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The map label for this gene is ureC

Identifier: 145294147

GI number: 145294147

Start: 120155

End: 121867

Strand: Direct

Name: ureC

Synonym: cgR_0105

Alternate gene names: 145294147

Gene position: 120155-121867 (Clockwise)

Preceding gene: 145294146

Following gene: 145294148

Centisome position: 3.63

GC content: 52.31

Gene sequence:

>1713_bases
ATGAGTTTTGAAATTTCCCGCAAGCAGTACACCGACCTTTATGGTCCAACCGTTGGCGATTCAGTACGTCTTGCTGATAC
TGAGCTTTTTCTCTGTGTGGAAAAAGATTACGCAGCAATCGGCGAAGAAGTAGCATTCGGCGGTGGCAAGGTCATTCGTG
ATGGCATGGGCCAAAATGGCACCTTGGTTCGCGATGTAGATATTCCCGATACCGTCATCACCAACGTCATCGTCCTTGAC
TATACGGGTGTGTACAAAGCTGACGTTGCGCTTCGAGATGGCAAAATCTTCCGAATCGGAAAGGCCGGAAACCCGAATGT
CATGGAAAACGTCGACATCGTCATCGGCGTTGCAACCGACATCATTGCTGGTGAAGGCAAGATCCTAACTGCAGGTGGCA
TTGATACTCACGTGCACTTCTTGGGCACAGACCAGGTCAACACTGCATTAGCGTCAGGCATCACCACGATGATCGGTGGA
GGCACCGGCCCAAGCCAGGCGTCGATGGCTACAACTGTCACGCCAGGTCAGTGGAATACCTACAACATGCTTAGTGCTTT
TGAAGGCATGCCCATGAACTTTGGCATTTTGGGTAAAGGCCATGGTTCTTCCAAATCTCCGCTGGCTGAGCAGGTTCGTG
CGGGTGCAATCGGTCTGAAAATTCACGAGGACTGGGGTGCCACACCATCGTCGATCAACACTGCCCTAGAAGTGGCCGAT
GATATGGACATCCAGGTGGCACTCCACTCCGATACCTTGAATGAGGCCGGTTTTGTGGAAGACACCATTGAAGCCATTGC
GGGCCGAGTCATCCATACCTTCCACACCGAAGGTGCTGGTGGTGGACACGCTCCTGACCTAATCCGAGTGGCTGCTCTGC
CAAACGTGTTGCCTGCATCCACCAACCCAACGCTTCCGTACACCAGAAACACTGTTGAAGAGCACCTGGATATGGTGATG
GTTGCCCACCACCTCAACCCAGATATTCCAGAAGACGTGGCTTTTGCGGATTCCCGTATTCGTGCGGAAACCATTGCTGC
CGAAGACGTGCTTCACGATATGGGCATTTTCTCTATTACTTCATCGGATTCCCAGGCGATGGGCCGAGTTGGAGAGACCA
TCACACGCACGTGGCAGGTCGCTGACCACATGAAACGCACCCGTGGATCACTAACGGGAGATGCTCCATACAACGACAAC
AACCGCTTGCGTCGATTCATCGCAAAGTACACCATCAACCCTGCGATTGCGCACGGTGTGGATTATGTTGTCGGTTCAGT
GGAGGAAGGCAAGTTCGCTGACCTCGTGCTGTGGGATCCAAAGTTCTTTGGTGTGAAACCTGATCTGGTGATCAAGGGTG
GGTTGATGGTGAACTCGCTCATGGGTGATTCCAACGGTTCCATTCCAACTCCGCAGCCCCGCACCCTGCGCAATACTTGG
GGTGCGTTTGGCCAGGCAGTTTCCAGAAGCTCCATTACATTCCTATCCCAGGATGCTATCGATGCAAATGTTCCTGATCT
GCTGAATCTGAGGAAGCAGATCCGGGGCGTTCGAGGTGTAAGGAATCTGACCAAACGAGACATGAAACTCAATGCAGAAA
TGCCTGATATTCGTGTCGATCCAGAGACCTACCAGGTGTTTGTCAACGGTGAGTTGATCACCAGCAAGCCAGCAGAGACA
GTGCCAATGGCACGTCGCTACTTCTTGTTCTAA

Upstream 100 bases:

>100_bases
ACAAGAATTGCCACAGGTCGAAGCTGCTGAACGTGGCCGGAAACTAGATGAGGCCACTGACGTGGGCACAGAAGATACCC
CGGAAGAAGGTCAAAATTAA

Downstream 100 bases:

>100_bases
TCCGCCAACAAGGAAGGAAGATCCATGATTATCACTGCGATCGACACCAACATCTACGATCAACCGGAGTTTGTTGAAGG
ACGCGATGTCATCGGTGTGC

Product: urease subunit alpha

Products: NA

Alternate protein names: Urea amidohydrolase subunit alpha

Number of amino acids: Translated: 570; Mature: 569

Protein sequence:

>570_residues
MSFEISRKQYTDLYGPTVGDSVRLADTELFLCVEKDYAAIGEEVAFGGGKVIRDGMGQNGTLVRDVDIPDTVITNVIVLD
YTGVYKADVALRDGKIFRIGKAGNPNVMENVDIVIGVATDIIAGEGKILTAGGIDTHVHFLGTDQVNTALASGITTMIGG
GTGPSQASMATTVTPGQWNTYNMLSAFEGMPMNFGILGKGHGSSKSPLAEQVRAGAIGLKIHEDWGATPSSINTALEVAD
DMDIQVALHSDTLNEAGFVEDTIEAIAGRVIHTFHTEGAGGGHAPDLIRVAALPNVLPASTNPTLPYTRNTVEEHLDMVM
VAHHLNPDIPEDVAFADSRIRAETIAAEDVLHDMGIFSITSSDSQAMGRVGETITRTWQVADHMKRTRGSLTGDAPYNDN
NRLRRFIAKYTINPAIAHGVDYVVGSVEEGKFADLVLWDPKFFGVKPDLVIKGGLMVNSLMGDSNGSIPTPQPRTLRNTW
GAFGQAVSRSSITFLSQDAIDANVPDLLNLRKQIRGVRGVRNLTKRDMKLNAEMPDIRVDPETYQVFVNGELITSKPAET
VPMARRYFLF

Sequences:

>Translated_570_residues
MSFEISRKQYTDLYGPTVGDSVRLADTELFLCVEKDYAAIGEEVAFGGGKVIRDGMGQNGTLVRDVDIPDTVITNVIVLD
YTGVYKADVALRDGKIFRIGKAGNPNVMENVDIVIGVATDIIAGEGKILTAGGIDTHVHFLGTDQVNTALASGITTMIGG
GTGPSQASMATTVTPGQWNTYNMLSAFEGMPMNFGILGKGHGSSKSPLAEQVRAGAIGLKIHEDWGATPSSINTALEVAD
DMDIQVALHSDTLNEAGFVEDTIEAIAGRVIHTFHTEGAGGGHAPDLIRVAALPNVLPASTNPTLPYTRNTVEEHLDMVM
VAHHLNPDIPEDVAFADSRIRAETIAAEDVLHDMGIFSITSSDSQAMGRVGETITRTWQVADHMKRTRGSLTGDAPYNDN
NRLRRFIAKYTINPAIAHGVDYVVGSVEEGKFADLVLWDPKFFGVKPDLVIKGGLMVNSLMGDSNGSIPTPQPRTLRNTW
GAFGQAVSRSSITFLSQDAIDANVPDLLNLRKQIRGVRGVRNLTKRDMKLNAEMPDIRVDPETYQVFVNGELITSKPAET
VPMARRYFLF
>Mature_569_residues
SFEISRKQYTDLYGPTVGDSVRLADTELFLCVEKDYAAIGEEVAFGGGKVIRDGMGQNGTLVRDVDIPDTVITNVIVLDY
TGVYKADVALRDGKIFRIGKAGNPNVMENVDIVIGVATDIIAGEGKILTAGGIDTHVHFLGTDQVNTALASGITTMIGGG
TGPSQASMATTVTPGQWNTYNMLSAFEGMPMNFGILGKGHGSSKSPLAEQVRAGAIGLKIHEDWGATPSSINTALEVADD
MDIQVALHSDTLNEAGFVEDTIEAIAGRVIHTFHTEGAGGGHAPDLIRVAALPNVLPASTNPTLPYTRNTVEEHLDMVMV
AHHLNPDIPEDVAFADSRIRAETIAAEDVLHDMGIFSITSSDSQAMGRVGETITRTWQVADHMKRTRGSLTGDAPYNDNN
RLRRFIAKYTINPAIAHGVDYVVGSVEEGKFADLVLWDPKFFGVKPDLVIKGGLMVNSLMGDSNGSIPTPQPRTLRNTWG
AFGQAVSRSSITFLSQDAIDANVPDLLNLRKQIRGVRGVRNLTKRDMKLNAEMPDIRVDPETYQVFVNGELITSKPAETV
PMARRYFLF

Specific function: Unknown

COG id: COG0804

COG function: function code E; Urea amidohydrolase (urease) alpha subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 urease domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): URE1_CORGL (Q79VJ3)

Other databases:

- EMBL:   AB029154
- EMBL:   AJ251883
- EMBL:   BA000036
- EMBL:   BX927148
- RefSeq:   NP_599338.1
- RefSeq:   YP_224383.1
- ProteinModelPortal:   Q79VJ3
- SMR:   Q79VJ3
- GeneID:   1021080
- GeneID:   3342915
- GenomeReviews:   BA000036_GR
- GenomeReviews:   BX927147_GR
- KEGG:   cgb:cg0115
- KEGG:   cgl:NCgl0085
- HOGENOM:   HBG357507
- OMA:   TIHAFHT
- ProtClustDB:   PRK13207
- BioCyc:   CGLU196627:CG0115-MONOMER
- BRENDA:   3.5.1.5
- GO:   GO:0005737
- HAMAP:   MF_01953
- InterPro:   IPR006680
- InterPro:   IPR011059
- InterPro:   IPR011612
- InterPro:   IPR005848
- InterPro:   IPR017951
- PRINTS:   PR01752
- TIGRFAMs:   TIGR01792

Pfam domain/function: PF01979 Amidohydro_1; PF00449 Urease_alpha; SSF51338 Metalo_hydrolase

EC number: =3.5.1.5

Molecular weight: Translated: 61452; Mature: 61321

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS01120 UREASE_1; PS00145 UREASE_2; PS51368 UREASE_3; PS00024 HEMOPEXIN

Important sites: ACT_SITE 323-323 BINDING 222-222

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFEISRKQYTDLYGPTVGDSVRLADTELFLCVEKDYAAIGEEVAFGGGKVIRDGMGQNG
CCCCCCHHHHHHHCCCCCCCCEEEECCEEEEEEECCHHHCCCHHCCCCCHHEECCCCCCC
TLVRDVDIPDTVITNVIVLDYTGVYKADVALRDGKIFRIGKAGNPNVMENVDIVIGVATD
CEEEECCCCHHHHCEEEEEECCCCEEEEEEEECCCEEEECCCCCCCCCCCCEEEEEEEHH
IIAGEGKILTAGGIDTHVHFLGTDQVNTALASGITTMIGGGTGPSQASMATTVTPGQWNT
EEECCCCEEEECCCCEEEEEEECCHHHHHHHHCHHHEECCCCCCCCCCEEEEECCCCCCC
YNMLSAFEGMPMNFGILGKGHGSSKSPLAEQVRAGAIGLKIHEDWGATPSSINTALEVAD
HHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHCCEEEEEEECCCCCCHHHHHHHHHCCC
DMDIQVALHSDTLNEAGFVEDTIEAIAGRVIHTFHTEGAGGGHAPDLIRVAALPNVLPAS
CCEEEEEEECCCCCCCCCHHHHHHHHHHHEEEEEECCCCCCCCCCHHEEEHHCCCCCCCC
TNPTLPYTRNTVEEHLDMVMVAHHLNPDIPEDVAFADSRIRAETIAAEDVLHDMGIFSIT
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCHHHHHHHHHHHHHHHCCEEEEE
SSDSQAMGRVGETITRTWQVADHMKRTRGSLTGDAPYNDNNRLRRFIAKYTINPAIAHGV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHCH
DYVVGSVEEGKFADLVLWDPKFFGVKPDLVIKGGLMVNSLMGDSNGSIPTPQPRTLRNTW
HHHCCCCCCCCEEEEEEECCHHCCCCCCEEEECCEEEEEEECCCCCCCCCCCCCHHHHHH
GAFGQAVSRSSITFLSQDAIDANVPDLLNLRKQIRGVRGVRNLTKRDMKLNAEMPDIRVD
HHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCCCEEC
PETYQVFVNGELITSKPAETVPMARRYFLF
CCEEEEEECCEEEECCCCCHHHHHHHHHCC
>Mature Secondary Structure 
SFEISRKQYTDLYGPTVGDSVRLADTELFLCVEKDYAAIGEEVAFGGGKVIRDGMGQNG
CCCCCHHHHHHHCCCCCCCCEEEECCEEEEEEECCHHHCCCHHCCCCCHHEECCCCCCC
TLVRDVDIPDTVITNVIVLDYTGVYKADVALRDGKIFRIGKAGNPNVMENVDIVIGVATD
CEEEECCCCHHHHCEEEEEECCCCEEEEEEEECCCEEEECCCCCCCCCCCCEEEEEEEHH
IIAGEGKILTAGGIDTHVHFLGTDQVNTALASGITTMIGGGTGPSQASMATTVTPGQWNT
EEECCCCEEEECCCCEEEEEEECCHHHHHHHHCHHHEECCCCCCCCCCEEEEECCCCCCC
YNMLSAFEGMPMNFGILGKGHGSSKSPLAEQVRAGAIGLKIHEDWGATPSSINTALEVAD
HHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHCCEEEEEEECCCCCCHHHHHHHHHCCC
DMDIQVALHSDTLNEAGFVEDTIEAIAGRVIHTFHTEGAGGGHAPDLIRVAALPNVLPAS
CCEEEEEEECCCCCCCCCHHHHHHHHHHHEEEEEECCCCCCCCCCHHEEEHHCCCCCCCC
TNPTLPYTRNTVEEHLDMVMVAHHLNPDIPEDVAFADSRIRAETIAAEDVLHDMGIFSIT
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCHHHHHHHHHHHHHHHCCEEEEE
SSDSQAMGRVGETITRTWQVADHMKRTRGSLTGDAPYNDNNRLRRFIAKYTINPAIAHGV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHCH
DYVVGSVEEGKFADLVLWDPKFFGVKPDLVIKGGLMVNSLMGDSNGSIPTPQPRTLRNTW
HHHCCCCCCCCEEEEEEECCHHCCCCCCEEEECCEEEEEEECCCCCCCCCCCCCHHHHHH
GAFGQAVSRSSITFLSQDAIDANVPDLLNLRKQIRGVRGVRNLTKRDMKLNAEMPDIRVD
HHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCCCEEC
PETYQVFVNGELITSKPAETVPMARRYFLF
CCEEEEEECCEEEECCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11328647; 10930756; 12948626