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The map label for this gene is panC

Identifier: 138895756

GI number: 138895756

Start: 2245781

End: 2246650

Strand: Reverse

Name: panC

Synonym: GTNG_2112

Alternate gene names: 138895756

Gene position: 2246650-2245781 (Counterclockwise)

Preceding gene: 138895757

Following gene: 138895755

Centisome position: 63.28

GC content: 55.98

Gene sequence:

>870_bases
ATGATCATCGTTGATCGGATTAGTGAAATGCAGGCGCTGATGCGTCAATACCACCGCGAAGGAAAAACGATCGGGTTCGT
CCCGACAATGGGTTATTTGCATGAAGGACATGCCGCCCTCATCGATCGGGCGCGTCAGGAAAATGACATTGTCGTCTTAA
GCGTTTTTGTCAATCCGCTTCAATTTGGGCCGAACGAAGATTTTGCCCGCTATCCGCGCGATTTTGAGCGCGATCGGCAT
ATCGCCGAACAGCACGGAGTTGACGTGCTGTTTCATCCGGAGGCAGGCGAGATGTATCCGGGGCCGCTCACGGTGCAAGT
CGTCGTGAAAGCACGCACGGATGTGCTCTGTGGACGGTCGCGCCCCGGCCATTTTGACGGCGTGGCAACGGTGCTTACTA
AGCTGTTTCATATCGTCATGCCTGACCGCGCTTATTTCGGTCTGAAAGATGCCCAGCAGGTAGCTGTTGTCGACGGCTTG
ATTCGCGATTTCAATTTCCCGATTGAGCTCGTGCCGGTACCGACGGTTCGCGAGGCCGACGGGCTGGCGAAAAGCTCGCG
CAACGTCTATTTATCGCCGCAAGAACGAGAGGAGGCGCCGGCGCTCTATCAGGCGCTGCGCGCGGCAGCGGCAGCCGTCG
ATGGCGGAGAGCGGAGCGCTGATGCCATTCGTCGTCTTGTGAAAGAGCATATTGAAGCACATACGCACGCTGAAATTGAT
TATGTCGAAGTGTGTTCGTATCCGGATTTGGCGCCGCTTGAAACGCTTCACGGAACGGTGCTCGTCGCGGTTGCCGTTCG
GTTTGCGAGCGCCCGCTTGATCGACAATATCATTCTTGAGCTGCCTAAGGCGCATAGACAAGAGGATTAG

Upstream 100 bases:

>100_bases
ACTATATCGCTGATGTCAAACTGCGCCAGTTTCCGGAGCCGGCGCACACGTTTACGATGAAGGAAGAAGAATGGGTGGCC
TTATACGGAGGAAAACAATC

Downstream 100 bases:

>100_bases
GGGGGATCGCCCATGTTTCGTACACTCATGAACGCCAAAATTCATCGTGCCCGTGTAACGGAAGCAAACTTGGATTATGT
AGGCAGCATTACAATCGACG

Product: pantoate--beta-alanine ligase

Products: NA

Alternate protein names: PS; Pantoate--beta-alanine ligase; Pantoate-activating enzyme

Number of amino acids: Translated: 289; Mature: 289

Protein sequence:

>289_residues
MIIVDRISEMQALMRQYHREGKTIGFVPTMGYLHEGHAALIDRARQENDIVVLSVFVNPLQFGPNEDFARYPRDFERDRH
IAEQHGVDVLFHPEAGEMYPGPLTVQVVVKARTDVLCGRSRPGHFDGVATVLTKLFHIVMPDRAYFGLKDAQQVAVVDGL
IRDFNFPIELVPVPTVREADGLAKSSRNVYLSPQEREEAPALYQALRAAAAAVDGGERSADAIRRLVKEHIEAHTHAEID
YVEVCSYPDLAPLETLHGTVLVAVAVRFASARLIDNIILELPKAHRQED

Sequences:

>Translated_289_residues
MIIVDRISEMQALMRQYHREGKTIGFVPTMGYLHEGHAALIDRARQENDIVVLSVFVNPLQFGPNEDFARYPRDFERDRH
IAEQHGVDVLFHPEAGEMYPGPLTVQVVVKARTDVLCGRSRPGHFDGVATVLTKLFHIVMPDRAYFGLKDAQQVAVVDGL
IRDFNFPIELVPVPTVREADGLAKSSRNVYLSPQEREEAPALYQALRAAAAAVDGGERSADAIRRLVKEHIEAHTHAEID
YVEVCSYPDLAPLETLHGTVLVAVAVRFASARLIDNIILELPKAHRQED
>Mature_289_residues
MIIVDRISEMQALMRQYHREGKTIGFVPTMGYLHEGHAALIDRARQENDIVVLSVFVNPLQFGPNEDFARYPRDFERDRH
IAEQHGVDVLFHPEAGEMYPGPLTVQVVVKARTDVLCGRSRPGHFDGVATVLTKLFHIVMPDRAYFGLKDAQQVAVVDGL
IRDFNFPIELVPVPTVREADGLAKSSRNVYLSPQEREEAPALYQALRAAAAAVDGGERSADAIRRLVKEHIEAHTHAEID
YVEVCSYPDLAPLETLHGTVLVAVAVRFASARLIDNIILELPKAHRQED

Specific function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate

COG id: COG0414

COG function: function code H; Panthothenate synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pantothenate synthetase family

Homologues:

Organism=Escherichia coli, GI1786325, Length=283, Percent_Identity=39.5759717314488, Blast_Score=211, Evalue=3e-56,
Organism=Saccharomyces cerevisiae, GI6322046, Length=310, Percent_Identity=39.0322580645161, Blast_Score=190, Evalue=2e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANC_GEOTN (A4IQ60)

Other databases:

- EMBL:   CP000557
- RefSeq:   YP_001126209.1
- ProteinModelPortal:   A4IQ60
- SMR:   A4IQ60
- STRING:   A4IQ60
- GeneID:   4967040
- GenomeReviews:   CP000557_GR
- KEGG:   gtn:GTNG_2112
- NMPDR:   fig|420246.5.peg.2019
- eggNOG:   COG0414
- HOGENOM:   HBG428839
- OMA:   RLIDNFT
- PhylomeDB:   A4IQ60
- ProtClustDB:   PRK00380
- BioCyc:   GTHE420246:GTNG_2112-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00158
- InterPro:   IPR004821
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1
- TIGRFAMs:   TIGR00125
- TIGRFAMs:   TIGR00018

Pfam domain/function: PF02569 Pantoate_ligase

EC number: =6.3.2.1

Molecular weight: Translated: 32314; Mature: 32314

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: NA

Important sites: ACT_SITE 37-37 BINDING 61-61 BINDING 61-61 BINDING 153-153 BINDING 176-176

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIVDRISEMQALMRQYHREGKTIGFVPTMGYLHEGHAALIDRARQENDIVVLSVFVNPL
CEEHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHCCHHHHHHHHCCCCCEEEEEEEECHH
QFGPNEDFARYPRDFERDRHIAEQHGVDVLFHPEAGEMYPGPLTVQVVVKARTDVLCGRS
HCCCCCCHHHCCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEEEEEHHHHHHCCCC
RPGHFDGVATVLTKLFHIVMPDRAYFGLKDAQQVAVVDGLIRDFNFPIELVPVPTVREAD
CCCCCHHHHHHHHHHHHHHCCCCHHCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCHHHC
GLAKSSRNVYLSPQEREEAPALYQALRAAAAAVDGGERSADAIRRLVKEHIEAHTHAEID
CHHHCCCCEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCC
YVEVCSYPDLAPLETLHGTVLVAVAVRFASARLIDNIILELPKAHRQED
CEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCC
>Mature Secondary Structure
MIIVDRISEMQALMRQYHREGKTIGFVPTMGYLHEGHAALIDRARQENDIVVLSVFVNPL
CEEHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHCCHHHHHHHHCCCCCEEEEEEEECHH
QFGPNEDFARYPRDFERDRHIAEQHGVDVLFHPEAGEMYPGPLTVQVVVKARTDVLCGRS
HCCCCCCHHHCCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEEEEEHHHHHHCCCC
RPGHFDGVATVLTKLFHIVMPDRAYFGLKDAQQVAVVDGLIRDFNFPIELVPVPTVREAD
CCCCCHHHHHHHHHHHHHHCCCCHHCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCHHHC
GLAKSSRNVYLSPQEREEAPALYQALRAAAAAVDGGERSADAIRRLVKEHIEAHTHAEID
CHHHCCCCEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCC
YVEVCSYPDLAPLETLHGTVLVAVAVRFASARLIDNIILELPKAHRQED
CEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA