Click here to switch to the map view.

The map label for this gene is hemN [H]

Identifier: 145296247

GI number: 145296247

Start: 2386613

End: 2387668

Strand: Reverse

Name: hemN [H]

Synonym: cgR_2164

Alternate gene names: 145296247

Gene position: 2387668-2386613 (Counterclockwise)

Preceding gene: 145296249

Following gene: 145296246

Centisome position: 72.04

GC content: 59.28

Gene sequence:

>1056_bases
TTGGGTAGTACTGCAGGCCCAGACACCTATCTTGACTCGTTGGAAGTTGAGTTGGAGATGGCTGTGGCTTCGCTGGATAA
TCCTCGGCAGGCGGAAACTATCTTTATTGGCGGGGGTACCCCGTCGTTGATTGGTGCGGACGGTTTGGCCAGGGTTTTGG
GGGCTGTGCGCAATACTTTTGGCATTGCGGATGGTGCGGAAGTCACCACGGAGTCCAATCCGGAGTCTACCTCGCCTGAG
TTTTTTGATGGCCTGCGTGAGGCGGGCTACAACAGGATTTCGTTAGGAATGCAGTCGGCGTCGTCAAGCGTTTTGAAGGT
GCTGGACCGCACGCACACCCCAGGTCGCCCGGTGGCGGCGGCCAAGGAGGCACGTCGGGCGGGGTTTGAGCATGTCAATT
TGGACATGATTTATGGCACGCCGACAGAGACCGATGATGATGTCCGCAAGACGCTGGATGCGGTGCTCGAAGCGAACGTG
GATCACGTGTCTGCCTATTCCTTGATCGTGGAAGATGGCACGGCGATGGCGCGCAAGGTGCGCAAGGGCGAGCTGCCAGC
GCCGGACGAGGATGTTTACGCTGATCGTTTTGAGCTTATCGACGCTCGCCTGCGCTCAGCGGGTTTCGATTGGTACGAGG
TATCCAACTGGGCGAAACCCGGCGGAGAATGCAAGCACAACATGGGCTATTGGGTCGATGGCGACTGGTGGGGTGCTGGC
CCGGGCGCGCACTCGCACATCGGCGACCGCCGCTTCTACAACATCAAGCACCCAGCGCGTTACTCCGCGCAGATTGCGGC
CGGCGAGCTGCCCATTAAGGAAACAGAGATGCTGACCGCGGAAGATCACCACACCGAGCGCGTCATGCTTGGTTTGCGCC
TGAAACAAGGCGTGCCGCTGAACCTTTTCACACCCGCAGCGCGCCCGGTCATCGACCGTCATATCGCAGGAGGCCTGCTA
CACGTCAATGCGCTGGGCAACCTGGCGGTGACCGATGCGGGACGTTTGCTTGCCGACGGCATCATCGCCGACATTTTGCT
TAGTGAAGAAGACTAA

Upstream 100 bases:

>100_bases
CTAGGCTTGGGGCATGTCAGTTTTTGGTGTGTATATTCATGTGCCGTTTTGTTCAACTCGGTGCGGTTATTGCGATTTCA
ACACCTATACTGCTGGGGAA

Downstream 100 bases:

>100_bases
ATATTTAGTAGGGTTACAGACATGGTGAGTGCAACAGAGAAACGTAGATACGAAGTGTTGCGGGCCATCGTCGCTGATTA
CATTGCGTCTCAGGAACCTG

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 351; Mature: 350

Protein sequence:

>351_residues
MGSTAGPDTYLDSLEVELEMAVASLDNPRQAETIFIGGGTPSLIGADGLARVLGAVRNTFGIADGAEVTTESNPESTSPE
FFDGLREAGYNRISLGMQSASSSVLKVLDRTHTPGRPVAAAKEARRAGFEHVNLDMIYGTPTETDDDVRKTLDAVLEANV
DHVSAYSLIVEDGTAMARKVRKGELPAPDEDVYADRFELIDARLRSAGFDWYEVSNWAKPGGECKHNMGYWVDGDWWGAG
PGAHSHIGDRRFYNIKHPARYSAQIAAGELPIKETEMLTAEDHHTERVMLGLRLKQGVPLNLFTPAARPVIDRHIAGGLL
HVNALGNLAVTDAGRLLADGIIADILLSEED

Sequences:

>Translated_351_residues
MGSTAGPDTYLDSLEVELEMAVASLDNPRQAETIFIGGGTPSLIGADGLARVLGAVRNTFGIADGAEVTTESNPESTSPE
FFDGLREAGYNRISLGMQSASSSVLKVLDRTHTPGRPVAAAKEARRAGFEHVNLDMIYGTPTETDDDVRKTLDAVLEANV
DHVSAYSLIVEDGTAMARKVRKGELPAPDEDVYADRFELIDARLRSAGFDWYEVSNWAKPGGECKHNMGYWVDGDWWGAG
PGAHSHIGDRRFYNIKHPARYSAQIAAGELPIKETEMLTAEDHHTERVMLGLRLKQGVPLNLFTPAARPVIDRHIAGGLL
HVNALGNLAVTDAGRLLADGIIADILLSEED
>Mature_350_residues
GSTAGPDTYLDSLEVELEMAVASLDNPRQAETIFIGGGTPSLIGADGLARVLGAVRNTFGIADGAEVTTESNPESTSPEF
FDGLREAGYNRISLGMQSASSSVLKVLDRTHTPGRPVAAAKEARRAGFEHVNLDMIYGTPTETDDDVRKTLDAVLEANVD
HVSAYSLIVEDGTAMARKVRKGELPAPDEDVYADRFELIDARLRSAGFDWYEVSNWAKPGGECKHNMGYWVDGDWWGAGP
GAHSHIGDRRFYNIKHPARYSAQIAAGELPIKETEMLTAEDHHTERVMLGLRLKQGVPLNLFTPAARPVIDRHIAGGLLH
VNALGNLAVTDAGRLLADGIIADILLSEED

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=275, Percent_Identity=34.5454545454545, Blast_Score=150, Evalue=2e-36,
Organism=Escherichia coli, GI1789325, Length=353, Percent_Identity=33.4277620396601, Blast_Score=162, Evalue=3e-41,
Organism=Escherichia coli, GI87082341, Length=271, Percent_Identity=29.520295202952, Blast_Score=119, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 37916; Mature: 37785

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSTAGPDTYLDSLEVELEMAVASLDNPRQAETIFIGGGTPSLIGADGLARVLGAVRNTF
CCCCCCCCHHHHHHHHHEEHHHHHCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHH
GIADGAEVTTESNPESTSPEFFDGLREAGYNRISLGMQSASSSVLKVLDRTHTPGRPVAA
CCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCHHH
AKEARRAGFEHVNLDMIYGTPTETDDDVRKTLDAVLEANVDHVSAYSLIVEDGTAMARKV
HHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEEECCHHHHHHH
RKGELPAPDEDVYADRFELIDARLRSAGFDWYEVSNWAKPGGECKHNMGYWVDGDWWGAG
HCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCEEECCCCCCCC
PGAHSHIGDRRFYNIKHPARYSAQIAAGELPIKETEMLTAEDHHTERVMLGLRLKQGVPL
CCCCCCCCCCCEEECCCCCCCCCEEECCCCCCCHHHEEECCCCCHHHEEEEEECCCCCCC
NLFTPAARPVIDRHIAGGLLHVNALGNLAVTDAGRLLADGIIADILLSEED
EEECCCHHHHHHHHHCCCEEEEECCCCEEECCCHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
GSTAGPDTYLDSLEVELEMAVASLDNPRQAETIFIGGGTPSLIGADGLARVLGAVRNTF
CCCCCCCHHHHHHHHHEEHHHHHCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHH
GIADGAEVTTESNPESTSPEFFDGLREAGYNRISLGMQSASSSVLKVLDRTHTPGRPVAA
CCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCHHH
AKEARRAGFEHVNLDMIYGTPTETDDDVRKTLDAVLEANVDHVSAYSLIVEDGTAMARKV
HHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEEECCHHHHHHH
RKGELPAPDEDVYADRFELIDARLRSAGFDWYEVSNWAKPGGECKHNMGYWVDGDWWGAG
HCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCEEECCCCCCCC
PGAHSHIGDRRFYNIKHPARYSAQIAAGELPIKETEMLTAEDHHTERVMLGLRLKQGVPL
CCCCCCCCCCCEEECCCCCCCCCEEECCCCCCCHHHEEECCCCCHHHEEEEEECCCCCCC
NLFTPAARPVIDRHIAGGLLHVNALGNLAVTDAGRLLADGIIADILLSEED
EEECCCHHHHHHHHHCCCEEEEECCCCEEECCCHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]