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The map label for this gene is citZ [H]

Identifier: 138896297

GI number: 138896297

Start: 2768709

End: 2769827

Strand: Reverse

Name: citZ [H]

Synonym: GTNG_2660

Alternate gene names: 138896297

Gene position: 2769827-2768709 (Counterclockwise)

Preceding gene: 138896298

Following gene: 138896296

Centisome position: 78.02

GC content: 51.65

Gene sequence:

>1119_bases
ATGACAGTAACCCGCGGTTTAGAAGGGGTTGTGGCGACAACCTCAAGCATCAGCTCGATCATCGATGATACATTGACGTA
TGTCGGCTATAACATTGATGATTTAGCCGAAAACGCTTCCTTCGAAGAGGTCATTTATTTGCTTTGGCATCGGGTGCTGC
CAACAAAAGAGCAGCTGGCGGAACTGAAGCAGCAGCTTGCGGAGAATGCGGAGATTCCGAACGAAATCATTGAGCATTTT
AAATTATACCCGATCGATAAAGTGCATCCGATGGCCGCGTTGCGCACGGCGATTTCGCTCCTCGGCCTGTATGATGAAGA
GGCGGATGTTATGACGAAAGAGGCAAACTACCGGAAAGCAATCCGCCTGCAGGCGAAAATCCCGACGATCGTCACCGCAT
TTGCCCGCGTGCGCAAAGGATTGGAACCGGTTGCGCCGCGCAAAGATTTAAGCTTTGCTGCGAATTTCTTGTATATGCTC
ACCGGTGAGGAGCCGAATGAAATTGCGGAGGAAGCGTTCAACAAGGCACTCGTGCTGCATGCTGACCATGAGCTGAACGC
ATCGACGTTCACGGCGCGTGTCTGCGTGGCGACGCTGTCGGACATTTATTCTGGCATTACTGCAGCGATCGGCGCCTTGA
AAGGGCCGCTTCACGGCGGGGCGAACGAAGCGGTCATGAAAATGTTGACGGAAATCGGCACGATCGACAACGTTGAGCCG
TACATCCGCGGAAAACTGGCCAATAAAGAGAAAATTATGGGGTTTGGCCACCGCGTCTACCGGAAAGGCGACCCGCGCGC
CAAGCATTTGAAAAAAATGTCGGAAAAACTGACGAAGCTTGTTGGTGAACCGCACTGGTATGAAATGTCGACGAAGATTG
AAGAAATCGTCACATCGGAAAAAGCGTTGCCGCCGAACGTTGACTTTTATTCCGCCTCGGTTTACCATTGTTTAGGAATC
GACCATGATTTATTTACGCCGATTTTTGCCGTCAGCCGGACATCGGGATGGTTAGCCCACATTTTAGAGCAATATGACAA
CAACCGTCTCATCCGTCCGCGTGCGGAGTACACCGGCCCGAGCAAGCAAGTGTACGTGCCGATTGAACAGCGCGGTTAA

Upstream 100 bases:

>100_bases
GCACTTTCTTGTGTATGTCTGTTTTTGCATCCATTTCGAGCAAGCGCTCACCAGCCGTCTAGTGGCAAGGCAGGAATTAT
GAAGAAAAGGGGAGATTCGT

Downstream 100 bases:

>100_bases
ACAAGTGGACAAGGCGCTGAAGGCCAACCTTCACGCCTTTTCAATAAAAAATGGCATTGGGGGTTTTACTCGTGACGCAA
GGGGAAAAAATTACTGTCAC

Product: citrate synthase

Products: NA

Alternate protein names: Citrate synthase II [H]

Number of amino acids: Translated: 372; Mature: 371

Protein sequence:

>372_residues
MTVTRGLEGVVATTSSISSIIDDTLTYVGYNIDDLAENASFEEVIYLLWHRVLPTKEQLAELKQQLAENAEIPNEIIEHF
KLYPIDKVHPMAALRTAISLLGLYDEEADVMTKEANYRKAIRLQAKIPTIVTAFARVRKGLEPVAPRKDLSFAANFLYML
TGEEPNEIAEEAFNKALVLHADHELNASTFTARVCVATLSDIYSGITAAIGALKGPLHGGANEAVMKMLTEIGTIDNVEP
YIRGKLANKEKIMGFGHRVYRKGDPRAKHLKKMSEKLTKLVGEPHWYEMSTKIEEIVTSEKALPPNVDFYSASVYHCLGI
DHDLFTPIFAVSRTSGWLAHILEQYDNNRLIRPRAEYTGPSKQVYVPIEQRG

Sequences:

>Translated_372_residues
MTVTRGLEGVVATTSSISSIIDDTLTYVGYNIDDLAENASFEEVIYLLWHRVLPTKEQLAELKQQLAENAEIPNEIIEHF
KLYPIDKVHPMAALRTAISLLGLYDEEADVMTKEANYRKAIRLQAKIPTIVTAFARVRKGLEPVAPRKDLSFAANFLYML
TGEEPNEIAEEAFNKALVLHADHELNASTFTARVCVATLSDIYSGITAAIGALKGPLHGGANEAVMKMLTEIGTIDNVEP
YIRGKLANKEKIMGFGHRVYRKGDPRAKHLKKMSEKLTKLVGEPHWYEMSTKIEEIVTSEKALPPNVDFYSASVYHCLGI
DHDLFTPIFAVSRTSGWLAHILEQYDNNRLIRPRAEYTGPSKQVYVPIEQRG
>Mature_371_residues
TVTRGLEGVVATTSSISSIIDDTLTYVGYNIDDLAENASFEEVIYLLWHRVLPTKEQLAELKQQLAENAEIPNEIIEHFK
LYPIDKVHPMAALRTAISLLGLYDEEADVMTKEANYRKAIRLQAKIPTIVTAFARVRKGLEPVAPRKDLSFAANFLYMLT
GEEPNEIAEEAFNKALVLHADHELNASTFTARVCVATLSDIYSGITAAIGALKGPLHGGANEAVMKMLTEIGTIDNVEPY
IRGKLANKEKIMGFGHRVYRKGDPRAKHLKKMSEKLTKLVGEPHWYEMSTKIEEIVTSEKALPPNVDFYSASVYHCLGID
HDLFTPIFAVSRTSGWLAHILEQYDNNRLIRPRAEYTGPSKQVYVPIEQRG

Specific function: Might regulate the synthesis and function of enzymes involved in later enzymatic steps of Krebs cycle. Loss in activity results in sporulation defect [H]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=373, Percent_Identity=28.1501340482574, Blast_Score=114, Evalue=1e-25,
Organism=Escherichia coli, GI1786527, Length=368, Percent_Identity=37.7717391304348, Blast_Score=253, Evalue=1e-68,
Organism=Escherichia coli, GI1786939, Length=382, Percent_Identity=37.17277486911, Blast_Score=222, Evalue=4e-59,
Organism=Caenorhabditis elegans, GI17555174, Length=376, Percent_Identity=28.9893617021277, Blast_Score=121, Evalue=5e-28,
Organism=Saccharomyces cerevisiae, GI6319850, Length=403, Percent_Identity=25.8064516129032, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6324328, Length=401, Percent_Identity=26.4339152119701, Blast_Score=97, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6325257, Length=342, Percent_Identity=24.2690058479532, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24640126, Length=373, Percent_Identity=27.6139410187668, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24640124, Length=373, Percent_Identity=27.6139410187668, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI21356863, Length=384, Percent_Identity=26.8229166666667, Blast_Score=96, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011278
- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.1 [H]

Molecular weight: Translated: 41629; Mature: 41498

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: PS00480 CITRATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVTRGLEGVVATTSSISSIIDDTLTYVGYNIDDLAENASFEEVIYLLWHRVLPTKEQLA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHCCCHHHHH
ELKQQLAENAEIPNEIIEHFKLYPIDKVHPMAALRTAISLLGLYDEEADVMTKEANYRKA
HHHHHHHHCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHH
IRLQAKIPTIVTAFARVRKGLEPVAPRKDLSFAANFLYMLTGEEPNEIAEEAFNKALVLH
EEEHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHEEEEEECCCHHHHHHHHHCCEEEEE
ADHELNASTFTARVCVATLSDIYSGITAAIGALKGPLHGGANEAVMKMLTEIGTIDNVEP
ECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCH
YIRGKLANKEKIMGFGHRVYRKGDPRAKHLKKMSEKLTKLVGEPHWYEMSTKIEEIVTSE
HHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHC
KALPPNVDFYSASVYHCLGIDHDLFTPIFAVSRTSGWLAHILEQYDNNRLIRPRAEYTGP
CCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCEECCCHHCCCC
SKQVYVPIEQRG
CCEEEEEECCCC
>Mature Secondary Structure 
TVTRGLEGVVATTSSISSIIDDTLTYVGYNIDDLAENASFEEVIYLLWHRVLPTKEQLA
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHCCCHHHHH
ELKQQLAENAEIPNEIIEHFKLYPIDKVHPMAALRTAISLLGLYDEEADVMTKEANYRKA
HHHHHHHHCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHH
IRLQAKIPTIVTAFARVRKGLEPVAPRKDLSFAANFLYMLTGEEPNEIAEEAFNKALVLH
EEEHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHEEEEEECCCHHHHHHHHHCCEEEEE
ADHELNASTFTARVCVATLSDIYSGITAAIGALKGPLHGGANEAVMKMLTEIGTIDNVEP
ECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCH
YIRGKLANKEKIMGFGHRVYRKGDPRAKHLKKMSEKLTKLVGEPHWYEMSTKIEEIVTSE
HHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHC
KALPPNVDFYSASVYHCLGIDHDLFTPIFAVSRTSGWLAHILEQYDNNRLIRPRAEYTGP
CCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCEECCCHHCCCC
SKQVYVPIEQRG
CCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8045898; 9387221; 9384377 [H]