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The map label for this gene is gcvPB [H]

Identifier: 138895999

GI number: 138895999

Start: 2478780

End: 2480318

Strand: Reverse

Name: gcvPB [H]

Synonym: GTNG_2362

Alternate gene names: 138895999

Gene position: 2480318-2478780 (Counterclockwise)

Preceding gene: 138896000

Following gene: 138895998

Centisome position: 69.86

GC content: 53.87

Gene sequence:

>1539_bases
ATGCATAACGATCAACCGCTCATTTTCGAACGAAGCAAGCCAGGACGAATTGCCTACAGCTTACCGACACTTGACGTTCC
TGCTGTTGATGTAAGCGAGCTTGTGCCGGCTGATTATCTTCGCACTGAGGAGCCGGAGCTGCCGGAAGTGTCAGAATTGG
ACTTAATGCGCCATTATACCGCGCTCTCCAAGCGGAACCACGGCGTCGATTCAGGATTTTACCCGCTCGGGTCGTGCACG
ATGAAATACAATCCGAAAATCAATGAAAATGTCGCCCGTCTCGCCGGGTTTGCTCACATCCATCCGCTGCAGCCGGAGGA
AACGGTGCAAGGGGCGCTTGAACTCATGTACGACTTGCAAGAGCACTTAAAAGAAATTACCGGAATGGATGCAGTTACGC
TGCAACCGGCGGCTGGCGCTCACGGCGAGTGGACCGGGCTGATGATGATCCGTGCCTATCACGAAGCAAACGGCGATTTC
GGACGGACGAAAGTGATCGTTCCTGACTCGGCGCACGGCACGAATCCGGCGTCGGCAACGGTTGCCGGCTTTGAAACAGT
TACGGTTCGCTCGACTGCTGATGGACTTGTTGACTTAGAGGACTTAAAGCGCGTTGTCGGCCCGGATACAGCGGCGCTTA
TGCTCACAAACCCGAACACACTCGGGCTGTTTGAAGAGCAGATCGTCGAAATGGCAGAAATCGTCCATGAGGCGGGCGGC
AAGCTGTATTATGACGGCGCGAACTTAAACGCCATTCTTGGTAAGGCGCGACCAGGTGATATGGGCTTTGACGTCGTCCA
TTTGAACTTGCATAAAACGTTTACCGGCCCGCACGGCGGCGGGGGCCCAGGTTCTGGTCCGGTCGGGGTGAAAGCTGACC
TCATCCCGTTTTTGCCGAAGCCGGTCATTGCCAAAGGAGAAAACGGCTATTATCTCGATGACGATCGCCCGCAATCGATC
GGACGTGTCAAGCCGTTTTACGGCAACTTCGGGATCAATGTCCGGGCGTACACGTACATCCGCTCGATGGGGCCGGACGG
CTTAAAAGCGGTGAGCGAATACGCCGTCTTAAACGCCAACTATATGATGCGTCGACTTGCCGACTATTACGATTTGCCGT
ATAACCGCCATTGCAAGCACGAGTTCGTTCTCTCCGGCAAACGGCAAAAGAAGCTTGGAGTCAGAACGTTGGATATAGCA
AAGCGGCTGCTGGATTTTGGCTTCCATCCGCCGACGATTTACTTCCCGCTCATCGTTGAAGAGTGCATGATGATCGAACC
GACTGAGACCGAATCGAAAGAAACGCTTGACGCGTTTATCGATGCGATGATTCAAATTGCCAAGGAAGCGGAAGAAACTC
CGGAAATCGTCCAAGAAGCGCCGCATACGACTGTTGTTAAACGGCTCGATGAAACGACTGCGGCCCGCAAGCGGGATTTT
GCGCTATCAAAAAACGAAAAACTAATACCGATAAGCGGCTCGTCCAAAAATGGGCGGGCCGTTTCGTTTAGCCCGGCTGC
GCCGCTATTGCAGCGTTGA

Upstream 100 bases:

>100_bases
TTCGATTATCCGGAGCTTGCCAACCATATGCTCGTTGCTGTCACAGAACTGCGGACGAAGGAAGAAATCGATCGGTTTGT
AAACGAATTGGGGGATGGCC

Downstream 100 bases:

>100_bases
CAGAAAAGTTTAGTTAGTTTATCATATAAACTAATGGCGGTGATCCATGAATAAGGGGGAGTGAGACATGCAATACCGGC
AGTTAGGAAGTACCGACCTT

Product: glycine dehydrogenase subunit 2

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 2; Glycine decarboxylase subunit 2 [H]

Number of amino acids: Translated: 512; Mature: 512

Protein sequence:

>512_residues
MHNDQPLIFERSKPGRIAYSLPTLDVPAVDVSELVPADYLRTEEPELPEVSELDLMRHYTALSKRNHGVDSGFYPLGSCT
MKYNPKINENVARLAGFAHIHPLQPEETVQGALELMYDLQEHLKEITGMDAVTLQPAAGAHGEWTGLMMIRAYHEANGDF
GRTKVIVPDSAHGTNPASATVAGFETVTVRSTADGLVDLEDLKRVVGPDTAALMLTNPNTLGLFEEQIVEMAEIVHEAGG
KLYYDGANLNAILGKARPGDMGFDVVHLNLHKTFTGPHGGGGPGSGPVGVKADLIPFLPKPVIAKGENGYYLDDDRPQSI
GRVKPFYGNFGINVRAYTYIRSMGPDGLKAVSEYAVLNANYMMRRLADYYDLPYNRHCKHEFVLSGKRQKKLGVRTLDIA
KRLLDFGFHPPTIYFPLIVEECMMIEPTETESKETLDAFIDAMIQIAKEAEETPEIVQEAPHTTVVKRLDETTAARKRDF
ALSKNEKLIPISGSSKNGRAVSFSPAAPLLQR

Sequences:

>Translated_512_residues
MHNDQPLIFERSKPGRIAYSLPTLDVPAVDVSELVPADYLRTEEPELPEVSELDLMRHYTALSKRNHGVDSGFYPLGSCT
MKYNPKINENVARLAGFAHIHPLQPEETVQGALELMYDLQEHLKEITGMDAVTLQPAAGAHGEWTGLMMIRAYHEANGDF
GRTKVIVPDSAHGTNPASATVAGFETVTVRSTADGLVDLEDLKRVVGPDTAALMLTNPNTLGLFEEQIVEMAEIVHEAGG
KLYYDGANLNAILGKARPGDMGFDVVHLNLHKTFTGPHGGGGPGSGPVGVKADLIPFLPKPVIAKGENGYYLDDDRPQSI
GRVKPFYGNFGINVRAYTYIRSMGPDGLKAVSEYAVLNANYMMRRLADYYDLPYNRHCKHEFVLSGKRQKKLGVRTLDIA
KRLLDFGFHPPTIYFPLIVEECMMIEPTETESKETLDAFIDAMIQIAKEAEETPEIVQEAPHTTVVKRLDETTAARKRDF
ALSKNEKLIPISGSSKNGRAVSFSPAAPLLQR
>Mature_512_residues
MHNDQPLIFERSKPGRIAYSLPTLDVPAVDVSELVPADYLRTEEPELPEVSELDLMRHYTALSKRNHGVDSGFYPLGSCT
MKYNPKINENVARLAGFAHIHPLQPEETVQGALELMYDLQEHLKEITGMDAVTLQPAAGAHGEWTGLMMIRAYHEANGDF
GRTKVIVPDSAHGTNPASATVAGFETVTVRSTADGLVDLEDLKRVVGPDTAALMLTNPNTLGLFEEQIVEMAEIVHEAGG
KLYYDGANLNAILGKARPGDMGFDVVHLNLHKTFTGPHGGGGPGSGPVGVKADLIPFLPKPVIAKGENGYYLDDDRPQSI
GRVKPFYGNFGINVRAYTYIRSMGPDGLKAVSEYAVLNANYMMRRLADYYDLPYNRHCKHEFVLSGKRQKKLGVRTLDIA
KRLLDFGFHPPTIYFPLIVEECMMIEPTETESKETLDAFIDAMIQIAKEAEETPEIVQEAPHTTVVKRLDETTAARKRDF
ALSKNEKLIPISGSSKNGRAVSFSPAAPLLQR

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG1003

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. C-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=413, Percent_Identity=43.8256658595642, Blast_Score=292, Evalue=5e-79,
Organism=Escherichia coli, GI1789269, Length=445, Percent_Identity=41.7977528089888, Blast_Score=297, Evalue=1e-81,
Organism=Caenorhabditis elegans, GI17535605, Length=409, Percent_Identity=43.0317848410758, Blast_Score=288, Evalue=4e-78,
Organism=Caenorhabditis elegans, GI32564013, Length=399, Percent_Identity=42.3558897243108, Blast_Score=270, Evalue=2e-72,
Organism=Saccharomyces cerevisiae, GI6323843, Length=455, Percent_Identity=43.956043956044, Blast_Score=337, Evalue=3e-93,
Organism=Drosophila melanogaster, GI24645648, Length=411, Percent_Identity=42.3357664233577, Blast_Score=293, Evalue=2e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023012
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF02347 GDC-P [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 56370; Mature: 56370

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHNDQPLIFERSKPGRIAYSLPTLDVPAVDVSELVPADYLRTEEPELPEVSELDLMRHYT
CCCCCCEEEECCCCCEEEEECCCCCCCCCCHHHHCCHHHHCCCCCCCCCHHHHHHHHHHH
ALSKRNHGVDSGFYPLGSCTMKYNPKINENVARLAGFAHIHPLQPEETVQGALELMYDLQ
HHHHCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
EHLKEITGMDAVTLQPAAGAHGEWTGLMMIRAYHEANGDFGRTKVIVPDSAHGTNPASAT
HHHHHHHCCCEEEECCCCCCCCCCCEEEEEEEEHHCCCCCCCEEEEECCCCCCCCCCCEE
VAGFETVTVRSTADGLVDLEDLKRVVGPDTAALMLTNPNTLGLFEEQIVEMAEIVHEAGG
EECCEEEEEECCCCCCEEHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCC
KLYYDGANLNAILGKARPGDMGFDVVHLNLHKTFTGPHGGGGPGSGPVGVKADLIPFLPK
EEEECCCCCEEEEECCCCCCCCEEEEEEEEEEEECCCCCCCCCCCCCCCCEECHHHCCCC
PVIAKGENGYYLDDDRPQSIGRVKPFYGNFGINVRAYTYIRSMGPDGLKAVSEYAVLNAN
CCEEECCCCEECCCCCCCCCCCCCCCCCCCCCEEEEEEEEHHCCCHHHHHHHHHHHHHHH
YMMRRLADYYDLPYNRHCKHEFVLSGKRQKKLGVRTLDIAKRLLDFGFHPPTIYFPLIVE
HHHHHHHHHHCCCCCCCCCHHHHCCCCHHHHCCCHHHHHHHHHHHCCCCCCCEEHHHHHH
ECMMIEPTETESKETLDAFIDAMIQIAKEAEETPEIVQEAPHTTVVKRLDETTAARKRDF
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHCC
ALSKNEKLIPISGSSKNGRAVSFSPAAPLLQR
EECCCCEEEEECCCCCCCCEEEECCCCHHHCC
>Mature Secondary Structure
MHNDQPLIFERSKPGRIAYSLPTLDVPAVDVSELVPADYLRTEEPELPEVSELDLMRHYT
CCCCCCEEEECCCCCEEEEECCCCCCCCCCHHHHCCHHHHCCCCCCCCCHHHHHHHHHHH
ALSKRNHGVDSGFYPLGSCTMKYNPKINENVARLAGFAHIHPLQPEETVQGALELMYDLQ
HHHHCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
EHLKEITGMDAVTLQPAAGAHGEWTGLMMIRAYHEANGDFGRTKVIVPDSAHGTNPASAT
HHHHHHHCCCEEEECCCCCCCCCCCEEEEEEEEHHCCCCCCCEEEEECCCCCCCCCCCEE
VAGFETVTVRSTADGLVDLEDLKRVVGPDTAALMLTNPNTLGLFEEQIVEMAEIVHEAGG
EECCEEEEEECCCCCCEEHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCC
KLYYDGANLNAILGKARPGDMGFDVVHLNLHKTFTGPHGGGGPGSGPVGVKADLIPFLPK
EEEECCCCCEEEEECCCCCCCCEEEEEEEEEEEECCCCCCCCCCCCCCCCEECHHHCCCC
PVIAKGENGYYLDDDRPQSIGRVKPFYGNFGINVRAYTYIRSMGPDGLKAVSEYAVLNAN
CCEEECCCCEECCCCCCCCCCCCCCCCCCCCCEEEEEEEEHHCCCHHHHHHHHHHHHHHH
YMMRRLADYYDLPYNRHCKHEFVLSGKRQKKLGVRTLDIAKRLLDFGFHPPTIYFPLIVE
HHHHHHHHHHCCCCCCCCCHHHHCCCCHHHHCCCHHHHHHHHHHHCCCCCCCEEHHHHHH
ECMMIEPTETESKETLDAFIDAMIQIAKEAEETPEIVQEAPHTTVVKRLDETTAARKRDF
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHCC
ALSKNEKLIPISGSSKNGRAVSFSPAAPLLQR
EECCCCEEEEECCCCCCCCEEEECCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12721630 [H]