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The map label for this gene is ptpA [H]

Identifier: 145296198

GI number: 145296198

Start: 2337618

End: 2338118

Strand: Direct

Name: ptpA [H]

Synonym: cgR_2116

Alternate gene names: 145296198

Gene position: 2337618-2338118 (Clockwise)

Preceding gene: 145296197

Following gene: 145296199

Centisome position: 70.53

GC content: 56.29

Gene sequence:

>501_bases
ATGACTGGGCCTAAAACTTCGCTACCTGTGGAAATTGTTTTCGTATGCACCGGAAACATTTGCCGATCCCCCATGGCGGA
AGTCATCGCGAAGGCAAAAGCGGAAGAAGCTGGCTTGGAAGACAACGTCATTTTCTCCTCCTGTGGCATGGGCAATTGGC
ACGTTGGCCAACCTGCTGACAAGCGAGCTCTCGCGGAACTGAAATCAGCCGGTTACAACGGCGACACCCACCGCGCAGCA
CAACTTGGTCCCGAGCACATGCGCGCAGATCTCTTCGTCGCGCTAGATTCCGGCCACGCCGGTGAGCTCGCCGCAACGGG
TGTTCCCAACGACAAAATCCGCCTCATGCGTTCCTTCGACCCAGAGTCCAACCCCACCGACGATGTCGCAGACCCTTACT
ACGGCACATCCCAGGATTTCGTGCTCACCCGTGAAAACATCGAAGATGCTATGCCGGGCCTTTTGGAGTGGGTCAGAGAT
CACATCCGCACTGATTCTTAG

Upstream 100 bases:

>100_bases
ATCGATTGTGTTGCCGTAACCTGGGGCTACGGCAGCAAAACTGAATGGGACGCTGCCCGCTACACCGTGAGCACCGCAGA
AGAATTAGAAAGGATCATCC

Downstream 100 bases:

>100_bases
GTCTTTGAGCTAAAAAGTCCTAAGGTAGACAAGTGTGGACAGCAAGGTAAATAGCCCTTCCGGGCACGATAAGCATGACG
TGAGCTCCCGCTATTCCGGA

Product: hypothetical protein

Products: NA

Alternate protein names: PTPase [H]

Number of amino acids: Translated: 166; Mature: 165

Protein sequence:

>166_residues
MTGPKTSLPVEIVFVCTGNICRSPMAEVIAKAKAEEAGLEDNVIFSSCGMGNWHVGQPADKRALAELKSAGYNGDTHRAA
QLGPEHMRADLFVALDSGHAGELAATGVPNDKIRLMRSFDPESNPTDDVADPYYGTSQDFVLTRENIEDAMPGLLEWVRD
HIRTDS

Sequences:

>Translated_166_residues
MTGPKTSLPVEIVFVCTGNICRSPMAEVIAKAKAEEAGLEDNVIFSSCGMGNWHVGQPADKRALAELKSAGYNGDTHRAA
QLGPEHMRADLFVALDSGHAGELAATGVPNDKIRLMRSFDPESNPTDDVADPYYGTSQDFVLTRENIEDAMPGLLEWVRD
HIRTDS
>Mature_165_residues
TGPKTSLPVEIVFVCTGNICRSPMAEVIAKAKAEEAGLEDNVIFSSCGMGNWHVGQPADKRALAELKSAGYNGDTHRAAQ
LGPEHMRADLFVALDSGHAGELAATGVPNDKIRLMRSFDPESNPTDDVADPYYGTSQDFVLTRENIEDAMPGLLEWVRDH
IRTDS

Specific function: Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates [H]

COG id: COG0394

COG function: function code T; Protein-tyrosine-phosphatase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the low molecular weight phosphotyrosine protein phosphatase family [H]

Homologues:

Organism=Homo sapiens, GI6005988, Length=150, Percent_Identity=29.3333333333333, Blast_Score=78, Evalue=3e-15,
Organism=Homo sapiens, GI4757714, Length=150, Percent_Identity=28, Blast_Score=67, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6325330, Length=143, Percent_Identity=30.7692307692308, Blast_Score=74, Evalue=1e-14,
Organism=Drosophila melanogaster, GI78706764, Length=126, Percent_Identity=32.5396825396825, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI78706766, Length=126, Percent_Identity=32.5396825396825, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI78706768, Length=126, Percent_Identity=32.5396825396825, Blast_Score=64, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000106
- InterPro:   IPR017867 [H]

Pfam domain/function: PF01451 LMWPc [H]

EC number: =3.1.3.48 [H]

Molecular weight: Translated: 17987; Mature: 17856

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGPKTSLPVEIVFVCTGNICRSPMAEVIAKAKAEEAGLEDNVIFSSCGMGNWHVGQPAD
CCCCCCCCCEEEEEEECCCHHCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCHH
KRALAELKSAGYNGDTHRAAQLGPEHMRADLFVALDSGHAGELAATGVPNDKIRLMRSFD
HHHHHHHHHCCCCCCCCHHHHCCHHHHCEEEEEEECCCCCCCEEECCCCCHHHHHHECCC
PESNPTDDVADPYYGTSQDFVLTRENIEDAMPGLLEWVRDHIRTDS
CCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TGPKTSLPVEIVFVCTGNICRSPMAEVIAKAKAEEAGLEDNVIFSSCGMGNWHVGQPAD
CCCCCCCCEEEEEEECCCHHCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCHH
KRALAELKSAGYNGDTHRAAQLGPEHMRADLFVALDSGHAGELAATGVPNDKIRLMRSFD
HHHHHHHHHCCCCCCCCHHHHCCHHHHCEEEEEEECCCCCCCEEECCCCCHHHHHHECCC
PESNPTDDVADPYYGTSQDFVLTRENIEDAMPGLLEWVRDHIRTDS
CCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]