| Definition | Corynebacterium glutamicum R chromosome, complete genome. |
|---|---|
| Accession | NC_009342 |
| Length | 3,314,179 |
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The map label for this gene is theD [H]
Identifier: 145295597
GI number: 145295597
Start: 1684148
End: 1686439
Strand: Reverse
Name: theD [H]
Synonym: cgR_1524
Alternate gene names: 145295597
Gene position: 1686439-1684148 (Counterclockwise)
Preceding gene: 145295598
Following gene: 145295596
Centisome position: 50.89
GC content: 57.11
Gene sequence:
>2292_bases GTGACTGATTTTTCTTTGTATCTGGTCACCGATCCCGTTTTGGGTGGCGGGCCAGAAAAAGTAGCTGGAATTGTTGACAG CGCAATTTCCGGCGGAGTTTCTGTGGTGCAGCTGCGCGATAAGAACTCAGGCGTGGAAGATGTTCGTGCGGCAGCGAAGG AGCTGAAAGAACTCTGCGATGCTCGCGGGGTGGCGCTTGTTGTCAACGATTACTTAGATATCGCCGTTGAGCTGGGTCTT CACCTGCACATTGGTCAAGGCGATACACCTTATACGCAAGCACGGGAGCTGCTTCCAGCTCATCTTGAATTGGGTTTGAG CATTGAAAACCTGGATCAATTGCATGCTGTGATCGCGCAGTGCGCCGAGACTGGTGTGGCATTGCCCGATGTGATTGGCA TTGGTCCGGTGGCCTCTACTGCGACCAAACCAGATGCGGCACCCGCATTGGGTGTGGAAGGCATCGCTGAGATCGCCGCT GTAGCTCAAGACCACGGCATCGCATCAGTAGCTATTGGAGGCGTTGGTCTACGCAACGCGGCCGAACTCGCTGCTACGCC CATCGACGGTCTGTGCGTGGTCTCTGAAATCATGACCGCCGCCAATCCAGCAGCTGCGGCAACTCGCCTGCGGACTGCTT TTCAACCTACTTTCTCGCCTGAAACTCAAACTGAACTCTCTCAAACAGAACTCCAAGGAGCTTTCGTGAATTCGCCTTCT GCCCCACGTGTGTTGTCTATTGCAGGCACTGATCCCACAGGTGGTGCAGGTATTCAGGCTGATCTGAAGTCCATTGCAGC AGGTGGCGGCTACGGCATGTGCATTGTAACCTCGCTGGTCGCGCAAAACACCCACGGCGTCAACACGATCCACACCCCAC CCTTGACCTTTTTGGAAGAACAGCTGGAAGCGGTCTTTTCCGACGTCACCGTCGATGCCATCAAGCTCGGCATGTTGGGC TCTGCCGACACCGTCGATCTGGTGGCTTCGTGGCTTGGCTCCCACGAGCACGGTCCCGTGGTGCTTGATCCCGTCATGAT CGCCACCAGCGGTGATCGCCTACTGGATGCGAGCGCTGAAGAATCGCTGCGCCGCCTAGCCGTGCACGTCGATGTGGTCA CCCCGAATATTCCCGAACTTGCCGTGTTGTGCGACAGTGCTCCTGCCATCACCATGGATGAGGCCATTGCTCAGGCTCAA GGATTTGCGCGGACTCATGACACCATCGTCATTGTCAAGGGTGGACATCTGACTGGCACGCTTGCTGATAACGCTGTCGT GCGTCCCGACGGCTCGGTGTTCCAGGTGGAAAACCTGCGTGTCAACACCACCAACTCCCATGGCACAGGCTGTTCGCTCT CTGCGTCACTTGCCACCAGGATCGCCGCCGGCGAAAGCGTGGAAAAAGCCCTCGAGTGGTCCACGCGTTGGCTCAACGAG GCGCTCCGCCACGCCGATCACTTGGCTGTAGGTACTGGAAACGGCCCTGTCGACCACGGTCACCTGGCACGACGCATGAC CCACGCGGCGGAAACCACTCCCTGGGCACACCTTCGGGCTCCGCGCCTAGACGGCGCCACCGCGGCAAGTTTCACCACAC CCTCCACGGTAAAAAGCCCAGCTCCACGCATCGAACCTGCCGGGCCTTTCACGCGCGCACTGTGGGAGGCAAGTGGCGAA ATCATCGCGGGCATCAACAGTTCTGATTTCATCACTATGCTTGGCGACGGCACCCTCCGGCGCCCAGAGTTCGATTTCTA CATCGACCAAGACGCCCAATACCTCGCCCAATATTCCCGAGCATTGGCACGACTCTCTTCGATCGCACCTGATTCACACG CACAAATCGAATGGGCTCAAAGCGCTGCAGAATGCCTGGTCGTGGAAGCCGAACTGCACCGCTCTTATATGACAGGAAAA GAAGTCTCCGCACCATCACACATCACGATGGCCTATACCGACTTCCTCATCGCACGCACCTACACTGAGGACTACGTCTG CGGTGTGGCGGCCGTACTGCCGTGCTACTGGCTTTACGCAGAGATCGGATTGATGCTGGCTGAACAAAACCACGACGAGC ACCCCTACAAGGACTGGCTCAACACTTACTCCGGTGAAGAATTCATCGCTGGAACCCGTGCGGCTATCGCACGTCTAGAA AAGGCTCTAGAAAATGCGGGTGCTGAACAACGCGTCGATGCTGCTCGAGCATTCTTGAGCGCCTCTGTCCATGAACGCGA GTTCTTTGATCAGGCAACTCGCCATGGTTGGACAATGGTTGGATCTAGCTAA
Upstream 100 bases:
>100_bases GCGCCAGGCAGCTTTGCGGTGGCGTTTATTGATGCGCTTTATGACGTGGATGCCCAGGCTGTGGCCTCGTTGGTTGATGT GCGAGAGGCCTGAAAAGTAC
Downstream 100 bases:
>100_bases ACCTGATCTCACTGCGCGCCGGGCCATCTCTGTCAATTAGGAGGTGGCCCGGCGCGCTTTTGCAGCTGTGGGGTTGGGCT GGGGGCAAGTGTTCATGTAG
Product: multifunctional thiamine-phosphate pyrophosphorylase/synthase/phosphomethylpyrimidine kinase
Products: NA
Alternate protein names: Thiamine-phosphate pyrophosphorylase; TMP pyrophosphorylase; TMP-PPase; Thiamine-phosphate synthase; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase; Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]
Number of amino acids: Translated: 763; Mature: 762
Protein sequence:
>763_residues MTDFSLYLVTDPVLGGGPEKVAGIVDSAISGGVSVVQLRDKNSGVEDVRAAAKELKELCDARGVALVVNDYLDIAVELGL HLHIGQGDTPYTQARELLPAHLELGLSIENLDQLHAVIAQCAETGVALPDVIGIGPVASTATKPDAAPALGVEGIAEIAA VAQDHGIASVAIGGVGLRNAAELAATPIDGLCVVSEIMTAANPAAAATRLRTAFQPTFSPETQTELSQTELQGAFVNSPS APRVLSIAGTDPTGGAGIQADLKSIAAGGGYGMCIVTSLVAQNTHGVNTIHTPPLTFLEEQLEAVFSDVTVDAIKLGMLG SADTVDLVASWLGSHEHGPVVLDPVMIATSGDRLLDASAEESLRRLAVHVDVVTPNIPELAVLCDSAPAITMDEAIAQAQ GFARTHDTIVIVKGGHLTGTLADNAVVRPDGSVFQVENLRVNTTNSHGTGCSLSASLATRIAAGESVEKALEWSTRWLNE ALRHADHLAVGTGNGPVDHGHLARRMTHAAETTPWAHLRAPRLDGATAASFTTPSTVKSPAPRIEPAGPFTRALWEASGE IIAGINSSDFITMLGDGTLRRPEFDFYIDQDAQYLAQYSRALARLSSIAPDSHAQIEWAQSAAECLVVEAELHRSYMTGK EVSAPSHITMAYTDFLIARTYTEDYVCGVAAVLPCYWLYAEIGLMLAEQNHDEHPYKDWLNTYSGEEFIAGTRAAIARLE KALENAGAEQRVDAARAFLSASVHEREFFDQATRHGWTMVGSS
Sequences:
>Translated_763_residues MTDFSLYLVTDPVLGGGPEKVAGIVDSAISGGVSVVQLRDKNSGVEDVRAAAKELKELCDARGVALVVNDYLDIAVELGL HLHIGQGDTPYTQARELLPAHLELGLSIENLDQLHAVIAQCAETGVALPDVIGIGPVASTATKPDAAPALGVEGIAEIAA VAQDHGIASVAIGGVGLRNAAELAATPIDGLCVVSEIMTAANPAAAATRLRTAFQPTFSPETQTELSQTELQGAFVNSPS APRVLSIAGTDPTGGAGIQADLKSIAAGGGYGMCIVTSLVAQNTHGVNTIHTPPLTFLEEQLEAVFSDVTVDAIKLGMLG SADTVDLVASWLGSHEHGPVVLDPVMIATSGDRLLDASAEESLRRLAVHVDVVTPNIPELAVLCDSAPAITMDEAIAQAQ GFARTHDTIVIVKGGHLTGTLADNAVVRPDGSVFQVENLRVNTTNSHGTGCSLSASLATRIAAGESVEKALEWSTRWLNE ALRHADHLAVGTGNGPVDHGHLARRMTHAAETTPWAHLRAPRLDGATAASFTTPSTVKSPAPRIEPAGPFTRALWEASGE IIAGINSSDFITMLGDGTLRRPEFDFYIDQDAQYLAQYSRALARLSSIAPDSHAQIEWAQSAAECLVVEAELHRSYMTGK EVSAPSHITMAYTDFLIARTYTEDYVCGVAAVLPCYWLYAEIGLMLAEQNHDEHPYKDWLNTYSGEEFIAGTRAAIARLE KALENAGAEQRVDAARAFLSASVHEREFFDQATRHGWTMVGSS >Mature_762_residues TDFSLYLVTDPVLGGGPEKVAGIVDSAISGGVSVVQLRDKNSGVEDVRAAAKELKELCDARGVALVVNDYLDIAVELGLH LHIGQGDTPYTQARELLPAHLELGLSIENLDQLHAVIAQCAETGVALPDVIGIGPVASTATKPDAAPALGVEGIAEIAAV AQDHGIASVAIGGVGLRNAAELAATPIDGLCVVSEIMTAANPAAAATRLRTAFQPTFSPETQTELSQTELQGAFVNSPSA PRVLSIAGTDPTGGAGIQADLKSIAAGGGYGMCIVTSLVAQNTHGVNTIHTPPLTFLEEQLEAVFSDVTVDAIKLGMLGS ADTVDLVASWLGSHEHGPVVLDPVMIATSGDRLLDASAEESLRRLAVHVDVVTPNIPELAVLCDSAPAITMDEAIAQAQG FARTHDTIVIVKGGHLTGTLADNAVVRPDGSVFQVENLRVNTTNSHGTGCSLSASLATRIAAGESVEKALEWSTRWLNEA LRHADHLAVGTGNGPVDHGHLARRMTHAAETTPWAHLRAPRLDGATAASFTTPSTVKSPAPRIEPAGPFTRALWEASGEI IAGINSSDFITMLGDGTLRRPEFDFYIDQDAQYLAQYSRALARLSSIAPDSHAQIEWAQSAAECLVVEAELHRSYMTGKE VSAPSHITMAYTDFLIARTYTEDYVCGVAAVLPCYWLYAEIGLMLAEQNHDEHPYKDWLNTYSGEEFIAGTRAAIARLEK ALENAGAEQRVDAARAFLSASVHEREFFDQATRHGWTMVGSS
Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P [H]
COG id: COG0351
COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: In the C-terminal section; belongs to the thiaminase-2 family [H]
Homologues:
Organism=Escherichia coli, GI1788420, Length=258, Percent_Identity=44.1860465116279, Blast_Score=193, Evalue=3e-50, Organism=Saccharomyces cerevisiae, GI6325378, Length=506, Percent_Identity=25.8893280632411, Blast_Score=140, Evalue=8e-34, Organism=Saccharomyces cerevisiae, GI6324517, Length=391, Percent_Identity=32.4808184143223, Blast_Score=138, Evalue=4e-33, Organism=Saccharomyces cerevisiae, GI6324997, Length=397, Percent_Identity=31.4861460957179, Blast_Score=136, Evalue=1e-32, Organism=Saccharomyces cerevisiae, GI6325042, Length=258, Percent_Identity=29.0697674418605, Blast_Score=97, Evalue=1e-20,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR013785 - InterPro: IPR016084 - InterPro: IPR013749 - InterPro: IPR004399 - InterPro: IPR004305 - InterPro: IPR022998 - InterPro: IPR003733 [H]
Pfam domain/function: PF08543 Phos_pyr_kin; PF03070 TENA_THI-4; PF02581 TMP-TENI [H]
EC number: =2.5.1.3; =2.7.1.49; =2.7.4.7 [H]
Molecular weight: Translated: 80472; Mature: 80341
Theoretical pI: Translated: 4.58; Mature: 4.58
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.2 %Cys (Translated Protein) 1.6 %Met (Translated Protein) 2.8 %Cys+Met (Translated Protein) 1.2 %Cys (Mature Protein) 1.4 %Met (Mature Protein) 2.6 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MTDFSLYLVTDPVLGGGPEKVAGIVDSAISGGVSVVQLRDKNSGVEDVRAAAKELKELCD CCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHC ARGVALVVNDYLDIAVELGLHLHIGQGDTPYTQARELLPAHLELGLSIENLDQLHAVIAQ CCCEEEEEHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH CAETGVALPDVIGIGPVASTATKPDAAPALGVEGIAEIAAVAQDHGIASVAIGGVGLRNA HHHCCCCCCHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCH AELAATPIDGLCVVSEIMTAANPAAAATRLRTAFQPTFSPETQTELSQTELQGAFVNSPS HHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCC APRVLSIAGTDPTGGAGIQADLKSIAAGGGYGMCIVTSLVAQNTHGVNTIHTPPLTFLEE CCEEEEEECCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHH QLEAVFSDVTVDAIKLGMLGSADTVDLVASWLGSHEHGPVVLDPVMIATSGDRLLDASAE HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCEEECCEEEEECCCCCCCCHHH ESLRRLAVHVDVVTPNIPELAVLCDSAPAITMDEAIAQAQGFARTHDTIVIVKGGHLTGT HHHHHHEEEEEEECCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCEEEEEECCEEEEE LADNAVVRPDGSVFQVENLRVNTTNSHGTGCSLSASLATRIAAGESVEKALEWSTRWLNE ECCCEEECCCCCEEEEEEEEEECCCCCCCCCEEHHHHHHHHHCCHHHHHHHHHHHHHHHH ALRHADHLAVGTGNGPVDHGHLARRMTHAAETTPWAHLRAPRLDGATAASFTTPSTVKSP HHHHCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCHHEECCCCCCCCCCCCCCCCCCCCC APRIEPAGPFTRALWEASGEIIAGINSSDFITMLGDGTLRRPEFDFYIDQDAQYLAQYSR CCCCCCCCHHHHHHHHCCCCEEEECCCCCEEEEECCCCCCCCCCCEEECCHHHHHHHHHH ALARLSSIAPDSHAQIEWAQSAAECLVVEAELHRSYMTGKEVSAPSHITMAYTDFLIART HHHHHHHCCCCCCCHHHHHHHHHHEEEEHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHH YTEDYVCGVAAVLPCYWLYAEIGLMLAEQNHDEHPYKDWLNTYSGEEFIAGTRAAIARLE CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHH KALENAGAEQRVDAARAFLSASVHEREFFDQATRHGWTMVGSS HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCC >Mature Secondary Structure TDFSLYLVTDPVLGGGPEKVAGIVDSAISGGVSVVQLRDKNSGVEDVRAAAKELKELCD CCEEEEEEECCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHC ARGVALVVNDYLDIAVELGLHLHIGQGDTPYTQARELLPAHLELGLSIENLDQLHAVIAQ CCCEEEEEHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH CAETGVALPDVIGIGPVASTATKPDAAPALGVEGIAEIAAVAQDHGIASVAIGGVGLRNA HHHCCCCCCHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCH AELAATPIDGLCVVSEIMTAANPAAAATRLRTAFQPTFSPETQTELSQTELQGAFVNSPS HHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCC APRVLSIAGTDPTGGAGIQADLKSIAAGGGYGMCIVTSLVAQNTHGVNTIHTPPLTFLEE CCEEEEEECCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHH QLEAVFSDVTVDAIKLGMLGSADTVDLVASWLGSHEHGPVVLDPVMIATSGDRLLDASAE HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCEEECCEEEEECCCCCCCCHHH ESLRRLAVHVDVVTPNIPELAVLCDSAPAITMDEAIAQAQGFARTHDTIVIVKGGHLTGT HHHHHHEEEEEEECCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCEEEEEECCEEEEE LADNAVVRPDGSVFQVENLRVNTTNSHGTGCSLSASLATRIAAGESVEKALEWSTRWLNE ECCCEEECCCCCEEEEEEEEEECCCCCCCCCEEHHHHHHHHHCCHHHHHHHHHHHHHHHH ALRHADHLAVGTGNGPVDHGHLARRMTHAAETTPWAHLRAPRLDGATAASFTTPSTVKSP HHHHCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCHHEECCCCCCCCCCCCCCCCCCCCC APRIEPAGPFTRALWEASGEIIAGINSSDFITMLGDGTLRRPEFDFYIDQDAQYLAQYSR CCCCCCCCHHHHHHHHCCCCEEEECCCCCEEEEECCCCCCCCCCCEEECCHHHHHHHHHH ALARLSSIAPDSHAQIEWAQSAAECLVVEAELHRSYMTGKEVSAPSHITMAYTDFLIART HHHHHHHCCCCCCCHHHHHHHHHHEEEEHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHH YTEDYVCGVAAVLPCYWLYAEIGLMLAEQNHDEHPYKDWLNTYSGEEFIAGTRAAIARLE CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHH KALENAGAEQRVDAARAFLSASVHEREFFDQATRHGWTMVGSS HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 12948626 [H]