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The map label for this gene is tmk [H]

Identifier: 145294916

GI number: 145294916

Start: 950345

End: 950956

Strand: Direct

Name: tmk [H]

Synonym: cgR_0862

Alternate gene names: 145294916

Gene position: 950345-950956 (Clockwise)

Preceding gene: 145294915

Following gene: 145294917

Centisome position: 28.68

GC content: 60.62

Gene sequence:

>612_bases
ATGATTGTCAGCATTGAGGGAATCGACGGCGCCGGCAAAAACACCCTGGTTTCGGCATTAACGCAGGTTATTGATGCAAA
AGTCCTTGCATTCCCACGTTATGAAACCTCGATTCACGCCCAATTGGCCGCGGAAGCACTCCACGGCCGCATGGGCGACC
TCACCGACAGCGCTTACGCCATGGCCACGCTTTTCGCCCTCGACCGCCACTTCGCGATCGATGACTTAAACGCGCCCGGC
GTGGTGCTGCTCGACCGATACGTCGCCTCCAACGCGGCTTATACCGCCGCCAGATTGCTTGACGACGACGCCCCCCGCTG
GGTTGCCGACCTGGAATTCGGGCGGCTTGGGCTCCCACGTCCGACGCTTCAAGTGTTGTTGGATACCCCCGCGGAGGTAG
CGCAAGATAGGGCTAGACGTCGGGAAGCTCTTGACTCCGCGCGTGCGCGGGACCGCTATGAATCGGATTCGGCGCTGCAG
CAACGCACCGCCGAGCACTATCGCCGCCTCGCGGCGGACAACTGGGAATCACCGTGGATCGTGGTTGCCCCTGATGAAGA
CCCCGGCCACGTTGCGCAGAGAATCGTGGAATTCCTGGGTACTATAAACTAA

Upstream 100 bases:

>100_bases
AGGCTCTCGGCGGTCAGCTCACCGAACTGACCAAGGAGCAGGCTGAGTACATCGGCGTTGACGTTGCAGGTCCATTCAAG
CCGGAGCACTACCGCTACTA

Downstream 100 bases:

>100_bases
TCCCAATTAGCAGGAAGGATTCTCATGTCACAGAAAATTCTCGTCGTTGATGATGATCCCGCCATCTCCGAGATGCTCAC
CATCGTGCTCAGCGCAGAAG

Product: thymidylate kinase

Products: NA

Alternate protein names: Thymidine monophosphate kinase; dTMP kinase; TMPK [H]

Number of amino acids: Translated: 203; Mature: 203

Protein sequence:

>203_residues
MIVSIEGIDGAGKNTLVSALTQVIDAKVLAFPRYETSIHAQLAAEALHGRMGDLTDSAYAMATLFALDRHFAIDDLNAPG
VVLLDRYVASNAAYTAARLLDDDAPRWVADLEFGRLGLPRPTLQVLLDTPAEVAQDRARRREALDSARARDRYESDSALQ
QRTAEHYRRLAADNWESPWIVVAPDEDPGHVAQRIVEFLGTIN

Sequences:

>Translated_203_residues
MIVSIEGIDGAGKNTLVSALTQVIDAKVLAFPRYETSIHAQLAAEALHGRMGDLTDSAYAMATLFALDRHFAIDDLNAPG
VVLLDRYVASNAAYTAARLLDDDAPRWVADLEFGRLGLPRPTLQVLLDTPAEVAQDRARRREALDSARARDRYESDSALQ
QRTAEHYRRLAADNWESPWIVVAPDEDPGHVAQRIVEFLGTIN
>Mature_203_residues
MIVSIEGIDGAGKNTLVSALTQVIDAKVLAFPRYETSIHAQLAAEALHGRMGDLTDSAYAMATLFALDRHFAIDDLNAPG
VVLLDRYVASNAAYTAARLLDDDAPRWVADLEFGRLGLPRPTLQVLLDTPAEVAQDRARRREALDSARARDRYESDSALQ
QRTAEHYRRLAADNWESPWIVVAPDEDPGHVAQRIVEFLGTIN

Specific function: Catalyzes the reversible phosphorylation of deoxythymidine monophosphate (dTMP) to deoxythymidine diphosphate (dTDP), using ATP as its preferred phosphoryl donor. Situated at the junction of both de novo and salvage pathways of deoxythymidine triphosphate

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018095
- InterPro:   IPR018094 [H]

Pfam domain/function: PF02223 Thymidylate_kin [H]

EC number: =2.7.4.9 [H]

Molecular weight: Translated: 22378; Mature: 22378

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: PS01331 THYMIDYLATE_KINASE ; PS00237 G_PROTEIN_RECEP_F1_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVSIEGIDGAGKNTLVSALTQVIDAKVLAFPRYETSIHAQLAAEALHGRMGDLTDSAYA
CEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCHHHHH
MATLFALDRHFAIDDLNAPGVVLLDRYVASNAAYTAARLLDDDAPRWVADLEFGRLGLPR
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCHHHHHHHHHCCCCCCEEHHCCCCCCCCCC
PTLQVLLDTPAEVAQDRARRREALDSARARDRYESDSALQQRTAEHYRRLAADNWESPWI
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCEE
VVAPDEDPGHVAQRIVEFLGTIN
EEECCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIVSIEGIDGAGKNTLVSALTQVIDAKVLAFPRYETSIHAQLAAEALHGRMGDLTDSAYA
CEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCHHHHH
MATLFALDRHFAIDDLNAPGVVLLDRYVASNAAYTAARLLDDDAPRWVADLEFGRLGLPR
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCHHHHHHHHHCCCCCCEEHHCCCCCCCCCC
PTLQVLLDTPAEVAQDRARRREALDSARARDRYESDSALQQRTAEHYRRLAADNWESPWI
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCEE
VVAPDEDPGHVAQRIVEFLGTIN
EEECCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036; 11369858; 10666613; 11469859; 11914484; 12454011; 12662932 [H]