Click here to switch to the map view.

The map label for this gene is pcaR [H]

Identifier: 145296358

GI number: 145296358

Start: 2503664

End: 2504431

Strand: Direct

Name: pcaR [H]

Synonym: cgR_2273

Alternate gene names: 145296358

Gene position: 2503664-2504431 (Clockwise)

Preceding gene: 145296355

Following gene: 145296359

Centisome position: 75.54

GC content: 57.16

Gene sequence:

>768_bases
ATGGTCGAACAATCGCCAGATTTCGTACAATCATTTGCCCGCGGCTTATCTGTGATCCGAAGTTTCAGCGCAGATAATCC
ATCGCAAACACTGTCCGAAGTCGCCAGCCAAACTGGACTCTCAAGGGCCACCGCTAGGCGCTTTCTCCACACCTTGACCG
ACCTTGGATATGCGGTAAACAACGATTCCCGGTTCCAGCTCACACCACGTGTTTTGGAGCTTGGAGCAAGCTACCTTTCC
GCATTATCCCTGCCTGCGATCGCGCAGCCCCGCCTGGAGGTACTCTCCCGCCAGGTCGGCGAATCAAGCTCCATGTCCGT
ACTCGACGGCACTGACATCATCTACGTTTGCCGCGTTCCGGTGCGCCGCATCATGACGGTGAACATCACCATCGGCACCC
GTTTCCCTGCGTACGCCACCTCCATGGGACGCGTCATGCTGGCCAACCTTCCCGAAGAAGAATTGGATGAAATGCTGGCG
GCGGCACCCCCTGAACAGTTGACCACCCGGTCACTGACCTCCATCGCCTCAATCCGGGAAGAGATCATTGCTACCCGCGA
AAGGGGGTGGTCATTGGTGGATCAGGAGCTCGAGCCGGGCCTGCGTTCGCTCGCGGCGCCGATCACCAATGCCCAGGGCG
AAGTGGTTGCTTCCATCAATGTGTCGACCCAATCGGCATCACATTCGGTGGAAGATATCCGCAAGCTGGTGCTGCCGCAG
CTTTTAGAAACGGCTCAAGCAATTTCGACAGATCTCTCTGCACTCTAA

Upstream 100 bases:

>100_bases
AGTGGAAGAAATGCTCTTGTTAATCATGTGAGACATGCTAACGTAATGTTCATCATATGCACAAGAGTTCGCAATGCGAA
CAAAAAGAGGAGTTGATGGG

Downstream 100 bases:

>100_bases
ATTTAAGGATCAAAAAATGAACCCTCAAGATATTGTCATCTGTTCCCCATTGCGCACCCCAGTTGGTGCTTACGGCGGAT
CCTTCACCGGCGTCCCTGTT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 255; Mature: 255

Protein sequence:

>255_residues
MVEQSPDFVQSFARGLSVIRSFSADNPSQTLSEVASQTGLSRATARRFLHTLTDLGYAVNNDSRFQLTPRVLELGASYLS
ALSLPAIAQPRLEVLSRQVGESSSMSVLDGTDIIYVCRVPVRRIMTVNITIGTRFPAYATSMGRVMLANLPEEELDEMLA
AAPPEQLTTRSLTSIASIREEIIATRERGWSLVDQELEPGLRSLAAPITNAQGEVVASINVSTQSASHSVEDIRKLVLPQ
LLETAQAISTDLSAL

Sequences:

>Translated_255_residues
MVEQSPDFVQSFARGLSVIRSFSADNPSQTLSEVASQTGLSRATARRFLHTLTDLGYAVNNDSRFQLTPRVLELGASYLS
ALSLPAIAQPRLEVLSRQVGESSSMSVLDGTDIIYVCRVPVRRIMTVNITIGTRFPAYATSMGRVMLANLPEEELDEMLA
AAPPEQLTTRSLTSIASIREEIIATRERGWSLVDQELEPGLRSLAAPITNAQGEVVASINVSTQSASHSVEDIRKLVLPQ
LLETAQAISTDLSAL
>Mature_255_residues
MVEQSPDFVQSFARGLSVIRSFSADNPSQTLSEVASQTGLSRATARRFLHTLTDLGYAVNNDSRFQLTPRVLELGASYLS
ALSLPAIAQPRLEVLSRQVGESSSMSVLDGTDIIYVCRVPVRRIMTVNITIGTRFPAYATSMGRVMLANLPEEELDEMLA
AAPPEQLTTRSLTSIASIREEIIATRERGWSLVDQELEPGLRSLAAPITNAQGEVVASINVSTQSASHSVEDIRKLVLPQ
LLETAQAISTDLSAL

Specific function: Positive regulator of all genes within the pca regulon, pcaBDC, pcaIJ and pcaF. Also required for the chemotactic response to aromatic compounds [H]

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI87082359, Length=218, Percent_Identity=33.0275229357798, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1786468, Length=218, Percent_Identity=27.9816513761468, Blast_Score=108, Evalue=2e-25,
Organism=Escherichia coli, GI1788131, Length=246, Percent_Identity=27.2357723577236, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1789999, Length=256, Percent_Identity=27.34375, Blast_Score=91, Evalue=9e-20,
Organism=Escherichia coli, GI1786715, Length=247, Percent_Identity=25.1012145748988, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1788581, Length=222, Percent_Identity=25.2252252252252, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI145693096, Length=252, Percent_Identity=30.1587301587302, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1790752, Length=223, Percent_Identity=23.7668161434978, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012794
- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 27643; Mature: 27643

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVEQSPDFVQSFARGLSVIRSFSADNPSQTLSEVASQTGLSRATARRFLHTLTDLGYAVN
CCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCHHCC
NDSRFQLTPRVLELGASYLSALSLPAIAQPRLEVLSRQVGESSSMSVLDGTDIIYVCRVP
CCCCEEECHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCEEECCCCEEEEECCC
VRRIMTVNITIGTRFPAYATSMGRVMLANLPEEELDEMLAAAPPEQLTTRSLTSIASIRE
HHHEEEEEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
EIIATRERGWSLVDQELEPGLRSLAAPITNAQGEVVASINVSTQSASHSVEDIRKLVLPQ
HHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHH
LLETAQAISTDLSAL
HHHHHHHHHHHHHCC
>Mature Secondary Structure
MVEQSPDFVQSFARGLSVIRSFSADNPSQTLSEVASQTGLSRATARRFLHTLTDLGYAVN
CCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCHHCC
NDSRFQLTPRVLELGASYLSALSLPAIAQPRLEVLSRQVGESSSMSVLDGTDIIYVCRVP
CCCCEEECHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCEEECCCCEEEEECCC
VRRIMTVNITIGTRFPAYATSMGRVMLANLPEEELDEMLAAAPPEQLTTRSLTSIASIRE
HHHEEEEEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
EIIATRERGWSLVDQELEPGLRSLAAPITNAQGEVVASINVSTQSASHSVEDIRKLVLPQ
HHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHH
LLETAQAISTDLSAL
HHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8083169 [H]