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The map label for this gene is cobS

Identifier: 145296163

GI number: 145296163

Start: 2297625

End: 2298548

Strand: Direct

Name: cobS

Synonym: cgR_2082

Alternate gene names: 145296163

Gene position: 2297625-2298548 (Clockwise)

Preceding gene: 145296162

Following gene: 145296166

Centisome position: 69.33

GC content: 56.17

Gene sequence:

>924_bases
ATGTCCGGCAAAGCAGGCTTTACCCCCGAAGATCCCGAAGATTCAGACAACCGCCACGGGAGCCCCCTTTTCGAAGGTAT
CTTTACCGCACTTAATTGGATGACCGTTCTCCCCGTCCCCGGCGCATCAGTTTTTGATCGCACCACGGGCGCCCGGGTAA
TGGCCTCTTTGCCCTTTGTTGGCTTCGTTTTCGGAATGTTCACCGCGATCATCATGTGGGCTATCGGCCCCATTTCAGGG
GTGATCCACGTCGATGGACTTTTAGTTGCCGTTCTGATCGTCGCGTTCTGGGAACTTCTTAATCGGTTTATGCACCTCGA
CGGCCTCGCAGATGTCTCCGATGCTTTGGGTTCCTACGCAGCCCCACCACGCGCACGAGAAATCCTCGCCGATCCCCGCA
CCGGACTTTTCGGCCTCGCCACCGCCATGCTTTCCGTTCTCGTGCAGGTCGCTGCAGTCGCATCGCTTGTCGATTCAACC
GTGTGGTGGATGATCTGCTTCATCCCCGTTCTCGGCCGCATCGCTGGACAAGTAACCGCACTGAAAAACCACCACGCCTT
CTCCCCCACCGGCTTTGGCGCACTAGTCATCGGAACCGTGAAATTTTGGTGGATCGCGCTGTGGCTCTTGGTTACTCCTG
CGTTGGCTTTTTGGTGCGCAGAATTAATTTCTCCACTTTCACCGCTGACCAGTGTTAACACTCCCTTTGTCGCTGGACCT
TTCCCCGCTGCAATCAACCCCGCCTGGCTTGGAGGCTGGGTTGCGATAACCGCAGTCGTGGCATGTGTTTTCGCAGCACT
TTTCAGCCGCCGCTTATCACGAAGTTTCGGTGGACTCAACGGAGACTGCATCGGCGCATGCATTCATCTCGGGGCGTCGA
TTTCTGCAGTGATGCTTGCTGTTGTCGCCAATGCAATGGTGTAA

Upstream 100 bases:

>100_bases
TGATGAACGACATGTCGACATTTTCTTCCGCCGGCGTCGATGGACCCCTAAACGCCTCTTCCGAAGCGCCCGAGCAAAAC
ACGGAGTAACTTTCTAAGCG

Downstream 100 bases:

>100_bases
AGCGGTGGCGTCTTTTGGGACTGGGTGGATTTCATGACATCTCCCTGCGTCGATTTAAGCCGTGCCAGTTTGTCCCCGGT
GTATTCCCTTAGCTTTAGCT

Product: cobalamin synthase

Products: GMP; adenosylcobalamin

Alternate protein names: NA

Number of amino acids: Translated: 307; Mature: 306

Protein sequence:

>307_residues
MSGKAGFTPEDPEDSDNRHGSPLFEGIFTALNWMTVLPVPGASVFDRTTGARVMASLPFVGFVFGMFTAIIMWAIGPISG
VIHVDGLLVAVLIVAFWELLNRFMHLDGLADVSDALGSYAAPPRAREILADPRTGLFGLATAMLSVLVQVAAVASLVDST
VWWMICFIPVLGRIAGQVTALKNHHAFSPTGFGALVIGTVKFWWIALWLLVTPALAFWCAELISPLSPLTSVNTPFVAGP
FPAAINPAWLGGWVAITAVVACVFAALFSRRLSRSFGGLNGDCIGACIHLGASISAVMLAVVANAMV

Sequences:

>Translated_307_residues
MSGKAGFTPEDPEDSDNRHGSPLFEGIFTALNWMTVLPVPGASVFDRTTGARVMASLPFVGFVFGMFTAIIMWAIGPISG
VIHVDGLLVAVLIVAFWELLNRFMHLDGLADVSDALGSYAAPPRAREILADPRTGLFGLATAMLSVLVQVAAVASLVDST
VWWMICFIPVLGRIAGQVTALKNHHAFSPTGFGALVIGTVKFWWIALWLLVTPALAFWCAELISPLSPLTSVNTPFVAGP
FPAAINPAWLGGWVAITAVVACVFAALFSRRLSRSFGGLNGDCIGACIHLGASISAVMLAVVANAMV
>Mature_306_residues
SGKAGFTPEDPEDSDNRHGSPLFEGIFTALNWMTVLPVPGASVFDRTTGARVMASLPFVGFVFGMFTAIIMWAIGPISGV
IHVDGLLVAVLIVAFWELLNRFMHLDGLADVSDALGSYAAPPRAREILADPRTGLFGLATAMLSVLVQVAAVASLVDSTV
WWMICFIPVLGRIAGQVTALKNHHAFSPTGFGALVIGTVKFWWIALWLLVTPALAFWCAELISPLSPLTSVNTPFVAGPF
PAAINPAWLGGWVAITAVVACVFAALFSRRLSRSFGGLNGDCIGACIHLGASISAVMLAVVANAMV

Specific function: Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin)

COG id: COG0368

COG function: function code H; Cobalamin-5-phosphate synthase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CobS family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COBS_CORGB (A4QFR6)

Other databases:

- EMBL:   AP009044
- RefSeq:   YP_001138984.1
- STRING:   A4QFR6
- GeneID:   4991671
- GenomeReviews:   AP009044_GR
- KEGG:   cgt:cgR_2082
- eggNOG:   COG0368
- HOGENOM:   HBG729392
- OMA:   IMKDPTS
- ProtClustDB:   PRK00235
- HAMAP:   MF_00719
- InterPro:   IPR003805

Pfam domain/function: PF02654 CobS

EC number: 2.7.8.26

Molecular weight: Translated: 32410; Mature: 32279

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1d705bc8)-; HASH(0x1b7bb9f8)-; HASH(0x1bf55b7c)-; HASH(0x1ddba67c)-; HASH(0x1dbb01bc)-; HASH(0x1e28084c)-; HASH(0x1e31552c)-; HASH(0x1de66dbc)-;

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGKAGFTPEDPEDSDNRHGSPLFEGIFTALNWMTVLPVPGASVFDRTTGARVMASLPFV
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHCCHH
GFVFGMFTAIIMWAIGPISGVIHVDGLLVAVLIVAFWELLNRFMHLDGLADVSDALGSYA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCC
APPRAREILADPRTGLFGLATAMLSVLVQVAAVASLVDSTVWWMICFIPVLGRIAGQVTA
CCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKNHHAFSPTGFGALVIGTVKFWWIALWLLVTPALAFWCAELISPLSPLTSVNTPFVAGP
HHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
FPAAINPAWLGGWVAITAVVACVFAALFSRRLSRSFGGLNGDCIGACIHLGASISAVMLA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHH
VVANAMV
HHHHHCH
>Mature Secondary Structure 
SGKAGFTPEDPEDSDNRHGSPLFEGIFTALNWMTVLPVPGASVFDRTTGARVMASLPFV
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHCCHH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HHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: adenosylcobinamide-GDP; alpha-ribazole

Specific reaction: adenosylcobinamide-GDP + alpha-ribazole = GMP + adenosylcobalamin

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA