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The map label for this gene is sucC [H]

Identifier: 145296561

GI number: 145296561

Start: 2724373

End: 2725581

Strand: Reverse

Name: sucC [H]

Synonym: cgR_2469

Alternate gene names: 145296561

Gene position: 2725581-2724373 (Counterclockwise)

Preceding gene: 145296562

Following gene: 145296560

Centisome position: 82.24

GC content: 54.18

Gene sequence:

>1209_bases
ATGGAATTGGCAGTGGATCTTTTTGAATACCAAGCACGGGACCTCTTTGAAACCCATGGTGTGCCAGTGTTGAAGGGAAT
TGTGGCATCAACGCCAGAGGCGGCGAGGAAAGCGGCTGAGGAAATCGGCGGACTGACCGTCGTCAAGGCTCAGGTCAAGG
TGGGCGGACGTGGCAAGGCGGGTGGCGTCCGTGTGGCACCGACGTCGGCTCAGGCTTTTGATGCTGCGGATGCGATTCTC
GGCATGGATATCAAAGGCCACACTGTTAATCAGGTGATGGTGGCGCAGGGCGCTGACATTGCTGAGGAATACTATTTCTC
CATTTTGTTGGATCGCGCGAATCGTTCGTATCTGGCTATGTGCTCTGTTGAAGGTGGCATGGAGATCGAGATCCTGGCGA
AGGAAAAGCCTGAAGCTTTGGCAAAGGTGGAAGTGGATCCCCTCACTGGTATTGATGAGGACAAAGCGCGGGAGATTGTC
ACTGCTGCTGGCTTTGAAACTGAGGTGGCAGAGAAAGTCATTCCGGTGCTGATCAAGATCTGGCAGGTGTATTACGAAGA
GGAAGCAACACTCGTTGAGGTGAACCCGTTGGTGCTCACGGATGGCGGCGATGTGATTGCGCTTGATGGCAAGATCACGC
TGGATGATAACGCTGATTTCCGCCATGATAACCGTGGTGCGTTGGCTGAATCTGCCGGTGGCTTGGACATTTTGGAACTG
AAGGCCAAGAAGAATGATCTGAACTACGTGAAACTTGATGGCTCTGTGGGCATCATTGGCAATGGTGCAGGTTTGGTGAT
GTCCACGTTGGATATCGTGGCTGCAGCTGGTGAACGCCATGGTGGGCAGCGCCCCGCGAACTTCCTAGACATTGGTGGCG
GAGCATCAGCTGAATCGATGGCTGCTGGTCTCGATGTGATCCTTGGGGATAGCCAGGTACGCAGTGTGTTTGTGAATGTG
TTTGGTGGCATCACCGCGTGTGATGTGGTGGCAAAGGGAATCGTTGGAGCTTTGGATGTGCTCGGTGATCAAGCAACGAA
GCCTCTTGTGGTGCGCCTTGATGGCAACAACGTGGTGGAAGGCAGACGAATCCTCGCGGAATATAACCACCCTTTGGTCA
CCGTTGTGGAGGGTATGGATGCAGCGGCTGATCACGCTGCCCATTTGGCCAATCTTGCCCAGCACGGCCAGTTCGCAACC
GCTAATTAG

Upstream 100 bases:

>100_bases
GTGTTAGACTTCACAATATGATCATATTAGTGAGTTGAAACACTTACTTTGATGGGAAGACTTTGTTAAAGACGCAGAAG
GCTCTAAGCATGGGCCGGAA

Downstream 100 bases:

>100_bases
TCAAGGAGCACCTGTTTAATCATGTCTATTTTTCTCAATTCAGATTCCCGCATCATCATTCAGGGCATTACCGGTTCGGA
AGGTTCAGAGCATGCGCGTC

Product: succinyl-CoA synthetase subunit beta

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit beta; SCS-beta [H]

Number of amino acids: Translated: 402; Mature: 402

Protein sequence:

>402_residues
MELAVDLFEYQARDLFETHGVPVLKGIVASTPEAARKAAEEIGGLTVVKAQVKVGGRGKAGGVRVAPTSAQAFDAADAIL
GMDIKGHTVNQVMVAQGADIAEEYYFSILLDRANRSYLAMCSVEGGMEIEILAKEKPEALAKVEVDPLTGIDEDKAREIV
TAAGFETEVAEKVIPVLIKIWQVYYEEEATLVEVNPLVLTDGGDVIALDGKITLDDNADFRHDNRGALAESAGGLDILEL
KAKKNDLNYVKLDGSVGIIGNGAGLVMSTLDIVAAAGERHGGQRPANFLDIGGGASAESMAAGLDVILGDSQVRSVFVNV
FGGITACDVVAKGIVGALDVLGDQATKPLVVRLDGNNVVEGRRILAEYNHPLVTVVEGMDAAADHAAHLANLAQHGQFAT
AN

Sequences:

>Translated_402_residues
MELAVDLFEYQARDLFETHGVPVLKGIVASTPEAARKAAEEIGGLTVVKAQVKVGGRGKAGGVRVAPTSAQAFDAADAIL
GMDIKGHTVNQVMVAQGADIAEEYYFSILLDRANRSYLAMCSVEGGMEIEILAKEKPEALAKVEVDPLTGIDEDKAREIV
TAAGFETEVAEKVIPVLIKIWQVYYEEEATLVEVNPLVLTDGGDVIALDGKITLDDNADFRHDNRGALAESAGGLDILEL
KAKKNDLNYVKLDGSVGIIGNGAGLVMSTLDIVAAAGERHGGQRPANFLDIGGGASAESMAAGLDVILGDSQVRSVFVNV
FGGITACDVVAKGIVGALDVLGDQATKPLVVRLDGNNVVEGRRILAEYNHPLVTVVEGMDAAADHAAHLANLAQHGQFAT
AN
>Mature_402_residues
MELAVDLFEYQARDLFETHGVPVLKGIVASTPEAARKAAEEIGGLTVVKAQVKVGGRGKAGGVRVAPTSAQAFDAADAIL
GMDIKGHTVNQVMVAQGADIAEEYYFSILLDRANRSYLAMCSVEGGMEIEILAKEKPEALAKVEVDPLTGIDEDKAREIV
TAAGFETEVAEKVIPVLIKIWQVYYEEEATLVEVNPLVLTDGGDVIALDGKITLDDNADFRHDNRGALAESAGGLDILEL
KAKKNDLNYVKLDGSVGIIGNGAGLVMSTLDIVAAAGERHGGQRPANFLDIGGGASAESMAAGLDVILGDSQVRSVFVNV
FGGITACDVVAKGIVGALDVLGDQATKPLVVRLDGNNVVEGRRILAEYNHPLVTVVEGMDAAADHAAHLANLAQHGQFAT
AN

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0045

COG function: function code C; Succinyl-CoA synthetase, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Homo sapiens, GI11321583, Length=403, Percent_Identity=34.2431761786601, Blast_Score=225, Evalue=6e-59,
Organism=Homo sapiens, GI157779135, Length=388, Percent_Identity=34.5360824742268, Blast_Score=217, Evalue=1e-56,
Organism=Homo sapiens, GI294862256, Length=366, Percent_Identity=34.9726775956284, Blast_Score=205, Evalue=5e-53,
Organism=Escherichia coli, GI1786948, Length=371, Percent_Identity=42.3180592991914, Blast_Score=267, Evalue=8e-73,
Organism=Caenorhabditis elegans, GI17567829, Length=402, Percent_Identity=36.318407960199, Blast_Score=227, Evalue=8e-60,
Organism=Caenorhabditis elegans, GI17539378, Length=402, Percent_Identity=33.0845771144279, Blast_Score=214, Evalue=8e-56,
Organism=Saccharomyces cerevisiae, GI6321683, Length=405, Percent_Identity=34.0740740740741, Blast_Score=222, Evalue=7e-59,
Organism=Drosophila melanogaster, GI21356231, Length=400, Percent_Identity=35, Blast_Score=228, Evalue=7e-60,
Organism=Drosophila melanogaster, GI161078106, Length=401, Percent_Identity=34.9127182044888, Blast_Score=209, Evalue=2e-54,
Organism=Drosophila melanogaster, GI24645208, Length=401, Percent_Identity=34.9127182044888, Blast_Score=209, Evalue=2e-54,
Organism=Drosophila melanogaster, GI281361397, Length=402, Percent_Identity=35.0746268656716, Blast_Score=208, Evalue=6e-54,
Organism=Drosophila melanogaster, GI281361395, Length=402, Percent_Identity=35.0746268656716, Blast_Score=208, Evalue=6e-54,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2361 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013650
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR005811
- InterPro:   IPR017866
- InterPro:   IPR005809
- InterPro:   IPR016102 [H]

Pfam domain/function: PF08442 ATP-grasp_2; PF00549 Ligase_CoA [H]

EC number: =6.2.1.5 [H]

Molecular weight: Translated: 42119; Mature: 42119

Theoretical pI: Translated: 4.38; Mature: 4.38

Prosite motif: PS50975 ATP_GRASP ; PS01217 SUCCINYL_COA_LIG_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELAVDLFEYQARDLFETHGVPVLKGIVASTPEAARKAAEEIGGLTVVKAQVKVGGRGKA
CCEEHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHCCEEEEEEEEEECCCCCC
GGVRVAPTSAQAFDAADAILGMDIKGHTVNQVMVAQGADIAEEYYFSILLDRANRSYLAM
CCEEECCCCCHHHHHHHHHEECCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCEEEE
CSVEGGMEIEILAKEKPEALAKVEVDPLTGIDEDKAREIVTAAGFETEVAEKVIPVLIKI
EECCCCCEEEEEECCCCCCEEEEEECCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHH
WQVYYEEEATLVEVNPLVLTDGGDVIALDGKITLDDNADFRHDNRGALAESAGGLDILEL
HHHHHCCCCEEEEECCEEEECCCCEEEECCEEEECCCCCCCCCCCCCHHHCCCCCEEEEE
KAKKNDLNYVKLDGSVGIIGNGAGLVMSTLDIVAAAGERHGGQRPANFLDIGGGASAESM
EECCCCCCEEEECCCEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCHHHH
AAGLDVILGDSQVRSVFVNVFGGITACDVVAKGIVGALDVLGDQATKPLVVRLDGNNVVE
HCCCEEEECCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCEEC
GRRILAEYNHPLVTVVEGMDAAADHAAHLANLAQHGQFATAN
HHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MELAVDLFEYQARDLFETHGVPVLKGIVASTPEAARKAAEEIGGLTVVKAQVKVGGRGKA
CCEEHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHCCEEEEEEEEEECCCCCC
GGVRVAPTSAQAFDAADAILGMDIKGHTVNQVMVAQGADIAEEYYFSILLDRANRSYLAM
CCEEECCCCCHHHHHHHHHEECCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCEEEE
CSVEGGMEIEILAKEKPEALAKVEVDPLTGIDEDKAREIVTAAGFETEVAEKVIPVLIKI
EECCCCCEEEEEECCCCCCEEEEEECCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHH
WQVYYEEEATLVEVNPLVLTDGGDVIALDGKITLDDNADFRHDNRGALAESAGGLDILEL
HHHHHCCCCEEEEECCEEEECCCCEEEECCEEEECCCCCCCCCCCCCHHHCCCCCEEEEE
KAKKNDLNYVKLDGSVGIIGNGAGLVMSTLDIVAAAGERHGGQRPANFLDIGGGASAESM
EECCCCCCEEEECCCEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCHHHH
AAGLDVILGDSQVRSVFVNVFGGITACDVVAKGIVGALDVLGDQATKPLVVRLDGNNVVE
HCCCEEEECCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCEEC
GRRILAEYNHPLVTVVEGMDAAADHAAHLANLAQHGQFATAN
HHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12948626 [H]