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The map label for this gene is pyrC [H]

Identifier: 145295733

GI number: 145295733

Start: 1847175

End: 1848518

Strand: Reverse

Name: pyrC [H]

Synonym: cgR_1660

Alternate gene names: 145295733

Gene position: 1848518-1847175 (Counterclockwise)

Preceding gene: 145295734

Following gene: 145295732

Centisome position: 55.78

GC content: 57.44

Gene sequence:

>1344_bases
GTGGTTGACAGCAACACCCAGTATCCAGAGACCGGCGCACTGGCACCGGCTCCTGCAGACTCACTCCTGATCAGCAACGT
TTTGGTCTACGGCGAAGGCGAGCCAACAAATGTATTGGTGAAAGATGGCGTGATCGCAGCTATCGGCGGCACCCATGAGG
CTGACCGCACCATCGACGGCAATGGGGGAGTCCTTCTTCCAGGTTTCGTGGACATGCACGTTCACCTGCGTGAGCCAGGC
CGCGAAGACACTGAAACTATTGCTACTGGTTCTGCCGCCGCAGCCAAGGGCGGATTCACCGCAGTATTCACTATGGCGAA
CACCTTTCCAGTGATGGATCAGCCGGTCATTGCAGAGTCCGTATGGTTCAAGAGCCAGAACATTGGCCTATGCGATGTGC
ACCCAGTTGGATCCATCACCAAGGGTCTTGAGGGCAAGGAGCTTACTGAGTTCGGCATGATGGCTCGCTCTGAAGCCAAG
GTGCGCATGTTCTCTGATGATGGCAAGTGCGTCGATGATCCTCAGGTCATGCGTCGCGCGCTGGAGTACGCCAAGGGCAT
GGACGTTCTGATCGCCCAGCACGCTGAGGATCACCGCCTGACTGAGGGCGCGTCAGCACACGAGGGTGAAAACGCAGCTC
GTCTGGGACTGCGTGGATGGCCACGTGTGGCTGAGGAATCTATCGTGGTGCGCGATGCCATCATGGCTCGTGACTACGGT
AACCGCGTGCACATCTGCCACGCATCCACCGAAGGCACCGTGGAGTTGCTTCGTTGGGCTAAGTCCCAGGGCATTCCAAT
CACCGCGGAAGTCACCCCGCACCACCTCACCTTGACCGATGAGCGCTTGGAAACCTACGACGCGGTCAACAAAGTCAATC
CGCCACTGCGCGAAAGCCGCGACGCCGAAGCGCTCAAGAAGGCGCTTCTCGACGGCACCATCGATGTTGTTGCAACCGAC
CACGCTCCTCACGGTTCCGAAGATAAGTGCTGTGAATTCGAAAACGCCAAGCCAGGCATGCTCGGATTGGAAACCTCACT
GTCCATTATCGTGGATACCTTCGTTGCCACCGGACTTGCAGACTGGCGCTTCGTTGCGCGTGTGATGAGTGAACGGCCAG
CAGAGATCACCCGTCTACCAGGCCAGGGCCGCCCAATCGCAGAAGGTGAGCCAGCAAACCTCGCGATTGTTGATCCAGGA
AAAACCTGGACGGCATGCGGTGCAGACTTTGCGTCTAAGGCTGAAAATACCCCATTTGAGGGCCAAGAATTCAGCGCCAA
GGTCACACACACAGTGCTTCGTGGCAAGGTGACTTGTGCAGACGGAGTTGCACAAAACGCTTAA

Upstream 100 bases:

>100_bases
ATGGCCATTTTGTTCGCCCTGGTCGCAGGCTCTGACGCGACTATCTGATCGCGACCATCTGATCGCGAAATTCTAGAAAA
GGTAACGAGGGATTAAAGAA

Downstream 100 bases:

>100_bases
CTGGCGAGTGAATAGTATGCACGCGCCACGTTGCATATAATGCAACATATTGAATAAACTACATTCAGGGTTATCAACCA
GCCAATTTCTTTTAAAAAGG

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MVDSNTQYPETGALAPAPADSLLISNVLVYGEGEPTNVLVKDGVIAAIGGTHEADRTIDGNGGVLLPGFVDMHVHLREPG
REDTETIATGSAAAAKGGFTAVFTMANTFPVMDQPVIAESVWFKSQNIGLCDVHPVGSITKGLEGKELTEFGMMARSEAK
VRMFSDDGKCVDDPQVMRRALEYAKGMDVLIAQHAEDHRLTEGASAHEGENAARLGLRGWPRVAEESIVVRDAIMARDYG
NRVHICHASTEGTVELLRWAKSQGIPITAEVTPHHLTLTDERLETYDAVNKVNPPLRESRDAEALKKALLDGTIDVVATD
HAPHGSEDKCCEFENAKPGMLGLETSLSIIVDTFVATGLADWRFVARVMSERPAEITRLPGQGRPIAEGEPANLAIVDPG
KTWTACGADFASKAENTPFEGQEFSAKVTHTVLRGKVTCADGVAQNA

Sequences:

>Translated_447_residues
MVDSNTQYPETGALAPAPADSLLISNVLVYGEGEPTNVLVKDGVIAAIGGTHEADRTIDGNGGVLLPGFVDMHVHLREPG
REDTETIATGSAAAAKGGFTAVFTMANTFPVMDQPVIAESVWFKSQNIGLCDVHPVGSITKGLEGKELTEFGMMARSEAK
VRMFSDDGKCVDDPQVMRRALEYAKGMDVLIAQHAEDHRLTEGASAHEGENAARLGLRGWPRVAEESIVVRDAIMARDYG
NRVHICHASTEGTVELLRWAKSQGIPITAEVTPHHLTLTDERLETYDAVNKVNPPLRESRDAEALKKALLDGTIDVVATD
HAPHGSEDKCCEFENAKPGMLGLETSLSIIVDTFVATGLADWRFVARVMSERPAEITRLPGQGRPIAEGEPANLAIVDPG
KTWTACGADFASKAENTPFEGQEFSAKVTHTVLRGKVTCADGVAQNA
>Mature_447_residues
MVDSNTQYPETGALAPAPADSLLISNVLVYGEGEPTNVLVKDGVIAAIGGTHEADRTIDGNGGVLLPGFVDMHVHLREPG
REDTETIATGSAAAAKGGFTAVFTMANTFPVMDQPVIAESVWFKSQNIGLCDVHPVGSITKGLEGKELTEFGMMARSEAK
VRMFSDDGKCVDDPQVMRRALEYAKGMDVLIAQHAEDHRLTEGASAHEGENAARLGLRGWPRVAEESIVVRDAIMARDYG
NRVHICHASTEGTVELLRWAKSQGIPITAEVTPHHLTLTDERLETYDAVNKVNPPLRESRDAEALKKALLDGTIDVVATD
HAPHGSEDKCCEFENAKPGMLGLETSLSIIVDTFVATGLADWRFVARVMSERPAEITRLPGQGRPIAEGEPANLAIVDPG
KTWTACGADFASKAENTPFEGQEFSAKVTHTVLRGKVTCADGVAQNA

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=381, Percent_Identity=32.0209973753281, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI4503051, Length=450, Percent_Identity=24.6666666666667, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI62422571, Length=450, Percent_Identity=24.6666666666667, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI190194363, Length=456, Percent_Identity=24.5614035087719, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI19923821, Length=454, Percent_Identity=24.0088105726872, Blast_Score=69, Evalue=7e-12,
Organism=Escherichia coli, GI1786722, Length=430, Percent_Identity=28.6046511627907, Blast_Score=158, Evalue=5e-40,
Organism=Escherichia coli, GI87082175, Length=453, Percent_Identity=25.3863134657837, Blast_Score=96, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI193204318, Length=377, Percent_Identity=28.1167108753316, Blast_Score=119, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI71989490, Length=438, Percent_Identity=22.8310502283105, Blast_Score=76, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6322218, Length=399, Percent_Identity=26.3157894736842, Blast_Score=97, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24642586, Length=386, Percent_Identity=30.3108808290155, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI18859883, Length=464, Percent_Identity=26.9396551724138, Blast_Score=95, Evalue=9e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 47885; Mature: 47885

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: PS00482 DIHYDROOROTASE_1 ; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDSNTQYPETGALAPAPADSLLISNVLVYGEGEPTNVLVKDGVIAAIGGTHEADRTIDG
CCCCCCCCCCCCCCCCCCCHHHHHEEEEEEECCCCCEEEEECCEEEEECCCCCCCCEECC
NGGVLLPGFVDMHVHLREPGREDTETIATGSAAAAKGGFTAVFTMANTFPVMDQPVIAES
CCCEEECCEEEEEEEECCCCCCCHHHHCCCCCHHCCCCCEEEEEECCCCCCCCCCHHHHH
VWFKSQNIGLCDVHPVGSITKGLEGKELTEFGMMARSEAKVRMFSDDGKCVDDPQVMRRA
HEEECCCCCEEECCCCCHHHCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHH
LEYAKGMDVLIAQHAEDHRLTEGASAHEGENAARLGLRGWPRVAEESIVVRDAIMARDYG
HHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHCCC
NRVHICHASTEGTVELLRWAKSQGIPITAEVTPHHLTLTDERLETYDAVNKVNPPLRESR
CEEEEEECCCCCHHHHHHHHHCCCCEEEEECCCCEEEEEHHHHHHHHHHHHCCCCHHCCC
DAEALKKALLDGTIDVVATDHAPHGSEDKCCEFENAKPGMLGLETSLSIIVDTFVATGLA
CHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHCCH
DWRFVARVMSERPAEITRLPGQGRPIAEGEPANLAIVDPGKTWTACGADFASKAENTPFE
HHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCEEEEECCCCCEECCCCHHHHHCCCCCCC
GQEFSAKVTHTVLRGKVTCADGVAQNA
CCCCHHHHHHHHHHCEEEECCCCCCCC
>Mature Secondary Structure
MVDSNTQYPETGALAPAPADSLLISNVLVYGEGEPTNVLVKDGVIAAIGGTHEADRTIDG
CCCCCCCCCCCCCCCCCCCHHHHHEEEEEEECCCCCEEEEECCEEEEECCCCCCCCEECC
NGGVLLPGFVDMHVHLREPGREDTETIATGSAAAAKGGFTAVFTMANTFPVMDQPVIAES
CCCEEECCEEEEEEEECCCCCCCHHHHCCCCCHHCCCCCEEEEEECCCCCCCCCCHHHHH
VWFKSQNIGLCDVHPVGSITKGLEGKELTEFGMMARSEAKVRMFSDDGKCVDDPQVMRRA
HEEECCCCCEEECCCCCHHHCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHH
LEYAKGMDVLIAQHAEDHRLTEGASAHEGENAARLGLRGWPRVAEESIVVRDAIMARDYG
HHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHCCC
NRVHICHASTEGTVELLRWAKSQGIPITAEVTPHHLTLTDERLETYDAVNKVNPPLRESR
CEEEEEECCCCCHHHHHHHHHCCCCEEEEECCCCEEEEEHHHHHHHHHHHHCCCCHHCCC
DAEALKKALLDGTIDVVATDHAPHGSEDKCCEFENAKPGMLGLETSLSIIVDTFVATGLA
CHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHCCH
DWRFVARVMSERPAEITRLPGQGRPIAEGEPANLAIVDPGKTWTACGADFASKAENTPFE
HHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCEEEEECCCCCEECCCCHHHHHCCCCCCC
GQEFSAKVTHTVLRGKVTCADGVAQNA
CCCCHHHHHHHHHHCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12948626 [H]