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The map label for this gene is lysA [H]

Identifier: 145295320

GI number: 145295320

Start: 1382574

End: 1383911

Strand: Direct

Name: lysA [H]

Synonym: cgR_1260

Alternate gene names: 145295320

Gene position: 1382574-1383911 (Clockwise)

Preceding gene: 145295319

Following gene: 145295322

Centisome position: 41.72

GC content: 59.04

Gene sequence:

>1338_bases
ATGGCTACAGTTGAAAATTTCAATGAACTTCCCGCACACGTGTGGCCCCGCAATGCCGTGCGCCAAGAAGACGGCGTTGT
CACCGTTGCTGGTGTGCCGCTTCCTGACCTCGCTGAAGAATACGGAACCCCACTGTTCGTAGTCGACGAGGACGATTTCC
GTTCCCGCTGTCGCGACATGGCTACCGCATTCGGTGGACCAGGCAATGTGCACTACGCATCCAAAGCGTTCCTGACCAAG
ACCATCGCCCGCTGGGTTGATGAAGAAGGTCTGGCACTGGACATTGCATCCATCAACGAACTGGGCATTGCCCTGGCCGC
TGGTTTTCCCGCCAGCCGTATCACCGCGCACGGCAACAACAAGGGCGTGGACTTCCTCCGCGCGTTGGTCCAAAACGGTG
TCGGGCATGTGGTGCTGGACTCCGCGCAGGAATTGGAACTGCTGGATTACGTTGCCGCTGGTGAAGGCAAAATCCAGGAC
GTTTTGATCCGCGTGAAGCCAGGTATCGAAGCCCACACCCACGAGTTCATCGCCACCAGCCACGAAGACCAAAAGTTCGG
ATTCTCCCTGGCATCCGGTTCCGCATTCGAAGCAGCGAAAGCCGCCAACAATGCAGAGAACTTGAACCTGGTTGGTCTGC
ACTGCCATGTTGGTTCCCAGGTGTTCGACGCCGAAGGCTTCAAGCTGGCAGCAGAGCGCGTGTTGGGCCTGTACTCACAG
ATCCACAGCGAACTGGGCGTCGCCCTTCCTGAACTGGATCTCGGTGGCGGATACGGCATTGCCTATACCGCAGTTGAAGA
ACCACTTAATGTCGCAGAAGTTGCCTCCGACCTGCTCACCGCAGTCGGAAAGATGGCAGCTGAACTAGGCATCGACGCAC
CAACCGTGCTTGTTGAGCCCGGCCGCGCTATCGCAGGCCCCTCCACCGTGACCATCTACGAAGTCGGCACCACCAAAGAC
GTCCACGTAGACGACGACAAAACCCGCCGTTACATCGCCGTGGACGGAGGCATGTCCGACAACATCCGCCCAGCACTCTA
CGGCTCCGAATACGACGCCCGCGTAGTATCCCGCTTCGCCGAAGGAGAACCAGTAAACACCCGCATCGTGGGCTCACACT
GCGAATCCGGCGACATCCTGATCAACGATGAAATCTACCCATCTGACATCACCAGCGGCGACTTCCTTGCACTCGCTGCC
ACCGGCGCATACTGCTACGCCATGAGCTCCCGCTACAACGCCTTCACACGGCCCGCCGTCGTGTCCGTCCGCGCTGGCAG
CTCCCGCCTCATGCTGCGCCGCGAAACGCTCGACGACATCCTCTCACTAGAGGCATAA

Upstream 100 bases:

>100_bases
CAATCCACTCAGCACGTCTGGCACTTGCAGCAGCAACCCGCCAGACCCTCGCTAACGCCCTGCACCTGGTTGGCGTTTCC
GCACCGGAGAAGATGTAACA

Downstream 100 bases:

>100_bases
CGCTTTTCGACGCCTGACCCCGCCCTTCACATTCCTCACGGATTTGTGGAGGGCGGTCTTCTTTTGGGATTGAGGTGCTC
TGGTGCTGTTTTAGCGGCTT

Product: hypothetical protein

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 445; Mature: 444

Protein sequence:

>445_residues
MATVENFNELPAHVWPRNAVRQEDGVVTVAGVPLPDLAEEYGTPLFVVDEDDFRSRCRDMATAFGGPGNVHYASKAFLTK
TIARWVDEEGLALDIASINELGIALAAGFPASRITAHGNNKGVDFLRALVQNGVGHVVLDSAQELELLDYVAAGEGKIQD
VLIRVKPGIEAHTHEFIATSHEDQKFGFSLASGSAFEAAKAANNAENLNLVGLHCHVGSQVFDAEGFKLAAERVLGLYSQ
IHSELGVALPELDLGGGYGIAYTAVEEPLNVAEVASDLLTAVGKMAAELGIDAPTVLVEPGRAIAGPSTVTIYEVGTTKD
VHVDDDKTRRYIAVDGGMSDNIRPALYGSEYDARVVSRFAEGEPVNTRIVGSHCESGDILINDEIYPSDITSGDFLALAA
TGAYCYAMSSRYNAFTRPAVVSVRAGSSRLMLRRETLDDILSLEA

Sequences:

>Translated_445_residues
MATVENFNELPAHVWPRNAVRQEDGVVTVAGVPLPDLAEEYGTPLFVVDEDDFRSRCRDMATAFGGPGNVHYASKAFLTK
TIARWVDEEGLALDIASINELGIALAAGFPASRITAHGNNKGVDFLRALVQNGVGHVVLDSAQELELLDYVAAGEGKIQD
VLIRVKPGIEAHTHEFIATSHEDQKFGFSLASGSAFEAAKAANNAENLNLVGLHCHVGSQVFDAEGFKLAAERVLGLYSQ
IHSELGVALPELDLGGGYGIAYTAVEEPLNVAEVASDLLTAVGKMAAELGIDAPTVLVEPGRAIAGPSTVTIYEVGTTKD
VHVDDDKTRRYIAVDGGMSDNIRPALYGSEYDARVVSRFAEGEPVNTRIVGSHCESGDILINDEIYPSDITSGDFLALAA
TGAYCYAMSSRYNAFTRPAVVSVRAGSSRLMLRRETLDDILSLEA
>Mature_444_residues
ATVENFNELPAHVWPRNAVRQEDGVVTVAGVPLPDLAEEYGTPLFVVDEDDFRSRCRDMATAFGGPGNVHYASKAFLTKT
IARWVDEEGLALDIASINELGIALAAGFPASRITAHGNNKGVDFLRALVQNGVGHVVLDSAQELELLDYVAAGEGKIQDV
LIRVKPGIEAHTHEFIATSHEDQKFGFSLASGSAFEAAKAANNAENLNLVGLHCHVGSQVFDAEGFKLAAERVLGLYSQI
HSELGVALPELDLGGGYGIAYTAVEEPLNVAEVASDLLTAVGKMAAELGIDAPTVLVEPGRAIAGPSTVTIYEVGTTKDV
HVDDDKTRRYIAVDGGMSDNIRPALYGSEYDARVVSRFAEGEPVNTRIVGSHCESGDILINDEIYPSDITSGDFLALAAT
GAYCYAMSSRYNAFTRPAVVSVRAGSSRLMLRRETLDDILSLEA

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=385, Percent_Identity=25.4545454545455, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1789203, Length=425, Percent_Identity=30.5882352941176, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1789307, Length=244, Percent_Identity=27.4590163934426, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 47467; Mature: 47335

Theoretical pI: Translated: 4.42; Mature: 4.42

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATVENFNELPAHVWPRNAVRQEDGVVTVAGVPLPDLAEEYGTPLFVVDEDDFRSRCRDM
CCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHCCEEEEECCHHHHHHHHHH
ATAFGGPGNVHYASKAFLTKTIARWVDEEGLALDIASINELGIALAAGFPASRITAHGNN
HHHCCCCCCEEHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEECCCCHHHEEECCCC
KGVDFLRALVQNGVGHVVLDSAQELELLDYVAAGEGKIQDVLIRVKPGIEAHTHEFIATS
CCHHHHHHHHHCCCCEEEECCCHHHHHHHHHHCCCCCEEEEEEEECCCCCHHHHHHHCCC
HEDQKFGFSLASGSAFEAAKAANNAENLNLVGLHCHVGSQVFDAEGFKLAAERVLGLYSQ
CCCCCCCEEECCCCHHHHHHHCCCCCCCEEEEEEEECCCEEECCCCHHHHHHHHHHHHHH
IHSELGVALPELDLGGGYGIAYTAVEEPLNVAEVASDLLTAVGKMAAELGIDAPTVLVEP
HHHHHCCCCCCEECCCCCEEEEEEHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECC
GRAIAGPSTVTIYEVGTTKDVHVDDDKTRRYIAVDGGMSDNIRPALYGSEYDARVVSRFA
CCEECCCCEEEEEECCCCCEEEECCCCCEEEEEEECCCCCCCCCEEECCCCHHHHHHHHH
EGEPVNTRIVGSHCESGDILINDEIYPSDITSGDFLALAATGAYCYAMSSRYNAFTRPAV
CCCCCCEEEEECCCCCCCEEECCCCCCCCCCCCCEEEEEECCEEEEEECCCCCCCCCCEE
VSVRAGSSRLMLRRETLDDILSLEA
EEEECCCCEEEEEHHHHHHHHHCCC
>Mature Secondary Structure 
ATVENFNELPAHVWPRNAVRQEDGVVTVAGVPLPDLAEEYGTPLFVVDEDDFRSRCRDM
CCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHCCEEEEECCHHHHHHHHHH
ATAFGGPGNVHYASKAFLTKTIARWVDEEGLALDIASINELGIALAAGFPASRITAHGNN
HHHCCCCCCEEHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEECCCCHHHEEECCCC
KGVDFLRALVQNGVGHVVLDSAQELELLDYVAAGEGKIQDVLIRVKPGIEAHTHEFIATS
CCHHHHHHHHHCCCCEEEECCCHHHHHHHHHHCCCCCEEEEEEEECCCCCHHHHHHHCCC
HEDQKFGFSLASGSAFEAAKAANNAENLNLVGLHCHVGSQVFDAEGFKLAAERVLGLYSQ
CCCCCCCEEECCCCHHHHHHHCCCCCCCEEEEEEEECCCEEECCCCHHHHHHHHHHHHHH
IHSELGVALPELDLGGGYGIAYTAVEEPLNVAEVASDLLTAVGKMAAELGIDAPTVLVEP
HHHHHCCCCCCEECCCCCEEEEEEHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECC
GRAIAGPSTVTIYEVGTTKDVHVDDDKTRRYIAVDGGMSDNIRPALYGSEYDARVVSRFA
CCEECCCCEEEEEECCCCCEEEECCCCCEEEEEEECCCCCCCCCEEECCCCHHHHHHHHH
EGEPVNTRIVGSHCESGDILINDEIYPSDITSGDFLALAATGAYCYAMSSRYNAFTRPAV
CCCCCCEEEEECCCCCCCEEECCCCCCCCCCCCCEEEEEECCEEEEEECCCCCCCCCCEE
VSVRAGSSRLMLRRETLDDILSLEA
EEEECCCCEEEEEHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2836698; 12948626; 2082143; 8226683 [H]