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The map label for this gene is rmlA [H]

Identifier: 145294460

GI number: 145294460

Start: 452968

End: 453825

Strand: Reverse

Name: rmlA [H]

Synonym: cgR_0415

Alternate gene names: 145294460

Gene position: 453825-452968 (Counterclockwise)

Preceding gene: 145294461

Following gene: 145294458

Centisome position: 13.69

GC content: 55.13

Gene sequence:

>858_bases
ATGAAAGGCATCATCCTCGCAGGCGGCTCCGGCACCCGGCTCTACCCCATCACCAAGGGCATCTCCAAGCAACTCATGCC
CATCTACGACAAGCCGATGGTCTACTACCCACTGACCACACTCATCCAGGCCGGCATTAAAGACATCCTGATTATCACCA
CCCCCGAAGACAGCGCCTCCTTTGAACGCTTGCTTGGCGACGGCTCCTCCTGGGGCATCAACCTCACCTACGCCGTCCAA
CCCTCCCCCGACGGACTAGCCCAGGCGTTTATCATCGGCGAAGACTTCATCGGTGATGATGATGTGGCACTGGTGCTTGG
CGATAACATCTTCGACGGCGCACAACTTGGCCGCGCACTAAAGCAGTGCTCCAACCCCGACGGTGGCATTGTCTTTGCTT
ATGAGGTCTCCGATCCTGAGCGTTATGGCGTGGTGGAATTTGATGCTGCTAATAAGGCGGTGTCTATTGAAGAAAAGCCC
ACCGCACCAAAATCCAACTTTGCCGTGGTAGGACTATATTTCTACGACAATCGCGTAGTAGACATCGCCAAGTCAATCAA
GCCTTCCTCGCGTGGCGAACTGGAAATCACCAGCATCAACGATGCTTACCTGCAACAAGGCGCACTCACCGTCCAACGCC
TTGACCGAGGCGACGTCTGGCTGGACACCGGCACGATCGATTCCATGTCCGAGGCGTCTTCCTATGTTGAGGTCCTGCAA
AAACGAACCGGCAATATCATTGGTTCCCCTGAAGTTGCTGCATACCGCGAGGGTTTCATCACAGCTTCGGAACTCACCGC
GCTTGGTGAGGAACTCAAGAAATCAGGCTACGGAAACTACCTCCTGCGGGCTGTATAG

Upstream 100 bases:

>100_bases
CCCACTGCGCTCCGTGCTGAATCTAGGCAAGATCGAAGCAACAGGATTTAGCGCACCCACCTGGCAAACCCGCCTCAACA
ACTACCTCAAGGAGCTGTAA

Downstream 100 bases:

>100_bases
GAATTAACTATTCCGCGTAATCGGCAACCATAATTGCGCCGATGCGGTGGAGAAATCTTCTGAGTATTCCGTGTGCAGCA
GCTGCGGCCCCGGAGCCCAT

Product: hypothetical protein

Products: NA

Alternate protein names: dTDP-glucose pyrophosphorylase; dTDP-glucose synthase [H]

Number of amino acids: Translated: 285; Mature: 285

Protein sequence:

>285_residues
MKGIILAGGSGTRLYPITKGISKQLMPIYDKPMVYYPLTTLIQAGIKDILIITTPEDSASFERLLGDGSSWGINLTYAVQ
PSPDGLAQAFIIGEDFIGDDDVALVLGDNIFDGAQLGRALKQCSNPDGGIVFAYEVSDPERYGVVEFDAANKAVSIEEKP
TAPKSNFAVVGLYFYDNRVVDIAKSIKPSSRGELEITSINDAYLQQGALTVQRLDRGDVWLDTGTIDSMSEASSYVEVLQ
KRTGNIIGSPEVAAYREGFITASELTALGEELKKSGYGNYLLRAV

Sequences:

>Translated_285_residues
MKGIILAGGSGTRLYPITKGISKQLMPIYDKPMVYYPLTTLIQAGIKDILIITTPEDSASFERLLGDGSSWGINLTYAVQ
PSPDGLAQAFIIGEDFIGDDDVALVLGDNIFDGAQLGRALKQCSNPDGGIVFAYEVSDPERYGVVEFDAANKAVSIEEKP
TAPKSNFAVVGLYFYDNRVVDIAKSIKPSSRGELEITSINDAYLQQGALTVQRLDRGDVWLDTGTIDSMSEASSYVEVLQ
KRTGNIIGSPEVAAYREGFITASELTALGEELKKSGYGNYLLRAV
>Mature_285_residues
MKGIILAGGSGTRLYPITKGISKQLMPIYDKPMVYYPLTTLIQAGIKDILIITTPEDSASFERLLGDGSSWGINLTYAVQ
PSPDGLAQAFIIGEDFIGDDDVALVLGDNIFDGAQLGRALKQCSNPDGGIVFAYEVSDPERYGVVEFDAANKAVSIEEKP
TAPKSNFAVVGLYFYDNRVVDIAKSIKPSSRGELEITSINDAYLQQGALTVQRLDRGDVWLDTGTIDSMSEASSYVEVLQ
KRTGNIIGSPEVAAYREGFITASELTALGEELKKSGYGNYLLRAV

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788351, Length=283, Percent_Identity=61.8374558303887, Blast_Score=365, Evalue=1e-102,
Organism=Escherichia coli, GI1790224, Length=283, Percent_Identity=60.7773851590106, Blast_Score=348, Evalue=2e-97,
Organism=Escherichia coli, GI1787488, Length=242, Percent_Identity=26.0330578512397, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI1788355, Length=236, Percent_Identity=25.4237288135593, Blast_Score=69, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI133931050, Length=192, Percent_Identity=25.5208333333333, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6320148, Length=261, Percent_Identity=29.5019157088123, Blast_Score=88, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21355443, Length=248, Percent_Identity=23.3870967741935, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24644084, Length=248, Percent_Identity=23.3870967741935, Blast_Score=75, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 30770; Mature: 30770

Theoretical pI: Translated: 4.29; Mature: 4.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGIILAGGSGTRLYPITKGISKQLMPIYDKPMVYYPLTTLIQAGIKDILIITTPEDSAS
CCCEEEECCCCCEEEEECCCCHHCCCCCCCCCEEEECHHHHHHCCCCEEEEEECCCCCHH
FERLLGDGSSWGINLTYAVQPSPDGLAQAFIIGEDFIGDDDVALVLGDNIFDGAQLGRAL
HHHHHCCCCCCCEEEEEEECCCCCCCEEEEEEECCCCCCCCEEEEECCCCCCHHHHHHHH
KQCSNPDGGIVFAYEVSDPERYGVVEFDAANKAVSIEEKPTAPKSNFAVVGLYFYDNRVV
HHHCCCCCCEEEEEECCCCCCCCEEEECCCCCEEEECCCCCCCCCCEEEEEEEEECCCCE
DIAKSIKPSSRGELEITSINDAYLQQGALTVQRLDRGDVWLDTGTIDSMSEASSYVEVLQ
EHHHHCCCCCCCCEEEEECCHHHHHCCCEEEEECCCCCEEEECCCCCCHHHHHHHHHHHH
KRTGNIIGSPEVAAYREGFITASELTALGEELKKSGYGNYLLRAV
HHCCCCCCCCCHHHHHHCCEEHHHHHHHHHHHHHCCCCCEEEEEC
>Mature Secondary Structure
MKGIILAGGSGTRLYPITKGISKQLMPIYDKPMVYYPLTTLIQAGIKDILIITTPEDSAS
CCCEEEECCCCCEEEEECCCCHHCCCCCCCCCEEEECHHHHHHCCCCEEEEEECCCCCHH
FERLLGDGSSWGINLTYAVQPSPDGLAQAFIIGEDFIGDDDVALVLGDNIFDGAQLGRAL
HHHHHCCCCCCCEEEEEEECCCCCCCEEEEEEECCCCCCCCEEEEECCCCCCHHHHHHHH
KQCSNPDGGIVFAYEVSDPERYGVVEFDAANKAVSIEEKPTAPKSNFAVVGLYFYDNRVV
HHHCCCCCCEEEEEECCCCCCCCEEEECCCCCEEEECCCCCCCCCCEEEEEEEEECCCCE
DIAKSIKPSSRGELEITSINDAYLQQGALTVQRLDRGDVWLDTGTIDSMSEASSYVEVLQ
EHHHHCCCCCCCCEEEEECCHHHHHCCCEEEEECCCCCEEEECCCCCCHHHHHHHHHHHH
KRTGNIIGSPEVAAYREGFITASELTALGEELKKSGYGNYLLRAV
HHCCCCCCCCCHHHHHHCCEEHHHHHHHHHHHHHCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12397186 [H]