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The map label for this gene is prpC1 [H]

Identifier: 145294869

GI number: 145294869

Start: 903708

End: 904853

Strand: Direct

Name: prpC1 [H]

Synonym: cgR_0816

Alternate gene names: 145294869

Gene position: 903708-904853 (Clockwise)

Preceding gene: 145294868

Following gene: 145294872

Centisome position: 27.27

GC content: 54.8

Gene sequence:

>1146_bases
ATGAGTGACAGCCAAGTCCGCAAAGGACTCAACGGCGTCATCTCTGACTACACAAGCATTTCCAAAGTGATGCCAGAGAG
CAACTCGCTGACTTACCGTGGCTACGCCGTGGAGGATTTGGTGGAAAACTGCAGCTTTGAAGAAGTGATCTACCTCCTGT
GGTTTGGGGAGCTGCCCACCACTGAACAACTCCGGACCTTCAACACGACAGGTCGAAGCTACCGCTCACTCGACGCCGGA
CTGATTTCCCTCATCCACTCCTTACCCAAGACCTGTCACCCGATGGACGTGCTGCGCACCGCAGTGTCCTACATGGGTAC
CTTTGATCCCGATCCGTTTACCCGCGATGCCGATCATATCCGAAGCATTGGACACAACCTGCTTGCGCAGCTTCCCATGG
TGGTTGCCATGGATATCCGCAGGCGAAGTGGGGAAGAGATCATCGCACCTGACCACAACAAAGGTATCGCTTCGAATTTC
TTATCCATGGTGTTTGGCAATGATGACGGTTCTGTAGCCAACTCCGCAGATGACATCCGCGATTTTGAACGCTCCCTCAT
CCTCTACGCCGAGCACTCCTTCAACGCCTCCACATTCTCAGCCCGCGTGATCTCATCAACGCGATCCGATACGTATTCGG
CGATCACAGGTGCGATCGGTGCTCTCAAAGGCCCACTGCACGGAGGTGCCAATGAGTTTGTCATGCACACCATGCTGGAT
ATCGACGATCCCAACAATGCTGCCGACTGGATGGGCAAGGCGTTGGATCGTAAAGAACGCATCATGGGATTCGGGCACCG
CGTGTACAAAAACGGCGACTCCAGGGTCCCCTCCATGGAGAAATCCATGCGCTCCCTTGCTGCTCGTCACCGTGGTCAAA
AATGGGTGCACATGTATGAGTCGATGCAGGAAGTCATGGAGGCTCGCACTGGCATTAAACCCAACCTCGACTTCCCGGCC
GGCCCTGCCTATTACATGCTGGGATTCCCCGTCGACTTCTTCACACCGCTGTTTGTGCTGGCCCGAGTGTCAGGGTGGAC
GGCACACATCGTGGAGCAATTTGAAAACAATGCGCTGATCCGACCATTGTCTGCCTACAACGGAGTGGAAGAAAGGGAGG
TGGTGCCCATTTCGGAGAGAACCTAA

Upstream 100 bases:

>100_bases
GACCGCATGCAACACCGCAGCAGATTATATGAGCTCCTGCGATACGAAGACTACAACGTCTTTGACCAGCACATTTTCAC
CTACAGAAAAGGAGAAAACA

Downstream 100 bases:

>100_bases
TCAGTGAGGCTGATTTCTAAATAGCCGTGTGCCCATCTGGTGATGGTGTCGCGGCCCTCCGCCACAGCATCGCCGATGGT
TTTCGGCGCGAGCACTGGAT

Product: citrate synthase

Products: NA

Alternate protein names: Methylcitrate synthase 1; Citrate synthase 1 [H]

Number of amino acids: Translated: 381; Mature: 380

Protein sequence:

>381_residues
MSDSQVRKGLNGVISDYTSISKVMPESNSLTYRGYAVEDLVENCSFEEVIYLLWFGELPTTEQLRTFNTTGRSYRSLDAG
LISLIHSLPKTCHPMDVLRTAVSYMGTFDPDPFTRDADHIRSIGHNLLAQLPMVVAMDIRRRSGEEIIAPDHNKGIASNF
LSMVFGNDDGSVANSADDIRDFERSLILYAEHSFNASTFSARVISSTRSDTYSAITGAIGALKGPLHGGANEFVMHTMLD
IDDPNNAADWMGKALDRKERIMGFGHRVYKNGDSRVPSMEKSMRSLAARHRGQKWVHMYESMQEVMEARTGIKPNLDFPA
GPAYYMLGFPVDFFTPLFVLARVSGWTAHIVEQFENNALIRPLSAYNGVEEREVVPISERT

Sequences:

>Translated_381_residues
MSDSQVRKGLNGVISDYTSISKVMPESNSLTYRGYAVEDLVENCSFEEVIYLLWFGELPTTEQLRTFNTTGRSYRSLDAG
LISLIHSLPKTCHPMDVLRTAVSYMGTFDPDPFTRDADHIRSIGHNLLAQLPMVVAMDIRRRSGEEIIAPDHNKGIASNF
LSMVFGNDDGSVANSADDIRDFERSLILYAEHSFNASTFSARVISSTRSDTYSAITGAIGALKGPLHGGANEFVMHTMLD
IDDPNNAADWMGKALDRKERIMGFGHRVYKNGDSRVPSMEKSMRSLAARHRGQKWVHMYESMQEVMEARTGIKPNLDFPA
GPAYYMLGFPVDFFTPLFVLARVSGWTAHIVEQFENNALIRPLSAYNGVEEREVVPISERT
>Mature_380_residues
SDSQVRKGLNGVISDYTSISKVMPESNSLTYRGYAVEDLVENCSFEEVIYLLWFGELPTTEQLRTFNTTGRSYRSLDAGL
ISLIHSLPKTCHPMDVLRTAVSYMGTFDPDPFTRDADHIRSIGHNLLAQLPMVVAMDIRRRSGEEIIAPDHNKGIASNFL
SMVFGNDDGSVANSADDIRDFERSLILYAEHSFNASTFSARVISSTRSDTYSAITGAIGALKGPLHGGANEFVMHTMLDI
DDPNNAADWMGKALDRKERIMGFGHRVYKNGDSRVPSMEKSMRSLAARHRGQKWVHMYESMQEVMEARTGIKPNLDFPAG
PAYYMLGFPVDFFTPLFVLARVSGWTAHIVEQFENNALIRPLSAYNGVEEREVVPISERT

Specific function: Catalyzes the synthesis of 2-methylcitrate from propionyl-CoA and oxaloacetate. Also has a citrate synthase activity [H]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=378, Percent_Identity=23.2804232804233, Blast_Score=79, Evalue=6e-15,
Organism=Escherichia coli, GI1786527, Length=373, Percent_Identity=38.8739946380697, Blast_Score=253, Evalue=1e-68,
Organism=Escherichia coli, GI1786939, Length=381, Percent_Identity=29.9212598425197, Blast_Score=171, Evalue=9e-44,
Organism=Caenorhabditis elegans, GI17555174, Length=382, Percent_Identity=21.9895287958115, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6325257, Length=404, Percent_Identity=23.019801980198, Blast_Score=69, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24640126, Length=328, Percent_Identity=23.780487804878, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24640124, Length=328, Percent_Identity=23.780487804878, Blast_Score=78, Evalue=9e-15,
Organism=Drosophila melanogaster, GI21356863, Length=402, Percent_Identity=23.3830845771144, Blast_Score=72, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011278
- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.5 [H]

Molecular weight: Translated: 42582; Mature: 42450

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: PS00480 CITRATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDSQVRKGLNGVISDYTSISKVMPESNSLTYRGYAVEDLVENCSFEEVIYLLWFGELPT
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCHHHHHHCCCHHHHHHHHEECCCCC
TEQLRTFNTTGRSYRSLDAGLISLIHSLPKTCHPMDVLRTAVSYMGTFDPDPFTRDADHI
HHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHH
RSIGHNLLAQLPMVVAMDIRRRSGEEIIAPDHNKGIASNFLSMVFGNDDGSVANSADDIR
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHH
DFERSLILYAEHSFNASTFSARVISSTRSDTYSAITGAIGALKGPLHGGANEFVMHTMLD
HHHHHEEEEEECCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHC
IDDPNNAADWMGKALDRKERIMGFGHRVYKNGDSRVPSMEKSMRSLAARHRGQKWVHMYE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHH
SMQEVMEARTGIKPNLDFPAGPAYYMLGFPVDFFTPLFVLARVSGWTAHIVEQFENNALI
HHHHHHHHHCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCEE
RPLSAYNGVEEREVVPISERT
EEHHHHCCCCCCEECCCCCCC
>Mature Secondary Structure 
SDSQVRKGLNGVISDYTSISKVMPESNSLTYRGYAVEDLVENCSFEEVIYLLWFGELPT
CHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCHHHHHHCCCHHHHHHHHEECCCCC
TEQLRTFNTTGRSYRSLDAGLISLIHSLPKTCHPMDVLRTAVSYMGTFDPDPFTRDADHI
HHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHH
RSIGHNLLAQLPMVVAMDIRRRSGEEIIAPDHNKGIASNFLSMVFGNDDGSVANSADDIR
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHH
DFERSLILYAEHSFNASTFSARVISSTRSDTYSAITGAIGALKGPLHGGANEFVMHTMLD
HHHHHEEEEEECCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHC
IDDPNNAADWMGKALDRKERIMGFGHRVYKNGDSRVPSMEKSMRSLAARHRGQKWVHMYE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHH
SMQEVMEARTGIKPNLDFPAGPAYYMLGFPVDFFTPLFVLARVSGWTAHIVEQFENNALI
HHHHHHHHHCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCEE
RPLSAYNGVEEREVVPISERT
EEHHHHCCCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11976302; 12948626 [H]