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The map label for this gene is atoB [H]

Identifier: 145296359

GI number: 145296359

Start: 2504448

End: 2505674

Strand: Direct

Name: atoB [H]

Synonym: cgR_2274

Alternate gene names: 145296359

Gene position: 2504448-2505674 (Clockwise)

Preceding gene: 145296358

Following gene: 145296360

Centisome position: 75.57

GC content: 60.31

Gene sequence:

>1227_bases
ATGAACCCTCAAGATATTGTCATCTGTTCCCCATTGCGCACCCCAGTTGGTGCTTACGGCGGATCCTTCACCGGCGTCCC
TGTTGAAGATTTGGCCACCACCGTGATCAACGCGATCGTTGAGGCAACCGGCATCACCGGCGACGATGTGGACGATCTGA
TCCTCGGCCAGGCATCCCCCAACGGTGCGGCTCCAGCACTGGGCCGTGTTGTTGCTCTAGATTCCAAGCTTGGCCAAAAC
GTTCCAGGCATGCAGCTTGATCGCCGCTGTGGTTCCGGCCTGCAGGCAATTGTCACCGCTGCTGCACACGTTGCATCCGG
TGCTGCTGATCTGATCATCGCAGGTGGCGCGGAATCCATGAGCCGCGTTGAGTACACCGTGTCCGGCGATATCCGTTGGG
GTGTCAAGGGCGGCGACATGCAGCTTCGTGACCGCCTTGCAGAAGCACGCGAAACCGCTGGCGGACGCAACCACCCGATC
CCTGGTGGCATGATCGAGACCGCTGAGAACCTGCGTCGCGAATACGGCATCTCCCGCGAGGAGCAGGACAAGATCTCCGC
AGCGTCCCAGCAGCGTTGGGGCAAGGCTGCTGATGCGGGGCTTTTCGACGACGAGATCGTGCCAGTCACCGTCCCTGCCA
AGAAGCGCGGCCAGGAGCCAACCATCGTTTCTCGTGACGAGCATGGTCGACCAGGAACAACCGTCGAAAAGCTTGCCGCT
TTGCGCCCCATCATGGGCCGCCAGGATGCGGAAGCAACCGTCACCGCTGGCAACGCGTCCGGCCAAAATGATGGCGCTGC
TGCCGTCATCGTGACCACTCGCGCCAAGGCCGAGGAGAAGGGCCTGCGCCCAGTCATGCGTTTGGCTGGCTGGTCTGTGG
CTGCTGTTCCCCCAGAGACCATGGGTATTGGACCTGTTCCTGCCACCAAGAAGGTCCTGGATCGTTTGGGCCTTACCCTC
GAGGACATCGGCGCGATCGAACTCAACGAAGCTTTCGCAGCTCAGGCACTGTCTGTGCTGAAGGAATGGAACATTTCTTG
GGAAGATGAGCGCGTCAACCCACTGGGTTCCGGTATTTCCATGGGACACCCAGTCGGTGCCACCGGTGCTCGCATGGCAG
TAACCTTGGCTCACCGCATGCAGCGTGAAAACACTCAGTACGGACTGGCCACCATGTGCATCGGTGGCGGCCAGGGTCTT
GCAGCTGTCTTTGAAAAGGAGAACTAA

Upstream 100 bases:

>100_bases
TCGGTGGAAGATATCCGCAAGCTGGTGCTGCCGCAGCTTTTAGAAACGGCTCAAGCAATTTCGACAGATCTCTCTGCACT
CTAAATTTAAGGATCAAAAA

Downstream 100 bases:

>100_bases
AAATGGCCATTTTGCACAGCGTTTCCTACGGAACTTCCGACAACACCTTGGTGTTCATTGGCTCGTTGGGTTCCACCACC
GACATGTGGCTGCCACAGCT

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 408; Mature: 408

Protein sequence:

>408_residues
MNPQDIVICSPLRTPVGAYGGSFTGVPVEDLATTVINAIVEATGITGDDVDDLILGQASPNGAAPALGRVVALDSKLGQN
VPGMQLDRRCGSGLQAIVTAAAHVASGAADLIIAGGAESMSRVEYTVSGDIRWGVKGGDMQLRDRLAEARETAGGRNHPI
PGGMIETAENLRREYGISREEQDKISAASQQRWGKAADAGLFDDEIVPVTVPAKKRGQEPTIVSRDEHGRPGTTVEKLAA
LRPIMGRQDAEATVTAGNASGQNDGAAAVIVTTRAKAEEKGLRPVMRLAGWSVAAVPPETMGIGPVPATKKVLDRLGLTL
EDIGAIELNEAFAAQALSVLKEWNISWEDERVNPLGSGISMGHPVGATGARMAVTLAHRMQRENTQYGLATMCIGGGQGL
AAVFEKEN

Sequences:

>Translated_408_residues
MNPQDIVICSPLRTPVGAYGGSFTGVPVEDLATTVINAIVEATGITGDDVDDLILGQASPNGAAPALGRVVALDSKLGQN
VPGMQLDRRCGSGLQAIVTAAAHVASGAADLIIAGGAESMSRVEYTVSGDIRWGVKGGDMQLRDRLAEARETAGGRNHPI
PGGMIETAENLRREYGISREEQDKISAASQQRWGKAADAGLFDDEIVPVTVPAKKRGQEPTIVSRDEHGRPGTTVEKLAA
LRPIMGRQDAEATVTAGNASGQNDGAAAVIVTTRAKAEEKGLRPVMRLAGWSVAAVPPETMGIGPVPATKKVLDRLGLTL
EDIGAIELNEAFAAQALSVLKEWNISWEDERVNPLGSGISMGHPVGATGARMAVTLAHRMQRENTQYGLATMCIGGGQGL
AAVFEKEN
>Mature_408_residues
MNPQDIVICSPLRTPVGAYGGSFTGVPVEDLATTVINAIVEATGITGDDVDDLILGQASPNGAAPALGRVVALDSKLGQN
VPGMQLDRRCGSGLQAIVTAAAHVASGAADLIIAGGAESMSRVEYTVSGDIRWGVKGGDMQLRDRLAEARETAGGRNHPI
PGGMIETAENLRREYGISREEQDKISAASQQRWGKAADAGLFDDEIVPVTVPAKKRGQEPTIVSRDEHGRPGTTVEKLAA
LRPIMGRQDAEATVTAGNASGQNDGAAAVIVTTRAKAEEKGLRPVMRLAGWSVAAVPPETMGIGPVPATKKVLDRLGLTL
EDIGAIELNEAFAAQALSVLKEWNISWEDERVNPLGSGISMGHPVGATGARMAVTLAHRMQRENTQYGLATMCIGGGQGL
AAVFEKEN

Specific function: SHORT-CHAIN FATTY ACIDS METABOLISM. [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=403, Percent_Identity=38.4615384615385, Blast_Score=274, Evalue=1e-73,
Organism=Homo sapiens, GI167614485, Length=402, Percent_Identity=38.0597014925373, Blast_Score=272, Evalue=4e-73,
Organism=Homo sapiens, GI4501853, Length=405, Percent_Identity=37.5308641975309, Blast_Score=243, Evalue=2e-64,
Organism=Homo sapiens, GI4557237, Length=405, Percent_Identity=34.320987654321, Blast_Score=209, Evalue=3e-54,
Organism=Homo sapiens, GI4504327, Length=431, Percent_Identity=31.7865429234339, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI194353979, Length=403, Percent_Identity=27.0471464019851, Blast_Score=138, Evalue=9e-33,
Organism=Escherichia coli, GI1788554, Length=405, Percent_Identity=42.7160493827161, Blast_Score=291, Evalue=3e-80,
Organism=Escherichia coli, GI1787663, Length=413, Percent_Identity=41.8886198547215, Blast_Score=285, Evalue=3e-78,
Organism=Escherichia coli, GI87082165, Length=404, Percent_Identity=42.5742574257426, Blast_Score=285, Evalue=4e-78,
Organism=Escherichia coli, GI48994986, Length=414, Percent_Identity=37.43961352657, Blast_Score=234, Evalue=9e-63,
Organism=Escherichia coli, GI1788683, Length=432, Percent_Identity=31.712962962963, Blast_Score=175, Evalue=5e-45,
Organism=Caenorhabditis elegans, GI133906874, Length=410, Percent_Identity=38.2926829268293, Blast_Score=266, Evalue=2e-71,
Organism=Caenorhabditis elegans, GI25147385, Length=408, Percent_Identity=32.843137254902, Blast_Score=202, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI17535921, Length=408, Percent_Identity=32.5980392156863, Blast_Score=200, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI17551802, Length=434, Percent_Identity=29.4930875576037, Blast_Score=167, Evalue=8e-42,
Organism=Caenorhabditis elegans, GI17535917, Length=417, Percent_Identity=25.8992805755396, Blast_Score=120, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6322031, Length=410, Percent_Identity=34.6341463414634, Blast_Score=218, Evalue=2e-57,
Organism=Saccharomyces cerevisiae, GI6325229, Length=412, Percent_Identity=35.9223300970874, Blast_Score=198, Evalue=1e-51,
Organism=Drosophila melanogaster, GI24655093, Length=407, Percent_Identity=37.8378378378378, Blast_Score=265, Evalue=3e-71,
Organism=Drosophila melanogaster, GI17648125, Length=403, Percent_Identity=39.7022332506204, Blast_Score=253, Evalue=1e-67,
Organism=Drosophila melanogaster, GI24640423, Length=403, Percent_Identity=31.2655086848635, Blast_Score=195, Evalue=5e-50,
Organism=Drosophila melanogaster, GI17137578, Length=432, Percent_Identity=30.0925925925926, Blast_Score=161, Evalue=9e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 42577; Mature: 42577

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPQDIVICSPLRTPVGAYGGSFTGVPVEDLATTVINAIVEATGITGDDVDDLILGQASP
CCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHEEECCCC
NGAAPALGRVVALDSKLGQNVPGMQLDRRCGSGLQAIVTAAAHVASGAADLIIAGGAESM
CCCCHHHHHEEEECHHHCCCCCCCHHHHHHCCHHHHHHHHHHHHHCCCCEEEEECCCHHH
SRVEYTVSGDIRWGVKGGDMQLRDRLAEARETAGGRNHPIPGGMIETAENLRREYGISRE
HHEEEEEECCEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCC
EQDKISAASQQRWGKAADAGLFDDEIVPVTVPAKKRGQEPTIVSRDEHGRPGTTVEKLAA
HHHHHHHHHHHHCCCHHCCCCCCCCEEEEECCHHHCCCCCCEECCCCCCCCCCHHHHHHH
LRPIMGRQDAEATVTAGNASGQNDGAAAVIVTTRAKAEEKGLRPVMRLAGWSVAAVPPET
HHHHCCCCCCCEEEEECCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHCCCEEEECCCHH
MGIGPVPATKKVLDRLGLTLEDIGAIELNEAFAAQALSVLKEWNISWEDERVNPLGSGIS
CCCCCCCHHHHHHHHHCCCHHHCCCEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
MGHPVGATGARMAVTLAHRMQRENTQYGLATMCIGGGQGLAAVFEKEN
CCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEECCC
>Mature Secondary Structure
MNPQDIVICSPLRTPVGAYGGSFTGVPVEDLATTVINAIVEATGITGDDVDDLILGQASP
CCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHEEECCCC
NGAAPALGRVVALDSKLGQNVPGMQLDRRCGSGLQAIVTAAAHVASGAADLIIAGGAESM
CCCCHHHHHEEEECHHHCCCCCCCHHHHHHCCHHHHHHHHHHHHHCCCCEEEEECCCHHH
SRVEYTVSGDIRWGVKGGDMQLRDRLAEARETAGGRNHPIPGGMIETAENLRREYGISRE
HHEEEEEECCEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCC
EQDKISAASQQRWGKAADAGLFDDEIVPVTVPAKKRGQEPTIVSRDEHGRPGTTVEKLAA
HHHHHHHHHHHHCCCHHCCCCCCCCEEEEECCHHHCCCCCCEECCCCCCCCCCHHHHHHH
LRPIMGRQDAEATVTAGNASGQNDGAAAVIVTTRAKAEEKGLRPVMRLAGWSVAAVPPET
HHHHCCCCCCCEEEEECCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHCCCEEEECCCHH
MGIGPVPATKKVLDRLGLTLEDIGAIELNEAFAAQALSVLKEWNISWEDERVNPLGSGIS
CCCCCCCHHHHHHHHHCCCHHHCCCEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
MGHPVGATGARMAVTLAHRMQRENTQYGLATMCIGGGQGLAAVFEKEN
CCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]