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The map label for this gene is cobD [H]

Identifier: 138895836

GI number: 138895836

Start: 2317799

End: 2318869

Strand: Reverse

Name: cobD [H]

Synonym: GTNG_2195

Alternate gene names: 138895836

Gene position: 2318869-2317799 (Counterclockwise)

Preceding gene: 138895837

Following gene: 138895835

Centisome position: 65.31

GC content: 54.81

Gene sequence:

>1071_bases
TTGTATTGGCCGGCGCATGGGGCGAATCCGCACGCGCTCTATAAGCAGTGCGGACTTACCCCTCCACATAAGTATGTTGA
TTTCAGCGTCAATACGAACCCGTACCAGCTGCCGCTTTCCGCCTGGCCGGACAGTGAGGAGTGGATTCGCTGGGTTGGTG
AATATCCTGATTTGGAAGCGGAAGCGCTTGTCGCATTGATCGCCAAGCAGGAAGGGATTGAGCGTAGACAAGTGCTCATG
ACGAACGGGGCGGCAGAGGCAATTTATTTGTTGGCGGCGCTGTTTGCCGGACGGCGAGTCGGTGTGTTAGAACCGACATT
TTCGGAATATCGGCGTGCCTGCCTCGCCTACGGTTGTGAGGTAGCGGCGTTGATGGCCGAGGAACAATGCGGCTTTTCAT
ATGATATTGATGAGGCGGCAGCATGGGCGGCGAGGCAGGACATCGTTTTTTTATGCCATCCGAACAATCCGACCGGGACG
GTGATGCCGGAACATGAACTTCGATTGTTCATTGATGCGGCCGATCAAGCCGGTACATATATCGTTGTGGATGAAGCATT
TTATCCGTTTTGGCGCGGCGGGTTTACTGCTGTGCGCTGGTTGGACCGCTACTCACGCCTCATCGTGCTCCGGTCATTGA
CGAAAATCCATCATTTAGCAGGAGCACGACTCGGCTATGTCGTTGCCAATGAGGAGATCGTTGCCACGTTAAAAACGAGG
CAGCCGCCATGGAGTGTGAGTCAAGTTGCCCAACAGCTAGCCATTCGCTTTTTGCAAATGGATTCGTTTGTGACGTGGAC
AAAAGAGCAACTAGCGGCTGAGCGGGAGCGGGTGTTCCAAGCGCTTCCAGCCGAACGGTACGACGTCTCGCCGTCAGTCG
TCAACTTTTACTTGTTGCGTCCACGGACAGGGCGGACGGAGGCGCTGCTCTACCATTTATTAAAGAAAGGGATTGTACCG
CGGCATACGATGAATTTCCCCGGACTTGACGGCCGCTATGTTCGGCTGGCCGTCAAAACACCGATGGAAAACGACCGGCT
TCTCGAAGCGCTTGCGGGGTGGGATGGATGA

Upstream 100 bases:

>100_bases
GACGTCCCGCTTCGCTCCGTCCATATTCGTCGGGCGGTCGGCATCATGATCGGAACGGTGCTTGTTTTTACGTTATGGCT
ATGGATCGGAGGGATGATCG

Downstream 100 bases:

>100_bases
TCGTGTTTGTGAGCGGCGCGGTGCGCAGCGGCAAAAGCGAAGTGGCGGAAGCATGTGCTAGGAGTCTCGCTCATGGCGGC
CGTCTCCATTATCTTGCCAC

Product: aminotransferase

Products: NA

Alternate protein names: L-threonine-O-3-phosphate decarboxylase [H]

Number of amino acids: Translated: 356; Mature: 356

Protein sequence:

>356_residues
MYWPAHGANPHALYKQCGLTPPHKYVDFSVNTNPYQLPLSAWPDSEEWIRWVGEYPDLEAEALVALIAKQEGIERRQVLM
TNGAAEAIYLLAALFAGRRVGVLEPTFSEYRRACLAYGCEVAALMAEEQCGFSYDIDEAAAWAARQDIVFLCHPNNPTGT
VMPEHELRLFIDAADQAGTYIVVDEAFYPFWRGGFTAVRWLDRYSRLIVLRSLTKIHHLAGARLGYVVANEEIVATLKTR
QPPWSVSQVAQQLAIRFLQMDSFVTWTKEQLAAERERVFQALPAERYDVSPSVVNFYLLRPRTGRTEALLYHLLKKGIVP
RHTMNFPGLDGRYVRLAVKTPMENDRLLEALAGWDG

Sequences:

>Translated_356_residues
MYWPAHGANPHALYKQCGLTPPHKYVDFSVNTNPYQLPLSAWPDSEEWIRWVGEYPDLEAEALVALIAKQEGIERRQVLM
TNGAAEAIYLLAALFAGRRVGVLEPTFSEYRRACLAYGCEVAALMAEEQCGFSYDIDEAAAWAARQDIVFLCHPNNPTGT
VMPEHELRLFIDAADQAGTYIVVDEAFYPFWRGGFTAVRWLDRYSRLIVLRSLTKIHHLAGARLGYVVANEEIVATLKTR
QPPWSVSQVAQQLAIRFLQMDSFVTWTKEQLAAERERVFQALPAERYDVSPSVVNFYLLRPRTGRTEALLYHLLKKGIVP
RHTMNFPGLDGRYVRLAVKTPMENDRLLEALAGWDG
>Mature_356_residues
MYWPAHGANPHALYKQCGLTPPHKYVDFSVNTNPYQLPLSAWPDSEEWIRWVGEYPDLEAEALVALIAKQEGIERRQVLM
TNGAAEAIYLLAALFAGRRVGVLEPTFSEYRRACLAYGCEVAALMAEEQCGFSYDIDEAAAWAARQDIVFLCHPNNPTGT
VMPEHELRLFIDAADQAGTYIVVDEAFYPFWRGGFTAVRWLDRYSRLIVLRSLTKIHHLAGARLGYVVANEEIVATLKTR
QPPWSVSQVAQQLAIRFLQMDSFVTWTKEQLAAERERVFQALPAERYDVSPSVVNFYLLRPRTGRTEALLYHLLKKGIVP
RHTMNFPGLDGRYVRLAVKTPMENDRLLEALAGWDG

Specific function: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1- amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin [H]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=308, Percent_Identity=28.5714285714286, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI48994949, Length=180, Percent_Identity=31.6666666666667, Blast_Score=68, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6322075, Length=369, Percent_Identity=26.8292682926829, Blast_Score=82, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005860
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.1.1.81 [H]

Molecular weight: Translated: 40391; Mature: 40391

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYWPAHGANPHALYKQCGLTPPHKYVDFSVNTNPYQLPLSAWPDSEEWIRWVGEYPDLEA
CCCCCCCCCHHHHHHHCCCCCCCCEEEEEECCCCEEEECCCCCCHHHHHHHHCCCCCCCH
EALVALIAKQEGIERRQVLMTNGAAEAIYLLAALFAGRRVGVLEPTFSEYRRACLAYGCE
HHHHHHHHHHCCCCHHHEEEECCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCH
VAALMAEEQCGFSYDIDEAAAWAARQDIVFLCHPNNPTGTVMPEHELRLFIDAADQAGTY
HHHHHHHHHCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCEEEEEEECCCCCCE
IVVDEAFYPFWRGGFTAVRWLDRYSRLIVLRSLTKIHHLAGARLGYVVANEEIVATLKTR
EEECCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEEEEECC
QPPWSVSQVAQQLAIRFLQMDSFVTWTKEQLAAERERVFQALPAERYDVSPSVVNFYLLR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEC
PRTGRTEALLYHLLKKGIVPRHTMNFPGLDGRYVRLAVKTPMENDRLLEALAGWDG
CCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHCCCC
>Mature Secondary Structure
MYWPAHGANPHALYKQCGLTPPHKYVDFSVNTNPYQLPLSAWPDSEEWIRWVGEYPDLEA
CCCCCCCCCHHHHHHHCCCCCCCCEEEEEECCCCEEEECCCCCCHHHHHHHHCCCCCCCH
EALVALIAKQEGIERRQVLMTNGAAEAIYLLAALFAGRRVGVLEPTFSEYRRACLAYGCE
HHHHHHHHHHCCCCHHHEEEECCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCH
VAALMAEEQCGFSYDIDEAAAWAARQDIVFLCHPNNPTGTVMPEHELRLFIDAADQAGTY
HHHHHHHHHCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCEEEEEEECCCCCCE
IVVDEAFYPFWRGGFTAVRWLDRYSRLIVLRSLTKIHHLAGARLGYVVANEEIVATLKTR
EEECCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEEEEECC
QPPWSVSQVAQQLAIRFLQMDSFVTWTKEQLAAERERVFQALPAERYDVSPSVVNFYLLR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEC
PRTGRTEALLYHLLKKGIVPRHTMNFPGLDGRYVRLAVKTPMENDRLLEALAGWDG
CCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]