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The map label for this gene is serA [H]

Identifier: 145295425

GI number: 145295425

Start: 1494618

End: 1496210

Strand: Direct

Name: serA [H]

Synonym: cgR_1362

Alternate gene names: 145295425

Gene position: 1494618-1496210 (Clockwise)

Preceding gene: 145295424

Following gene: 145295426

Centisome position: 45.1

GC content: 55.37

Gene sequence:

>1593_bases
GTGAGCCAGAATGGCCGTCCGGTAGTCCTCATCGCCGATAAGCTTGCGCAGTCCACTGTTGACGCGCTTGGAGATGCAGT
AGAAGTCCGTTGGGTTGACGGACCTAACCGCCCAGAACTGCTTGATGCAGTTAAGGAAGCGGACGCACTGCTCGTGCGTT
CTGCTACCACTGTCGATGCTGAAGTCATCGCCGCTGCCCCTAACTTGAAGATCGTCGGTCGTGCCGGCGTGGGCTTGGAC
AACGTTGACATCCCTGCTGCCACTGAAGCTGGCGTCATGGTTGCTAACGCACCGACCTCTAATATTCACTCTGCTTGTGA
GCACGCAATTTCTTTGCTGCTGTCTACTGCTCGCCAGATCCCTGCTGCTGATGCGACGCTGCGTGAGGGCGAGTGGAAGC
GGTCTTCTTTCAACGGTGTGGAAATTTTCGGAAAAACTGTCGGTATCGTCGGTTTTGGTCACATTGGTCAGTTGTTTGCT
CAGCGTCTTGCTGCGTTTGAGACCACCATCGTTGCTTACGATCCTTACGCTAACCCTGCTCGTGCGGCTCAGCTGAACGT
TGAGTTGGTTGAGTTGGATGAGCTGATGAGCCGTTCTGACTTTGTCACCATTCACCTTCCTAAGACCAAGGAAACTGCTG
GCATGTTTGATGCGCAGCTCCTTGCTAAGTCCAAGAAGGGTCAGATCATCATCAACGCTGCTCGTGGCGGTCTTGTTGAT
GAGCAGGCTTTGGCTGATGCGATTGAGTCCGGTCACATTCGTGGCGCTGGTTTCGATGTGTACTCCACCGAGCCTTGCAC
TGATTCTCCTTTGTTCAAGTTGCCTCAGGTTGTTGTGACTCCTCACTTGGGTGCTTCTACTGAAGAGGCTCAGGATCGTG
CGGGTACTGATGTTGCTGATTCCGTGCTCAAGGCGCTGGCTGGCGAGTTCGTGGCGGATGCTGTGAACGTTTCCGGTGGT
CGCGTGGGCGAAGAGGTTGCTGTGTGGATGGATCTGGCTCGCAAGCTTGGTCTTCTTGCTGGCAAGCTTGTCGACGCCGC
CCCAGTCTCCATTGAGGTTGAGGCTCGAGGCGAGCTTTCTTCCGAGCAGGTCGATGCGCTTGGTTTGTCCGCTGTTCGTG
GTTTGTTCTCCGGAATTATCGAAGAGTCCGTTACTTTCGTCAACGCTCCTCGTATTGCTGAAGAGCGCGGCCTGGACATC
TCCGTGAAGACCAACTCTGAGTCTGTTACTCACCGTTCCGTCCTGCAGGTCAAGGTCATTACTGGCAGCGGCGCGAGCGC
AACTGTTGTTGGTGCCCTGACTGGTCTTGAGCGCGTTGAGAAGATCACCCGCATCAATGGCCGTGGCCTGGATCTGCGCG
CAGAGGGTCTGAACCTCTTCCTGCAGTACACTGACGCTCCTGGTGCACTGGGTACCGTTGGTACCAAGCTGGGTGCTGCT
GGCATCAACATCGAGGCTGCTGCGTTGACTCAGGCTGAGAAGGGTGACGGCGCTGTCCTGATCCTGCGTGTTGAGTCTGC
TGTCTCTGAAGAGCTGGAAGCTGAAATCAACGCTGAGTTGGGTGCTACTTCCTTCCAGGTTGATCTTGACTAA

Upstream 100 bases:

>100_bases
TGTTTCTAGTCGCACGCCAAAACCCGGCGTGGACACGTCTGCAGCCGACGCGGTCGTGCCTGTTGTAGGCGGACATTCCT
AGTTTTTCCAGGAGTAACTT

Downstream 100 bases:

>100_bases
TTAGAGATTTACTTGCTTGAACCGCCTTCCCATCTTTGAATTCATTCAAGGTGGTAAGGCGGTTTTTGCTCTTTAAATAC
AGTTTTAAAGGTAGATTTGG

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 530; Mature: 529

Protein sequence:

>530_residues
MSQNGRPVVLIADKLAQSTVDALGDAVEVRWVDGPNRPELLDAVKEADALLVRSATTVDAEVIAAAPNLKIVGRAGVGLD
NVDIPAATEAGVMVANAPTSNIHSACEHAISLLLSTARQIPAADATLREGEWKRSSFNGVEIFGKTVGIVGFGHIGQLFA
QRLAAFETTIVAYDPYANPARAAQLNVELVELDELMSRSDFVTIHLPKTKETAGMFDAQLLAKSKKGQIIINAARGGLVD
EQALADAIESGHIRGAGFDVYSTEPCTDSPLFKLPQVVVTPHLGASTEEAQDRAGTDVADSVLKALAGEFVADAVNVSGG
RVGEEVAVWMDLARKLGLLAGKLVDAAPVSIEVEARGELSSEQVDALGLSAVRGLFSGIIEESVTFVNAPRIAEERGLDI
SVKTNSESVTHRSVLQVKVITGSGASATVVGALTGLERVEKITRINGRGLDLRAEGLNLFLQYTDAPGALGTVGTKLGAA
GINIEAAALTQAEKGDGAVLILRVESAVSEELEAEINAELGATSFQVDLD

Sequences:

>Translated_530_residues
MSQNGRPVVLIADKLAQSTVDALGDAVEVRWVDGPNRPELLDAVKEADALLVRSATTVDAEVIAAAPNLKIVGRAGVGLD
NVDIPAATEAGVMVANAPTSNIHSACEHAISLLLSTARQIPAADATLREGEWKRSSFNGVEIFGKTVGIVGFGHIGQLFA
QRLAAFETTIVAYDPYANPARAAQLNVELVELDELMSRSDFVTIHLPKTKETAGMFDAQLLAKSKKGQIIINAARGGLVD
EQALADAIESGHIRGAGFDVYSTEPCTDSPLFKLPQVVVTPHLGASTEEAQDRAGTDVADSVLKALAGEFVADAVNVSGG
RVGEEVAVWMDLARKLGLLAGKLVDAAPVSIEVEARGELSSEQVDALGLSAVRGLFSGIIEESVTFVNAPRIAEERGLDI
SVKTNSESVTHRSVLQVKVITGSGASATVVGALTGLERVEKITRINGRGLDLRAEGLNLFLQYTDAPGALGTVGTKLGAA
GINIEAAALTQAEKGDGAVLILRVESAVSEELEAEINAELGATSFQVDLD
>Mature_529_residues
SQNGRPVVLIADKLAQSTVDALGDAVEVRWVDGPNRPELLDAVKEADALLVRSATTVDAEVIAAAPNLKIVGRAGVGLDN
VDIPAATEAGVMVANAPTSNIHSACEHAISLLLSTARQIPAADATLREGEWKRSSFNGVEIFGKTVGIVGFGHIGQLFAQ
RLAAFETTIVAYDPYANPARAAQLNVELVELDELMSRSDFVTIHLPKTKETAGMFDAQLLAKSKKGQIIINAARGGLVDE
QALADAIESGHIRGAGFDVYSTEPCTDSPLFKLPQVVVTPHLGASTEEAQDRAGTDVADSVLKALAGEFVADAVNVSGGR
VGEEVAVWMDLARKLGLLAGKLVDAAPVSIEVEARGELSSEQVDALGLSAVRGLFSGIIEESVTFVNAPRIAEERGLDIS
VKTNSESVTHRSVLQVKVITGSGASATVVGALTGLERVEKITRINGRGLDLRAEGLNLFLQYTDAPGALGTVGTKLGAAG
INIEAAALTQAEKGDGAVLILRVESAVSEELEAEINAELGATSFQVDLD

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=397, Percent_Identity=36.5239294710327, Blast_Score=257, Evalue=2e-68,
Organism=Homo sapiens, GI145580578, Length=326, Percent_Identity=31.9018404907975, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI4557499, Length=326, Percent_Identity=31.9018404907975, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI4557497, Length=317, Percent_Identity=31.2302839116719, Blast_Score=147, Evalue=3e-35,
Organism=Homo sapiens, GI61743967, Length=317, Percent_Identity=31.2302839116719, Blast_Score=146, Evalue=4e-35,
Organism=Homo sapiens, GI6912396, Length=277, Percent_Identity=33.5740072202166, Blast_Score=145, Evalue=1e-34,
Organism=Homo sapiens, GI145580575, Length=328, Percent_Identity=31.7073170731707, Blast_Score=142, Evalue=9e-34,
Organism=Escherichia coli, GI1789279, Length=276, Percent_Identity=35.5072463768116, Blast_Score=165, Evalue=8e-42,
Organism=Escherichia coli, GI87082289, Length=276, Percent_Identity=35.5072463768116, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI1787645, Length=196, Percent_Identity=33.6734693877551, Blast_Score=125, Evalue=8e-30,
Organism=Escherichia coli, GI1788660, Length=279, Percent_Identity=31.5412186379928, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI87081824, Length=215, Percent_Identity=30.2325581395349, Blast_Score=87, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17532191, Length=305, Percent_Identity=41.6393442622951, Blast_Score=255, Evalue=3e-68,
Organism=Caenorhabditis elegans, GI25147481, Length=325, Percent_Identity=29.5384615384615, Blast_Score=142, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6320925, Length=281, Percent_Identity=36.6548042704626, Blast_Score=177, Evalue=4e-45,
Organism=Saccharomyces cerevisiae, GI6322116, Length=281, Percent_Identity=35.9430604982206, Blast_Score=173, Evalue=7e-44,
Organism=Saccharomyces cerevisiae, GI6324055, Length=248, Percent_Identity=31.8548387096774, Blast_Score=135, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6324964, Length=271, Percent_Identity=30.9963099630996, Blast_Score=118, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6324980, Length=194, Percent_Identity=28.8659793814433, Blast_Score=78, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6325144, Length=167, Percent_Identity=29.3413173652695, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6321253, Length=176, Percent_Identity=26.1363636363636, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI19921140, Length=300, Percent_Identity=41.6666666666667, Blast_Score=230, Evalue=2e-60,
Organism=Drosophila melanogaster, GI28574286, Length=284, Percent_Identity=33.4507042253521, Blast_Score=156, Evalue=3e-38,
Organism=Drosophila melanogaster, GI28574284, Length=311, Percent_Identity=32.475884244373, Blast_Score=155, Evalue=6e-38,
Organism=Drosophila melanogaster, GI45551003, Length=311, Percent_Identity=32.475884244373, Blast_Score=155, Evalue=6e-38,
Organism=Drosophila melanogaster, GI45552429, Length=311, Percent_Identity=32.475884244373, Blast_Score=155, Evalue=6e-38,
Organism=Drosophila melanogaster, GI24585514, Length=311, Percent_Identity=32.475884244373, Blast_Score=155, Evalue=8e-38,
Organism=Drosophila melanogaster, GI28574282, Length=311, Percent_Identity=32.475884244373, Blast_Score=155, Evalue=8e-38,
Organism=Drosophila melanogaster, GI28571528, Length=279, Percent_Identity=36.2007168458781, Blast_Score=151, Evalue=1e-36,
Organism=Drosophila melanogaster, GI24585516, Length=280, Percent_Identity=30.3571428571429, Blast_Score=145, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24646446, Length=314, Percent_Identity=29.6178343949045, Blast_Score=127, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24646448, Length=314, Percent_Identity=29.6178343949045, Blast_Score=127, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24646452, Length=314, Percent_Identity=29.6178343949045, Blast_Score=127, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24646450, Length=314, Percent_Identity=29.6178343949045, Blast_Score=127, Evalue=3e-29,
Organism=Drosophila melanogaster, GI62472511, Length=314, Percent_Identity=29.9363057324841, Blast_Score=124, Evalue=2e-28,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 55302; Mature: 55171

Theoretical pI: Translated: 4.42; Mature: 4.42

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQNGRPVVLIADKLAQSTVDALGDAVEVRWVDGPNRPELLDAVKEADALLVRSATTVDA
CCCCCCEEEEEEHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHEEEECCCCCCC
EVIAAAPNLKIVGRAGVGLDNVDIPAATEAGVMVANAPTSNIHSACEHAISLLLSTARQI
EEEEECCCEEEEEECCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHC
PAADATLREGEWKRSSFNGVEIFGKTVGIVGFGHIGQLFAQRLAAFETTIVAYDPYANPA
CCCCCHHCCCCCCCCCCCCEEEECCEEEEEEEHHHHHHHHHHHHHHHEEEEEECCCCCCC
RAAQLNVELVELDELMSRSDFVTIHLPKTKETAGMFDAQLLAKSKKGQIIINAARGGLVD
CCEEEEEEEEEHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCC
EQALADAIESGHIRGAGFDVYSTEPCTDSPLFKLPQVVVTPHLGASTEEAQDRAGTDVAD
HHHHHHHHHCCCCCCCCCEEECCCCCCCCCHHHCCCEEEECCCCCCCHHHHHHCCCHHHH
SVLKALAGEFVADAVNVSGGRVGEEVAVWMDLARKLGLLAGKLVDAAPVSIEVEARGELS
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCC
SEQVDALGLSAVRGLFSGIIEESVTFVNAPRIAEERGLDISVKTNSESVTHRSVLQVKVI
HHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHCCCEEEEECCCCCCCEEEEEEEEEE
TGSGASATVVGALTGLERVEKITRINGRGLDLRAEGLNLFLQYTDAPGALGTVGTKLGAA
ECCCCCEEHHHHHHHHHHHHHHHHCCCCCCEEEECCEEEEEEECCCCCCCHHHHHHHCCC
GINIEAAALTQAEKGDGAVLILRVESAVSEELEAEINAELGATSFQVDLD
CCCEEHHEEECCCCCCCEEEEEEECHHHHHHHHHHHCCCCCCEEEEEECC
>Mature Secondary Structure 
SQNGRPVVLIADKLAQSTVDALGDAVEVRWVDGPNRPELLDAVKEADALLVRSATTVDA
CCCCCEEEEEEHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHEEEECCCCCCC
EVIAAAPNLKIVGRAGVGLDNVDIPAATEAGVMVANAPTSNIHSACEHAISLLLSTARQI
EEEEECCCEEEEEECCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHC
PAADATLREGEWKRSSFNGVEIFGKTVGIVGFGHIGQLFAQRLAAFETTIVAYDPYANPA
CCCCCHHCCCCCCCCCCCCEEEECCEEEEEEEHHHHHHHHHHHHHHHEEEEEECCCCCCC
RAAQLNVELVELDELMSRSDFVTIHLPKTKETAGMFDAQLLAKSKKGQIIINAARGGLVD
CCEEEEEEEEEHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCC
EQALADAIESGHIRGAGFDVYSTEPCTDSPLFKLPQVVVTPHLGASTEEAQDRAGTDVAD
HHHHHHHHHCCCCCCCCCEEECCCCCCCCCHHHCCCEEEECCCCCCCHHHHHHCCCHHHH
SVLKALAGEFVADAVNVSGGRVGEEVAVWMDLARKLGLLAGKLVDAAPVSIEVEARGELS
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCC
SEQVDALGLSAVRGLFSGIIEESVTFVNAPRIAEERGLDISVKTNSESVTHRSVLQVKVI
HHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHCCCEEEEECCCCCCCEEEEEEEEEE
TGSGASATVVGALTGLERVEKITRINGRGLDLRAEGLNLFLQYTDAPGALGTVGTKLGAA
ECCCCCEEHHHHHHHHHHHHHHHHCCCCCCEEEECCEEEEEEECCCCCCCHHHHHHHCCC
GINIEAAALTQAEKGDGAVLILRVESAVSEELEAEINAELGATSFQVDLD
CCCEEHHEEECCCCCCCEEEEEEECHHHHHHHHHHHCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]