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The map label for this gene is mprB [H]

Identifier: 145295045

GI number: 145295045

Start: 1093362

End: 1094801

Strand: Direct

Name: mprB [H]

Synonym: cgR_0989

Alternate gene names: 145295045

Gene position: 1093362-1094801 (Clockwise)

Preceding gene: 145295044

Following gene: 145295046

Centisome position: 32.99

GC content: 49.38

Gene sequence:

>1440_bases
GTGACATTAAGGCGAATCGGCGCAGGGGAAAATGAGCCTGCCCCTACCGAAAGTGATGACTCCGACGGTTCAATGTCGTT
GCGTTGGCGCTTGGCTTTGCTGAGCGCCACTTTGGTAGCTTTCGCCGTTGGTGTTATTACTGTTGCTGCATATTGGTCTG
TCTCCAGCTATGTCACCAACTCAATCGATCGTGATCTGGAAAAACAAGCGGATGCAATGCTTGGACGAGCCAGTGAAGCG
GGATTCTATGCAACCGCAGAAACCGAAATTGCTCTGTTAGGTGAATATGCCAGTGACACTCGAATCGCCTTAATCCCACC
TGGGTGGGAATACGTCATCGGTGAATCCATATCACTGCCTGATTCAGATTTCCTTAAGAGCAATGAAGCGGGGAAACAGA
TCCTCGTAACAAGTGCTGAGCGCATTCTCATGAAACGAGATAGCTCGGGCACAGTGGTGGTTTTTGCTAAAGATATGGTG
GATACCGATCGGCAGCTCACGGTGCTTGGCGTCATTCTCTTGATCATTGGCGGCAGTGGTGTTTTGGCGTCGATTCTGCT
TGGTTTCATCATTGCGAAGGAGGGGCTGAAACCACTGTCAAAGCTGCAGCGCGCCGTTGAAGAAATCAAACGAACTGATG
AGCTTCGTGCGATTCCTGTGGTGGGAAATGATGAGTTCGCTAAGTTGACTCGTAGTTTCAATGACATGCTCAAGGCACTG
CGGGAGTCTCGTACCCGGCAATCTCAGTTGGTGGCAGATGCAGGACACGAGCTGAAAACTCCACTGACCTCAATGCGGAC
AAATATTGAATTGCTGTTGATGGCAACCAACAGTGGAGGATCGGGAATCCCCAAGGAAGAATTGGATGGCCTTCGGCGTG
ATGTATTGGCGCAGATGACCGAAATGTCTGATTTGATTGGTGATCTTGTTGATCTTGCGCGTGAAGAAACCGCCGAAACG
TCAAGCATTGTAGATCTCAACCAAGTGTTGGAAATTGCGCTTGACCGAATGGAAAGCCGTCGCATGACGGTGCGGATAGA
TGTTTCCGAGACTGTGGATTGGAAACTGCTGGGCGATGATTTTTCCTTAACCAGGGCATTAGTAAATGTTTTGGATAATG
CCATTAAATGGTCGCCTGAGAATGGCATTGTTCGAGTGTCGATGTCACAGATCGACAAAGCAACGGTCCGCATTGTTATT
GATGATTCAGGGCCTGGAATTGCTGAAAAAGAACGAGGATTAGTTTTGGAACGGTTTTATCGCGCCGTCAGCTCCCGTTC
CATGCCGGGATCGGGATTAGGTCTTGCCATCGTGAATCAGGTTGTGAATCGGCATGGTGGCCAACTCGTTGTGGGTGAAT
CAGATGATGGCGGAACGAGAATCACTATTGATTTGCCAGGGGAACCCATTCGCAGCGGGTTCGAAAATGTCGATGATTAA

Upstream 100 bases:

>100_bases
TCTACATTGGATACCTTCGACGCAAGACTGAATTGGAAGGAGAAGACCGCCTGATCCATACAGTACGAGGAGTCGGATAC
GTCCTGCGAGAGACCGCTCC

Downstream 100 bases:

>100_bases
ACCACTAAAGAGCTCACAGGAAGTGTTCAGACTACTTAGAGTGACGCCCCAGCCACAGGGTTCATAATCAAATCATGACA
AATCAATTCCCCACAAACAA

Product: hypothetical protein

Products: NA

Alternate protein names: Mycobacterial persistence regulator B [H]

Number of amino acids: Translated: 479; Mature: 478

Protein sequence:

>479_residues
MTLRRIGAGENEPAPTESDDSDGSMSLRWRLALLSATLVAFAVGVITVAAYWSVSSYVTNSIDRDLEKQADAMLGRASEA
GFYATAETEIALLGEYASDTRIALIPPGWEYVIGESISLPDSDFLKSNEAGKQILVTSAERILMKRDSSGTVVVFAKDMV
DTDRQLTVLGVILLIIGGSGVLASILLGFIIAKEGLKPLSKLQRAVEEIKRTDELRAIPVVGNDEFAKLTRSFNDMLKAL
RESRTRQSQLVADAGHELKTPLTSMRTNIELLLMATNSGGSGIPKEELDGLRRDVLAQMTEMSDLIGDLVDLAREETAET
SSIVDLNQVLEIALDRMESRRMTVRIDVSETVDWKLLGDDFSLTRALVNVLDNAIKWSPENGIVRVSMSQIDKATVRIVI
DDSGPGIAEKERGLVLERFYRAVSSRSMPGSGLGLAIVNQVVNRHGGQLVVGESDDGGTRITIDLPGEPIRSGFENVDD

Sequences:

>Translated_479_residues
MTLRRIGAGENEPAPTESDDSDGSMSLRWRLALLSATLVAFAVGVITVAAYWSVSSYVTNSIDRDLEKQADAMLGRASEA
GFYATAETEIALLGEYASDTRIALIPPGWEYVIGESISLPDSDFLKSNEAGKQILVTSAERILMKRDSSGTVVVFAKDMV
DTDRQLTVLGVILLIIGGSGVLASILLGFIIAKEGLKPLSKLQRAVEEIKRTDELRAIPVVGNDEFAKLTRSFNDMLKAL
RESRTRQSQLVADAGHELKTPLTSMRTNIELLLMATNSGGSGIPKEELDGLRRDVLAQMTEMSDLIGDLVDLAREETAET
SSIVDLNQVLEIALDRMESRRMTVRIDVSETVDWKLLGDDFSLTRALVNVLDNAIKWSPENGIVRVSMSQIDKATVRIVI
DDSGPGIAEKERGLVLERFYRAVSSRSMPGSGLGLAIVNQVVNRHGGQLVVGESDDGGTRITIDLPGEPIRSGFENVDD
>Mature_478_residues
TLRRIGAGENEPAPTESDDSDGSMSLRWRLALLSATLVAFAVGVITVAAYWSVSSYVTNSIDRDLEKQADAMLGRASEAG
FYATAETEIALLGEYASDTRIALIPPGWEYVIGESISLPDSDFLKSNEAGKQILVTSAERILMKRDSSGTVVVFAKDMVD
TDRQLTVLGVILLIIGGSGVLASILLGFIIAKEGLKPLSKLQRAVEEIKRTDELRAIPVVGNDEFAKLTRSFNDMLKALR
ESRTRQSQLVADAGHELKTPLTSMRTNIELLLMATNSGGSGIPKEELDGLRRDVLAQMTEMSDLIGDLVDLAREETAETS
SIVDLNQVLEIALDRMESRRMTVRIDVSETVDWKLLGDDFSLTRALVNVLDNAIKWSPENGIVRVSMSQIDKATVRIVID
DSGPGIAEKERGLVLERFYRAVSSRSMPGSGLGLAIVNQVVNRHGGQLVVGESDDGGTRITIDLPGEPIRSGFENVDD

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. In response to en

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=297, Percent_Identity=30.3030303030303, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI1788393, Length=282, Percent_Identity=29.7872340425532, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1790346, Length=279, Percent_Identity=33.3333333333333, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1789808, Length=301, Percent_Identity=28.5714285714286, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1787374, Length=297, Percent_Identity=26.9360269360269, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1790861, Length=254, Percent_Identity=27.9527559055118, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1788279, Length=291, Percent_Identity=27.4914089347079, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1786600, Length=225, Percent_Identity=28.4444444444444, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1789403, Length=290, Percent_Identity=28.2758620689655, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1790551, Length=302, Percent_Identity=25.4966887417219, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1786912, Length=226, Percent_Identity=26.5486725663717, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788713, Length=251, Percent_Identity=25.0996015936255, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1790436, Length=222, Percent_Identity=27.027027027027, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1787894, Length=284, Percent_Identity=27.112676056338, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1788549, Length=249, Percent_Identity=26.9076305220884, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI145693157, Length=251, Percent_Identity=25.8964143426295, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI87082128, Length=299, Percent_Identity=23.7458193979933, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1789149, Length=249, Percent_Identity=25.3012048192771, Blast_Score=66, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52039; Mature: 51908

Theoretical pI: Translated: 4.46; Mature: 4.46

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLRRIGAGENEPAPTESDDSDGSMSLRWRLALLSATLVAFAVGVITVAAYWSVSSYVTN
CCCCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SIDRDLEKQADAMLGRASEAGFYATAETEIALLGEYASDTRIALIPPGWEYVIGESISLP
HHHHHHHHHHHHHHCCCCCCCEEEECCCEEEEEECCCCCCEEEEECCCCCEECCCCCCCC
DSDFLKSNEAGKQILVTSAERILMKRDSSGTVVVFAKDMVDTDRQLTVLGVILLIIGGSG
CHHHHCCCCCCCEEEEEHHHHHHHEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCH
VLASILLGFIIAKEGLKPLSKLQRAVEEIKRTDELRAIPVVGNDEFAKLTRSFNDMLKAL
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHH
RESRTRQSQLVADAGHELKTPLTSMRTNIELLLMATNSGGSGIPKEELDGLRRDVLAQMT
HHHHHHHHHHHHHCCCHHHCCHHHHCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHH
EMSDLIGDLVDLAREETAETSSIVDLNQVLEIALDRMESRRMTVRIDVSETVDWKLLGDD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEEECCC
FSLTRALVNVLDNAIKWSPENGIVRVSMSQIDKATVRIVIDDSGPGIAEKERGLVLERFY
HHHHHHHHHHHHHHHEECCCCCEEEEEHHHCCCEEEEEEEECCCCCCCCHHCCHHHHHHH
RAVSSRSMPGSGLGLAIVNQVVNRHGGQLVVGESDDGGTRITIDLPGEPIRSGFENVDD
HHHHCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCEEEEEECCCHHHHHHHCCCCC
>Mature Secondary Structure 
TLRRIGAGENEPAPTESDDSDGSMSLRWRLALLSATLVAFAVGVITVAAYWSVSSYVTN
CCCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SIDRDLEKQADAMLGRASEAGFYATAETEIALLGEYASDTRIALIPPGWEYVIGESISLP
HHHHHHHHHHHHHHCCCCCCCEEEECCCEEEEEECCCCCCEEEEECCCCCEECCCCCCCC
DSDFLKSNEAGKQILVTSAERILMKRDSSGTVVVFAKDMVDTDRQLTVLGVILLIIGGSG
CHHHHCCCCCCCEEEEEHHHHHHHEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCH
VLASILLGFIIAKEGLKPLSKLQRAVEEIKRTDELRAIPVVGNDEFAKLTRSFNDMLKAL
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHH
RESRTRQSQLVADAGHELKTPLTSMRTNIELLLMATNSGGSGIPKEELDGLRRDVLAQMT
HHHHHHHHHHHHHCCCHHHCCHHHHCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHH
EMSDLIGDLVDLAREETAETSSIVDLNQVLEIALDRMESRRMTVRIDVSETVDWKLLGDD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEEECCC
FSLTRALVNVLDNAIKWSPENGIVRVSMSQIDKATVRIVIDDSGPGIAEKERGLVLERFY
HHHHHHHHHHHHHHHEECCCCCEEEEEHHHCCCEEEEEEEECCCCCCCCHHCCHHHHHHH
RAVSSRSMPGSGLGLAIVNQVVNRHGGQLVVGESDDGGTRITIDLPGEPIRSGFENVDD
HHHHCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCEEEEEECCCHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA