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The map label for this gene is benD [H]

Identifier: 145296374

GI number: 145296374

Start: 2519115

End: 2519945

Strand: Direct

Name: benD [H]

Synonym: cgR_2288

Alternate gene names: 145296374

Gene position: 2519115-2519945 (Clockwise)

Preceding gene: 145296373

Following gene: 145296375

Centisome position: 76.01

GC content: 56.92

Gene sequence:

>831_bases
ATGAGCGCGCCAGTAGGACAAGGCATCGAAGGTCGCCCCACTCACGTCACCCCGGAACGCTTCTTTGGCCAGGGTGTTGT
GGTGACCGGAGCGGCTCAAGGCATCGGCATGGCAGTGGCACACCGCATCGCACATGAGGATGGCAACCTAGTGTTGGTGG
ACCGTTCCCCGCTGGTGCATGAAGTTGCCGAAGAGCTGCGTAAAGCAGGCGCCGGAACGGTGGATTCTTTCATCGCCGAT
CTGGAAACCTTTGAAGGCGCAACTGATGCTTTGGAATTTGCCGGGCAGAAGTTGAAGAACCTTGATGTGGTGATCAACAA
CGTTGGTGGCACCATCTGGGCGAAGCCTTATCAGGAATACTCTGAGGAAGAGATCCGCAAGGAAATCAACCGAAGCCTCT
TCCCCACCTTGTGGATGTGCCGGGCCGCGTTGCCAATTCTGATCGGAAATGGTGGTGGAACGATCGTTAATGTGTCCTCC
ATCGCGACCGGTGGTATCAACCGTGTTCCTTATGCTGCAGCAAAGGGTGGCGTCAACGGCATTGTTTCTGCCATGGCCCG
CGAAGCTGCACCGCATAATGTGCGCGTGGTGGCAACGGCTCCCGGTGGCACGCTCGCTCCGGAACGTGCCGTCAAACGAG
GCCCTGGGCCAGAGGGCGAATTGGAAGAAAAGTGGTATCAGCAAATCGTTGATCAAACCATTGATTCCAGTTTGATGAAG
CGCTACGGCACCCTAGAGGAGCAGGCCGCGCCGATCTGTTTCCTCGCTTCTGAGGAAGCTTCCTACATCACTGGATCAGT
CATGCCAGTCGGTGGGGGCGACCAGGGATAA

Upstream 100 bases:

>100_bases
TTGTCGACGCCGTCTCCCAGAATGATCTCGAGACCGCGAGAACAATCATTCGTGAACACGCGGAGCACGGCATTGACACT
ATGGTTAAGGCCCTCGAGAA

Downstream 100 bases:

>100_bases
CCCTTGGTCAATCTTAGGGACTTGTACCTGTTTTTGCAGGTACAAGTCCCTTTTTTCGTCTAGTATTGATTTATGGTTGC
CTCAGTCTCTTTCACCCCGT

Product: 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase

Products: NA

Alternate protein names: 2-hydro-1,2-dihydroxybenzoate dehydrogenase; DHB dehydrogenase; Cis-1,2-dihydroxy-3,4-cyclohexadiene-1-carboxylate dehydrogenase; Cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate dehydrogenase [H]

Number of amino acids: Translated: 276; Mature: 275

Protein sequence:

>276_residues
MSAPVGQGIEGRPTHVTPERFFGQGVVVTGAAQGIGMAVAHRIAHEDGNLVLVDRSPLVHEVAEELRKAGAGTVDSFIAD
LETFEGATDALEFAGQKLKNLDVVINNVGGTIWAKPYQEYSEEEIRKEINRSLFPTLWMCRAALPILIGNGGGTIVNVSS
IATGGINRVPYAAAKGGVNGIVSAMAREAAPHNVRVVATAPGGTLAPERAVKRGPGPEGELEEKWYQQIVDQTIDSSLMK
RYGTLEEQAAPICFLASEEASYITGSVMPVGGGDQG

Sequences:

>Translated_276_residues
MSAPVGQGIEGRPTHVTPERFFGQGVVVTGAAQGIGMAVAHRIAHEDGNLVLVDRSPLVHEVAEELRKAGAGTVDSFIAD
LETFEGATDALEFAGQKLKNLDVVINNVGGTIWAKPYQEYSEEEIRKEINRSLFPTLWMCRAALPILIGNGGGTIVNVSS
IATGGINRVPYAAAKGGVNGIVSAMAREAAPHNVRVVATAPGGTLAPERAVKRGPGPEGELEEKWYQQIVDQTIDSSLMK
RYGTLEEQAAPICFLASEEASYITGSVMPVGGGDQG
>Mature_275_residues
SAPVGQGIEGRPTHVTPERFFGQGVVVTGAAQGIGMAVAHRIAHEDGNLVLVDRSPLVHEVAEELRKAGAGTVDSFIADL
ETFEGATDALEFAGQKLKNLDVVINNVGGTIWAKPYQEYSEEEIRKEINRSLFPTLWMCRAALPILIGNGGGTIVNVSSI
ATGGINRVPYAAAKGGVNGIVSAMAREAAPHNVRVVATAPGGTLAPERAVKRGPGPEGELEEKWYQQIVDQTIDSSLMKR
YGTLEEQAAPICFLASEEASYITGSVMPVGGGDQG

Specific function: Degradation of 2-hydro-1,2-dihydroxy benzoate (DHB) to catechol [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI15277342, Length=259, Percent_Identity=30.1158301158301, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI19923817, Length=270, Percent_Identity=26.2962962962963, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI32483357, Length=252, Percent_Identity=28.1746031746032, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI40254992, Length=254, Percent_Identity=27.1653543307087, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI10190704, Length=260, Percent_Identity=25.7692307692308, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI59889578, Length=182, Percent_Identity=31.3186813186813, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI66933014, Length=188, Percent_Identity=27.1276595744681, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI4758504, Length=189, Percent_Identity=30.1587301587302, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI126723750, Length=266, Percent_Identity=28.1954887218045, Blast_Score=68, Evalue=8e-12,
Organism=Homo sapiens, GI210032110, Length=169, Percent_Identity=28.4023668639053, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI87082100, Length=259, Percent_Identity=28.1853281853282, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1789208, Length=258, Percent_Identity=30.6201550387597, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1787905, Length=257, Percent_Identity=28.0155642023346, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI2367175, Length=256, Percent_Identity=29.296875, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI1789378, Length=271, Percent_Identity=27.6752767527675, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1790717, Length=260, Percent_Identity=24.6153846153846, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1788459, Length=193, Percent_Identity=30.5699481865285, Blast_Score=67, Evalue=9e-13,
Organism=Escherichia coli, GI1787335, Length=260, Percent_Identity=26.5384615384615, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71994604, Length=253, Percent_Identity=31.6205533596838, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI71994600, Length=255, Percent_Identity=30.1960784313725, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17561402, Length=261, Percent_Identity=27.2030651340996, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17555706, Length=255, Percent_Identity=29.4117647058824, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17562910, Length=268, Percent_Identity=28.3582089552239, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17559104, Length=272, Percent_Identity=28.6764705882353, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17560676, Length=251, Percent_Identity=24.7011952191235, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17565030, Length=266, Percent_Identity=29.6992481203008, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI25147288, Length=257, Percent_Identity=26.8482490272374, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17562904, Length=264, Percent_Identity=26.5151515151515, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI193204405, Length=194, Percent_Identity=29.3814432989691, Blast_Score=64, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17560150, Length=267, Percent_Identity=27.3408239700375, Blast_Score=64, Evalue=1e-10,
Organism=Saccharomyces cerevisiae, GI6323882, Length=202, Percent_Identity=28.2178217821782, Blast_Score=67, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6322861, Length=265, Percent_Identity=24.1509433962264, Blast_Score=62, Evalue=9e-11,
Organism=Drosophila melanogaster, GI28571526, Length=264, Percent_Identity=31.4393939393939, Blast_Score=91, Evalue=8e-19,
Organism=Drosophila melanogaster, GI24644339, Length=258, Percent_Identity=31.0077519379845, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI23397609, Length=257, Percent_Identity=31.1284046692607, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21357041, Length=258, Percent_Identity=29.8449612403101, Blast_Score=88, Evalue=7e-18,
Organism=Drosophila melanogaster, GI21355319, Length=267, Percent_Identity=29.9625468164794, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24644337, Length=127, Percent_Identity=35.4330708661417, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24643142, Length=256, Percent_Identity=25.390625, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI281364892, Length=171, Percent_Identity=29.8245614035088, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24639444, Length=263, Percent_Identity=27.7566539923954, Blast_Score=64, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.3.1.25 [H]

Molecular weight: Translated: 29077; Mature: 28946

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAPVGQGIEGRPTHVTPERFFGQGVVVTGAAQGIGMAVAHRIAHEDGNLVLVDRSPLVH
CCCCCCCCCCCCCCCCCHHHHHCCCEEEECCCCHHHHHHHHHHHCCCCCEEEEECCCHHH
EVAEELRKAGAGTVDSFIADLETFEGATDALEFAGQKLKNLDVVINNVGGTIWAKPYQEY
HHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCHHEEEECCCCCEEECCHHHH
SEEEIRKEINRSLFPTLWMCRAALPILIGNGGGTIVNVSSIATGGINRVPYAAAKGGVNG
HHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCEEEEHHHCCCCCCCCCCHHHCCCHHH
IVSAMAREAAPHNVRVVATAPGGTLAPERAVKRGPGPEGELEEKWYQQIVDQTIDSSLMK
HHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
RYGTLEEQAAPICFLASEEASYITGSVMPVGGGDQG
HHCCHHHHCCCEEEEECCCCCEEECCEEECCCCCCC
>Mature Secondary Structure 
SAPVGQGIEGRPTHVTPERFFGQGVVVTGAAQGIGMAVAHRIAHEDGNLVLVDRSPLVH
CCCCCCCCCCCCCCCCHHHHHCCCEEEECCCCHHHHHHHHHHHCCCCCEEEEECCCHHH
EVAEELRKAGAGTVDSFIADLETFEGATDALEFAGQKLKNLDVVINNVGGTIWAKPYQEY
HHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCHHEEEECCCCCEEECCHHHH
SEEEIRKEINRSLFPTLWMCRAALPILIGNGGGTIVNVSSIATGGINRVPYAAAKGGVNG
HHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCEEEEHHHCCCCCCCCCCHHHCCCHHH
IVSAMAREAAPHNVRVVATAPGGTLAPERAVKRGPGPEGELEEKWYQQIVDQTIDSSLMK
HHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
RYGTLEEQAAPICFLASEEASYITGSVMPVGGGDQG
HHCCHHHHCCCEEEEECCCCCEEECCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1740120 [H]