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The map label for this gene is gcvT

Identifier: 138896001

GI number: 138896001

Start: 2481677

End: 2482774

Strand: Reverse

Name: gcvT

Synonym: GTNG_2364

Alternate gene names: 138896001

Gene position: 2482774-2481677 (Counterclockwise)

Preceding gene: 138896004

Following gene: 138896000

Centisome position: 69.93

GC content: 54.28

Gene sequence:

>1098_bases
ATGCTGAAGCGCACGCCACTTTTTCCGGTATATGCCCGTTACGGCGCCAAGACAGTTGAATTTGGCGGCTGGGAAATGCC
GGTGCAATTTTCAAGCATCAAGGAAGAACACAATGCTGTAAGAACGCGCGCCGGGCTGTTTGATGTTTCCCATATGGGGG
AAATCATCGTCCGCGGCGGTGGCAGTCTCCCTTTTTTGCAAAAACTGATGACGAACGATGTCGCTAAGCTGCGGCCGGGA
CGGGTGCAATATACGCTCATGTGTGATGAAAGCGCTGGCACCGTTGATGACTTGTTGATTTATCAAAAAGGGGAAGACGA
CTATTTGCTTGTCGTCAACGCTGCAAATACGGAAAAAGATTTTGCGTGGCTAAGCGAGCACGCAGATGGTGACGTCGAAC
TCGAGGATGTGTCGGCGGAAACGGCGTTGCTTGCTTTGCAAGGGCCAGCTGCCGAACGCGTGCTGCAAAAATTGACCGAT
ATGGATTTGTCGGCGCTGCGTCCGTTTTCGTTCCAAGATGGTGTGGAAGTGGCCAGCGTAAAGACGCTCGTTTCCCGTAC
CGGCTATACCGGTGAGGACGGGTTTGAACTATACTGTCAAGCGGAAGATGCCATTACTTTATGGGAGGCTATCTTGACAG
CTGGAGCTGAGGACGGCGTCCTCCCGTGCGGGTTAGGGGCGCGTGACACGCTCCGCTTTGAAGCGTGTTTGCCGCTTTAC
GGCCAAGAACTCTCAGCAACGATCTCGCCGCTTGAAGCCGGGCTCGGCTTTGCCGTCAAAACGGAAAAAGAGCCGCCATT
TATCGGCCAAGCCGTGCTGAAGCAGCAAAAAGAAGCTGGGCCGCCGCGTCGGCTTGTCGGCATCGAGATGATCGATAAAG
GCATTCCGCGCCACGGTTACCGCGTGTTTGCCGCCGGCGAAGAAGCTGGCTTCGTCACAACCGGCACGCAGTCGCCGACG
TTGAAAAAAAACATCGGTCTAGCTCTTGTCAAAGCGGAAGTGGCTGCGATTGGCCAAGAAGTAGAAGTGGACATCCGTGG
CAAACGATTGAAAGCAACCATTGTACCGACCCCGTTTTACAAGCGGGCCAAGTCATAA

Upstream 100 bases:

>100_bases
GTCGACGGGAAACTTTCAGGTGCCAGGACAGAGCCCCCTTTTATATAAAGGGTGGAGTCTGTCCTTTTTTTGCGTCACAG
ATTAAAAAGGAGGGAATCGG

Downstream 100 bases:

>100_bases
GTAAGGGGGAAGGAAAACTGTGCTCCACCGTTATTTGCCGATGACGGAAGAAGACAAACAAGAGATGTTGAAGACGATCG
GTGTTGCCTCGATCGATGAG

Product: glycine cleavage system aminomethyltransferase T

Products: NA

Alternate protein names: Glycine cleavage system T protein

Number of amino acids: Translated: 365; Mature: 365

Protein sequence:

>365_residues
MLKRTPLFPVYARYGAKTVEFGGWEMPVQFSSIKEEHNAVRTRAGLFDVSHMGEIIVRGGGSLPFLQKLMTNDVAKLRPG
RVQYTLMCDESAGTVDDLLIYQKGEDDYLLVVNAANTEKDFAWLSEHADGDVELEDVSAETALLALQGPAAERVLQKLTD
MDLSALRPFSFQDGVEVASVKTLVSRTGYTGEDGFELYCQAEDAITLWEAILTAGAEDGVLPCGLGARDTLRFEACLPLY
GQELSATISPLEAGLGFAVKTEKEPPFIGQAVLKQQKEAGPPRRLVGIEMIDKGIPRHGYRVFAAGEEAGFVTTGTQSPT
LKKNIGLALVKAEVAAIGQEVEVDIRGKRLKATIVPTPFYKRAKS

Sequences:

>Translated_365_residues
MLKRTPLFPVYARYGAKTVEFGGWEMPVQFSSIKEEHNAVRTRAGLFDVSHMGEIIVRGGGSLPFLQKLMTNDVAKLRPG
RVQYTLMCDESAGTVDDLLIYQKGEDDYLLVVNAANTEKDFAWLSEHADGDVELEDVSAETALLALQGPAAERVLQKLTD
MDLSALRPFSFQDGVEVASVKTLVSRTGYTGEDGFELYCQAEDAITLWEAILTAGAEDGVLPCGLGARDTLRFEACLPLY
GQELSATISPLEAGLGFAVKTEKEPPFIGQAVLKQQKEAGPPRRLVGIEMIDKGIPRHGYRVFAAGEEAGFVTTGTQSPT
LKKNIGLALVKAEVAAIGQEVEVDIRGKRLKATIVPTPFYKRAKS
>Mature_365_residues
MLKRTPLFPVYARYGAKTVEFGGWEMPVQFSSIKEEHNAVRTRAGLFDVSHMGEIIVRGGGSLPFLQKLMTNDVAKLRPG
RVQYTLMCDESAGTVDDLLIYQKGEDDYLLVVNAANTEKDFAWLSEHADGDVELEDVSAETALLALQGPAAERVLQKLTD
MDLSALRPFSFQDGVEVASVKTLVSRTGYTGEDGFELYCQAEDAITLWEAILTAGAEDGVLPCGLGARDTLRFEACLPLY
GQELSATISPLEAGLGFAVKTEKEPPFIGQAVLKQQKEAGPPRRLVGIEMIDKGIPRHGYRVFAAGEEAGFVTTGTQSPT
LKKNIGLALVKAEVAAIGQEVEVDIRGKRLKATIVPTPFYKRAKS

Specific function: The glycine cleavage system catalyzes the degradation of glycine

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family

Homologues:

Organism=Homo sapiens, GI44662838, Length=369, Percent_Identity=35.230352303523, Blast_Score=192, Evalue=3e-49,
Organism=Homo sapiens, GI257796258, Length=355, Percent_Identity=35.2112676056338, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI24797151, Length=335, Percent_Identity=31.9402985074627, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI257796254, Length=363, Percent_Identity=32.2314049586777, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI257796256, Length=312, Percent_Identity=33.974358974359, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI197927446, Length=324, Percent_Identity=28.7037037037037, Blast_Score=128, Evalue=7e-30,
Organism=Homo sapiens, GI21361378, Length=324, Percent_Identity=28.7037037037037, Blast_Score=128, Evalue=7e-30,
Organism=Homo sapiens, GI194306651, Length=349, Percent_Identity=27.2206303724928, Blast_Score=114, Evalue=2e-25,
Organism=Escherichia coli, GI1789272, Length=376, Percent_Identity=39.0957446808511, Blast_Score=244, Evalue=5e-66,
Organism=Caenorhabditis elegans, GI17560118, Length=370, Percent_Identity=37.027027027027, Blast_Score=201, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI71994045, Length=381, Percent_Identity=27.8215223097113, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI71994052, Length=381, Percent_Identity=27.8215223097113, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI32563613, Length=345, Percent_Identity=26.9565217391304, Blast_Score=112, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6320222, Length=393, Percent_Identity=33.8422391857506, Blast_Score=179, Evalue=4e-46,
Organism=Drosophila melanogaster, GI20129441, Length=375, Percent_Identity=33.8666666666667, Blast_Score=187, Evalue=7e-48,
Organism=Drosophila melanogaster, GI28571104, Length=387, Percent_Identity=25.8397932816537, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI20130091, Length=365, Percent_Identity=24.9315068493151, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): GCST_GEOTN (A4IQV5)

Other databases:

- EMBL:   CP000557
- RefSeq:   YP_001126454.1
- ProteinModelPortal:   A4IQV5
- SMR:   A4IQV5
- STRING:   A4IQV5
- GeneID:   4967290
- GenomeReviews:   CP000557_GR
- KEGG:   gtn:GTNG_2364
- NMPDR:   fig|420246.5.peg.2270
- eggNOG:   COG0404
- HOGENOM:   HBG299834
- OMA:   NDISKPP
- PhylomeDB:   A4IQV5
- ProtClustDB:   PRK00389
- BioCyc:   GTHE420246:GTNG_2364-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00259
- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903
- PIRSF:   PIRSF006487
- TIGRFAMs:   TIGR00528

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C

EC number: =2.1.2.10

Molecular weight: Translated: 39687; Mature: 39687

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKRTPLFPVYARYGAKTVEFGGWEMPVQFSSIKEEHNAVRTRAGLFDVSHMGEIIVRGG
CCCCCCCCHHHHHCCCCEEECCCEECCEEHHHHHHHHHHHHHHHCEEEHHHCCEEEEECC
GSLPFLQKLMTNDVAKLRPGRVQYTLMCDESAGTVDDLLIYQKGEDDYLLVVNAANTEKD
CCCHHHHHHHHCCHHHCCCCCEEEEEEECCCCCCHHHEEEEEECCCCEEEEEECCCCCHH
FAWLSEHADGDVELEDVSAETALLALQGPAAERVLQKLTDMDLSALRPFSFQDGVEVASV
HHHHHHCCCCCEEEEECCCCEEEEEECCCHHHHHHHHHHCCCHHHCCCCCCCCCCHHHHH
KTLVSRTGYTGEDGFELYCQAEDAITLWEAILTAGAEDGVLPCGLGARDTLRFEACLPLY
HHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCEECCCCCCCCEEEEEECCCC
GQELSATISPLEAGLGFAVKTEKEPPFIGQAVLKQQKEAGPPRRLVGIEMIDKGIPRHGY
CCHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHCCCCHHEEEHHHHHCCCCCCCE
RVFAAGEEAGFVTTGTQSPTLKKNIGLALVKAEVAAIGQEVEVDIRGKRLKATIVPTPFY
EEEECCCCCCEEEECCCCCCHHHCCCEEEEEHHHHHCCCEEEEEECCCEEEEEEECCCHH
KRAKS
HHCCC
>Mature Secondary Structure
MLKRTPLFPVYARYGAKTVEFGGWEMPVQFSSIKEEHNAVRTRAGLFDVSHMGEIIVRGG
CCCCCCCCHHHHHCCCCEEECCCEECCEEHHHHHHHHHHHHHHHCEEEHHHCCEEEEECC
GSLPFLQKLMTNDVAKLRPGRVQYTLMCDESAGTVDDLLIYQKGEDDYLLVVNAANTEKD
CCCHHHHHHHHCCHHHCCCCCEEEEEEECCCCCCHHHEEEEEECCCCEEEEEECCCCCHH
FAWLSEHADGDVELEDVSAETALLALQGPAAERVLQKLTDMDLSALRPFSFQDGVEVASV
HHHHHHCCCCCEEEEECCCCEEEEEECCCHHHHHHHHHHCCCHHHCCCCCCCCCCHHHHH
KTLVSRTGYTGEDGFELYCQAEDAITLWEAILTAGAEDGVLPCGLGARDTLRFEACLPLY
HHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCEECCCCCCCCEEEEEECCCC
GQELSATISPLEAGLGFAVKTEKEPPFIGQAVLKQQKEAGPPRRLVGIEMIDKGIPRHGY
CCHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHCCCCHHEEEHHHHHCCCCCCCE
RVFAAGEEAGFVTTGTQSPTLKKNIGLALVKAEVAAIGQEVEVDIRGKRLKATIVPTPFY
EEEECCCCCCEEEECCCCCCHHHCCCEEEEEHHHHHCCCEEEEEECCCEEEEEEECCCHH
KRAKS
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA