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The map label for this gene is nhaK [H]

Identifier: 145295569

GI number: 145295569

Start: 1657357

End: 1658907

Strand: Reverse

Name: nhaK [H]

Synonym: cgR_1496

Alternate gene names: 145295569

Gene position: 1658907-1657357 (Counterclockwise)

Preceding gene: 145295570

Following gene: 145295565

Centisome position: 50.05

GC content: 55.77

Gene sequence:

>1551_bases
ATGACGATATTGTTCATGCTCATTACATTGCTGCTCGCCACCGTGATTGTGGTGGCCATAGGCGATAAAACTGGACTCCC
CTGGCCTGCTTTGATGACTATTGTCGCCGCAGGTGGAGCGTTGTTGCCATTTTTGCCGGAATTTACTATCCCGGCCGATC
TGATGTTGCCTATTTTCATTCCGCCGCTACTGTGGGCGCTGGCGAGGAAGTCATCGTGGGCGGTGATTAGGTCGCAGATG
TCTACCATCATCACGATGTCGGTGTTGTTGGTGTTCGTGACCATCGCGGCACTCACGGGTGCATCCATGCTGTTGCTTCC
TGGCATTGGTCTTGCTGGTGCGATCATGTTGGCTGCGGCTATTGCTCCACCGGATCCTGTTGCTGTTGATGCAGTGGCGG
AACCTGCGGGAATCCCGAAGCGCATCACCACCACTTTGCAGACGGAGGGTCTGTTTAATGATGCAGCCAGCATCGTGGCG
TTCCATGTGGCTTTAGCTGCCCTGGTCGCTGGTGAGGATTTGTCCTGGTCAACGGGTGTTTTGGAATTCTTGTGGTCGTG
TCTTGCTGCCGTTATTTTGGGCTTGGTTATTGGCCGGGCGGCTGCGTGGTTTACCGATCACGTGAGTTCCGTTGAGGCTC
GAAATGCGTTTACGTGGGTGCTGCCGTTTGCCATTTATGTGGTGGCGGAAGAAATCGGCGGTTCGGGCGTTATCGCCATT
GTGATCGCTGCAGTGGAGATGAATTCGAGGGCGTCGATTGGTGCGGAGGATCGTCTAACGGGTTCTGCGTTCTGGGGAAC
CATTGAGGTGCTGTTTACTGGCGTGGCCTTTGGTTTGATCGGCCTGAATGTGCGCACTGCGATTGATGAAGTCGGATCTG
AGCTGTGGCATGCCGTGGTCGTGGGCATTGTGCTCTCGGTGGTGGCGATCGTTGTCCGTGGTGTGTGGATGTTCGCGGCG
TATAAGCGCAATCGTTTCAAGATCGATAAGAAGGGTGCGACCAATAGTTCATTGCGGGCGCCTCTTCGACTGCAGGAATC
GTTGCTGATGACGTGGGCGGGCATGCGCGGTTTGGTGACGTTGGCGCTGGTGCTGTCTATTCCGGAGGATATTTTCCCGT
ATCACCACGAGTTGCAGGTCATTGCGCTGGTCGTTCTCTTAATCACCATGGTGGGCCCTGGTTTGGCGTTGCCGTGGCTG
ATGCGGAAGCTCAGCTTGGATAAGGGTCCCGATGCTGCGGGCGATGAGAGTATCGCCGCGCTGACAGAGAGGGCTCACAA
GGCCGCAACAACGTATTTGGTGGATACCACGGAGTTGCCGATGGAGCAGATGGTGGCGATCAAGAATTGGTTCTCGCAAG
AAATTGACGCTGATGAACTGCAGGAGAACGTCGATAAGCTGCATCAGCGCGCGCATCATGCGCGTGTCGGGGCAATCAAA
GCGGCCCAGGAGGAGCTGTTGAAGGCGCGTCGGGAGCGCGGCGTTAATCCGGCTTACGTTGATGAGGTGTTGACCAACAT
TGACCGGATGCTTGTTGCGGCTGAACGCTAG

Upstream 100 bases:

>100_bases
GTGTGCGCTCCCCCATGCAGCAGCATAATCGGGGAAAAATAGGAACTGTTTACTGAAAAAACTGAAAAGCTGACAGACCT
GACCCGAAGAGACCTTATTC

Downstream 100 bases:

>100_bases
ATAAACAGCAGCAGGCTGATCGCCATGACTGCCATGCCGGCGATGAGGCCGTAGATGGCGGTGTGGTGTTTGCCGCTGGA
GATGGCGGTGGGCAGCAGTT

Product: NhaP-type Na+/H+ and K+/H+ antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 516; Mature: 515

Protein sequence:

>516_residues
MTILFMLITLLLATVIVVAIGDKTGLPWPALMTIVAAGGALLPFLPEFTIPADLMLPIFIPPLLWALARKSSWAVIRSQM
STIITMSVLLVFVTIAALTGASMLLLPGIGLAGAIMLAAAIAPPDPVAVDAVAEPAGIPKRITTTLQTEGLFNDAASIVA
FHVALAALVAGEDLSWSTGVLEFLWSCLAAVILGLVIGRAAAWFTDHVSSVEARNAFTWVLPFAIYVVAEEIGGSGVIAI
VIAAVEMNSRASIGAEDRLTGSAFWGTIEVLFTGVAFGLIGLNVRTAIDEVGSELWHAVVVGIVLSVVAIVVRGVWMFAA
YKRNRFKIDKKGATNSSLRAPLRLQESLLMTWAGMRGLVTLALVLSIPEDIFPYHHELQVIALVVLLITMVGPGLALPWL
MRKLSLDKGPDAAGDESIAALTERAHKAATTYLVDTTELPMEQMVAIKNWFSQEIDADELQENVDKLHQRAHHARVGAIK
AAQEELLKARRERGVNPAYVDEVLTNIDRMLVAAER

Sequences:

>Translated_516_residues
MTILFMLITLLLATVIVVAIGDKTGLPWPALMTIVAAGGALLPFLPEFTIPADLMLPIFIPPLLWALARKSSWAVIRSQM
STIITMSVLLVFVTIAALTGASMLLLPGIGLAGAIMLAAAIAPPDPVAVDAVAEPAGIPKRITTTLQTEGLFNDAASIVA
FHVALAALVAGEDLSWSTGVLEFLWSCLAAVILGLVIGRAAAWFTDHVSSVEARNAFTWVLPFAIYVVAEEIGGSGVIAI
VIAAVEMNSRASIGAEDRLTGSAFWGTIEVLFTGVAFGLIGLNVRTAIDEVGSELWHAVVVGIVLSVVAIVVRGVWMFAA
YKRNRFKIDKKGATNSSLRAPLRLQESLLMTWAGMRGLVTLALVLSIPEDIFPYHHELQVIALVVLLITMVGPGLALPWL
MRKLSLDKGPDAAGDESIAALTERAHKAATTYLVDTTELPMEQMVAIKNWFSQEIDADELQENVDKLHQRAHHARVGAIK
AAQEELLKARRERGVNPAYVDEVLTNIDRMLVAAER
>Mature_515_residues
TILFMLITLLLATVIVVAIGDKTGLPWPALMTIVAAGGALLPFLPEFTIPADLMLPIFIPPLLWALARKSSWAVIRSQMS
TIITMSVLLVFVTIAALTGASMLLLPGIGLAGAIMLAAAIAPPDPVAVDAVAEPAGIPKRITTTLQTEGLFNDAASIVAF
HVALAALVAGEDLSWSTGVLEFLWSCLAAVILGLVIGRAAAWFTDHVSSVEARNAFTWVLPFAIYVVAEEIGGSGVIAIV
IAAVEMNSRASIGAEDRLTGSAFWGTIEVLFTGVAFGLIGLNVRTAIDEVGSELWHAVVVGIVLSVVAIVVRGVWMFAAY
KRNRFKIDKKGATNSSLRAPLRLQESLLMTWAGMRGLVTLALVLSIPEDIFPYHHELQVIALVVLLITMVGPGLALPWLM
RKLSLDKGPDAAGDESIAALTERAHKAATTYLVDTTELPMEQMVAIKNWFSQEIDADELQENVDKLHQRAHHARVGAIKA
AQEELLKARRERGVNPAYVDEVLTNIDRMLVAAER

Specific function: Transporter involved in the efflux of sodium, potassium, lithium and rubidium [H]

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. Nhak (TC 2.A.36.3.2) subfamily [H]

Homologues:

Organism=Homo sapiens, GI148727259, Length=387, Percent_Identity=23.5142118863049, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI15529998, Length=327, Percent_Identity=22.9357798165138, Blast_Score=73, Evalue=7e-13,
Organism=Escherichia coli, GI1790501, Length=559, Percent_Identity=27.7280858676207, Blast_Score=132, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI71999821, Length=265, Percent_Identity=26.0377358490566, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71999819, Length=269, Percent_Identity=25.2788104089219, Blast_Score=74, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71999817, Length=265, Percent_Identity=26.0377358490566, Blast_Score=74, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI25147678, Length=264, Percent_Identity=26.1363636363636, Blast_Score=72, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI71990932, Length=423, Percent_Identity=21.5130023640662, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71990924, Length=423, Percent_Identity=21.5130023640662, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI221510734, Length=405, Percent_Identity=23.7037037037037, Blast_Score=77, Evalue=4e-14,
Organism=Drosophila melanogaster, GI221510738, Length=483, Percent_Identity=22.9813664596273, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI221510732, Length=386, Percent_Identity=24.3523316062176, Blast_Score=73, Evalue=6e-13,
Organism=Drosophila melanogaster, GI221510736, Length=386, Percent_Identity=24.3523316062176, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24585580, Length=386, Percent_Identity=24.3523316062176, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24585578, Length=386, Percent_Identity=24.3523316062176, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI221510740, Length=386, Percent_Identity=24.3523316062176, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR018417
- InterPro:   IPR004705
- InterPro:   IPR002014 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 55319; Mature: 55188

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTILFMLITLLLATVIVVAIGDKTGLPWPALMTIVAAGGALLPFLPEFTIPADLMLPIFI
CHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHCCCCCCCCHHHHHHHHH
PPLLWALARKSSWAVIRSQMSTIITMSVLLVFVTIAALTGASMLLLPGIGLAGAIMLAAA
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHH
IAPPDPVAVDAVAEPAGIPKRITTTLQTEGLFNDAASIVAFHVALAALVAGEDLSWSTGV
CCCCCCCCHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
LEFLWSCLAAVILGLVIGRAAAWFTDHVSSVEARNAFTWVLPFAIYVVAEEIGGSGVIAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCHHHH
VIAAVEMNSRASIGAEDRLTGSAFWGTIEVLFTGVAFGLIGLNVRTAIDEVGSELWHAVV
HHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGIVLSVVAIVVRGVWMFAAYKRNRFKIDKKGATNSSLRAPLRLQESLLMTWAGMRGLVT
HHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
LALVLSIPEDIFPYHHELQVIALVVLLITMVGPGLALPWLMRKLSLDKGPDAAGDESIAA
HHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCHHHHH
LTERAHKAATTYLVDTTELPMEQMVAIKNWFSQEIDADELQENVDKLHQRAHHARVGAIK
HHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
AAQEELLKARRERGVNPAYVDEVLTNIDRMLVAAER
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TILFMLITLLLATVIVVAIGDKTGLPWPALMTIVAAGGALLPFLPEFTIPADLMLPIFI
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHCCCCCCCCHHHHHHHHH
PPLLWALARKSSWAVIRSQMSTIITMSVLLVFVTIAALTGASMLLLPGIGLAGAIMLAAA
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHH
IAPPDPVAVDAVAEPAGIPKRITTTLQTEGLFNDAASIVAFHVALAALVAGEDLSWSTGV
CCCCCCCCHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
LEFLWSCLAAVILGLVIGRAAAWFTDHVSSVEARNAFTWVLPFAIYVVAEEIGGSGVIAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCHHHH
VIAAVEMNSRASIGAEDRLTGSAFWGTIEVLFTGVAFGLIGLNVRTAIDEVGSELWHAVV
HHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGIVLSVVAIVVRGVWMFAAYKRNRFKIDKKGATNSSLRAPLRLQESLLMTWAGMRGLVT
HHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
LALVLSIPEDIFPYHHELQVIALVVLLITMVGPGLALPWLMRKLSLDKGPDAAGDESIAA
HHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCHHHHH
LTERAHKAATTYLVDTTELPMEQMVAIKNWFSQEIDADELQENVDKLHQRAHHARVGAIK
HHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
AAQEELLKARRERGVNPAYVDEVLTNIDRMLVAAER
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA