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The map label for this gene is icd [H]

Identifier: 138896296

GI number: 138896296

Start: 2767366

End: 2768637

Strand: Reverse

Name: icd [H]

Synonym: GTNG_2659

Alternate gene names: 138896296

Gene position: 2768637-2767366 (Counterclockwise)

Preceding gene: 138896297

Following gene: 138896295

Centisome position: 77.98

GC content: 51.42

Gene sequence:

>1272_bases
GTGACGCAAGGGGAAAAAATTACTGTCACCAATGGTGTTCTCAACGTTCCAAACAACCCGATCATCCCGTTCATTGAAGG
GGACGGAACGGGTCCGGACATTTGGGCAGCCGCTTCGCGCGTGCTCGAAGCAGCCGTTGAAAAAGCGTACAAAGGCGAGA
AGAAAATCGTCTGGAAGGAAGTGCTTGCTGGTGAAAAAGCGTACAAGCTGACGGGCAACTGGCTTCCAGATGAAACGCTT
GAGACGATCCGCGAATACATAATCGCTATTAAAGGGCCGTTGACGACGCCGGTTGGCGGTGGCATCCGTTCGTTGAACGT
TGCGCTCCGCCAAGAGCTGGACTTGTTCGTCTGCCTGCGTCCGGTTCGTTACTTCCAAGGTGTTCCGTCGCCGGTAAAAC
GTCCGGAAGATACCGACATGGTCATTTTCCGCGAAAATACGGAAGACATTTACGCCGGTATTGAGTATGCAAAAGGGACC
CCAGAAGTGAAAAAAGTGATTGACTTTTTGCAAAACGAAATGGGCGTGCGCAAAATCCGCTTCCCGGAAACGTCCGGTAT
CGGCATCAAACCGATTTCTGAAGAAGGAACGAAACGGCTCGTGCGCGCGGCAATCAACTATGCGATCGAACACGGCCGCA
AGTCGGTTACGCTCGTCCATAAAGGGAACATTATGAAGTTCACTGAAGGGGCGTTTAAAAACTGGGGTTATGAGCTGGCT
GAACAAGAGTTCGGCGACAAAGTGTTCACGTGGGCACAATATGACCGGATCGTTGAAGCAGAAGGAAAAGAAGCGGCGAA
CAAAGCGCTTGCTGACGCGGAAGCGACCGGTAAAATCATCATTAAAGACGCCATCGCCGACATCTTCCTGCAGCAAATTT
TGACGCGTCCGCGCGAATTTGATGTCATCGCGACGATGAACTTAAATGGCGATTACATTTCCGATGCACTCGCAGCCCAA
GTCGGCGGTATCGGCATCGCACCAGGAGCGAACATCAACTATGAAACCGGTCACGCCATTTTCGAAGCGACGCACGGCAC
GGCGCCGAAATATGCTGGTTTGGACAAAGTCAATCCGTCGTCGGTTATTTTGTCCGGCGTCATGATGTTTGAGCATCTCG
GCTGGAACGAAGCAGCTCAATTGATCATTCAAGCAATGGAAAAAACGATCGCGTCCAAAGTGGTCACGTACGATTTCGCC
CGTCTGATGGAAGGGGCAACCGAAGTGAAATGTTCGGAATTTGCTGATGCGCTCATCCGCAATATGGACTAA

Upstream 100 bases:

>100_bases
TGTACGTGCCGATTGAACAGCGCGGTTAAACAAGTGGACAAGGCGCTGAAGGCCAACCTTCACGCCTTTTCAATAAAAAA
TGGCATTGGGGGTTTTACTC

Downstream 100 bases:

>100_bases
CCTTTAACGAAGGGGATGGCAAACGATGGCGATGAAACGGAAAAAAATTTCGGTCATTGGCGCCGGATTTACGGGAGCGA
CGACGGCGTTCCTTTTGGCG

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 423; Mature: 422

Protein sequence:

>423_residues
MTQGEKITVTNGVLNVPNNPIIPFIEGDGTGPDIWAAASRVLEAAVEKAYKGEKKIVWKEVLAGEKAYKLTGNWLPDETL
ETIREYIIAIKGPLTTPVGGGIRSLNVALRQELDLFVCLRPVRYFQGVPSPVKRPEDTDMVIFRENTEDIYAGIEYAKGT
PEVKKVIDFLQNEMGVRKIRFPETSGIGIKPISEEGTKRLVRAAINYAIEHGRKSVTLVHKGNIMKFTEGAFKNWGYELA
EQEFGDKVFTWAQYDRIVEAEGKEAANKALADAEATGKIIIKDAIADIFLQQILTRPREFDVIATMNLNGDYISDALAAQ
VGGIGIAPGANINYETGHAIFEATHGTAPKYAGLDKVNPSSVILSGVMMFEHLGWNEAAQLIIQAMEKTIASKVVTYDFA
RLMEGATEVKCSEFADALIRNMD

Sequences:

>Translated_423_residues
MTQGEKITVTNGVLNVPNNPIIPFIEGDGTGPDIWAAASRVLEAAVEKAYKGEKKIVWKEVLAGEKAYKLTGNWLPDETL
ETIREYIIAIKGPLTTPVGGGIRSLNVALRQELDLFVCLRPVRYFQGVPSPVKRPEDTDMVIFRENTEDIYAGIEYAKGT
PEVKKVIDFLQNEMGVRKIRFPETSGIGIKPISEEGTKRLVRAAINYAIEHGRKSVTLVHKGNIMKFTEGAFKNWGYELA
EQEFGDKVFTWAQYDRIVEAEGKEAANKALADAEATGKIIIKDAIADIFLQQILTRPREFDVIATMNLNGDYISDALAAQ
VGGIGIAPGANINYETGHAIFEATHGTAPKYAGLDKVNPSSVILSGVMMFEHLGWNEAAQLIIQAMEKTIASKVVTYDFA
RLMEGATEVKCSEFADALIRNMD
>Mature_422_residues
TQGEKITVTNGVLNVPNNPIIPFIEGDGTGPDIWAAASRVLEAAVEKAYKGEKKIVWKEVLAGEKAYKLTGNWLPDETLE
TIREYIIAIKGPLTTPVGGGIRSLNVALRQELDLFVCLRPVRYFQGVPSPVKRPEDTDMVIFRENTEDIYAGIEYAKGTP
EVKKVIDFLQNEMGVRKIRFPETSGIGIKPISEEGTKRLVRAAINYAIEHGRKSVTLVHKGNIMKFTEGAFKNWGYELAE
QEFGDKVFTWAQYDRIVEAEGKEAANKALADAEATGKIIIKDAIADIFLQQILTRPREFDVIATMNLNGDYISDALAAQV
GGIGIAPGANINYETGHAIFEATHGTAPKYAGLDKVNPSSVILSGVMMFEHLGWNEAAQLIIQAMEKTIASKVVTYDFAR
LMEGATEVKCSEFADALIRNMD

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=403, Percent_Identity=32.0099255583127, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI28178816, Length=404, Percent_Identity=26.980198019802, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI28178821, Length=370, Percent_Identity=27.5675675675676, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI4758582, Length=373, Percent_Identity=28.1501340482574, Blast_Score=115, Evalue=9e-26,
Organism=Homo sapiens, GI28178838, Length=384, Percent_Identity=27.6041666666667, Blast_Score=115, Evalue=1e-25,
Organism=Escherichia coli, GI1787381, Length=423, Percent_Identity=67.612293144208, Blast_Score=569, Evalue=1e-163,
Organism=Escherichia coli, GI1788101, Length=394, Percent_Identity=29.1878172588832, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI87081683, Length=413, Percent_Identity=25.4237288135593, Blast_Score=88, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71986051, Length=404, Percent_Identity=32.1782178217822, Blast_Score=173, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI25144293, Length=374, Percent_Identity=27.0053475935829, Blast_Score=121, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI17505779, Length=371, Percent_Identity=27.2237196765499, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17550882, Length=406, Percent_Identity=26.6009852216749, Blast_Score=102, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6324709, Length=404, Percent_Identity=30.4455445544554, Blast_Score=168, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6322097, Length=376, Percent_Identity=30.8510638297872, Blast_Score=151, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6324291, Length=376, Percent_Identity=28.9893617021277, Blast_Score=136, Evalue=7e-33,
Organism=Drosophila melanogaster, GI24661184, Length=402, Percent_Identity=31.592039800995, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24643270, Length=402, Percent_Identity=31.8407960199005, Blast_Score=182, Evalue=3e-46,
Organism=Drosophila melanogaster, GI24643268, Length=402, Percent_Identity=31.8407960199005, Blast_Score=182, Evalue=4e-46,
Organism=Drosophila melanogaster, GI161078635, Length=326, Percent_Identity=28.2208588957055, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI161078639, Length=326, Percent_Identity=28.2208588957055, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI161078633, Length=326, Percent_Identity=28.2208588957055, Blast_Score=116, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24650122, Length=326, Percent_Identity=28.2208588957055, Blast_Score=116, Evalue=4e-26,
Organism=Drosophila melanogaster, GI161078637, Length=326, Percent_Identity=28.2208588957055, Blast_Score=116, Evalue=4e-26,
Organism=Drosophila melanogaster, GI281362242, Length=416, Percent_Identity=26.2019230769231, Blast_Score=101, Evalue=9e-22,
Organism=Drosophila melanogaster, GI24648872, Length=416, Percent_Identity=26.2019230769231, Blast_Score=101, Evalue=9e-22,
Organism=Drosophila melanogaster, GI20130355, Length=398, Percent_Identity=23.6180904522613, Blast_Score=95, Evalue=9e-20,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004439 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 46545; Mature: 46414

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQGEKITVTNGVLNVPNNPIIPFIEGDGTGPDIWAAASRVLEAAVEKAYKGEKKIVWKE
CCCCCEEEEECCEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHH
VLAGEKAYKLTGNWLPDETLETIREYIIAIKGPLTTPVGGGIRSLNVALRQELDLFVCLR
HHCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
PVRYFQGVPSPVKRPEDTDMVIFRENTEDIYAGIEYAKGTPEVKKVIDFLQNEMGVRKIR
HHHHHCCCCCCCCCCCCCCEEEEECCCHHHHHCCHHCCCCHHHHHHHHHHHHHCCCEEEE
FPETSGIGIKPISEEGTKRLVRAAINYAIEHGRKSVTLVHKGNIMKFTEGAFKNWGYELA
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEECCHHHHHCCHHHH
EQEFGDKVFTWAQYDRIVEAEGKEAANKALADAEATGKIIIKDAIADIFLQQILTRPREF
HHHCCCHHEEHHHHHHHHHCCCHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHCCCCCE
DVIATMNLNGDYISDALAAQVGGIGIAPGANINYETGHAIFEATHGTAPKYAGLDKVNPS
EEEEEEECCCHHHHHHHHHHHCCEEECCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCHH
SVILSGVMMFEHLGWNEAAQLIIQAMEKTIASKVVTYDFARLMEGATEVKCSEFADALIR
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
NMD
CCC
>Mature Secondary Structure 
TQGEKITVTNGVLNVPNNPIIPFIEGDGTGPDIWAAASRVLEAAVEKAYKGEKKIVWKE
CCCCEEEEECCEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHH
VLAGEKAYKLTGNWLPDETLETIREYIIAIKGPLTTPVGGGIRSLNVALRQELDLFVCLR
HHCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
PVRYFQGVPSPVKRPEDTDMVIFRENTEDIYAGIEYAKGTPEVKKVIDFLQNEMGVRKIR
HHHHHCCCCCCCCCCCCCCEEEEECCCHHHHHCCHHCCCCHHHHHHHHHHHHHCCCEEEE
FPETSGIGIKPISEEGTKRLVRAAINYAIEHGRKSVTLVHKGNIMKFTEGAFKNWGYELA
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEECCHHHHHCCHHHH
EQEFGDKVFTWAQYDRIVEAEGKEAANKALADAEATGKIIIKDAIADIFLQQILTRPREF
HHHCCCHHEEHHHHHHHHHCCCHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHCCCCCE
DVIATMNLNGDYISDALAAQVGGIGIAPGANINYETGHAIFEATHGTAPKYAGLDKVNPS
EEEEEEECCCHHHHHHHHHHHCCEEECCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCHH
SVILSGVMMFEHLGWNEAAQLIIQAMEKTIASKVVTYDFARLMEGATEVKCSEFADALIR
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
NMD
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8045898; 9387221; 9384377; 11751849; 11290745 [H]