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The map label for this gene is menB [H]

Identifier: 138896408

GI number: 138896408

Start: 2884643

End: 2885461

Strand: Reverse

Name: menB [H]

Synonym: GTNG_2771

Alternate gene names: 138896408

Gene position: 2885461-2884643 (Counterclockwise)

Preceding gene: 138896409

Following gene: 138896407

Centisome position: 81.27

GC content: 52.63

Gene sequence:

>819_bases
ATGCCGTTTGAATGGGTAAAAGAACACGATTATGAAGATATTATTTACGAAACGTACAACGGCATCGCTAAAATTACGAT
CAATCGTCCGGAAGTACATAATGCGTTTCGTCCGAAAACAGTTAACGAGCTGATTGATGCATTCACGCGGGCGCGTGATG
ATTCGAACATCGGCGTCATTATTTTGACCGGCGCGGGCGGCAAAGCGTTTTGCTCCGGCGGCGACCAAAAAGTGCGCGGC
CACGGGGGCTATGTCGGCGAGGACGAAATCCCACGCTTGAATGTGCTCGATTTGCAGCGGCTCATTCGCGTTATCCCGAA
ACCGGTCATCGCGATGGTTGCCGGGTATGCAATCGGCGGCGGTCATGTGCTTCATATCGTCTGCGACTTAACGATCGCAG
CAGACAATGCCATCTTCGGTCAAACCGGGCCGAAAGTCGGCAGCTTTGATGGCGGTTACGGCGCCGGTTATTTGGCGCGC
ATCGTCGGCCATAAAAAAGCGCGCGAAATTTGGTATTTGTGCCGCCAGTACAACGCCCAAGAAGCGCTCGAGATGGGGCT
CGTCAACAAAGTCGTGCCGCTTGAACAGCTCGAGGAAGAAACGGTCAAATGGGCGCAAGAAATTTTGGAGAAAAGTCCGA
CGGCGATTCGCTTCTTAAAAGCGGCGTTTAATGCCGATTCCGATGGCTTAGCCGGCATTCAGCAGCTCGCTGGCGATGCG
ACGCTTCTCTTCTATACGACGGAAGAAGCAAAAGAAGGAATGAGAGCGTTTAAGGAAAAACGGAAACCGGACTTCGGCCA
GTTCCCTCGTTTTCCGTGA

Upstream 100 bases:

>100_bases
AACTCGTCTGTGTCCAAAAGGTCGGACATGCAATTCATGTGGAACAACCCGGCATTTTTGCTAAAATAGTAAGTGAATTG
ATTAAAAGGGGGTAGTATGA

Downstream 100 bases:

>100_bases
TCATGTGCGCGCCTTGAGCCGACATTGTCACGGTTGGATGGGGGCCAATCTGCGCATGAATCATTTCCGTGAACATGCGC
ACGCTTGGCTCGATTGAGGG

Product: naphthoate synthase

Products: NA

Alternate protein names: DHNA-CoA synthase [H]

Number of amino acids: Translated: 272; Mature: 271

Protein sequence:

>272_residues
MPFEWVKEHDYEDIIYETYNGIAKITINRPEVHNAFRPKTVNELIDAFTRARDDSNIGVIILTGAGGKAFCSGGDQKVRG
HGGYVGEDEIPRLNVLDLQRLIRVIPKPVIAMVAGYAIGGGHVLHIVCDLTIAADNAIFGQTGPKVGSFDGGYGAGYLAR
IVGHKKAREIWYLCRQYNAQEALEMGLVNKVVPLEQLEEETVKWAQEILEKSPTAIRFLKAAFNADSDGLAGIQQLAGDA
TLLFYTTEEAKEGMRAFKEKRKPDFGQFPRFP

Sequences:

>Translated_272_residues
MPFEWVKEHDYEDIIYETYNGIAKITINRPEVHNAFRPKTVNELIDAFTRARDDSNIGVIILTGAGGKAFCSGGDQKVRG
HGGYVGEDEIPRLNVLDLQRLIRVIPKPVIAMVAGYAIGGGHVLHIVCDLTIAADNAIFGQTGPKVGSFDGGYGAGYLAR
IVGHKKAREIWYLCRQYNAQEALEMGLVNKVVPLEQLEEETVKWAQEILEKSPTAIRFLKAAFNADSDGLAGIQQLAGDA
TLLFYTTEEAKEGMRAFKEKRKPDFGQFPRFP
>Mature_271_residues
PFEWVKEHDYEDIIYETYNGIAKITINRPEVHNAFRPKTVNELIDAFTRARDDSNIGVIILTGAGGKAFCSGGDQKVRGH
GGYVGEDEIPRLNVLDLQRLIRVIPKPVIAMVAGYAIGGGHVLHIVCDLTIAADNAIFGQTGPKVGSFDGGYGAGYLARI
VGHKKAREIWYLCRQYNAQEALEMGLVNKVVPLEQLEEETVKWAQEILEKSPTAIRFLKAAFNADSDGLAGIQQLAGDAT
LLFYTTEEAKEGMRAFKEKRKPDFGQFPRFP

Specific function: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) [H]

COG id: COG0447

COG function: function code H; Dihydroxynaphthoic acid synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=262, Percent_Identity=34.7328244274809, Blast_Score=124, Evalue=8e-29,
Organism=Homo sapiens, GI31542718, Length=274, Percent_Identity=31.3868613138686, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI4502327, Length=268, Percent_Identity=30.5970149253731, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI45643119, Length=217, Percent_Identity=28.110599078341, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI260275230, Length=217, Percent_Identity=28.110599078341, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI260274832, Length=217, Percent_Identity=28.110599078341, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI70995211, Length=231, Percent_Identity=29.004329004329, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI68989263, Length=216, Percent_Identity=30.0925925925926, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI37594471, Length=154, Percent_Identity=27.2727272727273, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI37594469, Length=154, Percent_Identity=27.2727272727273, Blast_Score=68, Evalue=8e-12,
Organism=Escherichia coli, GI1788597, Length=277, Percent_Identity=69.3140794223827, Blast_Score=390, Evalue=1e-110,
Organism=Escherichia coli, GI221142681, Length=265, Percent_Identity=34.3396226415094, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI87082183, Length=265, Percent_Identity=31.3207547169811, Blast_Score=111, Evalue=5e-26,
Organism=Escherichia coli, GI1787659, Length=262, Percent_Identity=30.5343511450382, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1787660, Length=260, Percent_Identity=30.3846153846154, Blast_Score=88, Evalue=8e-19,
Organism=Escherichia coli, GI1788682, Length=191, Percent_Identity=27.2251308900524, Blast_Score=69, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI25145438, Length=249, Percent_Identity=35.7429718875502, Blast_Score=124, Evalue=7e-29,
Organism=Caenorhabditis elegans, GI17554946, Length=246, Percent_Identity=34.1463414634146, Blast_Score=124, Evalue=7e-29,
Organism=Caenorhabditis elegans, GI17540714, Length=213, Percent_Identity=30.9859154929577, Blast_Score=100, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI17549921, Length=216, Percent_Identity=28.2407407407407, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17560910, Length=188, Percent_Identity=34.0425531914894, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17534483, Length=279, Percent_Identity=26.8817204301075, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17536985, Length=218, Percent_Identity=29.3577981651376, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17535521, Length=252, Percent_Identity=23.8095238095238, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17540306, Length=260, Percent_Identity=27.3076923076923, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI20129971, Length=246, Percent_Identity=36.5853658536585, Blast_Score=124, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24653477, Length=246, Percent_Identity=36.5853658536585, Blast_Score=124, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24653139, Length=258, Percent_Identity=31.3953488372093, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI19922422, Length=264, Percent_Identity=27.6515151515151, Blast_Score=91, Evalue=6e-19,
Organism=Drosophila melanogaster, GI21357171, Length=189, Percent_Identity=32.2751322751323, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24650670, Length=192, Percent_Identity=29.1666666666667, Blast_Score=71, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376
- InterPro:   IPR010198 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.1.3.36 [H]

Molecular weight: Translated: 30086; Mature: 29955

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPFEWVKEHDYEDIIYETYNGIAKITINRPEVHNAFRPKTVNELIDAFTRARDDSNIGVI
CCCCHHHHCCHHHHHHHHCCCEEEEEECCCHHHCCCCCHHHHHHHHHHHHCCCCCCCEEE
ILTGAGGKAFCSGGDQKVRGHGGYVGEDEIPRLNVLDLQRLIRVIPKPVIAMVAGYAIGG
EEECCCCCCEECCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCC
GHVLHIVCDLTIAADNAIFGQTGPKVGSFDGGYGAGYLARIVGHKKAREIWYLCRQYNAQ
CEEEEEEEEEEEECCCCEECCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHCCHH
EALEMGLVNKVVPLEQLEEETVKWAQEILEKSPTAIRFLKAAFNADSDGLAGIQQLAGDA
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHCCCE
TLLFYTTEEAKEGMRAFKEKRKPDFGQFPRFP
EEEEEECHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
PFEWVKEHDYEDIIYETYNGIAKITINRPEVHNAFRPKTVNELIDAFTRARDDSNIGVI
CCCHHHHCCHHHHHHHHCCCEEEEEECCCHHHCCCCCHHHHHHHHHHHHCCCCCCCEEE
ILTGAGGKAFCSGGDQKVRGHGGYVGEDEIPRLNVLDLQRLIRVIPKPVIAMVAGYAIGG
EEECCCCCCEECCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCC
GHVLHIVCDLTIAADNAIFGQTGPKVGSFDGGYGAGYLARIVGHKKAREIWYLCRQYNAQ
CEEEEEEEEEEEECCCCEECCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHCCHH
EALEMGLVNKVVPLEQLEEETVKWAQEILEKSPTAIRFLKAAFNADSDGLAGIQQLAGDA
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHCCCE
TLLFYTTEEAKEGMRAFKEKRKPDFGQFPRFP
EEEEEECHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1629163; 8566759; 9387221; 9384377 [H]