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The map label for this gene is wecC [H]

Identifier: 138896732

GI number: 138896732

Start: 3192998

End: 3194290

Strand: Reverse

Name: wecC [H]

Synonym: GTNG_3095

Alternate gene names: 138896732

Gene position: 3194290-3192998 (Counterclockwise)

Preceding gene: 138896736

Following gene: 138896731

Centisome position: 89.97

GC content: 50.73

Gene sequence:

>1293_bases
ATGAAAAAAGTGTGTGTCGTCGGGCTAGGTTATATTGGACTTCCGACGTCAGCAATATTTGCCGCTGCTGGATTTGACGT
TGTCGGCGTGGATGTGAGCGAAACCGTCGTTGCAACGATCAACAGCGGCAACATTCATATTGAAAAAACAGGATTAGCCG
AACTTGTCAACCGGGTCGTCAAAGAAGGGAAATTCCGGGCGCAGCTCGCTCCGGAAGAGGCAAATGTGTTCATCATTGCC
GTTCCGACACCGATTCATGACGATTATACTGCCAACATCGACTACGTTATTGAAGCGACGAAATCGGTAGCGCCATATTT
GCGGAAAGGAAACGTCGTCATCGTTGAATCGACGATTCCACCACGCACGATGGACGATGTCGTCGCACCGATCATTCGCG
AGCACGGTTTTGACCCGGAGCAAGATGTGTATTTGGCTCATTGCCCAGAACGTGTCTTGCCGGGCCGCATTTTAATTGAA
CTCGTCGAGAACACAAGAATCGTCGGCGGTGTCACGAAAGAGGCAGCAAAACAAGCAGCCGACGTCTACCGGGCGATCGT
CAAAGGCGAAGTGATTGAGACGGAAGCTGTGACTGCTGAAATGGCGAAATTAATGGAAAATACGTTCCGTGATGTCAACA
TCGCTTTAGCAAATGAACTCGTAAAAATCGCGCAACGTGTCGGCGTCAATGCTCATAAAGTCATCGAGCTTGCCAATAAA
CACCCGCGCGTCAATATTCATTTGCCAGGCCCTGGTGTCGGTGGGCATTGCTTGGCCGTTGATCCGTACTTTATCGTCGA
AAAGGCGAAAGAAGAGTCGCAGCTCATCCAAACGGCGCGCCGCATTAATAACTCGATGCCACACTTTGTCGTCGAGCAAG
TGAAACGCATGACGGCGGAACTCGAAGCGCCGGTCATCGCCGTCTTCGGCTTAACGTACAAAGGCAATACGGACGATGTG
CGCGAGAGCCCGGCCATTGAAATCTACGAAGAGCTGCGGCGGAACGAGCGGTTTGACGTCCGTGCTTACGACCCGCACGT
TAAGCCGTCGCAAGTGCCGTTTCCGCTTTCTACGAAAGAGGAAGCACTCGATGGGGCACATCTTGTCGTTGTCTTAGCTG
ACCATAACGAATTCAAAACACTAACAGCCGAGGAATTGGCGTCGATGAAAACCAAGGTCATCTTCGATACGAAAAATTGC
ATCGGTCTTGACGATGAAGACGTGACGGTATATCAAATCGGCCATTTATCGGTCGTCCAAGCTATTCAAGAACAACCACC
GGAGAGAGTATGA

Upstream 100 bases:

>100_bases
AATGATGCAAAATGGATGATGGTTTGTTATACTATAACGTGATTGGTCGAAAAAGCTCGAAAAAAGGTAATTCTAGTTTA
CAAAAAGAGAGGTTTTCACG

Downstream 100 bases:

>100_bases
TCAGCTATGGAAAAAGAGCAATATTTAGGGGTGTACGTCTCCACCTTAACGTATGACGACATTCTTGCTGATATCGAAAA
GCGGATGGAAGCCGGCCAAA

Product: UDP-N-acetyl-D-mannosamine dehydrogenase

Products: GDP-D-mannuronate; NADH; H+

Alternate protein names: UDP-ManNAc 6-dehydrogenase [H]

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MKKVCVVGLGYIGLPTSAIFAAAGFDVVGVDVSETVVATINSGNIHIEKTGLAELVNRVVKEGKFRAQLAPEEANVFIIA
VPTPIHDDYTANIDYVIEATKSVAPYLRKGNVVIVESTIPPRTMDDVVAPIIREHGFDPEQDVYLAHCPERVLPGRILIE
LVENTRIVGGVTKEAAKQAADVYRAIVKGEVIETEAVTAEMAKLMENTFRDVNIALANELVKIAQRVGVNAHKVIELANK
HPRVNIHLPGPGVGGHCLAVDPYFIVEKAKEESQLIQTARRINNSMPHFVVEQVKRMTAELEAPVIAVFGLTYKGNTDDV
RESPAIEIYEELRRNERFDVRAYDPHVKPSQVPFPLSTKEEALDGAHLVVVLADHNEFKTLTAEELASMKTKVIFDTKNC
IGLDDEDVTVYQIGHLSVVQAIQEQPPERV

Sequences:

>Translated_430_residues
MKKVCVVGLGYIGLPTSAIFAAAGFDVVGVDVSETVVATINSGNIHIEKTGLAELVNRVVKEGKFRAQLAPEEANVFIIA
VPTPIHDDYTANIDYVIEATKSVAPYLRKGNVVIVESTIPPRTMDDVVAPIIREHGFDPEQDVYLAHCPERVLPGRILIE
LVENTRIVGGVTKEAAKQAADVYRAIVKGEVIETEAVTAEMAKLMENTFRDVNIALANELVKIAQRVGVNAHKVIELANK
HPRVNIHLPGPGVGGHCLAVDPYFIVEKAKEESQLIQTARRINNSMPHFVVEQVKRMTAELEAPVIAVFGLTYKGNTDDV
RESPAIEIYEELRRNERFDVRAYDPHVKPSQVPFPLSTKEEALDGAHLVVVLADHNEFKTLTAEELASMKTKVIFDTKNC
IGLDDEDVTVYQIGHLSVVQAIQEQPPERV
>Mature_430_residues
MKKVCVVGLGYIGLPTSAIFAAAGFDVVGVDVSETVVATINSGNIHIEKTGLAELVNRVVKEGKFRAQLAPEEANVFIIA
VPTPIHDDYTANIDYVIEATKSVAPYLRKGNVVIVESTIPPRTMDDVVAPIIREHGFDPEQDVYLAHCPERVLPGRILIE
LVENTRIVGGVTKEAAKQAADVYRAIVKGEVIETEAVTAEMAKLMENTFRDVNIALANELVKIAQRVGVNAHKVIELANK
HPRVNIHLPGPGVGGHCLAVDPYFIVEKAKEESQLIQTARRINNSMPHFVVEQVKRMTAELEAPVIAVFGLTYKGNTDDV
RESPAIEIYEELRRNERFDVRAYDPHVKPSQVPFPLSTKEEALDGAHLVVVLADHNEFKTLTAEELASMKTKVIFDTKNC
IGLDDEDVTVYQIGHLSVVQAIQEQPPERV

Specific function: Catalyzes the four-electron oxidation of UDP-N-acetyl-D- mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N- acetylmannosaminuronic acid (UDP-ManNAcA) [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=470, Percent_Identity=25.3191489361702, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI296040438, Length=370, Percent_Identity=24.0540540540541, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI48994968, Length=405, Percent_Identity=43.7037037037037, Blast_Score=335, Evalue=5e-93,
Organism=Escherichia coli, GI1788340, Length=425, Percent_Identity=24.7058823529412, Blast_Score=82, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17560350, Length=430, Percent_Identity=26.046511627907, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI17136908, Length=460, Percent_Identity=25.4347826086956, Blast_Score=104, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.132

Molecular weight: Translated: 47309; Mature: 47309

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKVCVVGLGYIGLPTSAIFAAAGFDVVGVDVSETVVATINSGNIHIEKTGLAELVNRVV
CCCEEEEECCCCCCCHHHHHHHCCCEEEECCCCCEEEEEEECCEEEEEECCHHHHHHHHH
KEGKFRAQLAPEEANVFIIAVPTPIHDDYTANIDYVIEATKSVAPYLRKGNVVIVESTIP
HCCCCEEEECCCCCCEEEEEECCCCCCCCCCCCCEEEEEHHHHHHHHHCCCEEEEECCCC
PRTMDDVVAPIIREHGFDPEQDVYLAHCPERVLPGRILIELVENTRIVGGVTKEAAKQAA
CCCHHHHHHHHHHHCCCCCCCCEEEECCCCHHCCHHHHHHHHHCCEEECCCHHHHHHHHH
DVYRAIVKGEVIETEAVTAEMAKLMENTFRDVNIALANELVKIAQRVGVNAHKVIELANK
HHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCC
HPRVNIHLPGPGVGGHCLAVDPYFIVEKAKEESQLIQTARRINNSMPHFVVEQVKRMTAE
CCEEEEEECCCCCCCEEEEECCHHEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
LEAPVIAVFGLTYKGNTDDVRESPAIEIYEELRRNERFDVRAYDPHVKPSQVPFPLSTKE
HCCCEEEEEEEEECCCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCHH
EALDGAHLVVVLADHNEFKTLTAEELASMKTKVIFDTKNCIGLDDEDVTVYQIGHLSVVQ
HHCCCCEEEEEEECCCCCCEECHHHHHHCCEEEEEECCCCCCCCCCCEEEEEECHHHHHH
AIQEQPPERV
HHHHCCCCCC
>Mature Secondary Structure
MKKVCVVGLGYIGLPTSAIFAAAGFDVVGVDVSETVVATINSGNIHIEKTGLAELVNRVV
CCCEEEEECCCCCCCHHHHHHHCCCEEEECCCCCEEEEEEECCEEEEEECCHHHHHHHHH
KEGKFRAQLAPEEANVFIIAVPTPIHDDYTANIDYVIEATKSVAPYLRKGNVVIVESTIP
HCCCCEEEECCCCCCEEEEEECCCCCCCCCCCCCEEEEEHHHHHHHHHCCCEEEEECCCC
PRTMDDVVAPIIREHGFDPEQDVYLAHCPERVLPGRILIELVENTRIVGGVTKEAAKQAA
CCCHHHHHHHHHHHCCCCCCCCEEEECCCCHHCCHHHHHHHHHCCEEECCCHHHHHHHHH
DVYRAIVKGEVIETEAVTAEMAKLMENTFRDVNIALANELVKIAQRVGVNAHKVIELANK
HHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCC
HPRVNIHLPGPGVGGHCLAVDPYFIVEKAKEESQLIQTARRINNSMPHFVVEQVKRMTAE
CCEEEEEECCCCCCCEEEEECCHHEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
LEAPVIAVFGLTYKGNTDDVRESPAIEIYEELRRNERFDVRAYDPHVKPSQVPFPLSTKE
HCCCEEEEEEEEECCCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCHH
EALDGAHLVVVLADHNEFKTLTAEELASMKTKVIFDTKNCIGLDDEDVTVYQIGHLSVVQ
HHCCCCEEEEEEECCCCCCEECHHHHHHCCEEEEEECCCCCCCCCCCEEEEEECHHHHHH
AIQEQPPERV
HHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: GDP-D-mannose; NAD+; H2O

Specific reaction: GDP-D-mannose + 2 NAD+ + H2O = GDP-D-mannuronate + 2 NADH + 2 H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]