| Definition | Corynebacterium glutamicum R chromosome, complete genome. |
|---|---|
| Accession | NC_009342 |
| Length | 3,314,179 |
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The map label for this gene is ppiA [H]
Identifier: 145294090
GI number: 145294090
Start: 54774
End: 55346
Strand: Direct
Name: ppiA [H]
Synonym: cgR_0048
Alternate gene names: 145294090
Gene position: 54774-55346 (Clockwise)
Preceding gene: 145294088
Following gene: 145294091
Centisome position: 1.65
GC content: 57.07
Gene sequence:
>573_bases ATGGGACATGTGGTTGGCATTTCGCTCGATGTAGTTATGATGGGCGTTATGACTTCTAAGACCGCAACTGCGATTCTGCA TACAAATCGCGGAGACATCACCATCGACCTGTTCGGCAACCACGCTCCAGAGACCGTCGCTAACTTCGTTGGCCTCGCTC AGGGCACCAAAGAGTACCAGGCCCAGAACGCTCAGGGCGACAGCGAAGGTCCGTTCTACAACGGATCTGTCTTCCACCGC GTCATCGACGGCTTCATGATCCAGGGTGGAGACCCAACCGGCACCGGCCGTGGCGGCCCTGGCTACACCTTCGCTGATGA ATTCCACCCAGAGCTGCGCTTCGACCGCGCATACCTGCTGGCAATGGCAAATGCGGGCCCAGGCACCAACGGTTCCCAGT TCTTCATCACTGTGACCCCAACCCCTCACCTGAACAACGCTCACACCATCTTCGGTGAGGTCACTGACGCTGAGTCTCAG AAGGTTGTGGATGCAATTGCAACCACCGCAACTGATCGTTACGACCGCCCAGCTGACGCAGTTGTCATCGAGTCTGTAGA GATCACCGCGTAA
Upstream 100 bases:
>100_bases TACGTGCGCCATCCACCACTAACTTGAGGTTGCCAATCGTGCTCATATTCAACTCTCCTTAATTGGTCGCTTTCTTCTAA GACCCCACATTAGTAAAAGC
Downstream 100 bases:
>100_bases CAGCCACCTCTACGTACACTAATCTTCAGGTTATGCCGCAAGCCGGTATGACCTGATTTTTTTATGCCACAAAAACCTGT TGAAAGACGAGTTGAAGATT
Product: hypothetical protein
Products: NA
Alternate protein names: PPIase A; Rotamase A [H]
Number of amino acids: Translated: 190; Mature: 189
Protein sequence:
>190_residues MGHVVGISLDVVMMGVMTSKTATAILHTNRGDITIDLFGNHAPETVANFVGLAQGTKEYQAQNAQGDSEGPFYNGSVFHR VIDGFMIQGGDPTGTGRGGPGYTFADEFHPELRFDRAYLLAMANAGPGTNGSQFFITVTPTPHLNNAHTIFGEVTDAESQ KVVDAIATTATDRYDRPADAVVIESVEITA
Sequences:
>Translated_190_residues MGHVVGISLDVVMMGVMTSKTATAILHTNRGDITIDLFGNHAPETVANFVGLAQGTKEYQAQNAQGDSEGPFYNGSVFHR VIDGFMIQGGDPTGTGRGGPGYTFADEFHPELRFDRAYLLAMANAGPGTNGSQFFITVTPTPHLNNAHTIFGEVTDAESQ KVVDAIATTATDRYDRPADAVVIESVEITA >Mature_189_residues GHVVGISLDVVMMGVMTSKTATAILHTNRGDITIDLFGNHAPETVANFVGLAQGTKEYQAQNAQGDSEGPFYNGSVFHRV IDGFMIQGGDPTGTGRGGPGYTFADEFHPELRFDRAYLLAMANAGPGTNGSQFFITVTPTPHLNNAHTIFGEVTDAESQK VVDAIATTATDRYDRPADAVVIESVEITA
Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]
COG id: COG0652
COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family
Gene ontology:
Cell location: Cytoplasm [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 PPIase cyclophilin-type domain [H]
Homologues:
Organism=Homo sapiens, GI24308049, Length=170, Percent_Identity=47.6470588235294, Blast_Score=146, Evalue=1e-35, Organism=Homo sapiens, GI7706339, Length=161, Percent_Identity=47.8260869565217, Blast_Score=142, Evalue=2e-34, Organism=Homo sapiens, GI64276486, Length=167, Percent_Identity=41.9161676646707, Blast_Score=128, Evalue=3e-30, Organism=Homo sapiens, GI19557636, Length=172, Percent_Identity=40.6976744186046, Blast_Score=121, Evalue=3e-28, Organism=Homo sapiens, GI6631100, Length=161, Percent_Identity=44.7204968944099, Blast_Score=113, Evalue=8e-26, Organism=Homo sapiens, GI4505991, Length=163, Percent_Identity=47.239263803681, Blast_Score=112, Evalue=2e-25, Organism=Homo sapiens, GI42560244, Length=167, Percent_Identity=40.1197604790419, Blast_Score=107, Evalue=5e-24, Organism=Homo sapiens, GI4758950, Length=157, Percent_Identity=42.6751592356688, Blast_Score=103, Evalue=1e-22, Organism=Homo sapiens, GI4826932, Length=160, Percent_Identity=41.875, Blast_Score=100, Evalue=9e-22, Organism=Homo sapiens, GI22547212, Length=181, Percent_Identity=37.0165745856354, Blast_Score=96, Evalue=1e-20, Organism=Homo sapiens, GI7657473, Length=181, Percent_Identity=37.0165745856354, Blast_Score=96, Evalue=1e-20, Organism=Homo sapiens, GI22547215, Length=181, Percent_Identity=37.0165745856354, Blast_Score=96, Evalue=2e-20, Organism=Homo sapiens, GI256017253, Length=139, Percent_Identity=41.726618705036, Blast_Score=91, Evalue=7e-19, Organism=Homo sapiens, GI221139811, Length=139, Percent_Identity=41.726618705036, Blast_Score=91, Evalue=7e-19, Organism=Homo sapiens, GI256017251, Length=139, Percent_Identity=41.726618705036, Blast_Score=91, Evalue=7e-19, Organism=Homo sapiens, GI10863927, Length=139, Percent_Identity=38.1294964028777, Blast_Score=91, Evalue=8e-19, Organism=Homo sapiens, GI5454154, Length=163, Percent_Identity=38.0368098159509, Blast_Score=89, Evalue=3e-18, Organism=Homo sapiens, GI178057341, Length=140, Percent_Identity=40.7142857142857, Blast_Score=88, Evalue=4e-18, Organism=Homo sapiens, GI209417936, Length=139, Percent_Identity=38.1294964028777, Blast_Score=87, Evalue=8e-18, Organism=Homo sapiens, GI30102944, Length=139, Percent_Identity=38.1294964028777, Blast_Score=87, Evalue=8e-18, Organism=Homo sapiens, GI219842199, Length=139, Percent_Identity=38.1294964028777, Blast_Score=87, Evalue=8e-18, Organism=Homo sapiens, GI310129267, Length=139, Percent_Identity=36.6906474820144, Blast_Score=84, Evalue=5e-17, Organism=Homo sapiens, GI310120620, Length=139, Percent_Identity=36.6906474820144, Blast_Score=84, Evalue=5e-17, Organism=Homo sapiens, GI150418007, Length=131, Percent_Identity=39.6946564885496, Blast_Score=84, Evalue=8e-17, Organism=Homo sapiens, GI169164185, Length=139, Percent_Identity=37.410071942446, Blast_Score=82, Evalue=2e-16, Organism=Homo sapiens, GI169163623, Length=139, Percent_Identity=37.410071942446, Blast_Score=82, Evalue=2e-16, Organism=Homo sapiens, GI169163387, Length=139, Percent_Identity=37.410071942446, Blast_Score=82, Evalue=2e-16, Organism=Homo sapiens, GI20911035, Length=161, Percent_Identity=32.9192546583851, Blast_Score=82, Evalue=3e-16, Organism=Homo sapiens, GI310110104, Length=139, Percent_Identity=35.9712230215827, Blast_Score=81, Evalue=5e-16, Organism=Homo sapiens, GI5031987, Length=157, Percent_Identity=37.5796178343949, Blast_Score=80, Evalue=9e-16, Organism=Homo sapiens, GI310127646, Length=139, Percent_Identity=34.5323741007194, Blast_Score=79, Evalue=3e-15, Organism=Homo sapiens, GI310114371, Length=139, Percent_Identity=34.5323741007194, Blast_Score=79, Evalue=3e-15, Organism=Homo sapiens, GI310119221, Length=139, Percent_Identity=34.5323741007194, Blast_Score=79, Evalue=3e-15, Organism=Homo sapiens, GI169214050, Length=139, Percent_Identity=35.2517985611511, Blast_Score=77, Evalue=8e-15, Organism=Homo sapiens, GI5174637, Length=156, Percent_Identity=35.2564102564103, Blast_Score=77, Evalue=1e-14, Organism=Homo sapiens, GI239751853, Length=139, Percent_Identity=35.2517985611511, Blast_Score=77, Evalue=1e-14, Organism=Homo sapiens, GI113428306, Length=139, Percent_Identity=35.2517985611511, Blast_Score=77, Evalue=1e-14, Organism=Homo sapiens, GI303305009, Length=129, Percent_Identity=37.984496124031, Blast_Score=77, Evalue=1e-14, Organism=Homo sapiens, GI45439316, Length=129, Percent_Identity=37.984496124031, Blast_Score=76, Evalue=1e-14, Organism=Homo sapiens, GI310132444, Length=129, Percent_Identity=34.8837209302326, Blast_Score=74, Evalue=8e-14, Organism=Homo sapiens, GI310113152, Length=129, Percent_Identity=34.8837209302326, Blast_Score=74, Evalue=8e-14, Organism=Homo sapiens, GI27735045, Length=143, Percent_Identity=32.1678321678322, Blast_Score=67, Evalue=7e-12, Organism=Homo sapiens, GI310127745, Length=137, Percent_Identity=34.3065693430657, Blast_Score=67, Evalue=7e-12, Organism=Homo sapiens, GI310119290, Length=137, Percent_Identity=34.3065693430657, Blast_Score=67, Evalue=7e-12, Organism=Homo sapiens, GI310114540, Length=137, Percent_Identity=34.3065693430657, Blast_Score=67, Evalue=8e-12, Organism=Escherichia coli, GI1786736, Length=178, Percent_Identity=35.9550561797753, Blast_Score=84, Evalue=4e-18, Organism=Caenorhabditis elegans, GI17539496, Length=162, Percent_Identity=48.1481481481481, Blast_Score=141, Evalue=2e-34, Organism=Caenorhabditis elegans, GI17506311, Length=170, Percent_Identity=47.6470588235294, Blast_Score=139, Evalue=7e-34, Organism=Caenorhabditis elegans, GI17551282, Length=157, Percent_Identity=47.1337579617834, Blast_Score=114, Evalue=4e-26, Organism=Caenorhabditis elegans, GI17551284, Length=157, Percent_Identity=47.1337579617834, Blast_Score=113, Evalue=5e-26, Organism=Caenorhabditis elegans, GI71997782, Length=140, Percent_Identity=42.1428571428571, Blast_Score=113, Evalue=7e-26, Organism=Caenorhabditis elegans, GI71980594, Length=171, Percent_Identity=38.0116959064327, Blast_Score=110, Evalue=3e-25, Organism=Caenorhabditis elegans, GI17552784, Length=160, Percent_Identity=43.125, Blast_Score=110, Evalue=5e-25, Organism=Caenorhabditis elegans, GI71980590, Length=158, Percent_Identity=38.6075949367089, Blast_Score=108, Evalue=2e-24, Organism=Caenorhabditis elegans, GI17532641, Length=174, Percent_Identity=38.5057471264368, Blast_Score=104, Evalue=3e-23, Organism=Caenorhabditis elegans, GI17552780, Length=157, Percent_Identity=45.859872611465, Blast_Score=102, Evalue=9e-23, Organism=Caenorhabditis elegans, GI17506307, Length=157, Percent_Identity=45.859872611465, Blast_Score=102, Evalue=1e-22, Organism=Caenorhabditis elegans, GI17565860, Length=157, Percent_Identity=42.6751592356688, Blast_Score=97, Evalue=5e-21, Organism=Caenorhabditis elegans, GI17559074, Length=165, Percent_Identity=35.7575757575758, Blast_Score=92, Evalue=1e-19, Organism=Caenorhabditis elegans, GI17566266, Length=132, Percent_Identity=40.1515151515151, Blast_Score=86, Evalue=1e-17, Organism=Caenorhabditis elegans, GI17532643, Length=157, Percent_Identity=40.1273885350318, Blast_Score=83, Evalue=7e-17, Organism=Caenorhabditis elegans, GI32563659, Length=170, Percent_Identity=31.1764705882353, Blast_Score=82, Evalue=1e-16, Organism=Caenorhabditis elegans, GI17539498, Length=162, Percent_Identity=36.4197530864198, Blast_Score=79, Evalue=2e-15, Organism=Caenorhabditis elegans, GI17552782, Length=162, Percent_Identity=36.4197530864198, Blast_Score=79, Evalue=2e-15, Organism=Saccharomyces cerevisiae, GI6323246, Length=162, Percent_Identity=38.2716049382716, Blast_Score=108, Evalue=7e-25, Organism=Saccharomyces cerevisiae, GI6323562, Length=169, Percent_Identity=42.0118343195266, Blast_Score=105, Evalue=6e-24, Organism=Saccharomyces cerevisiae, GI6320510, Length=179, Percent_Identity=41.340782122905, Blast_Score=100, Evalue=2e-22, Organism=Saccharomyces cerevisiae, GI6321848, Length=175, Percent_Identity=41.7142857142857, Blast_Score=99, Evalue=4e-22, Organism=Saccharomyces cerevisiae, GI6320359, Length=162, Percent_Identity=40.7407407407407, Blast_Score=98, Evalue=1e-21, Organism=Saccharomyces cerevisiae, GI6322492, Length=169, Percent_Identity=35.5029585798817, Blast_Score=80, Evalue=2e-16, Organism=Saccharomyces cerevisiae, GI6319914, Length=171, Percent_Identity=31.5789473684211, Blast_Score=69, Evalue=6e-13, Organism=Drosophila melanogaster, GI17986117, Length=166, Percent_Identity=47.5903614457831, Blast_Score=140, Evalue=4e-34, Organism=Drosophila melanogaster, GI19922912, Length=168, Percent_Identity=47.0238095238095, Blast_Score=125, Evalue=2e-29, Organism=Drosophila melanogaster, GI21357249, Length=138, Percent_Identity=42.7536231884058, Blast_Score=119, Evalue=2e-27, Organism=Drosophila melanogaster, GI19922376, Length=174, Percent_Identity=37.3563218390805, Blast_Score=117, Evalue=4e-27, Organism=Drosophila melanogaster, GI24650807, Length=163, Percent_Identity=41.7177914110429, Blast_Score=112, Evalue=1e-25, Organism=Drosophila melanogaster, GI20130249, Length=157, Percent_Identity=45.2229299363057, Blast_Score=103, Evalue=9e-23, Organism=Drosophila melanogaster, GI24652460, Length=137, Percent_Identity=37.956204379562, Blast_Score=98, Evalue=4e-21, Organism=Drosophila melanogaster, GI17136360, Length=177, Percent_Identity=36.1581920903955, Blast_Score=92, Evalue=3e-19, Organism=Drosophila melanogaster, GI45549139, Length=130, Percent_Identity=43.0769230769231, Blast_Score=91, Evalue=3e-19, Organism=Drosophila melanogaster, GI24664125, Length=160, Percent_Identity=39.375, Blast_Score=88, Evalue=4e-18, Organism=Drosophila melanogaster, GI21357783, Length=160, Percent_Identity=39.375, Blast_Score=88, Evalue=4e-18, Organism=Drosophila melanogaster, GI24586038, Length=167, Percent_Identity=37.125748502994, Blast_Score=80, Evalue=7e-16, Organism=Drosophila melanogaster, GI21355677, Length=177, Percent_Identity=30.5084745762712, Blast_Score=77, Evalue=7e-15, Organism=Drosophila melanogaster, GI17647301, Length=159, Percent_Identity=33.9622641509434, Blast_Score=75, Evalue=2e-14,
Paralogues:
None
Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR015891 - InterPro: IPR020892 - InterPro: IPR002130 [H]
Pfam domain/function: PF00160 Pro_isomerase [H]
EC number: =5.2.1.8 [H]
Molecular weight: Translated: 20179; Mature: 20047
Theoretical pI: Translated: 4.52; Mature: 4.52
Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.0 %Cys (Translated Protein) 3.2 %Met (Translated Protein) 3.2 %Cys+Met (Translated Protein) 0.0 %Cys (Mature Protein) 2.6 %Met (Mature Protein) 2.6 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MGHVVGISLDVVMMGVMTSKTATAILHTNRGDITIDLFGNHAPETVANFVGLAQGTKEYQ CCEEEEEEHHHHHHHHHCCCCEEEEEECCCCCEEEEECCCCCHHHHHHHHHHHCCCHHHH AQNAQGDSEGPFYNGSVFHRVIDGFMIQGGDPTGTGRGGPGYTFADEFHPELRFDRAYLL HCCCCCCCCCCEECCHHHHHHHCCEEEECCCCCCCCCCCCCCCCCCCCCCCCEECEEEEE AMANAGPGTNGSQFFITVTPTPHLNNAHTIFGEVTDAESQKVVDAIATTATDRYDRPADA EEECCCCCCCCCEEEEEECCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCE VVIESVEITA EEEEEEEECC >Mature Secondary Structure GHVVGISLDVVMMGVMTSKTATAILHTNRGDITIDLFGNHAPETVANFVGLAQGTKEYQ CEEEEEEHHHHHHHHHCCCCEEEEEECCCCCEEEEECCCCCHHHHHHHHHHHCCCHHHH AQNAQGDSEGPFYNGSVFHRVIDGFMIQGGDPTGTGRGGPGYTFADEFHPELRFDRAYLL HCCCCCCCCCCEECCHHHHHHHCCEEEECCCCCCCCCCCCCCCCCCCCCCCCEECEEEEE AMANAGPGTNGSQFFITVTPTPHLNNAHTIFGEVTDAESQKVVDAIATTATDRYDRPADA EEECCCCCCCCCEEEEEECCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCE VVIESVEITA EEEEEEEECC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 12788972 [H]