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The map label for this gene is atoC [H]

Identifier: 138896864

GI number: 138896864

Start: 3339345

End: 3341126

Strand: Direct

Name: atoC [H]

Synonym: GTNG_3229

Alternate gene names: 138896864

Gene position: 3339345-3341126 (Clockwise)

Preceding gene: 138896855

Following gene: 138896865

Centisome position: 94.06

GC content: 45.06

Gene sequence:

>1782_bases
ATGGATATGAACATAAAAACATTATTGATTGCCCCGTACCCTGGACTGAAAGAACTGGCCTCCACGTTAGCCAAAGAACA
ACAGGAACTCGATCTGACCGTTGTGCAAGGCGACTTGCAAGAGGCCATTCCGATTGTGAAACAGTACGAAAAAGAAGGGT
TCGATCTAGTTATTAGCCGCGGTGGCACGGCACAACTGTTACGCCAATATACTTCATTGCCCGTTATTGAGATTCAAGTG
TCGGGTTACGATATTTTACGTATATTGACACTGGTGAAAGACTATCACGCCCATCATTGGATTATCGGATTCACGAACAT
TTGCCAAGGATTTGTTTCTGTATCCAACCTTTTAGATATCCAGATCCCTTACACCATTATCCATGACCAAAAAGAAGTTG
ACGAAGCGGTAAAAGAGGCAAAGGCAGCAGGCGCTCAAACAATTATCGGGGATACAGTCACTTGCAGGACAGCGGAAGCG
CACGGACTGCAAAGCATTCTTATTACTTCCGGCAAAGAATCGGTCATCGAAGCGTTTGAACAGGCAAAGCAAACATATCA
AATGCTCAAAAATACAGCCAAAGAAGTCAAACGATATAAACAACTATTGCACCAAAGCCGTGTCGCCATTGCGGTTTACA
ATGAGCAGGGCACCATCGAGTATGCCAGCCCGGCTTTTCAAAACCGATTCAATTGGATGAAAAACAACTCCAACGAATCA
TCCATTTATGCCTGTTTCCCCTTTCTTGACCATGAATATAACGAGCTATGCCGAGCGATCGCACCTGTGGAAATTCAATC
CACCTGTATCGTCAATGATAAACGGATGCATTTGCGGCAAGGATGTTTAAACAAAGATCCGCTTGAACCTCACTATTACA
TACGCTTGGCTGAAAGCACTGAGCTCCAAGAAGAACATGACTTAACCGTTTCTGCTGTACAGCCTACGATGCGTTCGTTT
TCTCAAATCATCGGCAACAGCGAATCGATTCATCGAGTGATTGAGCAAGGCAAAAGGGCAGCGATGCATCGCGAACCAGT
GGCGCTATATGGTGAACAAGGAAGCGGCAAAAAAACGCTGGCGGGAATCATCCATTGCGAGGGCAAGCAAACAGGGGGTA
TGTTGTTGCACGTCCGCATAACAGCTGATGACGACCAGCTGATTGACCACCTCCACTCTATTTTCACCTATAGGGAAGGT
GGAACATGTGTATTGCAAGGAGTCGAACTGCTGCCGTTACTGCGGCAAGATGAGATTTCCCAACTCATTGCTACGGCAGT
GGTGAGGATCATCTTTTTATTTGAGAACGACCCGGCTCATTTAGCCCGACAAAAACAGCTATCTCATCATCTGTTCAAAC
AGTTTAAGGCCAATCAAATTCGTTTGCCATCGTTAAGCGAGTACACGGAAGACTTAGAAAAATATGCGCGAAAATTCATC
GCCCAATACAATGTAAAGTACGGAAAACAAGTGGTCGGCATCGACGAAGCGGCTCTCAAATGGCTGCACCGCCATCATTG
GAAAGGCAATTTGCAAGAATTAAACAAGGTGATGGAGCAAGCCATCCAAATAGCCCGCCATGAATATATCCAGGTCGAAG
ACTTAAAAACTATCGGTTTCCTTGACAGCGGAAACGATTTATGTTTGGATTTGCACAAGCCGTTGGCCGAGATTGAAAAA
GAGATCATTTGGAAGGTACTTGAAGAAGAAAACATGAACCAAACGAGAGCAGCGAAACGACTTGGCATTAACCGAAGCAC
CTTATGGAGAAAGCTGAAATAA

Upstream 100 bases:

>100_bases
ACCTATACAGGGGAAATGAATGTGTTCATATATGTCACATCTAGCTAAAGATTGGGCTATAATGAATGGGAACGAAAGAC
CAGAACAAAACAGGTGATGA

Downstream 100 bases:

>100_bases
TGTTGCAAAACGCAACATTATTTCAGTTTTTATTTATTTTAACAAAAATGTGTTGATAAATAAAACAAAACGAACTACAA
TTTAATTGCAAGCGATTTCA

Product: sigma-L-dependent transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 593; Mature: 593

Protein sequence:

>593_residues
MDMNIKTLLIAPYPGLKELASTLAKEQQELDLTVVQGDLQEAIPIVKQYEKEGFDLVISRGGTAQLLRQYTSLPVIEIQV
SGYDILRILTLVKDYHAHHWIIGFTNICQGFVSVSNLLDIQIPYTIIHDQKEVDEAVKEAKAAGAQTIIGDTVTCRTAEA
HGLQSILITSGKESVIEAFEQAKQTYQMLKNTAKEVKRYKQLLHQSRVAIAVYNEQGTIEYASPAFQNRFNWMKNNSNES
SIYACFPFLDHEYNELCRAIAPVEIQSTCIVNDKRMHLRQGCLNKDPLEPHYYIRLAESTELQEEHDLTVSAVQPTMRSF
SQIIGNSESIHRVIEQGKRAAMHREPVALYGEQGSGKKTLAGIIHCEGKQTGGMLLHVRITADDDQLIDHLHSIFTYREG
GTCVLQGVELLPLLRQDEISQLIATAVVRIIFLFENDPAHLARQKQLSHHLFKQFKANQIRLPSLSEYTEDLEKYARKFI
AQYNVKYGKQVVGIDEAALKWLHRHHWKGNLQELNKVMEQAIQIARHEYIQVEDLKTIGFLDSGNDLCLDLHKPLAEIEK
EIIWKVLEEENMNQTRAAKRLGINRSTLWRKLK

Sequences:

>Translated_593_residues
MDMNIKTLLIAPYPGLKELASTLAKEQQELDLTVVQGDLQEAIPIVKQYEKEGFDLVISRGGTAQLLRQYTSLPVIEIQV
SGYDILRILTLVKDYHAHHWIIGFTNICQGFVSVSNLLDIQIPYTIIHDQKEVDEAVKEAKAAGAQTIIGDTVTCRTAEA
HGLQSILITSGKESVIEAFEQAKQTYQMLKNTAKEVKRYKQLLHQSRVAIAVYNEQGTIEYASPAFQNRFNWMKNNSNES
SIYACFPFLDHEYNELCRAIAPVEIQSTCIVNDKRMHLRQGCLNKDPLEPHYYIRLAESTELQEEHDLTVSAVQPTMRSF
SQIIGNSESIHRVIEQGKRAAMHREPVALYGEQGSGKKTLAGIIHCEGKQTGGMLLHVRITADDDQLIDHLHSIFTYREG
GTCVLQGVELLPLLRQDEISQLIATAVVRIIFLFENDPAHLARQKQLSHHLFKQFKANQIRLPSLSEYTEDLEKYARKFI
AQYNVKYGKQVVGIDEAALKWLHRHHWKGNLQELNKVMEQAIQIARHEYIQVEDLKTIGFLDSGNDLCLDLHKPLAEIEK
EIIWKVLEEENMNQTRAAKRLGINRSTLWRKLK
>Mature_593_residues
MDMNIKTLLIAPYPGLKELASTLAKEQQELDLTVVQGDLQEAIPIVKQYEKEGFDLVISRGGTAQLLRQYTSLPVIEIQV
SGYDILRILTLVKDYHAHHWIIGFTNICQGFVSVSNLLDIQIPYTIIHDQKEVDEAVKEAKAAGAQTIIGDTVTCRTAEA
HGLQSILITSGKESVIEAFEQAKQTYQMLKNTAKEVKRYKQLLHQSRVAIAVYNEQGTIEYASPAFQNRFNWMKNNSNES
SIYACFPFLDHEYNELCRAIAPVEIQSTCIVNDKRMHLRQGCLNKDPLEPHYYIRLAESTELQEEHDLTVSAVQPTMRSF
SQIIGNSESIHRVIEQGKRAAMHREPVALYGEQGSGKKTLAGIIHCEGKQTGGMLLHVRITADDDQLIDHLHSIFTYREG
GTCVLQGVELLPLLRQDEISQLIATAVVRIIFLFENDPAHLARQKQLSHHLFKQFKANQIRLPSLSEYTEDLEKYARKFI
AQYNVKYGKQVVGIDEAALKWLHRHHWKGNLQELNKVMEQAIQIARHEYIQVEDLKTIGFLDSGNDLCLDLHKPLAEIEK
EIIWKVLEEENMNQTRAAKRLGINRSTLWRKLK

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG3829

COG function: function code KT; Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=311, Percent_Identity=24.7588424437299, Blast_Score=96, Evalue=6e-21,
Organism=Escherichia coli, GI1790437, Length=351, Percent_Identity=26.7806267806268, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1789087, Length=306, Percent_Identity=25.8169934640523, Blast_Score=87, Evalue=4e-18,
Organism=Escherichia coli, GI87081858, Length=322, Percent_Identity=25.4658385093168, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1789233, Length=328, Percent_Identity=23.780487804878, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI87082117, Length=314, Percent_Identity=24.5222929936306, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1788905, Length=300, Percent_Identity=24.3333333333333, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI87081872, Length=305, Percent_Identity=23.2786885245902, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 67624; Mature: 67624

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDMNIKTLLIAPYPGLKELASTLAKEQQELDLTVVQGDLQEAIPIVKQYEKEGFDLVISR
CCCCEEEEEEECCCCHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHCCCCEEEEEC
GGTAQLLRQYTSLPVIEIQVSGYDILRILTLVKDYHAHHWIIGFTNICQGFVSVSNLLDI
CCHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHEEE
QIPYTIIHDQKEVDEAVKEAKAAGAQTIIGDTVTCRTAEAHGLQSILITSGKESVIEAFE
EECEEEECCHHHHHHHHHHHHHCCCCEEECCCEEEECCHHCCCHHEEEECCHHHHHHHHH
QAKQTYQMLKNTAKEVKRYKQLLHQSRVAIAVYNEQGTIEYASPAFQNRFNWMKNNSNES
HHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCEEECCHHHHHHHHHHCCCCCCC
SIYACFPFLDHEYNELCRAIAPVEIQSTCIVNDKRMHLRQGCLNKDPLEPHYYIRLAEST
EEEEEECHHCCCHHHHHHHHCCCEECCEEEECHHHHHHHHCCCCCCCCCCEEEEEEECCC
ELQEEHDLTVSAVQPTMRSFSQIIGNSESIHRVIEQGKRAAMHREPVALYGEQGSGKKTL
CCHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCEE
AGIIHCEGKQTGGMLLHVRITADDDQLIDHLHSIFTYREGGTCVLQGVELLPLLRQDEIS
EEEEEECCCCCCCEEEEEEEECCHHHHHHHHHHHHEECCCCEEEECCHHHHHHHHHHHHH
QLIATAVVRIIFLFENDPAHLARQKQLSHHLFKQFKANQIRLPSLSEYTEDLEKYARKFI
HHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
AQYNVKYGKQVVGIDEAALKWLHRHHWKGNLQELNKVMEQAIQIARHEYIQVEDLKTIGF
HHHCHHHCCEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCEEEECCCEEEE
LDSGNDLCLDLHKPLAEIEKEIIWKVLEEENMNQTRAAKRLGINRSTLWRKLK
EECCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHCCC
>Mature Secondary Structure
MDMNIKTLLIAPYPGLKELASTLAKEQQELDLTVVQGDLQEAIPIVKQYEKEGFDLVISR
CCCCEEEEEEECCCCHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHCCCCEEEEEC
GGTAQLLRQYTSLPVIEIQVSGYDILRILTLVKDYHAHHWIIGFTNICQGFVSVSNLLDI
CCHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHEEE
QIPYTIIHDQKEVDEAVKEAKAAGAQTIIGDTVTCRTAEAHGLQSILITSGKESVIEAFE
EECEEEECCHHHHHHHHHHHHHCCCCEEECCCEEEECCHHCCCHHEEEECCHHHHHHHHH
QAKQTYQMLKNTAKEVKRYKQLLHQSRVAIAVYNEQGTIEYASPAFQNRFNWMKNNSNES
HHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCEEECCHHHHHHHHHHCCCCCCC
SIYACFPFLDHEYNELCRAIAPVEIQSTCIVNDKRMHLRQGCLNKDPLEPHYYIRLAEST
EEEEEECHHCCCHHHHHHHHCCCEECCEEEECHHHHHHHHCCCCCCCCCCEEEEEEECCC
ELQEEHDLTVSAVQPTMRSFSQIIGNSESIHRVIEQGKRAAMHREPVALYGEQGSGKKTL
CCHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCEE
AGIIHCEGKQTGGMLLHVRITADDDQLIDHLHSIFTYREGGTCVLQGVELLPLLRQDEIS
EEEEEECCCCCCCEEEEEEEECCHHHHHHHHHHHHEECCCCEEEECCHHHHHHHHHHHHH
QLIATAVVRIIFLFENDPAHLARQKQLSHHLFKQFKANQIRLPSLSEYTEDLEKYARKFI
HHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
AQYNVKYGKQVVGIDEAALKWLHRHHWKGNLQELNKVMEQAIQIARHEYIQVEDLKTIGF
HHHCHHHCCEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCEEEECCCEEEE
LDSGNDLCLDLHKPLAEIEKEIIWKVLEEENMNQTRAAKRLGINRSTLWRKLK
EECCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]