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The map label for this gene is clpP

Identifier: 145296394

GI number: 145296394

Start: 2542450

End: 2543043

Strand: Reverse

Name: clpP

Synonym: cgR_2308

Alternate gene names: 145296394

Gene position: 2543043-2542450 (Counterclockwise)

Preceding gene: 145296395

Following gene: 145296393

Centisome position: 76.73

GC content: 55.22

Gene sequence:

>594_bases
ATGAGCGATATTCGTATGGCAGCCCAGGGTGGGCCTGGTTTCGGAAATGACGTCTTTGATCGCCTCCTGAGTGAGCGCAT
CATTTTCCTGGGAAGCCAGGTAGACGATGAGATTGCAAACAAGCTATGCGCTCAGATCTTGCTGCTGTCCGCTGAGGATC
CAACCAGGGACATCTCCCTGTACATTAACTCCCCAGGTGGCTCCGTCACCGCAGGCATGGCAATTTACGACACCATGAAG
TACTCCCCATGCGACATCGCAACCTACGGCATGGGCCTGGCAGCATCCATGGGCCAGTTCCTGCTTTCCGGTGGCACTAA
GGGCAAGCGTTTCGCATTGCCACACGCACGTATCATGATGCACCAACCTTCCGCTGGTGTTGGTGGTACCGCAGCTGATA
TCGCTATCCAGGCTGAGCAGTTCGCAGCCACCAAGCGTGAAATGGCCCAGCTGATCGCTGAGCACACCGGCCAGACCTTT
GAACAGATCTCCAAGGATTCCGATCGTGACCGCTGGTTCACTGCACAGGAAGCTAAGGATTACGGACTTGTTGACCACGT
GATTACCTTGGCTGAAGGCCCAATCAGCAACTAG

Upstream 100 bases:

>100_bases
AGCGAACAGAGGCGGTTTCATGGAAATACGCGGGTAGTCTGGTGACATTGAACCAAATGAACGTACCCAAGATTTAAGAA
TGTAGGAGTTGACTGTTTTC

Downstream 100 bases:

>100_bases
GCGCACGGAAAACTTTAAAGGAGAGAAAAAGATTATGAGCAACGGATTCCAAATGCCAACGTCCCGTTACGTGCTGCCTT
CCTTCATTGAGCAGTCCGCA

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp 2

Number of amino acids: Translated: 197; Mature: 196

Protein sequence:

>197_residues
MSDIRMAAQGGPGFGNDVFDRLLSERIIFLGSQVDDEIANKLCAQILLLSAEDPTRDISLYINSPGGSVTAGMAIYDTMK
YSPCDIATYGMGLAASMGQFLLSGGTKGKRFALPHARIMMHQPSAGVGGTAADIAIQAEQFAATKREMAQLIAEHTGQTF
EQISKDSDRDRWFTAQEAKDYGLVDHVITLAEGPISN

Sequences:

>Translated_197_residues
MSDIRMAAQGGPGFGNDVFDRLLSERIIFLGSQVDDEIANKLCAQILLLSAEDPTRDISLYINSPGGSVTAGMAIYDTMK
YSPCDIATYGMGLAASMGQFLLSGGTKGKRFALPHARIMMHQPSAGVGGTAADIAIQAEQFAATKREMAQLIAEHTGQTF
EQISKDSDRDRWFTAQEAKDYGLVDHVITLAEGPISN
>Mature_196_residues
SDIRMAAQGGPGFGNDVFDRLLSERIIFLGSQVDDEIANKLCAQILLLSAEDPTRDISLYINSPGGSVTAGMAIYDTMKY
SPCDIATYGMGLAASMGQFLLSGGTKGKRFALPHARIMMHQPSAGVGGTAADIAIQAEQFAATKREMAQLIAEHTGQTFE
QISKDSDRDRWFTAQEAKDYGLVDHVITLAEGPISN

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=173, Percent_Identity=46.8208092485549, Blast_Score=175, Evalue=2e-44,
Organism=Escherichia coli, GI1786641, Length=186, Percent_Identity=53.2258064516129, Blast_Score=210, Evalue=4e-56,
Organism=Caenorhabditis elegans, GI17538017, Length=173, Percent_Identity=49.1329479768786, Blast_Score=179, Evalue=1e-45,
Organism=Drosophila melanogaster, GI20129427, Length=187, Percent_Identity=47.5935828877005, Blast_Score=181, Evalue=3e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP2_CORGL (Q8NN01)

Other databases:

- EMBL:   BA000036
- EMBL:   BX927155
- RefSeq:   NP_601612.1
- RefSeq:   YP_226656.1
- ProteinModelPortal:   Q8NN01
- SMR:   Q8NN01
- MEROPS:   S14.008
- World-2DPAGE:   0001:Q8NN01
- GeneID:   1020361
- GeneID:   3345290
- GenomeReviews:   BA000036_GR
- GenomeReviews:   BX927147_GR
- KEGG:   cgb:cg2645
- KEGG:   cgl:NCgl2328
- HOGENOM:   HBG558421
- OMA:   ANKLCAQ
- ProtClustDB:   PRK00277
- BioCyc:   CGLU196627:CG2645-MONOMER
- BRENDA:   3.4.21.92
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 21151; Mature: 21020

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 100-100 ACT_SITE 125-125

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDIRMAAQGGPGFGNDVFDRLLSERIIFLGSQVDDEIANKLCAQILLLSAEDPTRDISL
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEEEE
YINSPGGSVTAGMAIYDTMKYSPCDIATYGMGLAASMGQFLLSGGTKGKRFALPHARIMM
EEECCCCCEEECHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCEEEE
HQPSAGVGGTAADIAIQAEQFAATKREMAQLIAEHTGQTFEQISKDSDRDRWFTAQEAKD
ECCCCCCCCCHHHHEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCEEEHHHHCC
YGLVDHVITLAEGPISN
CCHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SDIRMAAQGGPGFGNDVFDRLLSERIIFLGSQVDDEIANKLCAQILLLSAEDPTRDISL
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEEEE
YINSPGGSVTAGMAIYDTMKYSPCDIATYGMGLAASMGQFLLSGGTKGKRFALPHARIMM
EEECCCCCEEECHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCEEEE
HQPSAGVGGTAADIAIQAEQFAATKREMAQLIAEHTGQTFEQISKDSDRDRWFTAQEAKD
ECCCCCCCCCHHHHEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCEEEHHHHCC
YGLVDHVITLAEGPISN
CCHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12948626