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The map label for this gene is obgE

Identifier: 145296325

GI number: 145296325

Start: 2469721

End: 2471226

Strand: Reverse

Name: obgE

Synonym: cgR_2240

Alternate gene names: 145296325

Gene position: 2471226-2469721 (Counterclockwise)

Preceding gene: 145296327

Following gene: 145296324

Centisome position: 74.57

GC content: 55.84

Gene sequence:

>1506_bases
ATGAACCGATTTATTGACCGCGTTGTGCTACACCTCGCCGCAGGTGACGGCGGCAATGGTTGTGTCTCGGTGCACCGCGA
AAAATTCAAGCCACTTGGTGGACCAGACGGCGGCAACGGCGGCCACGGTGGAGACATCATCTTGGAAGTCACCGCACAGG
TCCACACCCTGCTTGACTTCCACTTCCACCCACACGTGAAGGCCGAACGCGGCGCTAACGGCGCTGGCGATCATCGCAAC
GGTGCCCGAGGCAAGGACCTTGTCTTGGAAGTTCCACCAGGAACTGTCGTGCTTAATGAAAAGGGCGAGACTCTGGCAGA
CCTGACCAGCGTGGGCATGAAGTTCATTGCTGCGGCTGGCGGCAACGGCGGTTTGGGTAACGCAGCGCTTGCCTCCAAGG
CTCGTAAGGCCCCAGGCTTCGCCCTGATCGGTGAGCCAGGCGAGGCCCACGATTTGATTCTTGAACTCAAATCCATGGCA
GATGTGGGATTGGTGGGCTTCCCATCAGCCGGCAAATCATCACTGATTTCTGTGATGTCTGCAGCAAAGCCAAAGATCGG
TGATTACCCATTCACCACCCTGCAGCCAAACCTCGGCGTAGTTAACGTTGGTCATGAGACTTTCACCATGGCAGACGTGC
CTGGTTTGATCCCTGGTGCTTCTGAGGGCAAGGGCTTGGGTCTGGATTTCTTGCGCCACATTGAGCGCACCTCCGTGCTG
GTTCACGTTGTCGATACCGCAACGATGGATCCAGGCCGCGATCCGATCTCTGATATTGAGGCTTTGGAAGCAGAACTTGC
TGCCTACCAGTCGGCTTTGGATGAAGACACCGGACTTGGTGACTTAAGCCAGCGCCCTCGCATTGTTGTGTTGAACAAGG
CTGATGTCCCTGAGGCTGAAGAGCTTGCTGAGTTCCTCAAAGAAGATATTGAGAAGCAATTCGGATGGCCCGTGTTCATT
ATCTCCGCAGTGGCACGCAAGGGCTTGGATCCTTTGAAGTACAAGCTGCTGGAAATCGTCCAGGATGCCCGAAAGAAGCG
TCCAAAGGAGAAGGCTGAGTCTGTCATCATTAAGCCTAAGGCTGTTGATCACCGCACTAAGGGGCAGTTCCAGATCAAGC
CTGACCCAGAGGTTCAGGGCGGATTCATCATCACCGGCGAAAAGCCAGAGCGCTGGATTTTGCAGACCGACTTTGAAAAC
GATGAAGCAGTTGGCTACCTGGCTGACCGTCTGGCCAAGTTGGGCATTGAGGACGGGCTTCGTAAGGCAGGAGCACATGT
GGGTGCAAACGTCACCATCGGAGGCATTTCCTTCGAGTGGGAGCCAATGACCACCGCTGGCGACGATCCAATCCTTACCG
GACGTGGCACCGATGTGCGCCTTGAACAGACCTCTCGTATCTCTGCTGCAGAGCGTAAACGCGCATCTCAGGTACGTCGT
GGCCTCATCGATGAGTTGGATTACGGCGAGGATCAAGAGGCTTCCCGCGAACGCTGGGAAGGATAA

Upstream 100 bases:

>100_bases
CTGGTAGGATCGAAGAACCTTGGCGCCCACACATCCCCCCTTTATTTTTCTACTTATACGTCGGCGCCCGTTTTATCCCG
ATCAGGAGTGACACCGTTTT

Downstream 100 bases:

>100_bases
AACCGAGCACTTTTCAGGTCTACGTGTATACGATGGTAGCGCTATGAATGATACGCAGAACACACCTGAAAGCGTTCGAT
TACGGGATAATCTCCCAACG

Product: GTPase ObgE

Products: NA

Alternate protein names: GTP-binding protein obg

Number of amino acids: Translated: 501; Mature: 501

Protein sequence:

>501_residues
MNRFIDRVVLHLAAGDGGNGCVSVHREKFKPLGGPDGGNGGHGGDIILEVTAQVHTLLDFHFHPHVKAERGANGAGDHRN
GARGKDLVLEVPPGTVVLNEKGETLADLTSVGMKFIAAAGGNGGLGNAALASKARKAPGFALIGEPGEAHDLILELKSMA
DVGLVGFPSAGKSSLISVMSAAKPKIGDYPFTTLQPNLGVVNVGHETFTMADVPGLIPGASEGKGLGLDFLRHIERTSVL
VHVVDTATMDPGRDPISDIEALEAELAAYQSALDEDTGLGDLSQRPRIVVLNKADVPEAEELAEFLKEDIEKQFGWPVFI
ISAVARKGLDPLKYKLLEIVQDARKKRPKEKAESVIIKPKAVDHRTKGQFQIKPDPEVQGGFIITGEKPERWILQTDFEN
DEAVGYLADRLAKLGIEDGLRKAGAHVGANVTIGGISFEWEPMTTAGDDPILTGRGTDVRLEQTSRISAAERKRASQVRR
GLIDELDYGEDQEASRERWEG

Sequences:

>Translated_501_residues
MNRFIDRVVLHLAAGDGGNGCVSVHREKFKPLGGPDGGNGGHGGDIILEVTAQVHTLLDFHFHPHVKAERGANGAGDHRN
GARGKDLVLEVPPGTVVLNEKGETLADLTSVGMKFIAAAGGNGGLGNAALASKARKAPGFALIGEPGEAHDLILELKSMA
DVGLVGFPSAGKSSLISVMSAAKPKIGDYPFTTLQPNLGVVNVGHETFTMADVPGLIPGASEGKGLGLDFLRHIERTSVL
VHVVDTATMDPGRDPISDIEALEAELAAYQSALDEDTGLGDLSQRPRIVVLNKADVPEAEELAEFLKEDIEKQFGWPVFI
ISAVARKGLDPLKYKLLEIVQDARKKRPKEKAESVIIKPKAVDHRTKGQFQIKPDPEVQGGFIITGEKPERWILQTDFEN
DEAVGYLADRLAKLGIEDGLRKAGAHVGANVTIGGISFEWEPMTTAGDDPILTGRGTDVRLEQTSRISAAERKRASQVRR
GLIDELDYGEDQEASRERWEG
>Mature_501_residues
MNRFIDRVVLHLAAGDGGNGCVSVHREKFKPLGGPDGGNGGHGGDIILEVTAQVHTLLDFHFHPHVKAERGANGAGDHRN
GARGKDLVLEVPPGTVVLNEKGETLADLTSVGMKFIAAAGGNGGLGNAALASKARKAPGFALIGEPGEAHDLILELKSMA
DVGLVGFPSAGKSSLISVMSAAKPKIGDYPFTTLQPNLGVVNVGHETFTMADVPGLIPGASEGKGLGLDFLRHIERTSVL
VHVVDTATMDPGRDPISDIEALEAELAAYQSALDEDTGLGDLSQRPRIVVLNKADVPEAEELAEFLKEDIEKQFGWPVFI
ISAVARKGLDPLKYKLLEIVQDARKKRPKEKAESVIIKPKAVDHRTKGQFQIKPDPEVQGGFIITGEKPERWILQTDFEN
DEAVGYLADRLAKLGIEDGLRKAGAHVGANVTIGGISFEWEPMTTAGDDPILTGRGTDVRLEQTSRISAAERKRASQVRR
GLIDELDYGEDQEASRERWEG

Specific function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in t

COG id: COG0536

COG function: function code R; Predicted GTPase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 G (guanine nucleotide-binding) domain

Homologues:

Organism=Homo sapiens, GI24308117, Length=341, Percent_Identity=39.2961876832845, Blast_Score=175, Evalue=1e-43,
Organism=Homo sapiens, GI111955139, Length=239, Percent_Identity=37.6569037656904, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI111955063, Length=141, Percent_Identity=41.1347517730496, Blast_Score=102, Evalue=8e-22,
Organism=Homo sapiens, GI58761500, Length=128, Percent_Identity=31.25, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1789574, Length=364, Percent_Identity=43.6813186813187, Blast_Score=246, Evalue=2e-66,
Organism=Escherichia coli, GI1787454, Length=129, Percent_Identity=34.1085271317829, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17508313, Length=339, Percent_Identity=41.0029498525074, Blast_Score=156, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17552324, Length=318, Percent_Identity=29.2452830188679, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17509631, Length=140, Percent_Identity=30.7142857142857, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6321962, Length=206, Percent_Identity=37.378640776699, Blast_Score=135, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6321649, Length=141, Percent_Identity=34.0425531914894, Blast_Score=74, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6319281, Length=108, Percent_Identity=35.1851851851852, Blast_Score=63, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6321612, Length=134, Percent_Identity=32.089552238806, Blast_Score=63, Evalue=9e-11,
Organism=Drosophila melanogaster, GI20129375, Length=321, Percent_Identity=38.9408099688474, Blast_Score=169, Evalue=6e-42,
Organism=Drosophila melanogaster, GI24585318, Length=243, Percent_Identity=38.6831275720165, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24640873, Length=173, Percent_Identity=28.9017341040462, Blast_Score=75, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24640877, Length=173, Percent_Identity=28.9017341040462, Blast_Score=75, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24640875, Length=173, Percent_Identity=28.9017341040462, Blast_Score=75, Evalue=9e-14,
Organism=Drosophila melanogaster, GI21356473, Length=124, Percent_Identity=37.9032258064516, Blast_Score=66, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): OBG_CORGB (A4QG78)

Other databases:

- EMBL:   AP009044
- RefSeq:   YP_001139146.1
- ProteinModelPortal:   A4QG78
- SMR:   A4QG78
- STRING:   A4QG78
- GeneID:   4993351
- GenomeReviews:   AP009044_GR
- KEGG:   cgt:cgR_2240
- eggNOG:   COG0536
- HOGENOM:   HBG716038
- OMA:   HFTTLVP
- ProtClustDB:   PRK12296
- GO:   GO:0005737
- HAMAP:   MF_01454
- InterPro:   IPR014100
- InterPro:   IPR015349
- InterPro:   IPR006074
- InterPro:   IPR006073
- InterPro:   IPR006169
- InterPro:   IPR002917
- Gene3D:   G3DSA:2.70.210.12
- PANTHER:   PTHR11702:SF3
- PIRSF:   PIRSF002401
- PRINTS:   PR00326
- TIGRFAMs:   TIGR02729
- TIGRFAMs:   TIGR03595

Pfam domain/function: PF09269 DUF1967; PF01018 GTP1_OBG; PF01926 MMR_HSR1; SSF102741 GTP-bd_prot_GTP1/OBG_C; SSF82051 GTP1_OBG_sub

EC number: NA

Molecular weight: Translated: 53635; Mature: 53635

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS00905 GTP1_OBG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRFIDRVVLHLAAGDGGNGCVSVHREKFKPLGGPDGGNGGHGGDIILEVTAQVHTLLDF
CCHHHHHHHHHHCCCCCCCCEEEEEHHHCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHH
HFHPHVKAERGANGAGDHRNGARGKDLVLEVPPGTVVLNEKGETLADLTSVGMKFIAAAG
CCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCEEEECCCCCHHHHHHHHHHHHEEECC
GNGGLGNAALASKARKAPGFALIGEPGEAHDLILELKSMADVGLVGFPSAGKSSLISVMS
CCCCCCHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHH
AAKPKIGDYPFTTLQPNLGVVNVGHETFTMADVPGLIPGASEGKGLGLDFLRHIERTSVL
HCCCCCCCCCCCEECCCCCEEEECCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHEE
VHVVDTATMDPGRDPISDIEALEAELAAYQSALDEDTGLGDLSQRPRIVVLNKADVPEAE
EEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCHH
ELAEFLKEDIEKQFGWPVFIISAVARKGLDPLKYKLLEIVQDARKKRPKEKAESVIIKPK
HHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHCEEECCC
AVDHRTKGQFQIKPDPEVQGGFIITGEKPERWILQTDFENDEAVGYLADRLAKLGIEDGL
CCCCCCCCEEEECCCCCCCCCEEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHCHHHHH
RKAGAHVGANVTIGGISFEWEPMTTAGDDPILTGRGTDVRLEQTSRISAAERKRASQVRR
HHHCCCCCCEEEEECEEEEECCCCCCCCCCEEECCCCEEEEHHHHHHHHHHHHHHHHHHH
GLIDELDYGEDQEASRERWEG
HHHHHCCCCCCCHHHHHHCCC
>Mature Secondary Structure
MNRFIDRVVLHLAAGDGGNGCVSVHREKFKPLGGPDGGNGGHGGDIILEVTAQVHTLLDF
CCHHHHHHHHHHCCCCCCCCEEEEEHHHCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHH
HFHPHVKAERGANGAGDHRNGARGKDLVLEVPPGTVVLNEKGETLADLTSVGMKFIAAAG
CCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCEEEECCCCCHHHHHHHHHHHHEEECC
GNGGLGNAALASKARKAPGFALIGEPGEAHDLILELKSMADVGLVGFPSAGKSSLISVMS
CCCCCCHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHH
AAKPKIGDYPFTTLQPNLGVVNVGHETFTMADVPGLIPGASEGKGLGLDFLRHIERTSVL
HCCCCCCCCCCCEECCCCCEEEECCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHEE
VHVVDTATMDPGRDPISDIEALEAELAAYQSALDEDTGLGDLSQRPRIVVLNKADVPEAE
EEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCHH
ELAEFLKEDIEKQFGWPVFIISAVARKGLDPLKYKLLEIVQDARKKRPKEKAESVIIKPK
HHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHCEEECCC
AVDHRTKGQFQIKPDPEVQGGFIITGEKPERWILQTDFENDEAVGYLADRLAKLGIEDGL
CCCCCCCCEEEECCCCCCCCCEEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHCHHHHH
RKAGAHVGANVTIGGISFEWEPMTTAGDDPILTGRGTDVRLEQTSRISAAERKRASQVRR
HHHCCCCCCEEEEECEEEEECCCCCCCCCCEEECCCCEEEEHHHHHHHHHHHHHHHHHHH
GLIDELDYGEDQEASRERWEG
HHHHHCCCCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA