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The map label for this gene is proY [H]

Identifier: 145295297

GI number: 145295297

Start: 1350817

End: 1352223

Strand: Reverse

Name: proY [H]

Synonym: cgR_1237

Alternate gene names: 145295297

Gene position: 1352223-1350817 (Counterclockwise)

Preceding gene: 145295299

Following gene: 145295295

Centisome position: 40.8

GC content: 57.0

Gene sequence:

>1407_bases
ATGAATGCCTCCCCTGCCCCAACCCGATCTTTTAGAGGATTGCGGGCTCGACACATTCACTTCATCGCGCTGGGTTCCGC
GATCGGCACCGGCTTGTTCTACGGGTCCGCTGGCGCAATCCAAGCAGCTGGTCCATCTGTACTCTTGGTCTACCTTCTCG
GTGGTGCCGTCGTGTACTTCATGCTGCGCGCACTCGGCGAGATGGCTGTCCACCACCCAGTCCGTGGCTCCTTTGCCGTT
TACACCCGCGCACACCTTGGCGGATGGGCAGGCTACATCACCGGCTGGATGTTCGCCTTTGAGATGCTCATCGTCTGCCT
GGCTGACCTCACAGCCATCGGCATCTATATGAATTTCTGGTTCCCCGGCACCCCGCAATGGACTTGGGTGGTAGCCACCC
TTCTTATTGTCGGTGGCGCAAACCTCGCATCAGTGCGTTGGTTCGGTGAGCTCGAGTTCATCTTCACCATCATTAAGGTC
ACCGCAGTTGTCGCCATGATCGTCGGCGGCGCAGCCATTCTCGCATTCGGTCTCGGCGCCAACGCTGAAGTTGCCGGCGT
ATCCAACCTCTGGGAGCAAGGCGGATTCTTCCCCAACGGTGTTGAAGGCATGATCGCAGCCTTCATCCTTGTTCTCTTCG
CATTCGGTGGCACCGAAATCATCGGTGTTGCAGGCTCTGAAGCTGAAGATCCTGAGAAGTCCATCCCCAAGGCTGTTAAT
ACTGTCCCAGTACGCATCCTCCTCTTCTATGTGGGTGCCATCCTGGTGATCCTTGCCCTTAATCCTTGGCCTTCCATCAC
CGGAGAAGAATCCCCATTCGTCCAGATCTTCGACACCCTCGGCGTCAACTGGGCTGCTGGTCTCCTCAACGCCGTGGTCA
TCACCGCTGCACTGTCTGCCATCAACGCTGACCTCTTCGGCGCTGGCCGCGTTCTCACTGGTCTTGCGAAGGAAAACCTC
GCACCAAAGGCCATGGGCAAGATCGCCAAGAACGGCGTTCCAGTCATGACCACCACCATCATGATCATCGTCTTGATCGT
GGGAGTAATCCTCAACGCAGTGCTTCCCGAGCGCGTCTTCGAGATCGTCGCTTCCCTAGCAACTTTCGCCACAGTTTACG
TCTGGCTGATGATCCTGCTCGCACAGGTGGGATCCCGCCGAAACATGCCTGCCGACGAGGTCAAGTCCCTGAAGTTCCCT
GTCCCCTTCTACCCCTTCGGACAATACTTCGCGATCCTATTTATCGCCTTCACCTTCGGCATCATGGTCTGGTACGACAA
CTACCACCTGCCACTAGCCGTCGGCGTTGGATTCCTCGCCCTGATGACAATCCTTTACTACGCCACAGGCCGACCAAAAG
CGATCGCCCCGATCAACTATGAAGAGTTAGATCCGCGACGCGACTAA

Upstream 100 bases:

>100_bases
CAGTAAAAGTGCACCGACACTAAGAATCCTTATCCTTCAGAGTAAGGTGATCTGCGTCAAAAAATGTCCGCTATTCACCC
GAAACGAGGTCAGCATCTCG

Downstream 100 bases:

>100_bases
TCTAAACTCGCACCAATAAAGGCGGCACCTTCTCCACGGTGGAGAAGGTGCCGCTTTACGGATCTATTAATGATTTAAAT
ATGCCTTACATGAAGCAGGC

Product: hypothetical protein

Products: Proton [Cytoplasm]; L-proline [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 468; Mature: 468

Protein sequence:

>468_residues
MNASPAPTRSFRGLRARHIHFIALGSAIGTGLFYGSAGAIQAAGPSVLLVYLLGGAVVYFMLRALGEMAVHHPVRGSFAV
YTRAHLGGWAGYITGWMFAFEMLIVCLADLTAIGIYMNFWFPGTPQWTWVVATLLIVGGANLASVRWFGELEFIFTIIKV
TAVVAMIVGGAAILAFGLGANAEVAGVSNLWEQGGFFPNGVEGMIAAFILVLFAFGGTEIIGVAGSEAEDPEKSIPKAVN
TVPVRILLFYVGAILVILALNPWPSITGEESPFVQIFDTLGVNWAAGLLNAVVITAALSAINADLFGAGRVLTGLAKENL
APKAMGKIAKNGVPVMTTTIMIIVLIVGVILNAVLPERVFEIVASLATFATVYVWLMILLAQVGSRRNMPADEVKSLKFP
VPFYPFGQYFAILFIAFTFGIMVWYDNYHLPLAVGVGFLALMTILYYATGRPKAIAPINYEELDPRRD

Sequences:

>Translated_468_residues
MNASPAPTRSFRGLRARHIHFIALGSAIGTGLFYGSAGAIQAAGPSVLLVYLLGGAVVYFMLRALGEMAVHHPVRGSFAV
YTRAHLGGWAGYITGWMFAFEMLIVCLADLTAIGIYMNFWFPGTPQWTWVVATLLIVGGANLASVRWFGELEFIFTIIKV
TAVVAMIVGGAAILAFGLGANAEVAGVSNLWEQGGFFPNGVEGMIAAFILVLFAFGGTEIIGVAGSEAEDPEKSIPKAVN
TVPVRILLFYVGAILVILALNPWPSITGEESPFVQIFDTLGVNWAAGLLNAVVITAALSAINADLFGAGRVLTGLAKENL
APKAMGKIAKNGVPVMTTTIMIIVLIVGVILNAVLPERVFEIVASLATFATVYVWLMILLAQVGSRRNMPADEVKSLKFP
VPFYPFGQYFAILFIAFTFGIMVWYDNYHLPLAVGVGFLALMTILYYATGRPKAIAPINYEELDPRRD
>Mature_468_residues
MNASPAPTRSFRGLRARHIHFIALGSAIGTGLFYGSAGAIQAAGPSVLLVYLLGGAVVYFMLRALGEMAVHHPVRGSFAV
YTRAHLGGWAGYITGWMFAFEMLIVCLADLTAIGIYMNFWFPGTPQWTWVVATLLIVGGANLASVRWFGELEFIFTIIKV
TAVVAMIVGGAAILAFGLGANAEVAGVSNLWEQGGFFPNGVEGMIAAFILVLFAFGGTEIIGVAGSEAEDPEKSIPKAVN
TVPVRILLFYVGAILVILALNPWPSITGEESPFVQIFDTLGVNWAAGLLNAVVITAALSAINADLFGAGRVLTGLAKENL
APKAMGKIAKNGVPVMTTTIMIIVLIVGVILNAVLPERVFEIVASLATFATVYVWLMILLAQVGSRRNMPADEVKSLKFP
VPFYPFGQYFAILFIAFTFGIMVWYDNYHLPLAVGVGFLALMTILYYATGRPKAIAPINYEELDPRRD

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of proline [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI181337167, Length=313, Percent_Identity=25.2396166134185, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI258645169, Length=429, Percent_Identity=23.7762237762238, Blast_Score=66, Evalue=5e-11,
Organism=Escherichia coli, GI1786602, Length=433, Percent_Identity=50.8083140877598, Blast_Score=424, Evalue=1e-120,
Organism=Escherichia coli, GI1786302, Length=412, Percent_Identity=44.1747572815534, Blast_Score=344, Evalue=7e-96,
Organism=Escherichia coli, GI1786789, Length=429, Percent_Identity=41.958041958042, Blast_Score=336, Evalue=2e-93,
Organism=Escherichia coli, GI48994972, Length=453, Percent_Identity=40.3973509933775, Blast_Score=316, Evalue=2e-87,
Organism=Escherichia coli, GI1790653, Length=436, Percent_Identity=37.8440366972477, Blast_Score=313, Evalue=2e-86,
Organism=Escherichia coli, GI87081915, Length=400, Percent_Identity=39.25, Blast_Score=305, Evalue=4e-84,
Organism=Escherichia coli, GI87081708, Length=399, Percent_Identity=36.3408521303258, Blast_Score=259, Evalue=2e-70,
Organism=Escherichia coli, GI1789017, Length=443, Percent_Identity=33.1828442437923, Blast_Score=248, Evalue=5e-67,
Organism=Escherichia coli, GI1788480, Length=484, Percent_Identity=35.1239669421488, Blast_Score=236, Evalue=3e-63,
Organism=Escherichia coli, GI87081869, Length=241, Percent_Identity=24.896265560166, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17532491, Length=427, Percent_Identity=22.248243559719, Blast_Score=67, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6320772, Length=492, Percent_Identity=30.6910569105691, Blast_Score=188, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6324061, Length=430, Percent_Identity=29.5348837209302, Blast_Score=175, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6322892, Length=425, Percent_Identity=28.7058823529412, Blast_Score=165, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6324990, Length=444, Percent_Identity=28.1531531531532, Blast_Score=165, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6324924, Length=454, Percent_Identity=27.9735682819383, Blast_Score=160, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6324059, Length=438, Percent_Identity=28.310502283105, Blast_Score=157, Evalue=4e-39,
Organism=Saccharomyces cerevisiae, GI6320717, Length=393, Percent_Identity=25.6997455470738, Blast_Score=153, Evalue=5e-38,
Organism=Saccharomyces cerevisiae, GI6320251, Length=430, Percent_Identity=25.5813953488372, Blast_Score=153, Evalue=7e-38,
Organism=Saccharomyces cerevisiae, GI6319824, Length=394, Percent_Identity=26.6497461928934, Blast_Score=152, Evalue=9e-38,
Organism=Saccharomyces cerevisiae, GI6324553, Length=394, Percent_Identity=28.9340101522843, Blast_Score=147, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6319543, Length=456, Percent_Identity=24.780701754386, Blast_Score=144, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6319542, Length=394, Percent_Identity=24.1116751269036, Blast_Score=138, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6321629, Length=407, Percent_Identity=24.0786240786241, Blast_Score=138, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6321053, Length=480, Percent_Identity=25.2083333333333, Blast_Score=132, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6322967, Length=391, Percent_Identity=26.5984654731458, Blast_Score=127, Evalue=5e-30,
Organism=Saccharomyces cerevisiae, GI6319608, Length=437, Percent_Identity=25.4004576659039, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6324981, Length=392, Percent_Identity=25.765306122449, Blast_Score=108, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6320364, Length=493, Percent_Identity=21.7038539553753, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24667468, Length=410, Percent_Identity=26.5853658536585, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI221512776, Length=406, Percent_Identity=22.6600985221675, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24666159, Length=406, Percent_Identity=22.6600985221675, Blast_Score=76, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 50178; Mature: 50178

Theoretical pI: Translated: 7.16; Mature: 7.16

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNASPAPTRSFRGLRARHIHFIALGSAIGTGLFYGSAGAIQAAGPSVLLVYLLGGAVVYF
CCCCCCCCHHHCCCHHHHEEEEEEHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHH
MLRALGEMAVHHPVRGSFAVYTRAHLGGWAGYITGWMFAFEMLIVCLADLTAIGIYMNFW
HHHHHHHHHHCCCCCCCEEEEEHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEE
FPGTPQWTWVVATLLIVGGANLASVRWFGELEFIFTIIKVTAVVAMIVGGAAILAFGLGA
CCCCCCHHHHHHHHHHHCCCCHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
NAEVAGVSNLWEQGGFFPNGVEGMIAAFILVLFAFGGTEIIGVAGSEAEDPEKSIPKAVN
CCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHCCHHHH
TVPVRILLFYVGAILVILALNPWPSITGEESPFVQIFDTLGVNWAAGLLNAVVITAALSA
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHH
INADLFGAGRVLTGLAKENLAPKAMGKIAKNGVPVMTTTIMIIVLIVGVILNAVLPERVF
HHHHHHCCHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
EIVASLATFATVYVWLMILLAQVGSRRNMPADEVKSLKFPVPFYPFGQYFAILFIAFTFG
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
IMVWYDNYHLPLAVGVGFLALMTILYYATGRPKAIAPINYEELDPRRD
HHHEECCCCCHHHHHHHHHHHHHHHHHHCCCCCEECCCCHHCCCCCCC
>Mature Secondary Structure
MNASPAPTRSFRGLRARHIHFIALGSAIGTGLFYGSAGAIQAAGPSVLLVYLLGGAVVYF
CCCCCCCCHHHCCCHHHHEEEEEEHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHH
MLRALGEMAVHHPVRGSFAVYTRAHLGGWAGYITGWMFAFEMLIVCLADLTAIGIYMNFW
HHHHHHHHHHCCCCCCCEEEEEHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEE
FPGTPQWTWVVATLLIVGGANLASVRWFGELEFIFTIIKVTAVVAMIVGGAAILAFGLGA
CCCCCCHHHHHHHHHHHCCCCHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
NAEVAGVSNLWEQGGFFPNGVEGMIAAFILVLFAFGGTEIIGVAGSEAEDPEKSIPKAVN
CCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHCCHHHH
TVPVRILLFYVGAILVILALNPWPSITGEESPFVQIFDTLGVNWAAGLLNAVVITAALSA
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHH
INADLFGAGRVLTGLAKENLAPKAMGKIAKNGVPVMTTTIMIIVLIVGVILNAVLPERVF
HHHHHHCCHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
EIVASLATFATVYVWLMILLAQVGSRRNMPADEVKSLKFPVPFYPFGQYFAILFIAFTFG
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
IMVWYDNYHLPLAVGVGFLALMTILYYATGRPKAIAPINYEELDPRRD
HHHEECCCCCHHHHHHHHHHHHHHHHHHCCCCCEECCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-proline [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-proline [Periplasm] = Proton [Cytoplasm] + L-proline [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]