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The map label for this gene is bfmBAA [H]

Identifier: 138895948

GI number: 138895948

Start: 2428983

End: 2429978

Strand: Reverse

Name: bfmBAA [H]

Synonym: GTNG_2307

Alternate gene names: 138895948

Gene position: 2429978-2428983 (Counterclockwise)

Preceding gene: 138895949

Following gene: 138895947

Centisome position: 68.44

GC content: 53.71

Gene sequence:

>996_bases
ATGGCGCAAAACCGTCACCAAGCGCTCGGATTAAGCGATGACACTGTGTTGCAAATGTACGAAACGATGCTTCTCGCCCG
CAAGCTCGATGAGCGGATGTGGCTGTTAAACCGCGCTGGGAAAATTCCGTTTGTCATCTCGTGCCAAGGGCAAGAAGCAG
CGCAAGTCGGCGCGGCGTTTGCTCTTGACCGGACGAAAGACTACATCTTGCCATATTATCGCGATATGGGCGTTGTCTTG
ACGTTCGGTATGACGCCGACGGAATTGATGCTTGCCGCGTTTGCTAAAGCGGAAGACCCGAACTCCGGTGGCCGACAAAT
GCCGGGCCATTTCGGGCAAAAGAAAAACCGAATCGTCACCGGTTCCTCGCCTGTGACGACACAAGTGCCACATGCAGTTG
GTTTTGCTTTGGCGGCGAAAATGGAAAAGAAAGATTTTGTCGCCTTCGTCACGTTCGGGGAAGGATCGTCGAACCAAGGC
GACTTCCATGAAGGAGCAAACTTTGCCGGCGTTCATAAACTCCCTGTCATCTTTATGTGCGAAAACAACAAGTACGCCAT
TTCCGTGCCGATTTCGAAACAATTGGCGTGCGAAAAAGTATCCGACCGCGCCATTGGCTATGGCATGCCGGGCTATACGG
TCGATGGCACGGACCCGCTTGAAGTGTACCGCGTCGTCAAGGAAGCGGCTGACCGCGCTCGCCGCGGTGAAGGGCCGACG
CTCATTGAGGCGGTGACATACCGATTGACGTCGCACTCGTCCGATGACGATCACCGCGTCTACCGGACTGAGGAAGAATT
GGCTGAAGCACGCGCCAAAGATCCGATCGTCTCGTTTGCCAATTACTTAAAAGAAGTCGGTGTCTTAACTGATGCGCTTG
ATGAAGACATTCAAGCACGTGTCATGAAACAAGTGAACGAAGCGACTGACTATGCGGAAAAAGCACCGTACGCCGAGCCG
GAACATGCGCTTCGCTACGTGTATGCCGAGGAGTAA

Upstream 100 bases:

>100_bases
GCCATTCACTTTTAATTTTGCCGCATGAGGACGAAAGATTGGCAACAGGCAGCTTACATAATGAGCTGCAATGGATTTTT
AATTAAGGGAGGTTGTTCCG

Downstream 100 bases:

>100_bases
GGGGGAATTAGACGATGCCTGTTATTTCATATATTGATGCGGTCACGATGGCTATTCGCGAAGAGATGGAACGCGATTCG
CGCGTGTTTGTATTAGGGGA

Product: 2-oxoisovalerate dehydrogenase subunit alpha

Products: NA

Alternate protein names: Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain; BCKDH E1-alpha [H]

Number of amino acids: Translated: 331; Mature: 330

Protein sequence:

>331_residues
MAQNRHQALGLSDDTVLQMYETMLLARKLDERMWLLNRAGKIPFVISCQGQEAAQVGAAFALDRTKDYILPYYRDMGVVL
TFGMTPTELMLAAFAKAEDPNSGGRQMPGHFGQKKNRIVTGSSPVTTQVPHAVGFALAAKMEKKDFVAFVTFGEGSSNQG
DFHEGANFAGVHKLPVIFMCENNKYAISVPISKQLACEKVSDRAIGYGMPGYTVDGTDPLEVYRVVKEAADRARRGEGPT
LIEAVTYRLTSHSSDDDHRVYRTEEELAEARAKDPIVSFANYLKEVGVLTDALDEDIQARVMKQVNEATDYAEKAPYAEP
EHALRYVYAEE

Sequences:

>Translated_331_residues
MAQNRHQALGLSDDTVLQMYETMLLARKLDERMWLLNRAGKIPFVISCQGQEAAQVGAAFALDRTKDYILPYYRDMGVVL
TFGMTPTELMLAAFAKAEDPNSGGRQMPGHFGQKKNRIVTGSSPVTTQVPHAVGFALAAKMEKKDFVAFVTFGEGSSNQG
DFHEGANFAGVHKLPVIFMCENNKYAISVPISKQLACEKVSDRAIGYGMPGYTVDGTDPLEVYRVVKEAADRARRGEGPT
LIEAVTYRLTSHSSDDDHRVYRTEEELAEARAKDPIVSFANYLKEVGVLTDALDEDIQARVMKQVNEATDYAEKAPYAEP
EHALRYVYAEE
>Mature_330_residues
AQNRHQALGLSDDTVLQMYETMLLARKLDERMWLLNRAGKIPFVISCQGQEAAQVGAAFALDRTKDYILPYYRDMGVVLT
FGMTPTELMLAAFAKAEDPNSGGRQMPGHFGQKKNRIVTGSSPVTTQVPHAVGFALAAKMEKKDFVAFVTFGEGSSNQGD
FHEGANFAGVHKLPVIFMCENNKYAISVPISKQLACEKVSDRAIGYGMPGYTVDGTDPLEVYRVVKEAADRARRGEGPTL
IEAVTYRLTSHSSDDDHRVYRTEEELAEARAKDPIVSFANYLKEVGVLTDALDEDIQARVMKQVNEATDYAEKAPYAEPE
HALRYVYAEE

Specific function: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components:branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltran

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the BCKDHA family [H]

Homologues:

Organism=Homo sapiens, GI11386135, Length=321, Percent_Identity=38.6292834890966, Blast_Score=205, Evalue=5e-53,
Organism=Homo sapiens, GI258645172, Length=321, Percent_Identity=38.6292834890966, Blast_Score=201, Evalue=6e-52,
Organism=Homo sapiens, GI4885543, Length=317, Percent_Identity=31.8611987381703, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI291084742, Length=323, Percent_Identity=31.8885448916409, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI4505685, Length=323, Percent_Identity=31.8885448916409, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI291084744, Length=330, Percent_Identity=31.2121212121212, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI291084757, Length=324, Percent_Identity=28.0864197530864, Blast_Score=102, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI86563355, Length=329, Percent_Identity=39.209726443769, Blast_Score=211, Evalue=5e-55,
Organism=Caenorhabditis elegans, GI86563357, Length=329, Percent_Identity=39.209726443769, Blast_Score=211, Evalue=6e-55,
Organism=Caenorhabditis elegans, GI17536047, Length=318, Percent_Identity=31.4465408805031, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI32564172, Length=318, Percent_Identity=31.4465408805031, Blast_Score=132, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6321026, Length=324, Percent_Identity=33.3333333333333, Blast_Score=151, Evalue=2e-37,
Organism=Drosophila melanogaster, GI21355903, Length=302, Percent_Identity=33.4437086092715, Blast_Score=175, Evalue=4e-44,
Organism=Drosophila melanogaster, GI24639740, Length=323, Percent_Identity=33.1269349845201, Blast_Score=138, Evalue=5e-33,
Organism=Drosophila melanogaster, GI24639744, Length=323, Percent_Identity=33.1269349845201, Blast_Score=138, Evalue=6e-33,
Organism=Drosophila melanogaster, GI28571106, Length=323, Percent_Identity=33.1269349845201, Blast_Score=138, Evalue=6e-33,
Organism=Drosophila melanogaster, GI24639746, Length=284, Percent_Identity=34.1549295774648, Blast_Score=134, Evalue=8e-32,
Organism=Drosophila melanogaster, GI24639748, Length=325, Percent_Identity=30.7692307692308, Blast_Score=121, Evalue=8e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.4 [H]

Molecular weight: Translated: 36676; Mature: 36545

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQNRHQALGLSDDTVLQMYETMLLARKLDERMWLLNRAGKIPFVISCQGQEAAQVGAAF
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHH
ALDRTKDYILPYYRDMGVVLTFGMTPTELMLAAFAKAEDPNSGGRQMPGHFGQKKNRIVT
HHHCCCCCCCHHHHCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEE
GSSPVTTQVPHAVGFALAAKMEKKDFVAFVTFGEGSSNQGDFHEGANFAGVHKLPVIFMC
CCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHCCCCCCCEECCCEEEEE
ENNKYAISVPISKQLACEKVSDRAIGYGMPGYTVDGTDPLEVYRVVKEAADRARRGEGPT
CCCCEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCH
LIEAVTYRLTSHSSDDDHRVYRTEEELAEARAKDPIVSFANYLKEVGVLTDALDEDIQAR
HHHHHHHHHHCCCCCCCCCEEECHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VMKQVNEATDYAEKAPYAEPEHALRYVYAEE
HHHHHHHHHHHHHHCCCCCHHHHEEEEEECC
>Mature Secondary Structure 
AQNRHQALGLSDDTVLQMYETMLLARKLDERMWLLNRAGKIPFVISCQGQEAAQVGAAF
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHH
ALDRTKDYILPYYRDMGVVLTFGMTPTELMLAAFAKAEDPNSGGRQMPGHFGQKKNRIVT
HHHCCCCCCCHHHHCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEE
GSSPVTTQVPHAVGFALAAKMEKKDFVAFVTFGEGSSNQGDFHEGANFAGVHKLPVIFMC
CCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHCCCCCCCEECCCEEEEE
ENNKYAISVPISKQLACEKVSDRAIGYGMPGYTVDGTDPLEVYRVVKEAADRARRGEGPT
CCCCEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCH
LIEAVTYRLTSHSSDDDHRVYRTEEELAEARAKDPIVSFANYLKEVGVLTDALDEDIQAR
HHHHHHHHHHCCCCCCCCCEEECHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VMKQVNEATDYAEKAPYAEPEHALRYVYAEE
HHHHHHHHHHHHHHCCCCCHHHHEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8504804; 8969508; 9384377 [H]