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The map label for this gene is bfmBAB [H]

Identifier: 138895947

GI number: 138895947

Start: 2427985

End: 2428968

Strand: Reverse

Name: bfmBAB [H]

Synonym: GTNG_2306

Alternate gene names: 138895947

Gene position: 2428968-2427985 (Counterclockwise)

Preceding gene: 138895948

Following gene: 162330296

Centisome position: 68.42

GC content: 51.52

Gene sequence:

>984_bases
ATGCCTGTTATTTCATATATTGATGCGGTCACGATGGCTATTCGCGAAGAGATGGAACGCGATTCGCGCGTGTTTGTATT
AGGGGAAGACGTCGGGCGAAAAGGCGGGGTGTTTAAAGCGACGCAAGGATTGTATGAGCAATTTGGCGAAGAGCGCGTCA
TCGACACGCCGCTTGCCGAATCGGCGATTGTCGGTGTCGGCATCGGTGCGGCGATGTATGGCTTGCGCCCGATTGCCGAA
ATTCAGTTTGCGGATTTCATCATGCCTGCAGTTAACCAAATTATTTCTGAAGCGGCGCGCATCCGTTATCGTTCCAACAA
TGACTGGAACTGCCCGATTGTCATCCGTGCCCCGTACGGCGGTGGGGTACATGGCGCTTTGTACCATTCACAGTCGGTAG
AAGCGGTGTTCGCCAACCAGCCAGGGCTGAAAATCGTCATGCCGTCGACGCCATACGATGTGAAAGGGTTGCTGAAAGCA
GCAATTCGCGATGAAGATCCAGTGATCTTTTTTGAGCATAAGCGCGCTTATCGTCTCATTAAAGGGGAAGTGCCGGAAGA
TGACTATGTATTGCCGATCGGCAAAGCCGATGTCAAACGCGAAGGCGATGACATCACGGTGATCACATATGGGCTTTGTG
TTCACTTCGCCTTGCAGGCAGCTGAACGCGTCGCCCAAGACGGCATTTCGGTCCATCTGTTGGATTTGCGCACCGTTTAC
CCGTTAGATAAAGAAGCGATTATCGAAGCAGCAAGTAAAACCGGGAAAGTGCTGCTCATTACGGAAGACAATAAAGAAGG
CAGCGTCATGAGTGAAGTCGCCGCCATCATCGCTGAACATTGCTTGTTTGATCTCGATGCGCCGATTATGCGCCTTGCCG
GTCCAGATGTTCCGGCGATGCCGTATGCGCCGACGATGGAAAAATTCTTTATGGTCAACCCGGAAAAAGTGGAAAAAGCG
ATGCGCGAATTAGCGGCATTTTAA

Upstream 100 bases:

>100_bases
AAGTGAACGAAGCGACTGACTATGCGGAAAAAGCACCGTACGCCGAGCCGGAACATGCGCTTCGCTACGTGTATGCCGAG
GAGTAAGGGGGAATTAGACG

Downstream 100 bases:

>100_bases
TGCGTGAATAAAAGACGTCTCCCGCTTCGAAGAAATCGCAAAGTGGGGAATGTTGGTTCGGTGCCGCCTGACATTGTGGA
ACAGAAGGAAATCCATGGAG

Product: branched-chain alpha-keto acid dehydrogenase E1 subunit, 2-oxoisovalerate dehydrogenase subunit beta

Products: NA

Alternate protein names: Branched-chain alpha-keto acid dehydrogenase E1 component beta chain; BCKDH E1-beta [H]

Number of amino acids: Translated: 327; Mature: 326

Protein sequence:

>327_residues
MPVISYIDAVTMAIREEMERDSRVFVLGEDVGRKGGVFKATQGLYEQFGEERVIDTPLAESAIVGVGIGAAMYGLRPIAE
IQFADFIMPAVNQIISEAARIRYRSNNDWNCPIVIRAPYGGGVHGALYHSQSVEAVFANQPGLKIVMPSTPYDVKGLLKA
AIRDEDPVIFFEHKRAYRLIKGEVPEDDYVLPIGKADVKREGDDITVITYGLCVHFALQAAERVAQDGISVHLLDLRTVY
PLDKEAIIEAASKTGKVLLITEDNKEGSVMSEVAAIIAEHCLFDLDAPIMRLAGPDVPAMPYAPTMEKFFMVNPEKVEKA
MRELAAF

Sequences:

>Translated_327_residues
MPVISYIDAVTMAIREEMERDSRVFVLGEDVGRKGGVFKATQGLYEQFGEERVIDTPLAESAIVGVGIGAAMYGLRPIAE
IQFADFIMPAVNQIISEAARIRYRSNNDWNCPIVIRAPYGGGVHGALYHSQSVEAVFANQPGLKIVMPSTPYDVKGLLKA
AIRDEDPVIFFEHKRAYRLIKGEVPEDDYVLPIGKADVKREGDDITVITYGLCVHFALQAAERVAQDGISVHLLDLRTVY
PLDKEAIIEAASKTGKVLLITEDNKEGSVMSEVAAIIAEHCLFDLDAPIMRLAGPDVPAMPYAPTMEKFFMVNPEKVEKA
MRELAAF
>Mature_326_residues
PVISYIDAVTMAIREEMERDSRVFVLGEDVGRKGGVFKATQGLYEQFGEERVIDTPLAESAIVGVGIGAAMYGLRPIAEI
QFADFIMPAVNQIISEAARIRYRSNNDWNCPIVIRAPYGGGVHGALYHSQSVEAVFANQPGLKIVMPSTPYDVKGLLKAA
IRDEDPVIFFEHKRAYRLIKGEVPEDDYVLPIGKADVKREGDDITVITYGLCVHFALQAAERVAQDGISVHLLDLRTVYP
LDKEAIIEAASKTGKVLLITEDNKEGSVMSEVAAIIAEHCLFDLDAPIMRLAGPDVPAMPYAPTMEKFFMVNPEKVEKAM
RELAAF

Specific function: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components:branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltran

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557353, Length=323, Percent_Identity=42.1052631578947, Blast_Score=269, Evalue=2e-72,
Organism=Homo sapiens, GI34101272, Length=323, Percent_Identity=42.1052631578947, Blast_Score=269, Evalue=2e-72,
Organism=Homo sapiens, GI156564403, Length=304, Percent_Identity=39.1447368421053, Blast_Score=231, Evalue=8e-61,
Organism=Homo sapiens, GI291084858, Length=304, Percent_Identity=37.828947368421, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI133778974, Length=173, Percent_Identity=30.635838150289, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17538422, Length=320, Percent_Identity=41.5625, Blast_Score=254, Evalue=5e-68,
Organism=Caenorhabditis elegans, GI17506935, Length=316, Percent_Identity=42.0886075949367, Blast_Score=238, Evalue=3e-63,
Organism=Saccharomyces cerevisiae, GI6319698, Length=322, Percent_Identity=38.8198757763975, Blast_Score=235, Evalue=8e-63,
Organism=Drosophila melanogaster, GI21358145, Length=304, Percent_Identity=41.4473684210526, Blast_Score=245, Evalue=3e-65,
Organism=Drosophila melanogaster, GI24650940, Length=304, Percent_Identity=41.4473684210526, Blast_Score=245, Evalue=3e-65,
Organism=Drosophila melanogaster, GI160714832, Length=327, Percent_Identity=40.0611620795107, Blast_Score=244, Evalue=6e-65,
Organism=Drosophila melanogaster, GI160714828, Length=327, Percent_Identity=40.0611620795107, Blast_Score=244, Evalue=7e-65,
Organism=Drosophila melanogaster, GI24650943, Length=86, Percent_Identity=44.1860465116279, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24650945, Length=86, Percent_Identity=44.1860465116279, Blast_Score=92, Evalue=7e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.4 [H]

Molecular weight: Translated: 36003; Mature: 35872

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVISYIDAVTMAIREEMERDSRVFVLGEDVGRKGGVFKATQGLYEQFGEERVIDTPLAE
CCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCH
SAIVGVGIGAAMYGLRPIAEIQFADFIMPAVNQIISEAARIRYRSNNDWNCPIVIRAPYG
HHEECCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCEEEEECCCC
GGVHGALYHSQSVEAVFANQPGLKIVMPSTPYDVKGLLKAAIRDEDPVIFFEHKRAYRLI
CCCCCEEECCCCCEEEECCCCCCEEEECCCCCCHHHHHHHHHCCCCCEEEEECCCHHHHH
KGEVPEDDYVLPIGKADVKREGDDITVITYGLCVHFALQAAERVAQDGISVHLLDLRTVY
CCCCCCCCEEEECCCCHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEC
PLDKEAIIEAASKTGKVLLITEDNKEGSVMSEVAAIIAEHCLFDLDAPIMRLAGPDVPAM
CCCHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCC
PYAPTMEKFFMVNPEKVEKAMRELAAF
CCCCCCHHHEECCHHHHHHHHHHHHCC
>Mature Secondary Structure 
PVISYIDAVTMAIREEMERDSRVFVLGEDVGRKGGVFKATQGLYEQFGEERVIDTPLAE
CHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCH
SAIVGVGIGAAMYGLRPIAEIQFADFIMPAVNQIISEAARIRYRSNNDWNCPIVIRAPYG
HHEECCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCEEEEECCCC
GGVHGALYHSQSVEAVFANQPGLKIVMPSTPYDVKGLLKAAIRDEDPVIFFEHKRAYRLI
CCCCCEEECCCCCEEEECCCCCCEEEECCCCCCHHHHHHHHHCCCCCEEEEECCCHHHHH
KGEVPEDDYVLPIGKADVKREGDDITVITYGLCVHFALQAAERVAQDGISVHLLDLRTVY
CCCCCCCCEEEECCCCHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEC
PLDKEAIIEAASKTGKVLLITEDNKEGSVMSEVAAIIAEHCLFDLDAPIMRLAGPDVPAM
CCCHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCC
PYAPTMEKFFMVNPEKVEKAMRELAAF
CCCCCCHHHEECCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8504804; 8969508; 9384377 [H]