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The map label for this gene is 145294442

Identifier: 145294442

GI number: 145294442

Start: 431833

End: 433338

Strand: Reverse

Name: 145294442

Synonym: cgR_0397

Alternate gene names: NA

Gene position: 433338-431833 (Counterclockwise)

Preceding gene: 145294444

Following gene: 145294438

Centisome position: 13.08

GC content: 59.03

Gene sequence:

>1506_bases
TTGAAATGGCTGTGGGGCACATCGTGGCCGCTGTATGCTGCGACGGTGCTCGGCACGAATGTGTTTGGTGCGCTCGCAGT
AATGCTGTTTGTGCGCTTCCTCATTCCGCAGCCAGATGCTTCAAATTTCAACGCTGAGATCTCGTATCTGCCAGCTGTTG
GTTTCGCATACCTGGCGTTCGCCATTGTCGCGGGCATGCTGGTGACATTTTTGATGTTCCGCCCGGTGCTTGATTGGCAG
CGAAGCCCTGAAGATCATGACCGAAATATGGTGCGCAACTTGGTTATGCGCATCCCCATCTACCAGGCAATTCTGTGCGC
AGTGGTGTGGTTAATCGGCATTGCAATTGCAACGTTGATTTCGGCCAGTGTGTCTACCAGTTTGGCGCTGGTCGTGGCGT
TTTCCACGTTGATGGCTGCCGCAATCGTCGTGCTGCTCACCTTCCTTGAGGCTGAGCGTTTGGTGCGTCCGGTTGCTGCG
TCTGCCCTGGCGCGTCGATTTGAGGATTCCACGCTGGAACCACCTGTGAGCCAGCGCTTGCGTATGACGTGGTTGCTGAC
GTTGGGCATTCCAGTGATGGGAATTCTGCTGCTTATTTGGGGCTACTCGCAGGGCATTTTCGGCTCTGATGCCTCCGGAA
TTATGCCTGCCATCGCAGCGCTCGCGTTTGCATCGTTGGTCACGGGTTACCTGGGCAACCGGCTTGTGGTGTCCTCTGTG
GTGGATCCGATTCGGGAACTTCAGGAGGCCATCAACAGGGTGCGCCGCGGTGAAAACGATGTGCAGGTTGATATTTATGA
CGGCTCCGAAATCGGCGTGCTGCAGGCCGGATTCAATGAAATGATGCGTGGCCTGCGTGAACGTCAGCGCGTCCGTGACC
TTTTCGGTCGCTACGTGGGCGCTGAAGTGGCCAAGCGTGCGCTGGAGGAACGCCCCACTCTGGGTGGCGAGGACCGTAAG
GTTGCCGTGCTGTTTGTCGATGTCATCGGCTCCACCACCTTTGCCGTCAACCACACTCCTGAAGAGGTTGTGGAGGCGCT
CAATGAGTTCTTCGAGCACGTCGTGGAGGTTGTGCACCGCAACAAGGGTGTTATCAACAAGTTCCAGGGTGACGCGGCGT
TGGCGATTTTCGGCGCGCCCCTGCCCCTGTCTGATGCCACCGGTCATGCGCTTGCGGCTGCCCGTGAGCTCCGCGCAGAG
CTGAAAGATCTCCAGCTCAAGGCCGGAATTGGTGTGGCTGCTGGCCATGTCGTTGCTGGTCACATCGGTGGGCACGCCAG
GTTTGAGTACACCGTCATCGGCGACGCAGTCAACCAGGCTGCGCGCCTGACGGAGATCGCGAAAACGACCCCAGGCCGCA
CCGTCACCAACGCTTCCACGCTGCGTGAGGCCAACGAGGCGGAGCAGGCTCGCTGGACGCTCATGAAGTCCGTGGAGCTG
CGCGGACGCGGCCAGATGACGCAGATTGCGCGGCCTATTCGGCCGACGTTGGCGGACAGGTCCTAA

Upstream 100 bases:

>100_bases
ACTCGAATTAGTCACGATCTCTACACTACTTCCTCACTACATCCTCGCGATGTCGCACCGGCACGTTAGAGTATTGAGCA
TGAGTCGATTGCTTAGAGCA

Downstream 100 bases:

>100_bases
TTCGCTTTTCGACGCAAAAATCCCCCGTTTCACACTGTGAGACGGGGGATTTTTCTCTTGGCAACGCCAATGAGCTAGTC
CGAAAACAACCCATCTACTA

Product: hypothetical protein

Products: 3',5'-cyclic AMP; diphosphate

Alternate protein names: NA

Number of amino acids: Translated: 501; Mature: 501

Protein sequence:

>501_residues
MKWLWGTSWPLYAATVLGTNVFGALAVMLFVRFLIPQPDASNFNAEISYLPAVGFAYLAFAIVAGMLVTFLMFRPVLDWQ
RSPEDHDRNMVRNLVMRIPIYQAILCAVVWLIGIAIATLISASVSTSLALVVAFSTLMAAAIVVLLTFLEAERLVRPVAA
SALARRFEDSTLEPPVSQRLRMTWLLTLGIPVMGILLLIWGYSQGIFGSDASGIMPAIAALAFASLVTGYLGNRLVVSSV
VDPIRELQEAINRVRRGENDVQVDIYDGSEIGVLQAGFNEMMRGLRERQRVRDLFGRYVGAEVAKRALEERPTLGGEDRK
VAVLFVDVIGSTTFAVNHTPEEVVEALNEFFEHVVEVVHRNKGVINKFQGDAALAIFGAPLPLSDATGHALAAARELRAE
LKDLQLKAGIGVAAGHVVAGHIGGHARFEYTVIGDAVNQAARLTEIAKTTPGRTVTNASTLREANEAEQARWTLMKSVEL
RGRGQMTQIARPIRPTLADRS

Sequences:

>Translated_501_residues
MKWLWGTSWPLYAATVLGTNVFGALAVMLFVRFLIPQPDASNFNAEISYLPAVGFAYLAFAIVAGMLVTFLMFRPVLDWQ
RSPEDHDRNMVRNLVMRIPIYQAILCAVVWLIGIAIATLISASVSTSLALVVAFSTLMAAAIVVLLTFLEAERLVRPVAA
SALARRFEDSTLEPPVSQRLRMTWLLTLGIPVMGILLLIWGYSQGIFGSDASGIMPAIAALAFASLVTGYLGNRLVVSSV
VDPIRELQEAINRVRRGENDVQVDIYDGSEIGVLQAGFNEMMRGLRERQRVRDLFGRYVGAEVAKRALEERPTLGGEDRK
VAVLFVDVIGSTTFAVNHTPEEVVEALNEFFEHVVEVVHRNKGVINKFQGDAALAIFGAPLPLSDATGHALAAARELRAE
LKDLQLKAGIGVAAGHVVAGHIGGHARFEYTVIGDAVNQAARLTEIAKTTPGRTVTNASTLREANEAEQARWTLMKSVEL
RGRGQMTQIARPIRPTLADRS
>Mature_501_residues
MKWLWGTSWPLYAATVLGTNVFGALAVMLFVRFLIPQPDASNFNAEISYLPAVGFAYLAFAIVAGMLVTFLMFRPVLDWQ
RSPEDHDRNMVRNLVMRIPIYQAILCAVVWLIGIAIATLISASVSTSLALVVAFSTLMAAAIVVLLTFLEAERLVRPVAA
SALARRFEDSTLEPPVSQRLRMTWLLTLGIPVMGILLLIWGYSQGIFGSDASGIMPAIAALAFASLVTGYLGNRLVVSSV
VDPIRELQEAINRVRRGENDVQVDIYDGSEIGVLQAGFNEMMRGLRERQRVRDLFGRYVGAEVAKRALEERPTLGGEDRK
VAVLFVDVIGSTTFAVNHTPEEVVEALNEFFEHVVEVVHRNKGVINKFQGDAALAIFGAPLPLSDATGHALAAARELRAE
LKDLQLKAGIGVAAGHVVAGHIGGHARFEYTVIGDAVNQAARLTEIAKTTPGRTVTNASTLREANEAEQARWTLMKSVEL
RGRGQMTQIARPIRPTLADRS

Specific function: Unknown

COG id: COG2114

COG function: function code T; Adenylate cyclase, family 3 (some proteins contain HAMP domain)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HAMP domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR003660 [H]

Pfam domain/function: PF00211 Guanylate_cyc; PF00672 HAMP [H]

EC number: 4.6.1.1

Molecular weight: Translated: 54626; Mature: 54626

Theoretical pI: Translated: 7.82; Mature: 7.82

Prosite motif: PS50885 HAMP ; PS50125 GUANYLATE_CYCLASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCHHHHHHCCCCCCCCCC
>Mature Secondary Structure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CCCCCHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP

Specific reaction: ATP = 3',5'-cyclic AMP + diphosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]