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The map label for this gene is mprA [H]

Identifier: 145295044

GI number: 145295044

Start: 1092598

End: 1093365

Strand: Direct

Name: mprA [H]

Synonym: cgR_0988

Alternate gene names: 145295044

Gene position: 1092598-1093365 (Clockwise)

Preceding gene: 145295043

Following gene: 145295045

Centisome position: 32.97

GC content: 51.04

Gene sequence:

>768_bases
ATGTTCCAACGCGTGGACGTCTTCATTGGGAAGAAGTCTGTCACGGACTGGAAGACGAAAAGGGTATCGATGAAAATTTT
AGTTGTTGATGATGAGCAAGCTGTACGTGACTCCTTGCGACGTTCCCTTTCGTTCAACGGATACAACGTTGTTCTCGCAG
AAGACGGCATCCAAGCACTAGAGATGATTGACAAGGAACAGCCTGCTTTGGTGATCCTCGATGTCATGATGCCTCGTATG
GACGGACTTGAGGTCTGTCGTCACCTTCGCAGCGAAGGCGATGATCGGCCAATTCTTATTCTTACTGCCCGCGATAATGT
TTCTGATCGTGTCGGTGGCCTCGATGCTGGCGCAGATGACTATTTGGCTAAACCATTTGCTCTTGAAGAGCTGTTGGCGC
GCGTCCGTTCACTGGTGCGTCGCTCTGCAGTGGAATCAAATCAGAGTTCCAACATTGAACAGGCTCTATTATCTTGTGGC
GATTTGACGCTTGACCCAGAAAGTCGAGATGTCTACCGCAACGGACGCGCCATCAGCCTTACTCGAACAGAGTTCGCGCT
CCTGCAATTGCTCCTCAAAAACCAAAGGAAAGTGCTCACTCGCGCCCAGATTTTGGAAGAGGTCTGGGGCTATGATTTCC
CCACTTCAGGCAATGCCCTCGAGGTCTACATTGGATACCTTCGACGCAAGACTGAATTGGAAGGAGAAGACCGCCTGATC
CATACAGTACGAGGAGTCGGATACGTCCTGCGAGAGACCGCTCCGTGA

Upstream 100 bases:

>100_bases
CCTTTTGTAGGTAAGAATTTAACAAGAGCCAGTTATCTTCTCTTAAAATGAGGAGGTAACTGGCTTCTTTATGCTTAAGA
GGTGTTAGCATAAGTGAAAC

Downstream 100 bases:

>100_bases
CATTAAGGCGAATCGGCGCAGGGGAAAATGAGCCTGCCCCTACCGAAAGTGATGACTCCGACGGTTCAATGTCGTTGCGT
TGGCGCTTGGCTTTGCTGAG

Product: hypothetical protein

Products: NA

Alternate protein names: Mycobacterial persistence regulator A [H]

Number of amino acids: Translated: 255; Mature: 255

Protein sequence:

>255_residues
MFQRVDVFIGKKSVTDWKTKRVSMKILVVDDEQAVRDSLRRSLSFNGYNVVLAEDGIQALEMIDKEQPALVILDVMMPRM
DGLEVCRHLRSEGDDRPILILTARDNVSDRVGGLDAGADDYLAKPFALEELLARVRSLVRRSAVESNQSSNIEQALLSCG
DLTLDPESRDVYRNGRAISLTRTEFALLQLLLKNQRKVLTRAQILEEVWGYDFPTSGNALEVYIGYLRRKTELEGEDRLI
HTVRGVGYVLRETAP

Sequences:

>Translated_255_residues
MFQRVDVFIGKKSVTDWKTKRVSMKILVVDDEQAVRDSLRRSLSFNGYNVVLAEDGIQALEMIDKEQPALVILDVMMPRM
DGLEVCRHLRSEGDDRPILILTARDNVSDRVGGLDAGADDYLAKPFALEELLARVRSLVRRSAVESNQSSNIEQALLSCG
DLTLDPESRDVYRNGRAISLTRTEFALLQLLLKNQRKVLTRAQILEEVWGYDFPTSGNALEVYIGYLRRKTELEGEDRLI
HTVRGVGYVLRETAP
>Mature_255_residues
MFQRVDVFIGKKSVTDWKTKRVSMKILVVDDEQAVRDSLRRSLSFNGYNVVLAEDGIQALEMIDKEQPALVILDVMMPRM
DGLEVCRHLRSEGDDRPILILTARDNVSDRVGGLDAGADDYLAKPFALEELLARVRSLVRRSAVESNQSSNIEQALLSCG
DLTLDPESRDVYRNGRAISLTRTEFALLQLLLKNQRKVLTRAQILEEVWGYDFPTSGNALEVYIGYLRRKTELEGEDRLI
HTVRGVGYVLRETAP

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a tr

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=227, Percent_Identity=42.7312775330396, Blast_Score=175, Evalue=2e-45,
Organism=Escherichia coli, GI87082012, Length=225, Percent_Identity=40, Blast_Score=159, Evalue=2e-40,
Organism=Escherichia coli, GI1789402, Length=229, Percent_Identity=41.4847161572052, Blast_Score=159, Evalue=2e-40,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=37.4449339207048, Blast_Score=154, Evalue=7e-39,
Organism=Escherichia coli, GI1786599, Length=226, Percent_Identity=37.1681415929204, Blast_Score=153, Evalue=1e-38,
Organism=Escherichia coli, GI1786911, Length=225, Percent_Identity=39.1111111111111, Blast_Score=148, Evalue=3e-37,
Organism=Escherichia coli, GI1790552, Length=227, Percent_Identity=39.2070484581498, Blast_Score=138, Evalue=3e-34,
Organism=Escherichia coli, GI1790860, Length=227, Percent_Identity=37.4449339207048, Blast_Score=135, Evalue=4e-33,
Organism=Escherichia coli, GI1787375, Length=227, Percent_Identity=32.5991189427313, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=38.1578947368421, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1788394, Length=226, Percent_Identity=34.070796460177, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1790863, Length=228, Percent_Identity=30.2631578947368, Blast_Score=107, Evalue=6e-25,
Organism=Escherichia coli, GI1787487, Length=133, Percent_Identity=38.3458646616541, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1787229, Length=227, Percent_Identity=28.6343612334802, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI145693140, Length=235, Percent_Identity=30.6382978723404, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1788550, Length=163, Percent_Identity=30.6748466257669, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1790299, Length=148, Percent_Identity=29.7297297297297, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1788713, Length=115, Percent_Identity=39.1304347826087, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI1790437, Length=134, Percent_Identity=37.3134328358209, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI1788191, Length=120, Percent_Identity=38.3333333333333, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI145693157, Length=106, Percent_Identity=35.8490566037736, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI1788905, Length=124, Percent_Identity=29.8387096774194, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1788521, Length=125, Percent_Identity=34.4, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 28853; Mature: 28853

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQRVDVFIGKKSVTDWKTKRVSMKILVVDDEQAVRDSLRRSLSFNGYNVVLAEDGIQAL
CCCEEEEEECCCCCCCHHHEEEEEEEEEECCHHHHHHHHHHHCCCCCEEEEEECCCHHHH
EMIDKEQPALVILDVMMPRMDGLEVCRHLRSEGDDRPILILTARDNVSDRVGGLDAGADD
HHHCCCCCCEEEEEHHHCCCCHHHHHHHHHHCCCCCCEEEEEECCCCHHHHCCCCCCCHH
YLAKPFALEELLARVRSLVRRSAVESNQSSNIEQALLSCGDLTLDPESRDVYRNGRAISL
HHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCEECCCCHHHHHCCCEEEE
TRTEFALLQLLLKNQRKVLTRAQILEEVWGYDFPTSGNALEVYIGYLRRKTELEGEDRLI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHH
HTVRGVGYVLRETAP
HHHHHHHHHHHCCCC
>Mature Secondary Structure
MFQRVDVFIGKKSVTDWKTKRVSMKILVVDDEQAVRDSLRRSLSFNGYNVVLAEDGIQAL
CCCEEEEEECCCCCCCHHHEEEEEEEEEECCHHHHHHHHHHHCCCCCEEEEEECCCHHHH
EMIDKEQPALVILDVMMPRMDGLEVCRHLRSEGDDRPILILTARDNVSDRVGGLDAGADD
HHHCCCCCCEEEEEHHHCCCCHHHHHHHHHHCCCCCCEEEEEECCCCHHHHCCCCCCCHH
YLAKPFALEELLARVRSLVRRSAVESNQSSNIEQALLSCGDLTLDPESRDVYRNGRAISL
HHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCEECCCCHHHHHCCCEEEE
TRTEFALLQLLLKNQRKVLTRAQILEEVWGYDFPTSGNALEVYIGYLRRKTELEGEDRLI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHH
HTVRGVGYVLRETAP
HHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA