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The map label for this gene is fes [H]

Identifier: 145296473

GI number: 145296473

Start: 2620253

End: 2621443

Strand: Reverse

Name: fes [H]

Synonym: cgR_2385

Alternate gene names: 145296473

Gene position: 2621443-2620253 (Counterclockwise)

Preceding gene: 145296474

Following gene: 145296469

Centisome position: 79.1

GC content: 60.71

Gene sequence:

>1191_bases
GTGGAGTTGTCGCCAACCGTGCCACCACAAAACCCCAAACGCCACATGCGCATCCAAAGCCCCATGGAAATTTCCTGGAG
TGAAGCGGTGCGCGAAGGCGGGGAGCATTCCGCTCGCCGCTGTGGTGACATGGCTGTGTCCGCGTTGGCTAAGCCGAATC
CCATCATTGACGATGATCCGGAAGGCAACCCCGATGTTTGCATGTATACCTGGATCGTTGAGTGTCCCGGCGCTACCGCA
GTGCTGCTATGGATCAATGGGGTTTTTGATCACCAGCGCATTGAAGAATCTGAAATGACCCGCCTCGAGGGCTCTGATCT
GTGGATTCTCAGCTTGCGCATGCCTTCCGATTGGCGAGCCAGCTACACCGTCAACGCCTGGTCTGGCGACGGGGTTGCGC
CATGGCGTGAGGCGGGCGATCGGATGCATATCCGCAAAGCCGCGATGTCGGGTGGGCGTCCGGATTCCCGCGCGATGGGT
CATATCATGGATTCCTCGCTCGTTGAAGGCCCTGATGCGTTGCCGGACTGCTGGGTTGCGGCGTCGACAAGCGTAAAAGT
CGTGGAAGAAACCGTCGCTGGCGAGCATTTCTGGTTCTATGAGGCGCCGGTCAAGGCGCCGCTGCTGGTGCTGTTTGATG
GCCAACACTGGAACAACAGCATGAATCTGCCTGCGCAGGTCGACGCGGCCATCGCCATCGGCTTGCTGCCGCCGGTCAGC
CTGCTCATGATCGATTCCGTCAACACCGAACGCCGCTGGGATAGTGTCGGCGTGCCAGGTGGGCAGGTTGATGTGCTTAT
CGACGCCCTCCTCCCGCACGTCCGCGCAACCTACAACGTTTCCGCGCGCGGCGAGGACACCATTGTCACCGGTGCAAGCT
TCGGCGGCCTAGCGTCCCTGTGGGCTCTTGCGCTTTCCGACGGCGAAGTCGGCCACGCAATCGCGCAATCGCCAAGCCTG
TGGCGCTTCAACGTTGCCGACGCGCTTTCTGCAGCAGAGCAGTGGAGCTCAATCCACCTGCAAGCTGGAAAATACGAAGG
TGAAATGCTGCGCCTGTCGCATCAGCTCGCCGAAGATCTCTCCGGCGACATCCGCGAGGTTCGCGTGCGTGGCGTGCATG
GCGGCCACGATTGGGCCTGGTGGCGGGTGCATATGCTCACCGAACTCACCAGGCTGCTAAAAACCCTCTAA

Upstream 100 bases:

>100_bases
CGTTTAAAGCGAAATACATGTAATGACCAGGCCAAGGGGAAACTAGATGCCACCGTTGAGGCAGACAAAAACGTGGGTGG
ACCGCAATGGGTCCGCTCAT

Downstream 100 bases:

>100_bases
TCAAAGTAGGGTGCGAAACGGTCCACCGCTGCCTGCGCATCATCCGCGCACTGCTCAGAGGTAGGACCAGGCTCTGCAAC
AAAAAATGAGCGACGGTAGT

Product: hypothetical protein

Products: Fe [C]

Alternate protein names: Ferric enterobactin esterase [H]

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MELSPTVPPQNPKRHMRIQSPMEISWSEAVREGGEHSARRCGDMAVSALAKPNPIIDDDPEGNPDVCMYTWIVECPGATA
VLLWINGVFDHQRIEESEMTRLEGSDLWILSLRMPSDWRASYTVNAWSGDGVAPWREAGDRMHIRKAAMSGGRPDSRAMG
HIMDSSLVEGPDALPDCWVAASTSVKVVEETVAGEHFWFYEAPVKAPLLVLFDGQHWNNSMNLPAQVDAAIAIGLLPPVS
LLMIDSVNTERRWDSVGVPGGQVDVLIDALLPHVRATYNVSARGEDTIVTGASFGGLASLWALALSDGEVGHAIAQSPSL
WRFNVADALSAAEQWSSIHLQAGKYEGEMLRLSHQLAEDLSGDIREVRVRGVHGGHDWAWWRVHMLTELTRLLKTL

Sequences:

>Translated_396_residues
MELSPTVPPQNPKRHMRIQSPMEISWSEAVREGGEHSARRCGDMAVSALAKPNPIIDDDPEGNPDVCMYTWIVECPGATA
VLLWINGVFDHQRIEESEMTRLEGSDLWILSLRMPSDWRASYTVNAWSGDGVAPWREAGDRMHIRKAAMSGGRPDSRAMG
HIMDSSLVEGPDALPDCWVAASTSVKVVEETVAGEHFWFYEAPVKAPLLVLFDGQHWNNSMNLPAQVDAAIAIGLLPPVS
LLMIDSVNTERRWDSVGVPGGQVDVLIDALLPHVRATYNVSARGEDTIVTGASFGGLASLWALALSDGEVGHAIAQSPSL
WRFNVADALSAAEQWSSIHLQAGKYEGEMLRLSHQLAEDLSGDIREVRVRGVHGGHDWAWWRVHMLTELTRLLKTL
>Mature_396_residues
MELSPTVPPQNPKRHMRIQSPMEISWSEAVREGGEHSARRCGDMAVSALAKPNPIIDDDPEGNPDVCMYTWIVECPGATA
VLLWINGVFDHQRIEESEMTRLEGSDLWILSLRMPSDWRASYTVNAWSGDGVAPWREAGDRMHIRKAAMSGGRPDSRAMG
HIMDSSLVEGPDALPDCWVAASTSVKVVEETVAGEHFWFYEAPVKAPLLVLFDGQHWNNSMNLPAQVDAAIAIGLLPPVS
LLMIDSVNTERRWDSVGVPGGQVDVLIDALLPHVRATYNVSARGEDTIVTGASFGGLASLWALALSDGEVGHAIAQSPSL
WRFNVADALSAAEQWSSIHLQAGKYEGEMLRLSHQLAEDLSGDIREVRVRGVHGGHDWAWWRVHMLTELTRLLKTL

Specific function: Upon internalization, ferric enterobactin is processed via an exquisitely specific pathway that is dependent on FES activity, making iron available for metabolic use [H]

COG id: COG2382

COG function: function code P; Enterochelin esterase and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fes family [H]

Homologues:

Organism=Escherichia coli, GI1786799, Length=348, Percent_Identity=25.2873563218391, Blast_Score=87, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR021764
- InterPro:   IPR000801
- InterPro:   IPR014756 [H]

Pfam domain/function: PF11806 DUF3327; PF00756 Esterase [H]

EC number: NA

Molecular weight: Translated: 43558; Mature: 43558

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELSPTVPPQNPKRHMRIQSPMEISWSEAVREGGEHSARRCGDMAVSALAKPNPIIDDDP
CCCCCCCCCCCCHHCEEECCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCC
EGNPDVCMYTWIVECPGATAVLLWINGVFDHQRIEESEMTRLEGSDLWILSLRMPSDWRA
CCCCCEEEEEEEEECCCCEEEEEEEECHHHHHHCCHHHHHEECCCCEEEEEEECCCCCCC
SYTVNAWSGDGVAPWREAGDRMHIRKAAMSGGRPDSRAMGHIMDSSLVEGPDALPDCWVA
EEEEEECCCCCCCHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEE
ASTSVKVVEETVAGEHFWFYEAPVKAPLLVLFDGQHWNNSMNLPAQVDAAIAIGLLPPVS
CCCCHHHHHHHHCCCEEEEEECCCCCCEEEEECCCCCCCCCCCCCHHHHEEEEECCCCCE
LLMIDSVNTERRWDSVGVPGGQVDVLIDALLPHVRATYNVSARGEDTIVTGASFGGLASL
EEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHEEEEECCCCCCEEEECCCCCHHHHH
WALALSDGEVGHAIAQSPSLWRFNVADALSAAEQWSSIHLQAGKYEGEMLRLSHQLAEDL
HHHHCCCCCCCHHHHCCCCCEEEEHHHHHHHHHHHCEEEEECCCCCCHHHHHHHHHHHHH
SGDIREVRVRGVHGGHDWAWWRVHMLTELTRLLKTL
CCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MELSPTVPPQNPKRHMRIQSPMEISWSEAVREGGEHSARRCGDMAVSALAKPNPIIDDDP
CCCCCCCCCCCCHHCEEECCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCC
EGNPDVCMYTWIVECPGATAVLLWINGVFDHQRIEESEMTRLEGSDLWILSLRMPSDWRA
CCCCCEEEEEEEEECCCCEEEEEEEECHHHHHHCCHHHHHEECCCCEEEEEEECCCCCCC
SYTVNAWSGDGVAPWREAGDRMHIRKAAMSGGRPDSRAMGHIMDSSLVEGPDALPDCWVA
EEEEEECCCCCCCHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEE
ASTSVKVVEETVAGEHFWFYEAPVKAPLLVLFDGQHWNNSMNLPAQVDAAIAIGLLPPVS
CCCCHHHHHHHHCCCEEEEEECCCCCCEEEEECCCCCCCCCCCCCHHHHEEEEECCCCCE
LLMIDSVNTERRWDSVGVPGGQVDVLIDALLPHVRATYNVSARGEDTIVTGASFGGLASL
EEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHEEEEECCCCCCEEEECCCCCHHHHH
WALALSDGEVGHAIAQSPSLWRFNVADALSAAEQWSSIHLQAGKYEGEMLRLSHQLAEDL
HHHHCCCCCCCHHHHCCCCCEEEEHHHHHHHHHHHCEEEEECCCCCCHHHHHHHHHHHHH
SGDIREVRVRGVHGGHDWAWWRVHMLTELTRLLKTL
CCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ferrienterobactin [C]

Specific reaction: ferrienterobactin = Fe [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA