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The map label for this gene is lysA [H]

Identifier: 138895872

GI number: 138895872

Start: 2351018

End: 2352337

Strand: Reverse

Name: lysA [H]

Synonym: GTNG_2231

Alternate gene names: 138895872

Gene position: 2352337-2351018 (Counterclockwise)

Preceding gene: 138895873

Following gene: 138895869

Centisome position: 66.26

GC content: 52.58

Gene sequence:

>1320_bases
ATGTTTTTTCATGGGACGAGCCGCGTCAACGAAAAAGGGCATTTGGAAATCGGCGGCGTTGATACGGTCGAGTTGGCGAA
GATGTACGGAACGCCGCTTTATATTTATGATGTTGCGTTGATTCGCGCGCGGGCGCGCGCATTTAAGGAAGCATTCCATC
TTCAAGGTGTGCGGGCGCAAGTAGCTTACGCCAGCAAGGCGTTTTCCTCGATTGCCATGGTGCAGCTCGCCGCTGAGGAA
GGGCTGTCGCTTGACGTCGTGTCGGGCGGGGAACTGTATACGGCGATTGCTGCTGGATTCCCGTCAGAGCGCATCCATTT
TCACGGCAACAACAAAAGTCGGGATGAGCTGGCGATGGCGCTCGAACATGGCATCGGCTGCATTGTTGCCGACAACTTTT
ACGAACTGGAGTTGATTGAACAACTGGCGGCCGCTTCCGGTCGAGTGGTTCCGGTGTTGCTTCGCGTCACACCGGGCGTC
GAGGCGCATACGCACGATTATATTTTAACGGGACAGGAAGACTCCAAGTTTGGCTTTGACTTAAACAACGGCCAAGCAGA
TGAGGCGTTTCGCCGTGTTATGGCATCGTCGGCGTTTCAGTTGCTTGGCGTTCATTGCCATATCGGTTCGCAAATTTTTG
AAACGACCGGCTTTGTGCTTGCCGCACAAAAAGTATTTACAAAGATGGCGGAATGGAACAAGGCATATGGATTTATCCCT
TCAGTCATCAATCTTGGCGGAGGCTTTGGCATCCGCTATACAGAGGAAGACGATCCGATTCCGGTGTCCGCATACGTCGA
TTGCATTGTTGAAGAAGTGAAAAAGCAGGCTAAAGCGTGTCAGCTTCCGTTGCCGGAAATTTGGATCGAGCCGGGGCGTT
CGCTCGTTGGTGACGCGGGGACGACGATTTATACGATCGGTTCGCGCAAAGACGTGCCAAACATTCGTACGTATCTCGCG
GTTGATGGTGGCATGAGCGACAACATCCGTCCGGCGTTGTACGGGGCAAAATATGAAGCAGTGCTTGCCAATCGGGTGCT
AGGTGAGCGAACAGAAACCGTATCGATCGCTGGGAAATGCTGCGAGTCGGGCGATATGCTCATTTGGGATCTTGCGCTGC
CCGAGACGAAGCCGGGCGATTATTTGGCTGTTTTTTGCACCGGCGCTTACGGTTATTCAATGGCGAACAATTACAACCGC
CTGCCGCGTCCGGCGATCGTTTTCGTTGAAAACGGCGACGCTCAGCTCGTTGTCAAACGCGAAACATATGAAGATTTAAT
CCAGCATGATTTGCCGTTTAAGACGAAGGTGAGAAAATAA

Upstream 100 bases:

>100_bases
GAGCCGTTCGCTCTGCGGCTTTGTTTTTTAAGGCAGTTACCGGTTGCGAACTGTCTTTTTGCTTTTTCTGCGCCATTTTG
ATGAGGAATGAGGGATTTTC

Downstream 100 bases:

>100_bases
AAAAGCCCGCATAAAGCGGGTTTTTTTATTGATTCGAGGAGAGTGCCGACTTGATGGCATTCCAAATCTCTTTCAAGATG
TCGATAATGTTTTGGATAAA

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 439; Mature: 439

Protein sequence:

>439_residues
MFFHGTSRVNEKGHLEIGGVDTVELAKMYGTPLYIYDVALIRARARAFKEAFHLQGVRAQVAYASKAFSSIAMVQLAAEE
GLSLDVVSGGELYTAIAAGFPSERIHFHGNNKSRDELAMALEHGIGCIVADNFYELELIEQLAAASGRVVPVLLRVTPGV
EAHTHDYILTGQEDSKFGFDLNNGQADEAFRRVMASSAFQLLGVHCHIGSQIFETTGFVLAAQKVFTKMAEWNKAYGFIP
SVINLGGGFGIRYTEEDDPIPVSAYVDCIVEEVKKQAKACQLPLPEIWIEPGRSLVGDAGTTIYTIGSRKDVPNIRTYLA
VDGGMSDNIRPALYGAKYEAVLANRVLGERTETVSIAGKCCESGDMLIWDLALPETKPGDYLAVFCTGAYGYSMANNYNR
LPRPAIVFVENGDAQLVVKRETYEDLIQHDLPFKTKVRK

Sequences:

>Translated_439_residues
MFFHGTSRVNEKGHLEIGGVDTVELAKMYGTPLYIYDVALIRARARAFKEAFHLQGVRAQVAYASKAFSSIAMVQLAAEE
GLSLDVVSGGELYTAIAAGFPSERIHFHGNNKSRDELAMALEHGIGCIVADNFYELELIEQLAAASGRVVPVLLRVTPGV
EAHTHDYILTGQEDSKFGFDLNNGQADEAFRRVMASSAFQLLGVHCHIGSQIFETTGFVLAAQKVFTKMAEWNKAYGFIP
SVINLGGGFGIRYTEEDDPIPVSAYVDCIVEEVKKQAKACQLPLPEIWIEPGRSLVGDAGTTIYTIGSRKDVPNIRTYLA
VDGGMSDNIRPALYGAKYEAVLANRVLGERTETVSIAGKCCESGDMLIWDLALPETKPGDYLAVFCTGAYGYSMANNYNR
LPRPAIVFVENGDAQLVVKRETYEDLIQHDLPFKTKVRK
>Mature_439_residues
MFFHGTSRVNEKGHLEIGGVDTVELAKMYGTPLYIYDVALIRARARAFKEAFHLQGVRAQVAYASKAFSSIAMVQLAAEE
GLSLDVVSGGELYTAIAAGFPSERIHFHGNNKSRDELAMALEHGIGCIVADNFYELELIEQLAAASGRVVPVLLRVTPGV
EAHTHDYILTGQEDSKFGFDLNNGQADEAFRRVMASSAFQLLGVHCHIGSQIFETTGFVLAAQKVFTKMAEWNKAYGFIP
SVINLGGGFGIRYTEEDDPIPVSAYVDCIVEEVKKQAKACQLPLPEIWIEPGRSLVGDAGTTIYTIGSRKDVPNIRTYLA
VDGGMSDNIRPALYGAKYEAVLANRVLGERTETVSIAGKCCESGDMLIWDLALPETKPGDYLAVFCTGAYGYSMANNYNR
LPRPAIVFVENGDAQLVVKRETYEDLIQHDLPFKTKVRK

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Escherichia coli, GI1789203, Length=420, Percent_Identity=31.9047619047619, Blast_Score=157, Evalue=1e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 48109; Mature: 48109

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFFHGTSRVNEKGHLEIGGVDTVELAKMYGTPLYIYDVALIRARARAFKEAFHLQGVRAQ
CCCCCCCCCCCCCCEEECCCCHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHCCHHHH
VAYASKAFSSIAMVQLAAEEGLSLDVVSGGELYTAIAAGFPSERIHFHGNNKSRDELAMA
HHHHHHHHHHHHHHEEHHHCCCEEEEECCCCEEEHHHCCCCCCEEEECCCCCCHHHHHHH
LEHGIGCIVADNFYELELIEQLAAASGRVVPVLLRVTPGVEAHTHDYILTGQEDSKFGFD
HHHCCEEEEECCCHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCEEEECCCCCCCCCC
LNNGQADEAFRRVMASSAFQLLGVHCHIGSQIFETTGFVLAAQKVFTKMAEWNKAYGFIP
CCCCCHHHHHHHHHHHHHHHHEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
SVINLGGGFGIRYTEEDDPIPVSAYVDCIVEEVKKQAKACQLPLPEIWIEPGRSLVGDAG
HHHHCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCHHCCCCC
TTIYTIGSRKDVPNIRTYLAVDGGMSDNIRPALYGAKYEAVLANRVLGERTETVSIAGKC
CEEEEECCCCCCCCCEEEEEECCCCCCCCCHHHCCCHHHHHHHHHHHCCCCCEEEEHHHH
CESGDMLIWDLALPETKPGDYLAVFCTGAYGYSMANNYNRLPRPAIVFVENGDAQLVVKR
CCCCCEEEEEEECCCCCCCCEEEEEEECCCCHHHHCCCCCCCCCEEEEEECCCEEEEEEC
ETYEDLIQHDLPFKTKVRK
HHHHHHHHCCCCCHHCCCC
>Mature Secondary Structure
MFFHGTSRVNEKGHLEIGGVDTVELAKMYGTPLYIYDVALIRARARAFKEAFHLQGVRAQ
CCCCCCCCCCCCCCEEECCCCHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHCCHHHH
VAYASKAFSSIAMVQLAAEEGLSLDVVSGGELYTAIAAGFPSERIHFHGNNKSRDELAMA
HHHHHHHHHHHHHHEEHHHCCCEEEEECCCCEEEHHHCCCCCCEEEECCCCCCHHHHHHH
LEHGIGCIVADNFYELELIEQLAAASGRVVPVLLRVTPGVEAHTHDYILTGQEDSKFGFD
HHHCCEEEEECCCHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCEEEECCCCCCCCCC
LNNGQADEAFRRVMASSAFQLLGVHCHIGSQIFETTGFVLAAQKVFTKMAEWNKAYGFIP
CCCCCHHHHHHHHHHHHHHHHEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
SVINLGGGFGIRYTEEDDPIPVSAYVDCIVEEVKKQAKACQLPLPEIWIEPGRSLVGDAG
HHHHCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCHHCCCCC
TTIYTIGSRKDVPNIRTYLAVDGGMSDNIRPALYGAKYEAVLANRVLGERTETVSIAGKC
CEEEEECCCCCCCCCEEEEEECCCCCCCCCHHHCCCHHHHHHHHHHHCCCCCEEEEHHHH
CESGDMLIWDLALPETKPGDYLAVFCTGAYGYSMANNYNRLPRPAIVFVENGDAQLVVKR
CCCCCEEEEEEECCCCCCCCEEEEEEECCCCHHHHCCCCCCCCCEEEEEECCCEEEEEEC
ETYEDLIQHDLPFKTKVRK
HHHHHHHHCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2513554; 7934829; 1368705; 8969508; 9384377 [H]