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The map label for this gene is cobT

Identifier: 145296162

GI number: 145296162

Start: 2296537

End: 2297613

Strand: Direct

Name: cobT

Synonym: cgR_2081

Alternate gene names: 145296162

Gene position: 2296537-2297613 (Clockwise)

Preceding gene: 145296161

Following gene: 145296163

Centisome position: 69.29

GC content: 57.85

Gene sequence:

>1077_bases
ATGGTTCCAGCAGAGCTTTTTGCGCGTGTGGAATTTCCGGATCATAAAATCCTGGCTCAGACGAAGGATTTCCATGACTC
CCTCACCAAGCCACCCGGATCTTTGGGCAAGTTGGAGCAGATCGGCTGTTTCATTTCCGCATGCCAGGGCCAGATTCCGC
CACGTCCACTCAACAACTCAAAGATCGTTGTTTTCGCTGGCGATCACGGCGTTGCAACTAAAGGCGTGTCCGCGTACCCA
TCCTCAGTAAGCCTGCAGATGGCTGAAAACATTACAAACGGTGGCGCCGCCATCAACGTGATTGCACGCACCACCGGCAC
GTCCGTCCGACTTATTGATACCTCCCTCGACCACGAAGCATGGGGCGACGAGCGCGTATCTAGGTCCTGCGGATCCATCG
ATGTTGAAGACGCCATGACCCAAGAACAGGTCGAACGCGCACTGGAGATCGGTAAGCGTATTGCGGATCAAGAAGTGGAC
GCAGGCGCCGACATTTTAATCCCCGGCGATTTAGGAATTGGCAACACCACCACCGCCGCTGCCCTCGTTGGAACGTTCAC
CCTCGCAGAGCCTGTTGTTGTCGTAGGCCGCGGCACCGGAATCGACGATGAAGCCTGGAAACTCAAAGTCTCCGCGATCC
GCGACGCCATGTTCCGCGTCCGCGACCTGCGCCAAGACCCCATCGCCATCGCCCGGAAAATCTCTTCCCCAGACCTTGCA
GCCATGGCAGCATTCATTGCCCAAGCAGCAGTTCGACGCACCCCCGTGCTTCTCGACGGCGTTGTAGTCACCGCCGCAGC
CCTCCTAGCCAACAAACTTGCCCCAGGTGCCAGGCGTTGGTTCATCGCAGGACACCGTTCCACCGAACCAGCGCATTCCG
TAGCTCTAGACGCACTGGCCCTTGATCCCATCCTGGAATTTGGCATGTACCTTGGCGAAGGCTCCGGCGCAGCCACCGCA
CTCCCCATGGTCAAAATTGCCGTCGACCTGATGAACGACATGTCGACATTTTCTTCCGCCGGCGTCGATGGACCCCTAAA
CGCCTCTTCCGAAGCGCCCGAGCAAAACACGGAGTAA

Upstream 100 bases:

>100_bases
CGTGTCGCAGCGATTTGCGAGAGGGTTGTCTTCGTGGTCGCTGGTCTGCCACTAGAGTTGAAAACGTTTTAAGAAAACAG
TCGGTTTGAAGGAGTTGTTA

Downstream 100 bases:

>100_bases
CTTTCTAAGCGATGTCCGGCAAAGCAGGCTTTACCCCCGAAGATCCCGAAGATTCAGACAACCGCCACGGGAGCCCCCTT
TTCGAAGGTATCTTTACCGC

Product: nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase

Products: NA

Alternate protein names: NN:DBI PRT; N(1)-alpha-phosphoribosyltransferase

Number of amino acids: Translated: 358; Mature: 358

Protein sequence:

>358_residues
MVPAELFARVEFPDHKILAQTKDFHDSLTKPPGSLGKLEQIGCFISACQGQIPPRPLNNSKIVVFAGDHGVATKGVSAYP
SSVSLQMAENITNGGAAINVIARTTGTSVRLIDTSLDHEAWGDERVSRSCGSIDVEDAMTQEQVERALEIGKRIADQEVD
AGADILIPGDLGIGNTTTAAALVGTFTLAEPVVVVGRGTGIDDEAWKLKVSAIRDAMFRVRDLRQDPIAIARKISSPDLA
AMAAFIAQAAVRRTPVLLDGVVVTAAALLANKLAPGARRWFIAGHRSTEPAHSVALDALALDPILEFGMYLGEGSGAATA
LPMVKIAVDLMNDMSTFSSAGVDGPLNASSEAPEQNTE

Sequences:

>Translated_358_residues
MVPAELFARVEFPDHKILAQTKDFHDSLTKPPGSLGKLEQIGCFISACQGQIPPRPLNNSKIVVFAGDHGVATKGVSAYP
SSVSLQMAENITNGGAAINVIARTTGTSVRLIDTSLDHEAWGDERVSRSCGSIDVEDAMTQEQVERALEIGKRIADQEVD
AGADILIPGDLGIGNTTTAAALVGTFTLAEPVVVVGRGTGIDDEAWKLKVSAIRDAMFRVRDLRQDPIAIARKISSPDLA
AMAAFIAQAAVRRTPVLLDGVVVTAAALLANKLAPGARRWFIAGHRSTEPAHSVALDALALDPILEFGMYLGEGSGAATA
LPMVKIAVDLMNDMSTFSSAGVDGPLNASSEAPEQNTE
>Mature_358_residues
MVPAELFARVEFPDHKILAQTKDFHDSLTKPPGSLGKLEQIGCFISACQGQIPPRPLNNSKIVVFAGDHGVATKGVSAYP
SSVSLQMAENITNGGAAINVIARTTGTSVRLIDTSLDHEAWGDERVSRSCGSIDVEDAMTQEQVERALEIGKRIADQEVD
AGADILIPGDLGIGNTTTAAALVGTFTLAEPVVVVGRGTGIDDEAWKLKVSAIRDAMFRVRDLRQDPIAIARKISSPDLA
AMAAFIAQAAVRRTPVLLDGVVVTAAALLANKLAPGARRWFIAGHRSTEPAHSVALDALALDPILEFGMYLGEGSGAATA
LPMVKIAVDLMNDMSTFSSAGVDGPLNASSEAPEQNTE

Specific function: Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB)

COG id: COG2038

COG function: function code H; NaMN:DMB phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CobT family

Homologues:

Organism=Escherichia coli, GI1788300, Length=352, Percent_Identity=32.3863636363636, Blast_Score=169, Evalue=2e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COBT_CORGB (A4QFR5)

Other databases:

- EMBL:   AP009044
- RefSeq:   YP_001138983.1
- ProteinModelPortal:   A4QFR5
- SMR:   A4QFR5
- STRING:   A4QFR5
- GeneID:   4992215
- GenomeReviews:   AP009044_GR
- KEGG:   cgt:cgR_2081
- eggNOG:   COG2038
- HOGENOM:   HBG634399
- OMA:   KGFAMAR
- ProtClustDB:   PRK00105
- HAMAP:   MF_00230
- InterPro:   IPR003200
- InterPro:   IPR023195
- InterPro:   IPR017846
- Gene3D:   G3DSA:1.10.1610.10
- TIGRFAMs:   TIGR03160

Pfam domain/function: PF02277 DBI_PRT; SSF52733 NN:DBI_PRT

EC number: =2.4.2.21

Molecular weight: Translated: 37602; Mature: 37602

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: NA

Important sites: ACT_SITE 313-313

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVPAELFARVEFPDHKILAQTKDFHDSLTKPPGSLGKLEQIGCFISACQGQIPPRPLNNS
CCCHHHHEEECCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCC
KIVVFAGDHGVATKGVSAYPSSVSLQMAENITNGGAAINVIARTTGTSVRLIDTSLDHEA
EEEEEECCCCCCCCCCCCCCCCEEEHHHHCCCCCCCEEEEEEECCCCEEEEEECCCCCCC
WGDERVSRSCGSIDVEDAMTQEQVERALEIGKRIADQEVDAGADILIPGDLGIGNTTTAA
CCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHH
ALVGTFTLAEPVVVVGRGTGIDDEAWKLKVSAIRDAMFRVRDLRQDPIAIARKISSPDLA
HHHHHHHHHCCEEEEECCCCCCCHHHEEHHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHH
AMAAFIAQAAVRRTPVLLDGVVVTAAALLANKLAPGARRWFIAGHRSTEPAHSVALDALA
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHH
LDPILEFGMYLGEGSGAATALPMVKIAVDLMNDMSTFSSAGVDGPLNASSEAPEQNTE
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MVPAELFARVEFPDHKILAQTKDFHDSLTKPPGSLGKLEQIGCFISACQGQIPPRPLNNS
CCCHHHHEEECCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCC
KIVVFAGDHGVATKGVSAYPSSVSLQMAENITNGGAAINVIARTTGTSVRLIDTSLDHEA
EEEEEECCCCCCCCCCCCCCCCEEEHHHHCCCCCCCEEEEEEECCCCEEEEEECCCCCCC
WGDERVSRSCGSIDVEDAMTQEQVERALEIGKRIADQEVDAGADILIPGDLGIGNTTTAA
CCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHH
ALVGTFTLAEPVVVVGRGTGIDDEAWKLKVSAIRDAMFRVRDLRQDPIAIARKISSPDLA
HHHHHHHHHCCEEEEECCCCCCCHHHEEHHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHH
AMAAFIAQAAVRRTPVLLDGVVVTAAALLANKLAPGARRWFIAGHRSTEPAHSVALDALA
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHH
LDPILEFGMYLGEGSGAATALPMVKIAVDLMNDMSTFSSAGVDGPLNASSEAPEQNTE
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA