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The map label for this gene is clpP1 [H]

Identifier: 145296393

GI number: 145296393

Start: 2541789

End: 2542415

Strand: Reverse

Name: clpP1 [H]

Synonym: cgR_2307

Alternate gene names: 145296393

Gene position: 2542415-2541789 (Counterclockwise)

Preceding gene: 145296394

Following gene: 145296386

Centisome position: 76.71

GC content: 57.42

Gene sequence:

>627_bases
ATGAGCAACGGATTCCAAATGCCAACGTCCCGTTACGTGCTGCCTTCCTTCATTGAGCAGTCCGCATACGGCACCAAAGA
GACCAACCCTTACGCAAAACTCTTTGAAGAGCGCATCATCTTCCTGGGCACCCAGGTCGACGACACCTCTGCAAACGACA
TCATGGCGCAGCTCCTTGTCCTCGAAGGCATGGACCCAGACCGCGATATCACCTTGTACATCAACTCACCTGGTGGATCC
TTCACCGCGTTGATGGCAATTTACGACACCATGCAGTACGTCCGCCCAGACGTTCAGACCGTCTGCCTTGGTCAGGCAGC
ATCCGCAGCCGCAGTTCTTCTTGCAGCCGGTGCGCCAGGTAAGCGCGCTGTTCTTCCTAACTCCCGCGTGCTGATCCACC
AGCCAGCAACCCAGGGCACCCAGGGTCAGGTTTCTGACCTCGAGATCCAGGCAGCTGAAATCGAGCGCATGCGTCGTTTG
ATGGAAACCACCTTGGCTGAGCACACCGGCAAGACCGCGGAGCAGATCCGCATCGACACCGACCGTGACAAGATCCTCAC
CGCTGAGGAAGCACTCGAGTACGGCATCGTTGACCAGGTCTTCGATTACCGCAAGCTCAAGCGCTAG

Upstream 100 bases:

>100_bases
GAAGCTAAGGATTACGGACTTGTTGACCACGTGATTACCTTGGCTGAAGGCCCAATCAGCAACTAGGCGCACGGAAAACT
TTAAAGGAGAGAAAAAGATT

Downstream 100 bases:

>100_bases
AAATACGAGAAAGGCCCCGCACTTTAAGTCCAAAGTGCGGGGCCTTTTTAGTAAGTTGTGGGTTAGTTTGCCATCAGCTG
TGGTAGGAAGAGAACAATCG

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp 1 [H]

Number of amino acids: Translated: 208; Mature: 207

Protein sequence:

>208_residues
MSNGFQMPTSRYVLPSFIEQSAYGTKETNPYAKLFEERIIFLGTQVDDTSANDIMAQLLVLEGMDPDRDITLYINSPGGS
FTALMAIYDTMQYVRPDVQTVCLGQAASAAAVLLAAGAPGKRAVLPNSRVLIHQPATQGTQGQVSDLEIQAAEIERMRRL
METTLAEHTGKTAEQIRIDTDRDKILTAEEALEYGIVDQVFDYRKLKR

Sequences:

>Translated_208_residues
MSNGFQMPTSRYVLPSFIEQSAYGTKETNPYAKLFEERIIFLGTQVDDTSANDIMAQLLVLEGMDPDRDITLYINSPGGS
FTALMAIYDTMQYVRPDVQTVCLGQAASAAAVLLAAGAPGKRAVLPNSRVLIHQPATQGTQGQVSDLEIQAAEIERMRRL
METTLAEHTGKTAEQIRIDTDRDKILTAEEALEYGIVDQVFDYRKLKR
>Mature_207_residues
SNGFQMPTSRYVLPSFIEQSAYGTKETNPYAKLFEERIIFLGTQVDDTSANDIMAQLLVLEGMDPDRDITLYINSPGGSF
TALMAIYDTMQYVRPDVQTVCLGQAASAAAVLLAAGAPGKRAVLPNSRVLIHQPATQGTQGQVSDLEIQAAEIERMRRLM
ETTLAEHTGKTAEQIRIDTDRDKILTAEEALEYGIVDQVFDYRKLKR

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=189, Percent_Identity=42.8571428571429, Blast_Score=167, Evalue=6e-42,
Organism=Escherichia coli, GI1786641, Length=193, Percent_Identity=53.8860103626943, Blast_Score=218, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI17538017, Length=191, Percent_Identity=43.455497382199, Blast_Score=168, Evalue=1e-42,
Organism=Drosophila melanogaster, GI20129427, Length=191, Percent_Identity=43.455497382199, Blast_Score=173, Evalue=8e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 23038; Mature: 22906

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: PS00381 CLP_PROTEASE_SER ; PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNGFQMPTSRYVLPSFIEQSAYGTKETNPYAKLFEERIIFLGTQVDDTSANDIMAQLLV
CCCCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHEEEECCCCCCCHHHHHHHHHH
LEGMDPDRDITLYINSPGGSFTALMAIYDTMQYVRPDVQTVCLGQAASAAAVLLAAGAPG
HCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHEEEEECCCCC
KRAVLPNSRVLIHQPATQGTQGQVSDLEIQAAEIERMRRLMETTLAEHTGKTAEQIRIDT
CEEECCCCEEEEECCCCCCCCCCCCHHEEHHHHHHHHHHHHHHHHHHHCCCCHHHEEEEC
DRDKILTAEEALEYGIVDQVFDYRKLKR
CCCCEEEHHHHHHHCCHHHHHHHHHHCC
>Mature Secondary Structure 
SNGFQMPTSRYVLPSFIEQSAYGTKETNPYAKLFEERIIFLGTQVDDTSANDIMAQLLV
CCCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHEEEECCCCCCCHHHHHHHHHH
LEGMDPDRDITLYINSPGGSFTALMAIYDTMQYVRPDVQTVCLGQAASAAAVLLAAGAPG
HCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHEEEEECCCCC
KRAVLPNSRVLIHQPATQGTQGQVSDLEIQAAEIERMRRLMETTLAEHTGKTAEQIRIDT
CEEECCCCEEEEECCCCCCCCCCCCHHEEHHHHHHHHHHHHHHHHHHHCCCCHHHEEEEC
DRDKILTAEEALEYGIVDQVFDYRKLKR
CCCCEEEHHHHHHHCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12840036 [H]