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The map label for this gene is kynU [H]

Identifier: 138896803

GI number: 138896803

Start: 3267743

End: 3269050

Strand: Direct

Name: kynU [H]

Synonym: GTNG_3166

Alternate gene names: 138896803

Gene position: 3267743-3269050 (Clockwise)

Preceding gene: 138896801

Following gene: 138896804

Centisome position: 92.04

GC content: 43.2

Gene sequence:

>1308_bases
ATGGAACAGGAGGTTATATTCGTGAACAGCACAGCCCTGGAACCTACATTAGAATTCGCTCGAAAACTTGACCAAGAAGA
CCCATTACGTCATTTTCGCGATGAATTTTACTTACCGCCGAATTCCATTTATATGGATGGCAACTCACTAGGTCTTCTTT
CCAAAAGGGCGGAAAAAACACTATTCACCATATTACAAGATTGGAAATTGTTAGGGATCGATGGGTGGACAAAAGGAACC
TATCCATGGTTTGACCTATCGGAGAAGATAGGAGCTATGTTGGCGCCATTAGTCGGTGCTTCACCGGAAGAAGTGATTGC
TACAGGTTCTACCACTGTCAATTTGCACCAGCTAGTTTCTACCTTTTACCAACCAGAAGGAAAGAGGACAAAGATTTTAG
CTGATGAATTGACCTTCCCATCAGACATTTATGCGTTGCAAAGTCAGCTTCGTATTCACGGTTATGATCCCAGCACTCAT
CTGATTCGAGTGAAAAGTCGTGATGGGCGTTTTTTGGAAGAAGAAGATATTATTGCAGCCATGTCCGAAGACGTTGCCTT
AGTTGTTTTGCCGACTGTGTTATACCGCAGTGGTCAAATTTTGGACATCCAACTTCTGACTGATGAAGCACATAAGCGTG
GCATCTTGATCGGATTCGATGCTTGCCACTCCATTGGAGCCATTCCGCATTCATTTAGCGAATGGGGAGTTGATTTCGCT
TTTTGGTGCAACTACAAGTATATGAACGGGGGACCTGGCTGTGTCGCAGGACTCTACGTCCATCGTAAACATTTCGGTTC
AGCACCTGGCTTGGCTGGATGGTTTGGCTCGAAAAAAGATAAACAATTTGATATGGAACATACATTCACCCCTTCCTTGA
CGGCTGGAGCTTATCAAATTGGAACTCCACATCTTTTGAGTCTAGCTCCTTTGATTGGATCCTTAGAAATCTTCCAAGAA
GCCGGAATTGAACGGATTCGTCAAAAGTCGTTGCAACTGACTAATTACTTTATGTACTTAATCGAACAAGAGCTTTCCCA
TTTCGGCTTTATCATTGGCAATCCGAAAGACGATGTGCGCCGTGGAGGACATATTAGCTTGGAGCACGAGGAAGCTGCCC
GCATTTGCAAGTCATTAAAAGAAAATGGTGTCATTCCAGACTTCCGAGCACCAAATATTATTCGCTTAGCGCCTATTGCT
TTGTACACATCTTATGAAGAAGTATGGAACGTTGTACAAATTATGAAGAAAATCATGCAAGAGAAACAGTATAAGAAGTT
TTCCAACGAGCGTGAAGTAGTCGCCTAA

Upstream 100 bases:

>100_bases
GAAGAAGACAAAAAACGAACAACAAAATATAATATTTCAAAAATTTAATAATTGACATAATGTCAACTTTTTATGTAAAA
TTTTTTTAACATCTCACCGA

Downstream 100 bases:

>100_bases
ATATAAGGGGGGAGAGAGAATGGCCAAGCAAAATCATGATACGCGTAAATCGCAAGAAAAGGACACCGGATTACATCGTG
AATTAAAGACGAACCAACTA

Product: kynureninase

Products: NA

Alternate protein names: L-kynurenine hydrolase [H]

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MEQEVIFVNSTALEPTLEFARKLDQEDPLRHFRDEFYLPPNSIYMDGNSLGLLSKRAEKTLFTILQDWKLLGIDGWTKGT
YPWFDLSEKIGAMLAPLVGASPEEVIATGSTTVNLHQLVSTFYQPEGKRTKILADELTFPSDIYALQSQLRIHGYDPSTH
LIRVKSRDGRFLEEEDIIAAMSEDVALVVLPTVLYRSGQILDIQLLTDEAHKRGILIGFDACHSIGAIPHSFSEWGVDFA
FWCNYKYMNGGPGCVAGLYVHRKHFGSAPGLAGWFGSKKDKQFDMEHTFTPSLTAGAYQIGTPHLLSLAPLIGSLEIFQE
AGIERIRQKSLQLTNYFMYLIEQELSHFGFIIGNPKDDVRRGGHISLEHEEAARICKSLKENGVIPDFRAPNIIRLAPIA
LYTSYEEVWNVVQIMKKIMQEKQYKKFSNEREVVA

Sequences:

>Translated_435_residues
MEQEVIFVNSTALEPTLEFARKLDQEDPLRHFRDEFYLPPNSIYMDGNSLGLLSKRAEKTLFTILQDWKLLGIDGWTKGT
YPWFDLSEKIGAMLAPLVGASPEEVIATGSTTVNLHQLVSTFYQPEGKRTKILADELTFPSDIYALQSQLRIHGYDPSTH
LIRVKSRDGRFLEEEDIIAAMSEDVALVVLPTVLYRSGQILDIQLLTDEAHKRGILIGFDACHSIGAIPHSFSEWGVDFA
FWCNYKYMNGGPGCVAGLYVHRKHFGSAPGLAGWFGSKKDKQFDMEHTFTPSLTAGAYQIGTPHLLSLAPLIGSLEIFQE
AGIERIRQKSLQLTNYFMYLIEQELSHFGFIIGNPKDDVRRGGHISLEHEEAARICKSLKENGVIPDFRAPNIIRLAPIA
LYTSYEEVWNVVQIMKKIMQEKQYKKFSNEREVVA
>Mature_435_residues
MEQEVIFVNSTALEPTLEFARKLDQEDPLRHFRDEFYLPPNSIYMDGNSLGLLSKRAEKTLFTILQDWKLLGIDGWTKGT
YPWFDLSEKIGAMLAPLVGASPEEVIATGSTTVNLHQLVSTFYQPEGKRTKILADELTFPSDIYALQSQLRIHGYDPSTH
LIRVKSRDGRFLEEEDIIAAMSEDVALVVLPTVLYRSGQILDIQLLTDEAHKRGILIGFDACHSIGAIPHSFSEWGVDFA
FWCNYKYMNGGPGCVAGLYVHRKHFGSAPGLAGWFGSKKDKQFDMEHTFTPSLTAGAYQIGTPHLLSLAPLIGSLEIFQE
AGIERIRQKSLQLTNYFMYLIEQELSHFGFIIGNPKDDVRRGGHISLEHEEAARICKSLKENGVIPDFRAPNIIRLAPIA
LYTSYEEVWNVVQIMKKIMQEKQYKKFSNEREVVA

Specific function: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively [H]

COG id: COG3844

COG function: function code E; Kynureninase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kynureninase family [H]

Homologues:

Organism=Homo sapiens, GI4504937, Length=441, Percent_Identity=34.0136054421769, Blast_Score=248, Evalue=1e-65,
Organism=Homo sapiens, GI74101437, Length=271, Percent_Identity=37.2693726937269, Blast_Score=174, Evalue=2e-43,
Organism=Escherichia coli, GI48994898, Length=173, Percent_Identity=29.4797687861272, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17550466, Length=448, Percent_Identity=31.4732142857143, Blast_Score=246, Evalue=1e-65,
Organism=Saccharomyces cerevisiae, GI6323261, Length=453, Percent_Identity=35.5408388520971, Blast_Score=257, Evalue=2e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR010111
- InterPro:   IPR015424
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =3.7.1.3 [H]

Molecular weight: Translated: 49179; Mature: 49179

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQEVIFVNSTALEPTLEFARKLDQEDPLRHFRDEFYLPPNSIYMDGNSLGLLSKRAEKT
CCCCEEEEECCCCCHHHHHHHHCCCCCHHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHH
LFTILQDWKLLGIDGWTKGTYPWFDLSEKIGAMLAPLVGASPEEVIATGSTTVNLHQLVS
HHHHHHCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHEEECCCCEEHHHHHHH
TFYQPEGKRTKILADELTFPSDIYALQSQLRIHGYDPSTHLIRVKSRDGRFLEEEDIIAA
HHHCCCCCCEEEEECCCCCCHHHHHHHHCCEEECCCCCCEEEEEECCCCCCCCHHHHHHH
MSEDVALVVLPTVLYRSGQILDIQLLTDEAHKRGILIGFDACHSIGAIPHSFSEWGVDFA
HCCCEEEEEEHHHHHCCCCEEEEEEECCHHHHCCEEEEEHHHHHHCCCCCCHHHHCCCEE
FWCNYKYMNGGPGCVAGLYVHRKHFGSAPGLAGWFGSKKDKQFDMEHTFTPSLTAGAYQI
EEEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEC
GTPHLLSLAPLIGSLEIFQEAGIERIRQKSLQLTNYFMYLIEQELSHFGFIIGNPKDDVR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCHHHHH
RGGHISLEHEEAARICKSLKENGVIPDFRAPNIIRLAPIALYTSYEEVWNVVQIMKKIMQ
CCCCEEECHHHHHHHHHHHHHCCCCCCCCCCCEEEEEHHHHHHCHHHHHHHHHHHHHHHH
EKQYKKFSNEREVVA
HHHHHHHCCCCCCCC
>Mature Secondary Structure
MEQEVIFVNSTALEPTLEFARKLDQEDPLRHFRDEFYLPPNSIYMDGNSLGLLSKRAEKT
CCCCEEEEECCCCCHHHHHHHHCCCCCHHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHH
LFTILQDWKLLGIDGWTKGTYPWFDLSEKIGAMLAPLVGASPEEVIATGSTTVNLHQLVS
HHHHHHCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHEEECCCCEEHHHHHHH
TFYQPEGKRTKILADELTFPSDIYALQSQLRIHGYDPSTHLIRVKSRDGRFLEEEDIIAA
HHHCCCCCCEEEEECCCCCCHHHHHHHHCCEEECCCCCCEEEEEECCCCCCCCHHHHHHH
MSEDVALVVLPTVLYRSGQILDIQLLTDEAHKRGILIGFDACHSIGAIPHSFSEWGVDFA
HCCCEEEEEEHHHHHCCCCEEEEEEECCHHHHCCEEEEEHHHHHHCCCCCCHHHHCCCEE
FWCNYKYMNGGPGCVAGLYVHRKHFGSAPGLAGWFGSKKDKQFDMEHTFTPSLTAGAYQI
EEEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEC
GTPHLLSLAPLIGSLEIFQEAGIERIRQKSLQLTNYFMYLIEQELSHFGFIIGNPKDDVR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCHHHHH
RGGHISLEHEEAARICKSLKENGVIPDFRAPNIIRLAPIALYTSYEEVWNVVQIMKKIMQ
CCCCEEECHHHHHHHHHHHHHCCCCCCCCCCCEEEEEHHHHHHCHHHHHHHHHHHHHHHH
EKQYKKFSNEREVVA
HHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA