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The map label for this gene is ahcY [H]

Identifier: 145294915

GI number: 145294915

Start: 948909

End: 950345

Strand: Direct

Name: ahcY [H]

Synonym: cgR_0861

Alternate gene names: 145294915

Gene position: 948909-950345 (Clockwise)

Preceding gene: 145294914

Following gene: 145294916

Centisome position: 28.63

GC content: 57.2

Gene sequence:

>1437_bases
ATGGCACAGGTTATGGACTTCAAGGTTGCCGATCTTTCACTAGCAGAGGCAGGACGTCACCAGATTCGTCTTGCAGAGTA
TGAGATGCCAGGTCTCATGCAGCTGCGCAAGGAATTCGCAGACGAGCAGCCTTTGAAGGGCGCCCGAATTGCTGGTTCCA
TCCACATGACGGTCCAGACCGCCGTGCTTATTGAGACCCTCACTGCTTTGGGCGCTGAGGTTCGTTGGGCTTCCTGCAAC
ATTTTCTCCACCCAGGATGAGGCTGCAGCGGCTATCGTTGTCGGCTCCGGCACCGTCGAAGAGCCAGCTGGTGTTCCAGT
ATTCGCGTGGAAGGGTGAGTCACTGGAGGAGTACTGGTGGTGCATCAACCAGATCTTCAGCTGGGGCGATGAGCTGCCAA
ACATGATCCTCGACGACGGCGGTGACGCCACCATGGCTGTTATTCGCGGTCGCGAATACGAGCAGGCTGGTCTGGTTCCA
CCAGCAGAGGCCAACGATTCCGATGAGTACATCGCATTCTTGGGCATGCTGCGTGAGGTTCTTGCTGCAGAGCCTGGCAA
GTGGGGCAAGATCGCTGAGGCCGTTAAGGGTGTCACCGAGGAAACCACCACCGGTGTGCACCGCCTGTACCACTTCGCTG
AAGAAGGCGTACTGCCTTTCCCAGCGATGAACGTCAACGACGCTGTCACCAAGTCCAAGTTTGATAACAAGTACGGCACC
CGCCACTCCCTGATCGACGGCATCAACCGCGCCACCGACATGCTCATGGGCGGCAAGAACGTGCTTGTCTGCGGTTACGG
CGATGTCGGCAAGGGCTGCGCTGAGGCTTTCGACGGCCAGGGCGCTCGCGTCAAGGTCACCGAAGCTGACCCAATCAACG
CTCTTCAGGCTCTGATGGATGGCTACTCTGTGGTCACCGTTGATGAGGCCATCGAGGACGCCGACATCGTGATCACCGCG
ACCGGCAACAAGGACATCATTTCCTTCGAGCAGATGCTCAAGATGAAGGATCACGCTCTGCTGGGCAACATCGGTCACTT
TGATAATGAGATCGATATGCATTCCCTGTTGCACCGCGACGACGTCACCCGCACCACGATCAAGCCACAGGTCGACGAGT
TCACCTTCTCCACCGGTCGCTCCATCATCGTGCTGTCTGAAGGCCGTCTGCTGAACCTTGGCAACGCCACCGGACACCCA
TCATTTGTCATGTCCAACTCTTTCGCCGATCAGACCATTGCGCAGATCGAACTGTTCCAAAACGAAGGACAGTACGAGAA
CGAGGTCTACCGTCTGCCTAAGGTTCTCGACGAAAAGGTGGCACGCATCCACGTTGAGGCTCTCGGCGGTCAGCTCACCG
AACTGACCAAGGAGCAGGCTGAGTACATCGGCGTTGACGTTGCAGGTCCATTCAAGCCGGAGCACTACCGCTACTAA

Upstream 100 bases:

>100_bases
AACAGCTTCAATCAATTCGGTGTCCACTCCAACATGTAGAGTGGTGCGCGTTAAAAAAGTTTTCCTAATTTTCATTTTCT
TAAAAGGAGCTCGCCAGGAC

Downstream 100 bases:

>100_bases
TGATTGTCAGCATTGAGGGAATCGACGGCGCCGGCAAAAACACCCTGGTTTCGGCATTAACGCAGGTTATTGATGCAAAA
GTCCTTGCATTCCCACGTTA

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 478; Mature: 477

Protein sequence:

>478_residues
MAQVMDFKVADLSLAEAGRHQIRLAEYEMPGLMQLRKEFADEQPLKGARIAGSIHMTVQTAVLIETLTALGAEVRWASCN
IFSTQDEAAAAIVVGSGTVEEPAGVPVFAWKGESLEEYWWCINQIFSWGDELPNMILDDGGDATMAVIRGREYEQAGLVP
PAEANDSDEYIAFLGMLREVLAAEPGKWGKIAEAVKGVTEETTTGVHRLYHFAEEGVLPFPAMNVNDAVTKSKFDNKYGT
RHSLIDGINRATDMLMGGKNVLVCGYGDVGKGCAEAFDGQGARVKVTEADPINALQALMDGYSVVTVDEAIEDADIVITA
TGNKDIISFEQMLKMKDHALLGNIGHFDNEIDMHSLLHRDDVTRTTIKPQVDEFTFSTGRSIIVLSEGRLLNLGNATGHP
SFVMSNSFADQTIAQIELFQNEGQYENEVYRLPKVLDEKVARIHVEALGGQLTELTKEQAEYIGVDVAGPFKPEHYRY

Sequences:

>Translated_478_residues
MAQVMDFKVADLSLAEAGRHQIRLAEYEMPGLMQLRKEFADEQPLKGARIAGSIHMTVQTAVLIETLTALGAEVRWASCN
IFSTQDEAAAAIVVGSGTVEEPAGVPVFAWKGESLEEYWWCINQIFSWGDELPNMILDDGGDATMAVIRGREYEQAGLVP
PAEANDSDEYIAFLGMLREVLAAEPGKWGKIAEAVKGVTEETTTGVHRLYHFAEEGVLPFPAMNVNDAVTKSKFDNKYGT
RHSLIDGINRATDMLMGGKNVLVCGYGDVGKGCAEAFDGQGARVKVTEADPINALQALMDGYSVVTVDEAIEDADIVITA
TGNKDIISFEQMLKMKDHALLGNIGHFDNEIDMHSLLHRDDVTRTTIKPQVDEFTFSTGRSIIVLSEGRLLNLGNATGHP
SFVMSNSFADQTIAQIELFQNEGQYENEVYRLPKVLDEKVARIHVEALGGQLTELTKEQAEYIGVDVAGPFKPEHYRY
>Mature_477_residues
AQVMDFKVADLSLAEAGRHQIRLAEYEMPGLMQLRKEFADEQPLKGARIAGSIHMTVQTAVLIETLTALGAEVRWASCNI
FSTQDEAAAAIVVGSGTVEEPAGVPVFAWKGESLEEYWWCINQIFSWGDELPNMILDDGGDATMAVIRGREYEQAGLVPP
AEANDSDEYIAFLGMLREVLAAEPGKWGKIAEAVKGVTEETTTGVHRLYHFAEEGVLPFPAMNVNDAVTKSKFDNKYGTR
HSLIDGINRATDMLMGGKNVLVCGYGDVGKGCAEAFDGQGARVKVTEADPINALQALMDGYSVVTVDEAIEDADIVITAT
GNKDIISFEQMLKMKDHALLGNIGHFDNEIDMHSLLHRDDVTRTTIKPQVDEFTFSTGRSIIVLSEGRLLNLGNATGHPS
FVMSNSFADQTIAQIELFQNEGQYENEVYRLPKVLDEKVARIHVEALGGQLTELTKEQAEYIGVDVAGPFKPEHYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=478, Percent_Identity=52.510460251046, Blast_Score=479, Evalue=1e-135,
Organism=Homo sapiens, GI239937451, Length=450, Percent_Identity=53.1111111111111, Blast_Score=458, Evalue=1e-129,
Organism=Homo sapiens, GI298286489, Length=474, Percent_Identity=46.6244725738397, Blast_Score=437, Evalue=1e-123,
Organism=Homo sapiens, GI24308043, Length=474, Percent_Identity=46.6244725738397, Blast_Score=437, Evalue=1e-123,
Organism=Homo sapiens, GI195539337, Length=474, Percent_Identity=46.6244725738397, Blast_Score=437, Evalue=1e-123,
Organism=Homo sapiens, GI195539349, Length=474, Percent_Identity=46.6244725738397, Blast_Score=437, Evalue=1e-122,
Organism=Homo sapiens, GI21361647, Length=474, Percent_Identity=44.7257383966245, Blast_Score=412, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI17506425, Length=476, Percent_Identity=53.5714285714286, Blast_Score=484, Evalue=1e-137,
Organism=Saccharomyces cerevisiae, GI6320882, Length=493, Percent_Identity=51.7241379310345, Blast_Score=471, Evalue=1e-134,
Organism=Drosophila melanogaster, GI24642172, Length=473, Percent_Identity=54.3340380549683, Blast_Score=487, Evalue=1e-138,
Organism=Drosophila melanogaster, GI24656245, Length=475, Percent_Identity=46.7368421052632, Blast_Score=441, Evalue=1e-124,
Organism=Drosophila melanogaster, GI45553387, Length=474, Percent_Identity=46.8354430379747, Blast_Score=421, Evalue=1e-118,
Organism=Drosophila melanogaster, GI45553385, Length=473, Percent_Identity=46.723044397463, Blast_Score=418, Evalue=1e-117,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 52426; Mature: 52295

Theoretical pI: Translated: 4.40; Mature: 4.40

Prosite motif: PS00738 ADOHCYASE_1 ; PS00739 ADOHCYASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQVMDFKVADLSLAEAGRHQIRLAEYEMPGLMQLRKEFADEQPLKGARIAGSIHMTVQT
CCCCCCEEEHHHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCEEECEEEEHHHH
AVLIETLTALGAEVRWASCNIFSTQDEAAAAIVVGSGTVEEPAGVPVFAWKGESLEEYWW
HHHHHHHHHHCCCEEEEEEEEECCCCCCEEEEEECCCCCCCCCCCEEEEECCCCHHHHHH
CINQIFSWGDELPNMILDDGGDATMAVIRGREYEQAGLVPPAEANDSDEYIAFLGMLREV
HHHHHHHHHHHCCCCEECCCCCEEEEEEECCCHHHCCCCCCCCCCCCHHHHHHHHHHHHH
LAAEPGKWGKIAEAVKGVTEETTTGVHRLYHFAEEGVLPFPAMNVNDAVTKSKFDNKYGT
HHCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCCC
RHSLIDGINRATDMLMGGKNVLVCGYGDVGKGCAEAFDGQGARVKVTEADPINALQALMD
HHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHCCCCCEEEEECCCCHHHHHHHHC
GYSVVTVDEAIEDADIVITATGNKDIISFEQMLKMKDHALLGNIGHFDNEIDMHSLLHRD
CCEEEEEHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHC
DVTRTTIKPQVDEFTFSTGRSIIVLSEGRLLNLGNATGHPSFVMSNSFADQTIAQIELFQ
CCCCCCCCCCHHHEEECCCCEEEEEECCCEEECCCCCCCCCEEEECCCHHHHHHHHHHHH
NEGQYENEVYRLPKVLDEKVARIHVEALGGQLTELTKEQAEYIGVDVAGPFKPEHYRY
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHEEEECCCCCCCCCCCC
>Mature Secondary Structure 
AQVMDFKVADLSLAEAGRHQIRLAEYEMPGLMQLRKEFADEQPLKGARIAGSIHMTVQT
CCCCCEEEHHHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCEEECEEEEHHHH
AVLIETLTALGAEVRWASCNIFSTQDEAAAAIVVGSGTVEEPAGVPVFAWKGESLEEYWW
HHHHHHHHHHCCCEEEEEEEEECCCCCCEEEEEECCCCCCCCCCCEEEEECCCCHHHHHH
CINQIFSWGDELPNMILDDGGDATMAVIRGREYEQAGLVPPAEANDSDEYIAFLGMLREV
HHHHHHHHHHHCCCCEECCCCCEEEEEEECCCHHHCCCCCCCCCCCCHHHHHHHHHHHHH
LAAEPGKWGKIAEAVKGVTEETTTGVHRLYHFAEEGVLPFPAMNVNDAVTKSKFDNKYGT
HHCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCCC
RHSLIDGINRATDMLMGGKNVLVCGYGDVGKGCAEAFDGQGARVKVTEADPINALQALMD
HHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHCCCCCEEEEECCCCHHHHHHHHC
GYSVVTVDEAIEDADIVITATGNKDIISFEQMLKMKDHALLGNIGHFDNEIDMHSLLHRD
CCEEEEEHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHC
DVTRTTIKPQVDEFTFSTGRSIIVLSEGRLLNLGNATGHPSFVMSNSFADQTIAQIELFQ
CCCCCCCCCCHHHEEECCCCEEEEEECCCEEECCCCCCCCCEEEECCCHHHHHHHHHHHH
NEGQYENEVYRLPKVLDEKVARIHVEALGGQLTELTKEQAEYIGVDVAGPFKPEHYRY
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12840036 [H]