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The map label for this gene is panB [H]

Identifier: 138895757

GI number: 138895757

Start: 2246647

End: 2247486

Strand: Reverse

Name: panB [H]

Synonym: GTNG_2113

Alternate gene names: 138895757

Gene position: 2247486-2246647 (Counterclockwise)

Preceding gene: 138895758

Following gene: 138895756

Centisome position: 63.3

GC content: 56.9

Gene sequence:

>840_bases
GTGAAGACGAAAGCCGATTTTTTCCGCATGAAGCAGGCGGACGAGCCGATCGTGATGGTGACCGCCTACGACTTTCCATC
GGCGAAGCTTGTTGAACAGGCCGGGGTGGATATGATTTTAGTCGGCGATTCGCTCGGCATGGTCGTGCTCGGTTACGACT
CGACGATCCCGGTGACGGTCGATGACATGATCCACCATACGAAGGCGGTCCGCCGTGGTGCGCCGAACACGTTTATCGTC
ACGGACATGCCGTTTATGTCGTACCACGCCTCCAAGGAAGAGGCGTTGCAAAACGCCCGGCGCATCATGCAACAGTCGGG
GGCGAACGCTGTCAAAGTCGAAGGGGCGGATGAAGTCGTTGAGACGATCGCCGCACTGACGAAAGCGGGCGTGCCGGTCG
TCGCCCATCTCGGGCTAACGCCGCAATCTGTCGGCGTCCTTGGCGGCTATAAAGTGCAAGGCAAAGATGCGGAAAGCGCA
AAAAAGCTGCTCAATGATGCGAAACAGTGCGAACAAGCAGGAGCGATCGCGCTCGTCTTAGAGTGTGTACCGAAGCAGCT
TGGGGCGGCTGTAGCCCGAGAGCTTACCATTCCTGTCATCGGCATCGGTGCCGGGGCGGAAGTCGACGGCCAGGTACTGG
TTTACCATGACTTGCTTGGCTACGGTGTCAACCGCGTGCCGAAGTTTGTCAAACAATACGCTGCCATTCAAGAGACGATC
GTCGAGGCACTGGCCAACTATATCGCTGATGTCAAACTGCGCCAGTTTCCGGAGCCGGCGCACACGTTTACGATGAAGGA
AGAAGAATGGGTGGCCTTATACGGAGGAAAACAATCATGA

Upstream 100 bases:

>100_bases
CGACGGTGGTTTATGGCGTCCTTCTTTCTCAAGGCGGGAAAGAAGGACGTTTTGTTTCGGTCGCGTCATCTCCTCTGCAA
TCAAAGAGGAGGGAACAAAG

Downstream 100 bases:

>100_bases
TCATCGTTGATCGGATTAGTGAAATGCAGGCGCTGATGCGTCAATACCACCGCGAAGGAAAAACGATCGGGTTCGTCCCG
ACAATGGGTTATTTGCATGA

Product: 3-methyl-2-oxobutanoate hydroxymethyltransferase

Products: NA

Alternate protein names: Ketopantoate hydroxymethyltransferase; KPHMT [H]

Number of amino acids: Translated: 279; Mature: 279

Protein sequence:

>279_residues
MKTKADFFRMKQADEPIVMVTAYDFPSAKLVEQAGVDMILVGDSLGMVVLGYDSTIPVTVDDMIHHTKAVRRGAPNTFIV
TDMPFMSYHASKEEALQNARRIMQQSGANAVKVEGADEVVETIAALTKAGVPVVAHLGLTPQSVGVLGGYKVQGKDAESA
KKLLNDAKQCEQAGAIALVLECVPKQLGAAVARELTIPVIGIGAGAEVDGQVLVYHDLLGYGVNRVPKFVKQYAAIQETI
VEALANYIADVKLRQFPEPAHTFTMKEEEWVALYGGKQS

Sequences:

>Translated_279_residues
MKTKADFFRMKQADEPIVMVTAYDFPSAKLVEQAGVDMILVGDSLGMVVLGYDSTIPVTVDDMIHHTKAVRRGAPNTFIV
TDMPFMSYHASKEEALQNARRIMQQSGANAVKVEGADEVVETIAALTKAGVPVVAHLGLTPQSVGVLGGYKVQGKDAESA
KKLLNDAKQCEQAGAIALVLECVPKQLGAAVARELTIPVIGIGAGAEVDGQVLVYHDLLGYGVNRVPKFVKQYAAIQETI
VEALANYIADVKLRQFPEPAHTFTMKEEEWVALYGGKQS
>Mature_279_residues
MKTKADFFRMKQADEPIVMVTAYDFPSAKLVEQAGVDMILVGDSLGMVVLGYDSTIPVTVDDMIHHTKAVRRGAPNTFIV
TDMPFMSYHASKEEALQNARRIMQQSGANAVKVEGADEVVETIAALTKAGVPVVAHLGLTPQSVGVLGGYKVQGKDAESA
KKLLNDAKQCEQAGAIALVLECVPKQLGAAVARELTIPVIGIGAGAEVDGQVLVYHDLLGYGVNRVPKFVKQYAAIQETI
VEALANYIADVKLRQFPEPAHTFTMKEEEWVALYGGKQS

Specific function: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate [H]

COG id: COG0413

COG function: function code H; Ketopantoate hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the panB family [H]

Homologues:

Organism=Escherichia coli, GI1786326, Length=255, Percent_Identity=50.1960784313725, Blast_Score=251, Evalue=4e-68,
Organism=Saccharomyces cerevisiae, GI6319653, Length=263, Percent_Identity=42.5855513307985, Blast_Score=211, Evalue=1e-55,

Paralogues:

None

Copy number: 1080 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003700
- InterPro:   IPR015813 [H]

Pfam domain/function: PF02548 Pantoate_transf [H]

EC number: =2.1.2.11 [H]

Molecular weight: Translated: 30029; Mature: 30029

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTKADFFRMKQADEPIVMVTAYDFPSAKLVEQAGVDMILVGDSLGMVVLGYDSTIPVTV
CCCHHHHHHHHCCCCCEEEEEECCCCCHHHHHHCCCCEEEECCCCCEEEEECCCCCCEEH
DDMIHHTKAVRRGAPNTFIVTDMPFMSYHASKEEALQNARRIMQQSGANAVKVEGADEVV
HHHHHHHHHHHCCCCCEEEEECCCHHHHCCCHHHHHHHHHHHHHHCCCCEEEECCHHHHH
ETIAALTKAGVPVVAHLGLTPQSVGVLGGYKVQGKDAESAKKLLNDAKQCEQAGAIALVL
HHHHHHHHCCCCEEEECCCCHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHHCHHHHHH
ECVPKQLGAAVARELTIPVIGIGAGAEVDGQVLVYHDLLGYGVNRVPKFVKQYAAIQETI
HHHHHHHHHHHHHHHCCEEEEECCCCCCCCCEEEEHHHHHCCHHHHHHHHHHHHHHHHHH
VEALANYIADVKLRQFPEPAHTFTMKEEEWVALYGGKQS
HHHHHHHHHHHHHHCCCCCHHEEEECCCCEEEEECCCCC
>Mature Secondary Structure
MKTKADFFRMKQADEPIVMVTAYDFPSAKLVEQAGVDMILVGDSLGMVVLGYDSTIPVTV
CCCHHHHHHHHCCCCCEEEEEECCCCCHHHHHHCCCCEEEECCCCCEEEEECCCCCCEEH
DDMIHHTKAVRRGAPNTFIVTDMPFMSYHASKEEALQNARRIMQQSGANAVKVEGADEVV
HHHHHHHHHHHCCCCCEEEEECCCHHHHCCCHHHHHHHHHHHHHHCCCCEEEECCHHHHH
ETIAALTKAGVPVVAHLGLTPQSVGVLGGYKVQGKDAESAKKLLNDAKQCEQAGAIALVL
HHHHHHHHCCCCEEEECCCCHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHHCHHHHHH
ECVPKQLGAAVARELTIPVIGIGAGAEVDGQVLVYHDLLGYGVNRVPKFVKQYAAIQETI
HHHHHHHHHHHHHHHCCEEEEECCCCCCCCCEEEEHHHHHCCHHHHHHHHHHHHHHHHHH
VEALANYIADVKLRQFPEPAHTFTMKEEEWVALYGGKQS
HHHHHHHHHHHHHHCCCCCHHEEEECCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA