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The map label for this gene is gcvPA [H]

Identifier: 138896000

GI number: 138896000

Start: 2480311

End: 2481657

Strand: Reverse

Name: gcvPA [H]

Synonym: GTNG_2363

Alternate gene names: 138896000

Gene position: 2481657-2480311 (Counterclockwise)

Preceding gene: 138896001

Following gene: 138895999

Centisome position: 69.9

GC content: 53.3

Gene sequence:

>1347_bases
GTGCTCCACCGTTATTTGCCGATGACGGAAGAAGACAAACAAGAGATGTTGAAGACGATCGGTGTTGCCTCGATCGATGA
GCTGTTCGCTGACATTCCGGAACAAGTCCGCTTCCGCGGTGAACTGAATGTGAAACGGGCAAAATCGGAACCGGAACTGT
GGAAAGAGTTAAGTGCGCTGGCGGACAAAAACGCTAATGCGAGACAATATGTTTCTTTTTTAGGTGCCGGGGTGTACGAT
CATTATATTCCGGCCGTCGTCGACCATGTTTTAATGCGTTCCGAGTTTTACACGGCGTATACGCCGTACCAGCCGGAAAT
TTCGCAAGGCGAGCTGCAGGCCATTTTCGAATTCCAAACGATGGTGTGCGAGCTGACCGGCATGGACGTCGCCAACTCGT
CGATGTATGACGGCGGCACGGCGCTTGCAGAAGCAGTGCTGCTGAGCGCGGCCCATACGAAGCGCCGCAAAGTGCTTATC
TCTAACGCCGTCCATCCGCAATATCGTGAAGTCGTGCGCACGTATGCGAACGGACAGCGGCTTGAGGTGAAAGAAATTCC
GTATAACGGCGGTGTCACTGATCTTGAGGTGCTTGCAGCCGAAATGGGAGACGATGTGGCGTGCGTTGTAATCCAATATC
CAAACTTTTTCGGCCAGATTGAGCCGCTCAAAGCGATTGAGCCGCTCGTCCATGAAAAGAAGAGTTTATTTGTTGTTGCT
AGCAATCCGCTCGCCCTTGGTGTTTTGACCCCGCCTGGGGAGTTTGGGGCCGACATCGTCGTCGGTGATATGCAGCCGTT
TGGTATCCCGATGCAATTTGGAGGTCCACACTGCGGTTATTTTGCCGTCAAAGCGCCGCTCATGCGGAAGATTCCGGGGC
GTCTTGTCGGGCAGACGACCGACGAGGAAGGTCGCCGTGGATTTGTGTTGACGTTGCAGGCACGTGAACAGCATATACGT
CGCGATAAAGCGACATCGAACATTTGTTCAAACCAAGCGTTAAACGCCTTGGCTGCTTCAGTGGCGCTCTCGGCGCTCGG
CAAGCGGGGGGTGAAAGAGATGGCGACGATGAACATGCAAAAGGCGCATTATGCGAAAAGCGAGCTCCAAAAACGCGGCT
TATTATCGCCATTTGCCGGCCCGTTTTTTAACGAGTTTGTCATCCGGCTCAACCAGCCGGTCGATGATGTCAACGCCCGC
CTGCGGCAAAAAGGGATCATCGGCGGCTATAATCTCGGCTTCGATTATCCGGAGCTTGCCAACCATATGCTCGTTGCTGT
CACAGAACTGCGGACGAAGGAAGAAATCGATCGGTTTGTAAACGAATTGGGGGATGGCCATGCATAA

Upstream 100 bases:

>100_bases
GAAGTAGAAGTGGACATCCGTGGCAAACGATTGAAAGCAACCATTGTACCGACCCCGTTTTACAAGCGGGCCAAGTCATA
AGTAAGGGGGAAGGAAAACT

Downstream 100 bases:

>100_bases
CGATCAACCGCTCATTTTCGAACGAAGCAAGCCAGGACGAATTGCCTACAGCTTACCGACACTTGACGTTCCTGCTGTTG
ATGTAAGCGAGCTTGTGCCG

Product: glycine dehydrogenase subunit 1

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 1; Glycine decarboxylase subunit 1 [H]

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MLHRYLPMTEEDKQEMLKTIGVASIDELFADIPEQVRFRGELNVKRAKSEPELWKELSALADKNANARQYVSFLGAGVYD
HYIPAVVDHVLMRSEFYTAYTPYQPEISQGELQAIFEFQTMVCELTGMDVANSSMYDGGTALAEAVLLSAAHTKRRKVLI
SNAVHPQYREVVRTYANGQRLEVKEIPYNGGVTDLEVLAAEMGDDVACVVIQYPNFFGQIEPLKAIEPLVHEKKSLFVVA
SNPLALGVLTPPGEFGADIVVGDMQPFGIPMQFGGPHCGYFAVKAPLMRKIPGRLVGQTTDEEGRRGFVLTLQAREQHIR
RDKATSNICSNQALNALAASVALSALGKRGVKEMATMNMQKAHYAKSELQKRGLLSPFAGPFFNEFVIRLNQPVDDVNAR
LRQKGIIGGYNLGFDYPELANHMLVAVTELRTKEEIDRFVNELGDGHA

Sequences:

>Translated_448_residues
MLHRYLPMTEEDKQEMLKTIGVASIDELFADIPEQVRFRGELNVKRAKSEPELWKELSALADKNANARQYVSFLGAGVYD
HYIPAVVDHVLMRSEFYTAYTPYQPEISQGELQAIFEFQTMVCELTGMDVANSSMYDGGTALAEAVLLSAAHTKRRKVLI
SNAVHPQYREVVRTYANGQRLEVKEIPYNGGVTDLEVLAAEMGDDVACVVIQYPNFFGQIEPLKAIEPLVHEKKSLFVVA
SNPLALGVLTPPGEFGADIVVGDMQPFGIPMQFGGPHCGYFAVKAPLMRKIPGRLVGQTTDEEGRRGFVLTLQAREQHIR
RDKATSNICSNQALNALAASVALSALGKRGVKEMATMNMQKAHYAKSELQKRGLLSPFAGPFFNEFVIRLNQPVDDVNAR
LRQKGIIGGYNLGFDYPELANHMLVAVTELRTKEEIDRFVNELGDGHA
>Mature_448_residues
MLHRYLPMTEEDKQEMLKTIGVASIDELFADIPEQVRFRGELNVKRAKSEPELWKELSALADKNANARQYVSFLGAGVYD
HYIPAVVDHVLMRSEFYTAYTPYQPEISQGELQAIFEFQTMVCELTGMDVANSSMYDGGTALAEAVLLSAAHTKRRKVLI
SNAVHPQYREVVRTYANGQRLEVKEIPYNGGVTDLEVLAAEMGDDVACVVIQYPNFFGQIEPLKAIEPLVHEKKSLFVVA
SNPLALGVLTPPGEFGADIVVGDMQPFGIPMQFGGPHCGYFAVKAPLMRKIPGRLVGQTTDEEGRRGFVLTLQAREQHIR
RDKATSNICSNQALNALAASVALSALGKRGVKEMATMNMQKAHYAKSELQKRGLLSPFAGPFFNEFVIRLNQPVDDVNAR
LRQKGIIGGYNLGFDYPELANHMLVAVTELRTKEEIDRFVNELGDGHA

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG0403

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. N-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=408, Percent_Identity=40.9313725490196, Blast_Score=288, Evalue=6e-78,
Organism=Escherichia coli, GI1789269, Length=452, Percent_Identity=33.1858407079646, Blast_Score=206, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI17535605, Length=386, Percent_Identity=38.3419689119171, Blast_Score=241, Evalue=4e-64,
Organism=Saccharomyces cerevisiae, GI6323843, Length=362, Percent_Identity=40.8839779005525, Blast_Score=256, Evalue=4e-69,
Organism=Drosophila melanogaster, GI24645648, Length=415, Percent_Identity=38.3132530120482, Blast_Score=271, Evalue=1e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023010
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF02347 GDC-P [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 49694; Mature: 49694

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLHRYLPMTEEDKQEMLKTIGVASIDELFADIPEQVRFRGELNVKRAKSEPELWKELSAL
CCCCCCCCCCHHHHHHHHHHCHHHHHHHHHCCHHHHHHCCCCCHHHCCCCHHHHHHHHHH
ADKNANARQYVSFLGAGVYDHYIPAVVDHVLMRSEFYTAYTPYQPEISQGELQAIFEFQT
HCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHH
MVCELTGMDVANSSMYDGGTALAEAVLLSAAHTKRRKVLISNAVHPQYREVVRTYANGQR
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCE
LEVKEIPYNGGVTDLEVLAAEMGDDVACVVIQYPNFFGQIEPLKAIEPLVHEKKSLFVVA
EEEEECCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHHHHHHHCCCCEEEEE
SNPLALGVLTPPGEFGADIVVGDMQPFGIPMQFGGPHCGYFAVKAPLMRKIPGRLVGQTT
CCCEEEEEECCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHCCCCC
DEEGRRGFVLTLQAREQHIRRDKATSNICSNQALNALAASVALSALGKRGVKEMATMNMQ
CCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KAHYAKSELQKRGLLSPFAGPFFNEFVIRLNQPVDDVNARLRQKGIIGGYNLGFDYPELA
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCHHHH
NHMLVAVTELRTKEEIDRFVNELGDGHA
HHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MLHRYLPMTEEDKQEMLKTIGVASIDELFADIPEQVRFRGELNVKRAKSEPELWKELSAL
CCCCCCCCCCHHHHHHHHHHCHHHHHHHHHCCHHHHHHCCCCCHHHCCCCHHHHHHHHHH
ADKNANARQYVSFLGAGVYDHYIPAVVDHVLMRSEFYTAYTPYQPEISQGELQAIFEFQT
HCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHH
MVCELTGMDVANSSMYDGGTALAEAVLLSAAHTKRRKVLISNAVHPQYREVVRTYANGQR
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCE
LEVKEIPYNGGVTDLEVLAAEMGDDVACVVIQYPNFFGQIEPLKAIEPLVHEKKSLFVVA
EEEEECCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHHHHHHHCCCCEEEEE
SNPLALGVLTPPGEFGADIVVGDMQPFGIPMQFGGPHCGYFAVKAPLMRKIPGRLVGQTT
CCCEEEEEECCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHCCCCC
DEEGRRGFVLTLQAREQHIRRDKATSNICSNQALNALAASVALSALGKRGVKEMATMNMQ
CCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KAHYAKSELQKRGLLSPFAGPFFNEFVIRLNQPVDDVNARLRQKGIIGGYNLGFDYPELA
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCHHHH
NHMLVAVTELRTKEEIDRFVNELGDGHA
HHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA