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The map label for this gene is gntZ [H]

Identifier: 138895930

GI number: 138895930

Start: 2408443

End: 2409855

Strand: Reverse

Name: gntZ [H]

Synonym: GTNG_2289

Alternate gene names: 138895930

Gene position: 2409855-2408443 (Counterclockwise)

Preceding gene: 138895931

Following gene: 138895929

Centisome position: 67.88

GC content: 50.53

Gene sequence:

>1413_bases
ATGGCGAAACAGCAAATTGGTGTCATCGGACTGGCGGTCATGGGGAAAAATTTGGCGCTGAACATTGAAAGCAGAGGCTA
TTCGGTGGCGGTGTACAACCGTTCACGCGAAAAAACGGATGAATTTTTGGAAGAAGCGAAAGGAAAAAACATTGTCGGTA
CATACAGCATCGAAGAATTCGTCAACGCCTTAGAAAAACCGCGGAAAATTTTGTTGATGGTGAAAGCGGGCGCGCCGACG
GATGCAACGATTGAACAGCTGAAGCCGTATTTGGAAAAAGGCGATATTTTGATCGATGGCGGCAACACGTATTTTAAAGA
TACTCAGCGCCGCAACGAAGAGCTGGCCAAACTCGGCATCCACTTTATCGGCACTGGCGTCTCCGGCGGTGAGGAAGGGG
CGCTGAAAGGTCCATCGATCATGCCAGGAGGCCAAAAAGAAGCGCATGAACTCGTGCGTCCGATTTTCGAAGCGATCGCT
GCCAAAGTCGACGGCGAGCCATGTACGACATATATCGGTCCAGACGGTGCCGGTCATTATGTGAAAATGGTGCATAACGG
CATTGAATACGGCGACATGCAATTGATTGCTGAAGCGTATTTCTTGCTGAAACATGTGCTTGGCATGGATGCCGCTGAGC
TGCACGAAGTGTTTGCCGACTGGAACAAAGGGGAACTGAACAGCTACTTAATCGAAATTACGGCCGATATTTTCACGAAA
ATCGACGATGAAACCGGCAAGCCGTTGGTCGACGTCATTTTGGATAAAGCCGGACAAAAAGGGACGGGCAAATGGACAAG
CCAAAACGCCCTTGATTTAGGTGTGCCGCTGCCAATTATCACCGAGTCGGTATTCGCCCGCTTCATCTCGGCGATGAAAG
ACGAGCGCGTCAAAGCTAGCAAACTGTTGTCTGGCCCGGCGGTGAAGCCGTTTGAAGGCGATCGAGATCACTTCATTGAA
GCGGTGCGCCGCGCTTTGTACATGAGCAAAATTTGCTCGTACGCCCAAGGATTCGCGCAAATGAAAGCTGCATCCGATGA
GTATAATTGGAACTTGCGTTACGGCGATATCGCCATGATTTTCCGAGGCGGCTGCATCATCCGCGCGCAATTTTTGCAAA
AAATTAAAGAGGCGTACGACCGCGATCCAGCGCTTCCGAACTTGTTGTTGGATCCATACTTCAAAAACATCGTCGAAAGC
TACCAAGATTCGCTCCGTGAAATCGTCGCTACTGCCGCAATGCGCGGCATCCCAGTGCCGGCGTTCGCAAGTGCTCTCGC
GTACTATGACAGCTACCGCAACGAAGTATTGCCGGCCAACTTAATCCAAGCACAGCGCGATTACTTCGGCGCTCACACAT
ATGAACGCGTTGACAAGGAAGGCATTTTCCATACGGAATGGCTTGCGAAATAA

Upstream 100 bases:

>100_bases
TATAAGGCGTTCATAAATCGGTTTAGAAAAACTTGCAGGCAAGCGTCAAATTATGATATGTTGTTTGGTGAATGAACAAA
AACAGAAAGGAACGTTGGCA

Downstream 100 bases:

>100_bases
GCAAGATCCATGGCAGCCCCAACCGGGTAAACTGGTTGGGGTTGTTTTTTTGTTTTCTGGCCATTCATAAAAAAGCCCTC
TTGAAGTGCTTTCTAGCCGA

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: GNTZII [H]

Number of amino acids: Translated: 470; Mature: 469

Protein sequence:

>470_residues
MAKQQIGVIGLAVMGKNLALNIESRGYSVAVYNRSREKTDEFLEEAKGKNIVGTYSIEEFVNALEKPRKILLMVKAGAPT
DATIEQLKPYLEKGDILIDGGNTYFKDTQRRNEELAKLGIHFIGTGVSGGEEGALKGPSIMPGGQKEAHELVRPIFEAIA
AKVDGEPCTTYIGPDGAGHYVKMVHNGIEYGDMQLIAEAYFLLKHVLGMDAAELHEVFADWNKGELNSYLIEITADIFTK
IDDETGKPLVDVILDKAGQKGTGKWTSQNALDLGVPLPIITESVFARFISAMKDERVKASKLLSGPAVKPFEGDRDHFIE
AVRRALYMSKICSYAQGFAQMKAASDEYNWNLRYGDIAMIFRGGCIIRAQFLQKIKEAYDRDPALPNLLLDPYFKNIVES
YQDSLREIVATAAMRGIPVPAFASALAYYDSYRNEVLPANLIQAQRDYFGAHTYERVDKEGIFHTEWLAK

Sequences:

>Translated_470_residues
MAKQQIGVIGLAVMGKNLALNIESRGYSVAVYNRSREKTDEFLEEAKGKNIVGTYSIEEFVNALEKPRKILLMVKAGAPT
DATIEQLKPYLEKGDILIDGGNTYFKDTQRRNEELAKLGIHFIGTGVSGGEEGALKGPSIMPGGQKEAHELVRPIFEAIA
AKVDGEPCTTYIGPDGAGHYVKMVHNGIEYGDMQLIAEAYFLLKHVLGMDAAELHEVFADWNKGELNSYLIEITADIFTK
IDDETGKPLVDVILDKAGQKGTGKWTSQNALDLGVPLPIITESVFARFISAMKDERVKASKLLSGPAVKPFEGDRDHFIE
AVRRALYMSKICSYAQGFAQMKAASDEYNWNLRYGDIAMIFRGGCIIRAQFLQKIKEAYDRDPALPNLLLDPYFKNIVES
YQDSLREIVATAAMRGIPVPAFASALAYYDSYRNEVLPANLIQAQRDYFGAHTYERVDKEGIFHTEWLAK
>Mature_469_residues
AKQQIGVIGLAVMGKNLALNIESRGYSVAVYNRSREKTDEFLEEAKGKNIVGTYSIEEFVNALEKPRKILLMVKAGAPTD
ATIEQLKPYLEKGDILIDGGNTYFKDTQRRNEELAKLGIHFIGTGVSGGEEGALKGPSIMPGGQKEAHELVRPIFEAIAA
KVDGEPCTTYIGPDGAGHYVKMVHNGIEYGDMQLIAEAYFLLKHVLGMDAAELHEVFADWNKGELNSYLIEITADIFTKI
DDETGKPLVDVILDKAGQKGTGKWTSQNALDLGVPLPIITESVFARFISAMKDERVKASKLLSGPAVKPFEGDRDHFIEA
VRRALYMSKICSYAQGFAQMKAASDEYNWNLRYGDIAMIFRGGCIIRAQFLQKIKEAYDRDPALPNLLLDPYFKNIVESY
QDSLREIVATAAMRGIPVPAFASALAYYDSYRNEVLPANLIQAQRDYFGAHTYERVDKEGIFHTEWLAK

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH [H]

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=470, Percent_Identity=58.0851063829787, Blast_Score=535, Evalue=1e-152,
Organism=Escherichia coli, GI1788341, Length=469, Percent_Identity=71.0021321961621, Blast_Score=693, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17542558, Length=471, Percent_Identity=55.2016985138004, Blast_Score=536, Evalue=1e-152,
Organism=Saccharomyces cerevisiae, GI6321695, Length=452, Percent_Identity=58.1858407079646, Blast_Score=536, Evalue=1e-153,
Organism=Saccharomyces cerevisiae, GI6321977, Length=452, Percent_Identity=57.7433628318584, Blast_Score=516, Evalue=1e-147,
Organism=Drosophila melanogaster, GI24639279, Length=464, Percent_Identity=55.8189655172414, Blast_Score=504, Evalue=1e-143,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: =1.1.1.44 [H]

Molecular weight: Translated: 52199; Mature: 52068

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKQQIGVIGLAVMGKNLALNIESRGYSVAVYNRSREKTDEFLEEAKGKNIVGTYSIEEF
CCCCHHHHEEHEEECCCEEEEEECCCEEEEEECCCHHHHHHHHHHHCCCCEEEECCHHHH
VNALEKPRKILLMVKAGAPTDATIEQLKPYLEKGDILIDGGNTYFKDTQRRNEELAKLGI
HHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHH
HFIGTGVSGGEEGALKGPSIMPGGQKEAHELVRPIFEAIAAKVDGEPCTTYIGPDGAGHY
HHEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHH
VKMVHNGIEYGDMQLIAEAYFLLKHVLGMDAAELHEVFADWNKGELNSYLIEITADIFTK
HHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
IDDETGKPLVDVILDKAGQKGTGKWTSQNALDLGVPLPIITESVFARFISAMKDERVKAS
CCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
KLLSGPAVKPFEGDRDHFIEAVRRALYMSKICSYAQGFAQMKAASDEYNWNLRYGDIAMI
HHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCEEEE
FRGGCIIRAQFLQKIKEAYDRDPALPNLLLDPYFKNIVESYQDSLREIVATAAMRGIPVP
HHCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
AFASALAYYDSYRNEVLPANLIQAQRDYFGAHTYERVDKEGIFHTEWLAK
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHCC
>Mature Secondary Structure 
AKQQIGVIGLAVMGKNLALNIESRGYSVAVYNRSREKTDEFLEEAKGKNIVGTYSIEEF
CCCHHHHEEHEEECCCEEEEEECCCEEEEEECCCHHHHHHHHHHHCCCCEEEECCHHHH
VNALEKPRKILLMVKAGAPTDATIEQLKPYLEKGDILIDGGNTYFKDTQRRNEELAKLGI
HHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHH
HFIGTGVSGGEEGALKGPSIMPGGQKEAHELVRPIFEAIAAKVDGEPCTTYIGPDGAGHY
HHEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHH
VKMVHNGIEYGDMQLIAEAYFLLKHVLGMDAAELHEVFADWNKGELNSYLIEITADIFTK
HHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
IDDETGKPLVDVILDKAGQKGTGKWTSQNALDLGVPLPIITESVFARFISAMKDERVKAS
CCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
KLLSGPAVKPFEGDRDHFIEAVRRALYMSKICSYAQGFAQMKAASDEYNWNLRYGDIAMI
HHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCEEEE
FRGGCIIRAQFLQKIKEAYDRDPALPNLLLDPYFKNIVESYQDSLREIVATAAMRGIPVP
HHCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
AFASALAYYDSYRNEVLPANLIQAQRDYFGAHTYERVDKEGIFHTEWLAK
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377; 10568751; 9298659 [H]