATCGTGC
CGTCGAACTCTTTGCACCAATGGCCAAGCGCGCCACCCGCCCAGAGGTTCTTGGCAACCTCGGAGGCTTCGCAGGACTCT
TTGAGCTCGGAAAATACAAGAAGCCAATCCTCGCAGCAGGATCTGACGGAGTCGGCACCAAGCTTGTCATCGCCCAGATG
ATGGACAAGCACGACACCATCGGCATCGACCTTGTTGCAATGTGTGTGGATGACCTCGTTGTCACCGGCGCAGAGCCACT
GTTCCTCCAGGACTACATCGCCATCGGCAAGGTTGTCCCAGAGCACGTTGCTGAGATCGTCTCCGGTATCGCAGAAGGCT
GTGTCCAGGCAGGCTGTGCTCTGCTCGGTGGCGAAACCGCAGAACACCCAGGTGTTATGGAACCAGACCACTACGATGTC
TCCGCAACTGCGGTCGGCGTTGTCGAAGCAGATGAACTGCTAGGACCAGACCGCGTCCGCGCAGGCGACGTCCTCATCGG
CATGGCTTCCTCCGGTCTGCACTCCAACGGTTACTCCCTGGCTCGCCACGTCCTCCTGGAAAAGGCAGGCCTGGCGCTTG
ACGGACACATCGAAGAACTCGGACGCACCCTCGGTGAAGAACTTCTCGAGCCAACCCGCATCTACGCCAAGGACTGCCTG
GCACTGATCGCAGAGTGCGAAGTTCACACCTTCTGCCACGTCACCGGCGGCGGCCTCGCAGGCAACCTCGAGCGGGTTAT
CCCAGAAGGACTCGTCGCAGAAATGTCCCGAGCAACTTGGACCCCAGGCCAAATCTTCCGCACCATCTCCTCTGTGGGCA
AGGTTTCCCGCGAAGAAATGGAAAAGACCTTCAACATGGGTGTCGGCATGGTTGCAGTCGTTGCTGAAAAGGACCGCGAC
CGCGCCCTGGCAATGCTCACCGCACGTCACATTGACTGCTGGGAAATCGGAACCGTACGTAACGGTGAAGAGGGAGAGCC
TCGCGTGATCCTCAACGGCGAGCACCCTGGCTACTAA

Upstream 100 bases:

>100_bases
ATTTTTGCTCTCCCCGTATGCGTGGGGGTTGTCCCGCGCACTTTTAGATAGTTATGTTCCTAATAAGTTCCAAACCCCAG
CAGGAGAAGCGAAGTACACG

Downstream 100 bases:

>100_bases
GCCCAACTGTCTGCTCTAAGAATTAGCCGGCCTTGCACTTAATTGTGCGGGCCGGCTTTTGCAGTGAAATGGGGCATTTT
AAGAGGCTGGAATTGTCTCA

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 358; Mature: 357

Protein sequence:

>358_residues
MSDHQDTTAEGVSYAAAGVDIEAGDRAVELFAPMAKRATRPEVLGNLGGFAGLFELGKYKKPILAAGSDGVGTKLVIAQM
MDKHDTIGIDLVAMCVDDLVVTGAEPLFLQDYIAIGKVVPEHVAEIVSGIAEGCVQAGCALLGGETAEHPGVMEPDHYDV
SATAVGVVEADELLGPDRVRAGDVLIGMASSGLHSNGYSLARHVLLEKAGLALDGHIEELGRTLGEELLEPTRIYAKDCL
ALIAECEVHTFCHVTGGGLAGNLERVIPEGLVAEMSRATWTPGQIFRTISSVGKVSREEMEKTFNMGVGMVAVVAEKDRD
RALAMLTARHIDCWEIGTVRNGEEGEPRVILNGEHPGY

Sequences:

>Translated_358_residues
MSDHQDTTAEGVSYAAAGVDIEAGDRAVELFAPMAKRATRPEVLGNLGGFAGLFELGKYKKPILAAGSDGVGTKLVIAQM
MDKHDTIGIDLVAMCVDDLVVTGAEPLFLQDYIAIGKVVPEHVAEIVSGIAEGCVQAGCALLGGETAEHPGVMEPDHYDV
SATAVGVVEADELLGPDRVRAGDVLIGMASSGLHSNGYSLARHVLLEKAGLALDGHIEELGRTLGEELLEPTRIYAKDCL
ALIAECEVHTFCHVTGGGLAGNLERVIPEGLVAEMSRATWTPGQIFRTISSVGKVSREEMEKTFNMGVGMVAVVAEKDRD
RALAMLTARHIDCWEIGTVRNGEEGEPRVILNGEHPGY
>Mature_357_residues
SDHQDTTAEGVSYAAAGVDIEAGDRAVELFAPMAKRATRPEVLGNLGGFAGLFELGKYKKPILAAGSDGVGTKLVIAQMM
DKHDTIGIDLVAMCVDDLVVTGAEPLFLQDYIAIGKVVPEHVAEIVSGIAEGCVQAGCALLGGETAEHPGVMEPDHYDVS
ATAVGVVEADELLGPDRVRAGDVLIGMASSGLHSNGYSLARHVLLEKAGLALDGHIEELGRTLGEELLEPTRIYAKDCLA
LIAECEVHTFCHVTGGGLAGNLERVIPEGLVAEMSRATWTPGQIFRTISSVGKVSREEMEKTFNMGVGMVAVVAEKDRDR
ALAMLTARHIDCWEIGTVRNGEEGEPRVILNGEHPGY

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=345, Percent_Identity=46.3768115942029, Blast_Score=293, Evalue=1e-79,
Organism=Homo sapiens, GI209869995, Length=345, Percent_Identity=46.3768115942029, Blast_Score=293, Evalue=1e-79,
Organism=Homo sapiens, GI209869993, Length=345, Percent_Identity=46.3768115942029, Blast_Score=293, Evalue=1e-79,
Organism=Escherichia coli, GI1788845, Length=347, Percent_Identity=47.5504322766571, Blast_Score=311, Evalue=4e-86,
Organism=Caenorhabditis elegans, GI17567511, Length=358, Percent_Identity=35.195530726257, Blast_Score=211, Evalue=5e-55,
Organism=Saccharomyces cerevisiae, GI6321203, Length=358, Percent_Identity=41.6201117318436, Blast_Score=273, Evalue=2e-74,
Organism=Drosophila melanogaster, GI24582400, Length=272, Percent_Identity=40.4411764705882, Blast_Score=200, Evalue=1e-51,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 37866; Mature: 37734

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDHQDTTAEGVSYAAAGVDIEAGDRAVELFAPMAKRATRPEVLGNLGGFAGLFELGKYK
CCCCCCCHHHCCHHHHCCCEECCCCHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHCCC
KPILAAGSDGVGTKLVIAQMMDKHDTIGIDLVAMCVDDLVVTGAEPLFLQDYIAIGKVVP
CCEEECCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
EHVAEIVSGIAEGCVQAGCALLGGETAEHPGVMEPDHYDVSATAVGVVEADELLGPDRVR
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHEEEEEEHHHHCCCCCCC
AGDVLIGMASSGLHSNGYSLARHVLLEKAGLALDGHIEELGRTLGEELLEPTRIYAKDCL
CCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
ALIAECEVHTFCHVTGGGLAGNLERVIPEGLVAEMSRATWTPGQIFRTISSVGKVSREEM
HHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
EKTFNMGVGMVAVVAEKDRDRALAMLTARHIDCWEIGTVRNGEEGEPRVILNGEHPGY
HHHHHCCCCEEEEEECCCCHHHHHHHHHHCCCCEECCCCCCCCCCCCEEEECCCCCCC
>Mature Secondary Structure 
SDHQDTTAEGVSYAAAGVDIEAGDRAVELFAPMAKRATRPEVLGNLGGFAGLFELGKYK
CCCCCCHHHCCHHHHCCCEECCCCHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHCCC
KPILAAGSDGVGTKLVIAQMMDKHDTIGIDLVAMCVDDLVVTGAEPLFLQDYIAIGKVVP
CCEEECCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
EHVAEIVSGIAEGCVQAGCALLGGETAEHPGVMEPDHYDVSATAVGVVEADELLGPDRVR
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHEEEEEEHHHHCCCCCCC
AGDVLIGMASSGLHSNGYSLARHVLLEKAGLALDGHIEELGRTLGEELLEPTRIYAKDCL
CCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
ALIAECEVHTFCHVTGGGLAGNLERVIPEGLVAEMSRATWTPGQIFRTISSVGKVSREEM
HHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
EKTFNMGVGMVAVVAEKDRDRALAMLTARHIDCWEIGTVRNGEEGEPRVILNGEHPGY
HHHHHCCCCEEEEEECCCCHHHHHHHHHHCCCCEECCCCCCCCCCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA