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The map label for this gene is sucD [H]

Identifier: 145296560

GI number: 145296560

Start: 2723467

End: 2724351

Strand: Reverse

Name: sucD [H]

Synonym: cgR_2468

Alternate gene names: 145296560

Gene position: 2724351-2723467 (Counterclockwise)

Preceding gene: 145296561

Following gene: 145296559

Centisome position: 82.2

GC content: 51.86

Gene sequence:

>885_bases
ATGTCTATTTTTCTCAATTCAGATTCCCGCATCATCATTCAGGGCATTACCGGTTCGGAAGGTTCAGAGCATGCGCGTCG
AATTTTAGCCTCTGGTGCGAAGCTCGTGGGTGGCACCAACCCCCGCAAAGCTGGGCAAACCATTTTGATCAATGACACTG
AGTTGCCTGTATTTGGCACTGTTAAGGAAGCAATGGAGGAAACGGGTGCGGATGTCACCGTAATTTTCGTTCCTCCAGCC
TTTGCCAAAGCTGCGATCATTGAAGCTATCGACGCTCACATCCCACTGTGCGTGATTATTACTGAGGGCATTCCAGTACG
TGACGCTTCTGAGGCATGGGCTTATGCCAAGAAGGTGGGACACACCCGCATCATTGGCCCTAACTGCCCAGGCATTATTA
CTCCCGGCGAATCTCTTGCAGGAATTACGCCGGCAAACATTGCAGGTTCCGGCCCGATCGGGTTGATCTCAAAGTCGGGA
ACACTGACTTATCAGATGATGTACGAACTCTCAGATATTGGCATTTCTACGGCGATTGGTATTGGCGGTGACCCAATCAT
CGGTACAACCCATATCGATGCTCTGGAGGCCTTTGAAGCTGATCCTGAGACCAAGGCAATCGTCATGATCGGTGAGATCG
GTGGAGATGCAGAGGAACGCGCTGCTGACTTCATTTCTAAGCACGTGACAAAACCAGTTGTGGGTTACGTGGCAGGCTTT
ACCGCCCCTGAAGGAAAGACCATGGGGCATGCTGGCGCCATCGTGACAGGTTCAGAAGGTACTGCGCGAGCAAAGAAGCA
TGCATTGGAGGCCGTGGGTGTTCGCGTGGGAACAACTCCGAGTGAAACCGCGAAGCTTATGCGTGAGGTAGTTGCAGCTT
TGTAA

Upstream 100 bases:

>100_bases
GGGTATGGATGCAGCGGCTGATCACGCTGCCCATTTGGCCAATCTTGCCCAGCACGGCCAGTTCGCAACCGCTAATTAGT
CAAGGAGCACCTGTTTAATC

Downstream 100 bases:

>100_bases
CTAACAGGCCACAGATCTTAGCTTTGACCAGCTGATTTGTGGCTAATCGCCCGGTCTGTGTAGAGTATTCATCTGTGCGC
AGGACAGTGTGACAAACACT

Product: succinyl-CoA synthetase subunit alpha

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit alpha; SCS-alpha [H]

Number of amino acids: Translated: 294; Mature: 293

Protein sequence:

>294_residues
MSIFLNSDSRIIIQGITGSEGSEHARRILASGAKLVGGTNPRKAGQTILINDTELPVFGTVKEAMEETGADVTVIFVPPA
FAKAAIIEAIDAHIPLCVIITEGIPVRDASEAWAYAKKVGHTRIIGPNCPGIITPGESLAGITPANIAGSGPIGLISKSG
TLTYQMMYELSDIGISTAIGIGGDPIIGTTHIDALEAFEADPETKAIVMIGEIGGDAEERAADFISKHVTKPVVGYVAGF
TAPEGKTMGHAGAIVTGSEGTARAKKHALEAVGVRVGTTPSETAKLMREVVAAL

Sequences:

>Translated_294_residues
MSIFLNSDSRIIIQGITGSEGSEHARRILASGAKLVGGTNPRKAGQTILINDTELPVFGTVKEAMEETGADVTVIFVPPA
FAKAAIIEAIDAHIPLCVIITEGIPVRDASEAWAYAKKVGHTRIIGPNCPGIITPGESLAGITPANIAGSGPIGLISKSG
TLTYQMMYELSDIGISTAIGIGGDPIIGTTHIDALEAFEADPETKAIVMIGEIGGDAEERAADFISKHVTKPVVGYVAGF
TAPEGKTMGHAGAIVTGSEGTARAKKHALEAVGVRVGTTPSETAKLMREVVAAL
>Mature_293_residues
SIFLNSDSRIIIQGITGSEGSEHARRILASGAKLVGGTNPRKAGQTILINDTELPVFGTVKEAMEETGADVTVIFVPPAF
AKAAIIEAIDAHIPLCVIITEGIPVRDASEAWAYAKKVGHTRIIGPNCPGIITPGESLAGITPANIAGSGPIGLISKSGT
LTYQMMYELSDIGISTAIGIGGDPIIGTTHIDALEAFEADPETKAIVMIGEIGGDAEERAADFISKHVTKPVVGYVAGFT
APEGKTMGHAGAIVTGSEGTARAKKHALEAVGVRVGTTPSETAKLMREVVAAL

Specific function: Unknown

COG id: COG0074

COG function: function code C; Succinyl-CoA synthetase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the succinate/malate CoA ligase alpha subunit family [H]

Homologues:

Organism=Homo sapiens, GI109452591, Length=286, Percent_Identity=50.6993006993007, Blast_Score=225, Evalue=4e-59,
Organism=Homo sapiens, GI38569423, Length=255, Percent_Identity=29.8039215686275, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI38569421, Length=255, Percent_Identity=29.8039215686275, Blast_Score=83, Evalue=3e-16,
Organism=Escherichia coli, GI1786949, Length=293, Percent_Identity=52.2184300341297, Blast_Score=286, Evalue=1e-78,
Organism=Caenorhabditis elegans, GI17550194, Length=292, Percent_Identity=46.9178082191781, Blast_Score=241, Evalue=4e-64,
Organism=Caenorhabditis elegans, GI17553126, Length=296, Percent_Identity=46.9594594594595, Blast_Score=240, Evalue=7e-64,
Organism=Caenorhabditis elegans, GI17557344, Length=319, Percent_Identity=26.0188087774295, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17551266, Length=255, Percent_Identity=27.0588235294118, Blast_Score=79, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6324716, Length=303, Percent_Identity=45.5445544554455, Blast_Score=229, Evalue=3e-61,
Organism=Drosophila melanogaster, GI21356559, Length=297, Percent_Identity=44.1077441077441, Blast_Score=243, Evalue=7e-65,
Organism=Drosophila melanogaster, GI28574296, Length=296, Percent_Identity=47.2972972972973, Blast_Score=221, Evalue=4e-58,
Organism=Drosophila melanogaster, GI281363477, Length=256, Percent_Identity=29.6875, Blast_Score=85, Evalue=7e-17,
Organism=Drosophila melanogaster, GI281363475, Length=256, Percent_Identity=29.6875, Blast_Score=84, Evalue=9e-17,
Organism=Drosophila melanogaster, GI281363473, Length=256, Percent_Identity=29.6875, Blast_Score=84, Evalue=9e-17,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017440
- InterPro:   IPR003781
- InterPro:   IPR005810
- InterPro:   IPR005811
- InterPro:   IPR016040
- InterPro:   IPR016102 [H]

Pfam domain/function: PF02629 CoA_binding; PF00549 Ligase_CoA [H]

EC number: =6.2.1.5 [H]

Molecular weight: Translated: 30260; Mature: 30129

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: PS01216 SUCCINYL_COA_LIG_1 ; PS00399 SUCCINYL_COA_LIG_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIFLNSDSRIIIQGITGSEGSEHARRILASGAKLVGGTNPRKAGQTILINDTELPVFGT
CEEEEECCCEEEEEECCCCCCHHHHHHHHHCCCCEECCCCCCCCCCEEEEECCCCCCHHH
VKEAMEETGADVTVIFVPPAFAKAAIIEAIDAHIPLCVIITEGIPVRDASEAWAYAKKVG
HHHHHHHCCCCEEEEEECCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHCC
HTRIIGPNCPGIITPGESLAGITPANIAGSGPIGLISKSGTLTYQMMYELSDIGISTAIG
CEEEECCCCCEEECCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEEEEHHHHCCCEEEEC
IGGDPIIGTTHIDALEAFEADPETKAIVMIGEIGGDAEERAADFISKHVTKPVVGYVAGF
CCCCCCEECCHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCC
TAPEGKTMGHAGAIVTGSEGTARAKKHALEAVGVRVGTTPSETAKLMREVVAAL
CCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHCEEECCCHHHHHHHHHHHHHHC
>Mature Secondary Structure 
SIFLNSDSRIIIQGITGSEGSEHARRILASGAKLVGGTNPRKAGQTILINDTELPVFGT
EEEEECCCEEEEEECCCCCCHHHHHHHHHCCCCEECCCCCCCCCCEEEEECCCCCCHHH
VKEAMEETGADVTVIFVPPAFAKAAIIEAIDAHIPLCVIITEGIPVRDASEAWAYAKKVG
HHHHHHHCCCCEEEEEECCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHCC
HTRIIGPNCPGIITPGESLAGITPANIAGSGPIGLISKSGTLTYQMMYELSDIGISTAIG
CEEEECCCCCEEECCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEEEEHHHHCCCEEEEC
IGGDPIIGTTHIDALEAFEADPETKAIVMIGEIGGDAEERAADFISKHVTKPVVGYVAGF
CCCCCCEECCHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCC
TAPEGKTMGHAGAIVTGSEGTARAKKHALEAVGVRVGTTPSETAKLMREVVAAL
CCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHCEEECCCHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]